| URN | urn:agi-llid:1499 |
|---|---|
| Connectivity | 1798 |
| Name | Ctnnb1 |
| Description | catenin (cadherin associated protein), beta 1 |
| Notes | involved in mediating the interaction between cadherins and the actin cytoskeleton [RGD] |
| Pathway | InsulinR -> CTNNB/FOXA/FOXO signaling |
|---|---|
| FibronectinR -> CTNNB signaling | |
| Sialophorin -> CTNNB/MYC/TP53 signaling | |
| ICAM2 -> CTNNB/FOXO/STAT3 signaling | |
| PECAM -> CTNNB1 signaling | |
| EGFR/ERBB2 -> CTNNB signaling | |
| VEGFR -> CTNNB signaling | |
| FrizzledR -> CTNNB signaling | |
| PTPRF -> CTNNB signaling | |
| PTPRU -> CTNNB signaling | |
| canonical Wnt signaling pathway | |
| colorectal cancer pathway | |
| canonical Wnt signaling pathway | |
| endometrial cancer pathway | |
| Wnt signaling, canonical pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| chromatin binding | |
| transcription activator activity | |
| transcription factor activity | |
| alpha-catenin binding | |
| transcription factor binding | |
| protein C-terminus binding | |
| protein complex binding | |
| transcription repressor binding | |
| SMAD binding | |
| enzyme binding | |
| DNA binding | |
| I-SMAD binding | |
| cadherin binding | |
| kinase binding | |
| nuclear hormone receptor binding | |
| ionotropic glutamate receptor binding | |
| androgen receptor binding | |
| protein phosphatase binding | |
| transcription coactivator activity | |
| promoter binding | |
| double-stranded DNA binding |
| GO Cellular Component | synapse |
|---|---|
| protein complex | |
| protein-DNA complex | |
| apical part of cell | |
| membrane | |
| plasma membrane | |
| neuron projection | |
| lamellipodium | |
| cytoplasm | |
| cell projection membrane | |
| dendritic shaft | |
| Axin-APC-beta-catenin-GSK3B complex | |
| perinuclear region of cytoplasm | |
| cytosol | |
| beta-catenin destruction complex | |
| Z disc | |
| centrosome | |
| beta-catenin-TCF7L2 complex | |
| transcription factor complex | |
| cytoskeleton | |
| nucleus | |
| membrane fraction | |
| basolateral plasma membrane | |
| cell junction | |
| lateral plasma membrane | |
| cell-cell junction | |
| catenin complex | |
| microvillus membrane | |
| apical junction complex | |
| cell-cell adherens junction | |
| adherens junction | |
| fascia adherens |
| GO Biological Process | cell proliferation |
|---|---|
| cellular process | |
| cell adhesion | |
| negative regulation of cell proliferation | |
| regulation of cell proliferation | |
| positive regulation of cell proliferation | |
| cell maturation | |
| positive regulation of branching involved in lung morphogenesis | |
| forebrain development | |
| organ development | |
| renal outer medulla development | |
| renal inner medulla development | |
| regulation of cell differentiation | |
| hair follicle morphogenesis | |
| patterning of blood vessels | |
| negative regulation of cell differentiation | |
| cell differentiation | |
| cell fate determination | |
| cell fate specification | |
| epithelial cell differentiation involved in prostate gland development | |
| genitalia morphogenesis | |
| renal vesicle formation | |
| regulation of osteoblast differentiation | |
| positive regulation of osteoblast differentiation | |
| endoderm formation | |
| trachea formation | |
| hair follicle placode formation | |
| regulation of angiogenesis | |
| lung induction | |
| nephron tubule formation | |
| proximal-distal pattern formation | |
| dorsal-ventral pattern formation | |
| anterior-posterior axis specification | |
| dorsal-ventral axis specification | |
| ectoderm development | |
| skeletal system development | |
| renal system development | |
| midgut development | |
| embryonic heart tube development | |
