| URN | urn:agi-llid:2932 |
|---|---|
| Connectivity | 1095 |
| Name | Gsk3b |
| Description | glycogen synthase kinase 3 beta |
| Notes | mediates Par6-atypical protein kinase C (aPKC) complex regulation of cell polarity; may induce apoptosis [RGD] |
| Pathway | NTRK -> FOXO/MYCN signaling |
|---|---|
| GDNF -> HSF1 signaling | |
| InsulinR -> CTNNB/FOXA/FOXO signaling | |
| InsulinR -> ELK-SRF/SREBF signaling | |
| FibronectinR -> CTNNB signaling | |
| ICAM2 -> CTNNB/FOXO/STAT3 signaling | |
| MacrophageR -> CEBPB/NF-kB signaling | |
| VEGFR -> CTNNB signaling | |
| IL12R -> NF-kB/NFATC signaling | |
| IL15R -> NF-kB/NFATC signaling | |
| TNFRSF5/13B -> NFATC1 signaling | |
| FrizzledR -> CTNNB signaling | |
| canonical Wnt signaling pathway | |
| integrin mediated signaling pathway | |
| altered canonical Wnt signaling pathway | |
| integrin mediated signaling pathway | |
| canonical Wnt signaling pathway | |
| altered canonical Wnt signaling pathway | |
| integrin mediated signaling pathway | |
| Wnt signaling, canonical pathway | |
| altered Wnt signaling, canonical pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| beta-catenin binding | |
| p53 binding | |
| tau protein binding | |
| NF-kappaB binding | |
| integrin binding | |
| protein kinase A catalytic subunit binding | |
| ionotropic glutamate receptor binding | |
| protein kinase binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| tau-protein kinase activity | |
| protein serine-threonine kinase activity | |
| glycogen synthase kinase 3 activity |
| GO Cellular Component | protein complex |
|---|---|
| membrane-bounded organelle | |
| soluble fraction | |
| neuronal cell body | |
| growth cone | |
| cytoplasm | |
| dendritic spine | |
| dendritic shaft | |
| membrane raft | |
| Axin-APC-beta-catenin-GSK3B complex | |
| cytosol | |
| beta-catenin destruction complex | |
| nucleoplasm | |
| nucleus |
| GO Biological Process | cell proliferation |
|---|---|
| establishment or maintenance of cell polarity | |
| response to stress | |
| organ morphogenesis | |
| negative regulation of dendrite morphogenesis | |
| fat cell differentiation | |
| regulation of neuronal synaptic plasticity | |
| establishment of cell polarity | |
| re-entry into mitotic cell cycle | |
| negative regulation of MAP kinase activity | |
| negative regulation of transcription, DNA-dependent | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of peptidyl-threonine phosphorylation | |
| induction of apoptosis | |
| negative regulation of apoptosis | |
| anti-apoptosis | |
| positive regulation of protein export from nucleus | |
| cell migration | |
| glycogen metabolic process | |
| protein amino acid phosphorylation | |
| peptidyl-serine phosphorylation | |
| phosphorylation | |
| ER overload response | |
| response to drug | |
| response to lithium ion | |
| positive regulation of protein complex assembly | |
| protein export from nucleus | |
| intracellular signaling pathway | |
| Wnt receptor signaling pathway | |
| Wnt receptor signaling pathway through beta-catenin |
| Ariadne Ontology | GSK3 |
|---|
| Group | GSK3 |
|---|---|
| cell proliferation | |
| establishment or maintenance of cell polarity | |
| response to stress | |
| organ morphogenesis | |
| negative regulation of dendrite morphogenesis | |
| fat cell differentiation | |
| regulation of neuronal synaptic plasticity | |
| establishment of cell polarity | |
| re-entry into mitotic cell cycle | |
| negative regulation of MAP kinase activity | |
| negative regulation of transcription, DNA-dependent | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of peptidyl-threonine phosphorylation | |
| induction of apoptosis | |
