| URN | urn:agi-llid:83999 |
|---|---|
| Total Entities | 0 |
| Connectivity | 24 |
| Name | Kremen1 |
| Description | kringle containing transmembrane protein 1 |
| Notes | This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. |
| Ariadne Ontology | DKK |
|---|---|
| Secreted proteins |
| GO Cellular Component | membrane |
|---|---|
| integral to membrane |
| GO Biological Process | cell communication |
|---|---|
| regulation of canonical Wnt receptor signaling pathway | |
| Wnt receptor signaling pathway | |
| nervous system development | |
| muscle organ development |
| Pathway | Wnt signaling, canonical pathway |
|---|---|
| altered Wnt signaling, canonical pathway | |
| canonical Wnt signaling pathway | |
| Wnt signaling, canonical pathway |
| Group | DKK |
|---|---|
| cell communication | |
| regulation of canonical Wnt receptor signaling pathway | |
| Wnt receptor signaling pathway | |
| nervous system development | |
| muscle organ development | |
| membrane | |
| integral to membrane | |
| Secreted proteins |
| MedScan ID | 83999 |
|---|
| Hugo ID | 17550 |
|---|
| Human chromosome position | 22q12.1 |
|---|
| LocusLink ID | 83999 |
|---|---|
| 84035 | |
| 114107 |
| Alias | KRM1 |
|---|---|
| KREMEN | |
| CTA-57G9.2 | |
| kremen protein 1 | |
| dickkopf receptor | |
| kringle-coding gene marking the eye and the nose | |
| kringle domain-containing transmembrane protein 1 | |
| kringle-containing protein marking the eye and the nose | |
| AV002070 | |
| RP23-293J16.1 | |
| kringle-containing transmembrane protein 1 isoform 1 | |
| kringle-containing transmembrane protein 1 isoform 2 | |
| KRM I | |
| OTTHUMP00000028977 | |
| OTTMUSP00000005299 | |
| KREMEN1 | |
| OTTHUMP00000198939 | |
| KREMEM1 | |
| kringle containing transmembrane protein 1 | |
| FLJ31863 | |
| KREMEN I | |
| kringle containing transmembrane protein | |
| kringle containing transmembrane protein I | |
| kringle-containing transmembrane protein 1 | |
| kringle-containing transmembrane protein 1 isoform 2 precursor | |
| kringle-containing transmembrane protein 1 isoform 1 precursor | |
| expressed sequence AV002070 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 609898 |
|---|
| Unigene ID | Hs.229335 |
|---|---|
| Mm.209989 | |
| Rn.90021 |
| KEGG ID | hsa:83999 |
|---|---|
| mmu:84035 | |
| rno:114107 |
| Swiss-Prot Accession | Q96MU8 |
|---|---|
| Q99N43 | |
| Q924S4 | |
| B0QY46 | |
| B0QY47 | |
| B1AJR5 | |
| Q5TIB9 | |
| Q6P3X6 | |
| Q9BY70 | |
| Q9UGS5 | |
| Q9UGU1 | |
| Q640Q6 | |
| Q8BNJ0 |
| GO ID | 0016055 |
|---|---|
| 0007154 | |
| 0060828 | |
| 0016021 | |
| 0016020 | |
| 0007517 | |
| 0007399 | |
| 0005624 | |
| 0003674 | |
| 0008150 |
| Swiss-Prot ID | KREM1_RAT |
|---|---|
| KREM1_HUMAN | |
| KREM1_MOUSE | |
| Q640Q6_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Extracellular |
| IPI ID | IPI00205075 |
|---|---|
| IPI00140177 | |
| IPI00218929 | |
| IPI00651704 | |
| IPI00118065 | |
| IPI00471172 | |
| IPI00441871 | |
| IPI00900300 | |
| IPI00878720 |
| Mouse chromosome position | 11 |
|---|---|
| 11 A1 |
| Rat chromosome position | 14q21 |
|---|
| Homologene ID | 12935 |
|---|
| MGI ID | 1933988 |
|---|
| RGD ID | 620789 |
|---|
| Primary Cell Localization | Extracellular |
|---|