| pancreas development | |
| kidney development | |
| lung development | |
| heart development | |
| liver development | |
| thymus development | |
| hemopoiesis | |
| lung-associated mesenchyme development | |
| negative regulation of chondrocyte differentiation | |
| myoblast differentiation | |
| smooth muscle cell differentiation | |
| lung cell differentiation | |
| vasculogenesis | |
| glial cell fate determination | |
| cell morphogenesis involved in differentiation | |
| epithelial to mesenchymal transition | |
| mesenchymal to epithelial transition involved in metanephros morphogenesis | |
| regulation of epithelial cell differentiation | |
| central nervous system vasculogenesis | |
| positive regulation of epithelial cell differentiation | |
| positive regulation of endothelial cell differentiation | |
| negative regulation of osteoclast differentiation | |
| T cell differentiation | |
| osteoclast differentiation | |
| T cell differentiation in the thymus | |
| regulation of osteoclast differentiation | |
| endodermal cell fate commitment | |
| morphogenesis of embryonic epithelium | |
| embryonic digit morphogenesis | |
| embryonic foregut morphogenesis | |
| trachea morphogenesis | |
| branching involved in ureteric bud morphogenesis | |
| epithelial tube branching involved in lung morphogenesis | |
| gastrulation with mouth forming second | |
| embryonic hindlimb morphogenesis | |
| embryonic arm morphogenesis | |
| metanephros morphogenesis | |
| camera-type eye morphogenesis | |
| odontogenesis of dentine-containing tooth | |
| positive regulation of epithelial cell proliferation involved in prostate gland development | |
| in utero embryonic development | |
| hair cycle process | |
| synaptic vesicle transport | |
| cell-cell adhesion | |
| synapse organization | |
| regulation of centriole-centriole cohesion | |
| synaptic transmission | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of MAPKKK cascade | |
| positive regulation of fibroblast growth factor receptor signaling pathway | |
| regulation of fibroblast proliferation | |
| regulation of transcription | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| positive regulation of heparan sulfate proteoglycan biosynthetic process | |
| positive regulation of transcription | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| positive regulation of transcription factor activity | |
| regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of mesenchymal cell proliferation | |
| regulation of T cell proliferation | |
| positive regulation of apoptosis | |
| regulation of apoptosis | |
| cell-matrix adhesion | |
| transcription | |
| cellular response to growth factor stimulus | |
| cellular response to indole-3-methanol | |
| apoptosis | |
| cellular protein localization | |
| Schwann cell proliferation | |
| mesenchymal cell proliferation involved in lung development | |
| response to drug | |
| response to hormone stimulus | |
| response to organic cyclic substance | |
| response to cytokine stimulus | |
| response to cadmium ion | |
| response to estrogen stimulus | |
| positive regulation of gene expression | |
| protein heterooligomerization | |
| Wnt receptor signaling pathway | |
| Wnt receptor signaling pathway through beta-catenin | |
| androgen receptor signaling pathway | |
| bone resorption |
| Ariadne Ontology | Adherens junction assembly |
|---|---|
| CTNNB1 |
| Group | Adherens junction assembly |
|---|---|
| CTNNB1 | |
| synapse | |
| cell proliferation | |
| cellular process | |
| cell adhesion | |
| negative regulation of cell proliferation | |
| regulation of cell proliferation | |
| positive regulation of cell proliferation | |
| cell maturation | |
| positive regulation of branching involved in lung morphogenesis | |
