| URN | urn:agi-llid:55366 |
|---|---|
| Total Entities | 0 |
| Connectivity | 57 |
| Name | Lgr4 |
| Description | leucine-rich repeat-containing G protein-coupled receptor 4 |
| Notes | G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[supplied by OMIM] |
| Ariadne Ontology | GPCR-Other |
|---|---|
| Secreted proteins |
| GO Molecular Function | G-protein coupled receptor activity |
|---|---|
| protein-hormone receptor activity | |
| signal transducer activity |
| GO Cellular Component | membrane |
|---|---|
| integral to membrane | |
| plasma membrane |
| GO Biological Process | canonical Wnt receptor signaling pathway involved in metanephric kidney development |
|---|---|
| signal transduction | |
| G-protein coupled receptor signaling pathway | |
| positive regulation of transcription, DNA-dependent | |
| negative regulation of transcription, DNA-dependent | |
| cell differentiation involved in metanephros development | |
| epithelial cell proliferation | |
| positive regulation of branching involved in ureteric bud morphogenesis | |
| male genitalia development | |
| metanephric nephron tubule morphogenesis | |
| metanephric glomerulus development | |
| tube morphogenesis |
| Pathway | Wnt signaling, canonical pathway |
|---|---|
| altered Wnt signaling, canonical pathway | |
| Wnt signaling, canonical pathway |
| Group | GPCR-Other |
|---|---|
| canonical Wnt receptor signaling pathway involved in metanephric kidney development | |
| signal transduction | |
| G-protein coupled receptor signaling pathway | |
| positive regulation of transcription, DNA-dependent | |
| negative regulation of transcription, DNA-dependent | |
| cell differentiation involved in metanephros development | |
| epithelial cell proliferation | |
| positive regulation of branching involved in ureteric bud morphogenesis | |
| male genitalia development | |
| metanephric nephron tubule morphogenesis | |
| metanephric glomerulus development | |
| tube morphogenesis | |
| G-protein coupled receptor activity | |
| protein-hormone receptor activity | |
| signal transducer activity | |
| membrane | |
| integral to membrane | |
| plasma membrane | |
| Secreted proteins |
| MedScan ID | 55366 |
|---|
| Hugo ID | 13299 |
|---|
| Human chromosome position | 11p14-p13 |
|---|
| LocusLink ID | 55366 |
|---|---|
| 107515 | |
| 286994 |
| Alias | GPR48 |
|---|---|
| leucine-rich repeat-containing G-protein coupled receptor 4 | |
| G protein-coupled receptor 48 | |
| 9130225G07 | |
| A330106J01Rik | |
| A930009A08Rik | |
| RP23-431J22.1 | |
| G-protein coupled receptor 48 | |
| G protein-coupled receptor GPR48 | |
| Leucine-rich repeat-containing G-coupled receptor IV | |
| LOC295991 | |
| LOC639127 | |
| LOC669588 | |
| OTTHUMP00000164775 | |
| OTTMUSP00000016116 | |
| toll-like receptor Tlr2.1 (Strongylocentrotus purpuratus) | |
| leucine-rich repeat-containing G protein-coupled receptor 4 | |
| A930009A08 | |
| A330106J01 | |
| LGR4 | |
| G-protein-coupled receptor 48 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 606666 |
|---|---|
| 181500 |
| Unigene ID | Hs.502176 |
|---|---|
| Mm.277351 | |
| Mm.485992 | |
| Rn.162671 | |
| Mm.480092 |
| KEGG ID | hsa:55366 |
|---|---|
| mmu:107515 | |
| rno:286994 |
| Swiss-Prot Accession | Q59ER8 |
|---|---|
| Q9BXB1 | |
| A2ARI4 | |
| Q8BZR7 | |
| Q9Z2H4 | |
| A6NCH3 | |
| Q9NYD1 | |
| Q6PHA3 | |
| Q80T31 | |
| Q8BXS9 | |
| Q8N537 |
| GO ID | 0004930 |
|---|---|
| 0016500 | |
| 0061290 | |
| 0072202 | |
| 0050673 | |
| 0030539 | |
| 0072224 | |
| 0072282 | |
| 0045892 | |
| 0090190 | |
| 0045893 | |
| 0016021 | |
| 0005886 | |
| 0004871 | |
| 0007186 | |
| 0007165 | |
| 0035239 | |
| 0016020 | |
| 0004872 |
| Swiss-Prot ID | LGR4_RAT |
|---|---|
| LGR4_HUMAN | |
| LGR4_MOUSE | |
| Q59ER8_HUMAN | |
| Q8BZR7_MOUSE |
| Cell Localization | Cell membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00339207 |
|---|---|
| IPI00217954 | |
| IPI00753252 | |
| IPI00667018 | |
| IPI00798136 |
| Mouse chromosome position | 2 |
|---|
| Rat chromosome position | 3q33 |
|---|
| Homologene ID | 10226 |
|---|
| MGI ID | 1891468 |
|---|
| RGD ID | 628615 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|