| forebrain development | |
| organ development | |
| renal outer medulla development | |
| renal inner medulla development | |
| regulation of cell differentiation | |
| hair follicle morphogenesis | |
| patterning of blood vessels | |
| negative regulation of cell differentiation | |
| cell differentiation | |
| cell fate determination | |
| cell fate specification | |
| epithelial cell differentiation involved in prostate gland development | |
| genitalia morphogenesis | |
| renal vesicle formation | |
| regulation of osteoblast differentiation | |
| positive regulation of osteoblast differentiation | |
| endoderm formation | |
| trachea formation | |
| hair follicle placode formation | |
| regulation of angiogenesis | |
| lung induction | |
| nephron tubule formation | |
| proximal-distal pattern formation | |
| dorsal-ventral pattern formation | |
| anterior-posterior axis specification | |
| dorsal-ventral axis specification | |
| ectoderm development | |
| skeletal system development | |
| renal system development | |
| midgut development | |
| embryonic heart tube development | |
| pancreas development | |
| kidney development | |
| lung development | |
| heart development | |
| liver development | |
| thymus development | |
| hemopoiesis | |
| lung-associated mesenchyme development | |
| negative regulation of chondrocyte differentiation | |
| myoblast differentiation | |
| smooth muscle cell differentiation | |
| lung cell differentiation | |
| vasculogenesis | |
| glial cell fate determination | |
| cell morphogenesis involved in differentiation | |
| epithelial to mesenchymal transition | |
| mesenchymal to epithelial transition involved in metanephros morphogenesis | |
| regulation of epithelial cell differentiation | |
| central nervous system vasculogenesis | |
| positive regulation of epithelial cell differentiation | |
| positive regulation of endothelial cell differentiation | |
| negative regulation of osteoclast differentiation | |
| T cell differentiation | |
| osteoclast differentiation | |
| T cell differentiation in the thymus | |
| regulation of osteoclast differentiation | |
| endodermal cell fate commitment | |
| morphogenesis of embryonic epithelium | |
| embryonic digit morphogenesis | |
| embryonic foregut morphogenesis | |
| trachea morphogenesis | |
| branching involved in ureteric bud morphogenesis | |
| epithelial tube branching involved in lung morphogenesis | |
| gastrulation with mouth forming second | |
| embryonic hindlimb morphogenesis | |
| embryonic arm morphogenesis | |
| metanephros morphogenesis | |
| camera-type eye morphogenesis | |
| odontogenesis of dentine-containing tooth | |
| positive regulation of epithelial cell proliferation involved in prostate gland development | |
| in utero embryonic development | |
| hair cycle process | |
| synaptic vesicle transport | |
| cell-cell adhesion | |
| synapse organization | |
| regulation of centriole-centriole cohesion | |
| synaptic transmission | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of MAPKKK cascade | |
| positive regulation of fibroblast growth factor receptor signaling pathway | |
| regulation of fibroblast proliferation | |
| regulation of transcription | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| positive regulation of heparan sulfate proteoglycan biosynthetic process | |
| positive regulation of transcription | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| positive regulation of transcription factor activity | |
| regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of mesenchymal cell proliferation | |
| regulation of T cell proliferation | |
| positive regulation of apoptosis | |
| regulation of apoptosis | |
| cell-matrix adhesion | |
| transcription | |
| cellular response to growth factor stimulus | |
| cellular response to indole-3-methanol | |
| apoptosis | |
| cellular protein localization | |
| Schwann cell proliferation | |
| mesenchymal cell proliferation involved in lung development | |
| response to drug | |
| response to hormone stimulus | |
| response to organic cyclic substance | |
| response to cytokine stimulus | |
| response to cadmium ion | |
| response to estrogen stimulus | |
| positive regulation of gene expression | |
| protein heterooligomerization | |
| Wnt receptor signaling pathway | |
| Wnt receptor signaling pathway through beta-catenin | |
| androgen receptor signaling pathway | |
| bone resorption | |
| signal transducer activity | |
| chromatin binding | |
| transcription activator activity | |
| transcription factor activity | |
| alpha-catenin binding | |
| transcription factor binding | |
| protein C-terminus binding | |
| protein complex binding | |
| transcription repressor binding | |
| SMAD binding | |
| enzyme binding | |
| DNA binding | |
| I-SMAD binding | |
| cadherin binding | |
| kinase binding | |
| nuclear hormone receptor binding | |
| ionotropic glutamate receptor binding | |
| androgen receptor binding | |
| protein phosphatase binding | |
| transcription coactivator activity | |
| promoter binding | |
| double-stranded DNA binding | |
| protein complex | |
| protein-DNA complex | |
| apical part of cell | |
| membrane | |
| plasma membrane | |
| neuron projection | |
| lamellipodium | |
| cytoplasm | |
| cell projection membrane | |
| dendritic shaft | |
| Axin-APC-beta-catenin-GSK3B complex | |
| perinuclear region of cytoplasm | |
| cytosol | |
| beta-catenin destruction complex | |
| Z disc | |
| centrosome | |
| beta-catenin-TCF7L2 complex | |
| transcription factor complex | |
| cytoskeleton | |
| nucleus | |
| membrane fraction | |
| basolateral plasma membrane | |
| cell junction | |
| lateral plasma membrane | |
| cell-cell junction | |
| catenin complex | |
| microvillus membrane | |
| apical junction complex | |
| cell-cell adherens junction | |
| adherens junction | |
| fascia adherens |
| MedScan ID | 1499 |
|---|
| Hugo ID | 2514 |
|---|
| Human chromosome position | 3p21 |
|---|
| LocusLink ID | 1499 |
|---|---|
| 12387 | |
| 84353 | |
| 360543 | |
| 252926 | |
| 209012 |
| Alias | CTNNB |
|---|---|
| FLJ25606 | |
| FLJ37923 | |
| DKFZp686D02253 | |
| OK/SW-cl.35 | |
| catenin beta-1 | |
| OTTHUMP00000209289 | |
| Mesc | |
| Catnb | |
| beta-catenin | |
| OTTMUSP00000017750 | |
| catenin beta | |
| catenin (cadherin associated protein), beta 1, 88kDa | |
| 88 kDa catenin (cadherin-associated protein), beta 1 | |
| 88 kDa catenin (cadherin-associated protein), beta I | |
| b-catenin | |
| beta 1 catenin | |
| beta catenin | |
| Beta-cat | |
| cadherin-associated protein beta 1 | |
| catenin (cadherin associated protein), beta 1 | |
| catenin (cadherin associated protein), beta I | |
| catenin beta I | |
| CTNB | |
| CTNB_HUMAN | |
| CTNNB I | |
| CTNNB1 | |
| eta-catenin | |
| LOC316084 | |
| OTTHUMP00000165222 | |
| OTTHUMP00000165223 | |
| catenin (cadherin-associated protein), beta 1, 88kDa | |
| catenin (cadherin-associated protein), beta 1 (88kD) | |
| cadherin associated protein | |
| catenin (cadherin-associated protein), beta 1 | |
| Ctnnb1s | |
| catenin (cadherin-associated protein), beta I | |
| catenin beta 1 | |
| Postsynaptic density protein PSD-93 | |
| catenin (cadherin-associated protein), beta 1 (88kDa | |
| Ctnnb Is |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 116806 |
|---|---|
| 114550 | |
| 155255 | |
| 167000 | |
| 132600 |
| Mouse chromosome position | 9 72.0 cM |
|---|
| GO ID | 0070411 |
|---|---|
| 0046332 | |
| 0045294 | |
| 0050681 | |
| 0045296 | |
| 0003682 | |
| 0003690 | |
| 0019899 | |
| 0019900 | |
| 0035257 | |
| 0010843 | |
| 0008022 | |
| 0032403 | |
| 0019903 | |
| 0004871 | |
| 0003713 | |
| 0003700 | |
| 0008134 | |
| 0070491 | |
| 0014010 | |
| 0033077 | |
| 0016055 | |
| 0060070 | |
| 0030521 | |
| 0009948 | |
| 0045453 | |
| 0048593 | |
| 0001708 | |
| 0048469 | |
| 0016337 | |
| 0007160 | |
| 0034613 | |
| 0071363 | |
| 0071681 | |
| 0009950 | |
| 0007398 | |
| 0035117 | |
| 0042733 | |
| 0048617 | |
| 0035050 | |
| 0035116 | |
| 0001711 | |
| 0060742 | |
| 0001837 | |
| 0060441 | |
| 0030900 | |
| 0001702 | |
| 0007403 | |
| 0030097 | |
| 0001701 | |
| 0001889 | |
| 0060492 | |
| 0060916 | |
| 0007494 | |
| 0016331 | |
| 0045445 | |
| 0008285 | |
| 0032331 | |
| 0045671 | |
| 0000122 | |
| 0042475 | |
| 0031016 | |
| 0001569 | |
| 0043410 | |
| 0043065 | |
| 0045603 | |
| 0060769 | |
| 0045743 | |
| 0010552 | |
| 0010909 | |
| 0002053 | |
| 0045669 | |
| 0045941 | |
| 0051291 | |
| 0009954 | |
| 0042129 | |
| 0045765 | |
| 0030997 | |
| 0048145 | |
| 0046686 | |
| 0034097 | |
| 0042493 | |
| 0043627 | |
| 0009725 | |
| 0014070 | |
| 0001501 | |
| 0050808 | |
| 0007268 | |
| 0048489 | |
| 0048538 | |
| 0060439 | |
| 0001570 | |
| 0034747 | |
| 0030018 | |
| 0005912 | |
| 0043296 | |
| 0045177 | |
| 0016323 | |
| 0070369 | |
| 0016342 | |
| 0005913 | |
| 0005911 | |
| 0005813 | |
| 0005737 | |
| 0005856 | |
| 0005829 | |
| 0043198 | |
| 0005916 | |
| 0030027 | |
| 0016328 | |
| 0005624 | |
| 0031528 | |
| 0043005 | |
| 0005634 | |
| 0048471 | |
| 0005886 | |
| 0032993 | |
| 0045202 | |
| 0005667 | |
| 0003677 | |
| 0016563 | |
| 0030217 | |
| 0006915 | |
| 0001658 | |
| 0007155 | |
| 0030154 | |
| 0001709 | |
| 0000904 | |
| 0008283 | |
| 0009987 | |
| 0022009 | |
| 0009953 | |
| 0001706 | |
| 0035112 | |
| 0022405 | |
| 0031069 | |
| 0060789 | |
| 0007507 | |
| 0001822 | |
| 0060479 | |
| 0030324 | |
| 0060484 | |
| 0003337 | |
| 0003338 | |
| 0045596 | |
| 0045892 | |
| 0072079 | |
| 0048513 | |
| 0030316 | |
| 0043123 | |
| 0061047 | |
| 0008284 | |
| 0030858 | |
| 0010628 | |
| 0045944 | |
| 0045893 | |
| 0042981 | |
| 0045595 | |
| 0042127 | |
| 0030856 | |
| 0010551 | |
| 0045667 | |
| 0045670 | |
| 0045449 | |
| 0006355 | |
| 0072053 | |
| 0072054 | |
| 0072001 | |
| 0072033 | |
| 0051145 | |
| 0060440 | |
| 0006350 | |
| 0030054 | |
| 0031253 | |
| 0016020 | |
| 0043234 | |
| 0035255 | |
| 0030877 | |
| 0051091 | |
| 0042301 | |
| 0005488 | |
| 0005515 | |
| 0005198 | |
| 0016301 | |
| 0005524 | |
| 0006357 | |
| 0016740 | |
| 0008013 | |
| 0050875 | |
| 0010003 | |
| 0048595 | |
| 0000166 |
| Rat chromosome position | 8q32 |
|---|
| Swiss-Prot Accession | P35222 |
|---|---|
| Q02248 | |
| Q3UZT7 | |
| Q80VE7 | |
| Q9WU82 | |
| A8K1L7 | |
| Q8NEW9 | |
| Q8NI94 | |
| Q9H391 | |
| Q922W1 | |
| Q9D335 |
| PIR ID | A38973 |
|---|---|
| S35091 |
| Unigene ID | Hs.476018 |
|---|---|
| Mm.291928 | |
| Rn.112601 | |
| Mm.387252 | |
| Mm.358836 | |
| Mm.371804 |
| KEGG ID | hsa:1499 |
|---|---|
| mmu:12387 | |
| rno:84353 |
| Swiss-Prot ID | CTNB1_RAT |
|---|---|
| CTNB1_HUMAN | |
| CTNB1_MOUSE | |
| A8K1L7_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| cytoskeleton | |
| Nucleus | |
| Cell junction | |
| adherens junction | |
| Plasma membrane |
| IPI ID | IPI00325912 |
|---|---|
| IPI00017292 | |
| IPI00792321 | |
| IPI00125899 | |
| IPI00219893 | |
| IPI00903028 | |
| IPI00788993 | |
| IPI00753025 | |
| IPI00754516 | |
| IPI00753627 |
| Homologene ID | 1434 |
|---|
| RGD ID | 70487 |
|---|---|
| 620703 |
| MGI ID | 88276 |
|---|---|
| 1921622 |
| Source | Curated |
|---|
| LocatorString | pmquery:regulation+of+canonical+Wnt+pathway |
|---|