| negative regulation of apoptosis | |
| anti-apoptosis | |
| positive regulation of protein export from nucleus | |
| cell migration | |
| glycogen metabolic process | |
| protein amino acid phosphorylation | |
| peptidyl-serine phosphorylation | |
| phosphorylation | |
| ER overload response | |
| response to drug | |
| response to lithium ion | |
| positive regulation of protein complex assembly | |
| protein export from nucleus | |
| intracellular signaling pathway | |
| Wnt receptor signaling pathway | |
| Wnt receptor signaling pathway through beta-catenin | |
| nucleotide binding | |
| transferase activity | |
| beta-catenin binding | |
| p53 binding | |
| tau protein binding | |
| NF-kappaB binding | |
| integrin binding | |
| protein kinase A catalytic subunit binding | |
| ionotropic glutamate receptor binding | |
| protein kinase binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| tau-protein kinase activity | |
| protein serine-threonine kinase activity | |
| glycogen synthase kinase 3 activity | |
| protein complex | |
| membrane-bounded organelle | |
| soluble fraction | |
| neuronal cell body | |
| growth cone | |
| cytoplasm | |
| dendritic spine | |
| dendritic shaft | |
| membrane raft | |
| Axin-APC-beta-catenin-GSK3B complex | |
| cytosol | |
| beta-catenin destruction complex | |
| nucleoplasm | |
| nucleus |
| MedScan ID | 2932 |
|---|
| Hugo ID | 4617 |
|---|
| Human chromosome position | 3q13.3 |
|---|
| LocusLink ID | 2932 |
|---|---|
| 56637 | |
| 84027 | |
| 56493 | |
| 78144 | |
| 98033 | |
| 66806 |
| Alias | glycogen synthase kinase-3 beta |
|---|---|
| GSK-3 beta | |
| GSK3beta isoform | |
| GSK3 | |
| GSK-3 | |
| C86142 | |
| GSK-3beta | |
| 7330414F15Rik | |
| 8430431H08Rik | |
| OTTMUSP00000017445 | |
| OTTMUSP00000017446 | |
| FA | |
| factor A | |
| 7330414F15 | |
| 8430431H08 | |
| glycogen synthase kinase 3 beta | |
| glycogen synthetase kinase 3 beta | |
| GSK3B | |
| KG3B | |
| KG3B_HUMAN | |
| LOC56493 | |
| GSK IIIs | |
| RIKEN cDNA 7330414F15 gene | |
| GSK III | |
| RIKEN cDNA 8430431H08 gene | |
| C86142s | |
| expressed sequence C86142 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605004 |
|---|
| Mouse chromosome position | 16 |
|---|---|
| 16 B4 |
| GO ID | 0005524 |
|---|---|
| 0051059 | |
| 0008013 | |
| 0004696 | |
| 0000166 | |
| 0002039 | |
| 0034236 | |
| 0004674 | |
| 0050321 | |
| 0016740 | |
| 0006983 | |
| 0060070 | |
| 0005977 | |
| 0023034 | |
| 0043066 | |
| 0018105 | |
| 0031334 | |
| 0046827 | |
| 0006468 | |
| 0034747 | |
| 0030877 | |
| 0005737 | |
| 0005829 | |
| 0005634 | |
| 0005178 | |
| 0035255 | |
| 0016301 | |
| 0004672 | |
| 0019901 | |
| 0048156 | |
| 0016055 | |
| 0006916 | |
| 0016477 | |
| 0008283 | |
| 0030010 | |
| 0007163 | |
| 0045444 | |
| 0006917 | |
| 0043407 | |
| 0050774 | |
| 0045892 | |
| 0009887 | |
| 0016310 | |
| 0033138 | |
| 0010800 | |
| 0006611 | |
| 0000320 | |
| 0048168 | |
| 0006950 | |
| 0043198 | |
| 0043197 | |
| 0030426 | |
| 0045121 | |
| 0043227 | |
| 0043025 | |
| 0005654 | |
| 0043234 | |
| 0005625 | |
| 0042493 | |
| 0010226 | |
| 0007242 | |
| 0005515 | |
| 0004682 | |
| 0004691 |
| Rat chromosome position | 11q21 |
|---|
| Swiss-Prot Accession | P49841 |
|---|---|
| Q6FI27 | |
| Q5KU03 | |
| Q9WV60 | |
| Q3TB31 | |
| P18266 | |
| Q9BWH3 | |
| Q9UL47 | |
| D3DN89 |
| PIR ID | S53324 |
|---|---|
| S14708 |
| Unigene ID | Hs.445733 |
|---|---|
| Mm.394930 | |
| Rn.10426 | |
| Hs.593022 | |
| Mm.200770 |
| KEGG ID | hsa:2932 |
|---|---|
| mmu:56637 | |
| rno:84027 |
| EC Number | 2.7.11.26 |
|---|
| Swiss-Prot ID | GSK3B_MOUSE |
|---|---|
| GSK3B_HUMAN | |
| GSK3B_RAT | |
| D3DN89_HUMAN | |
| Q6FI27_HUMAN | |
| Q5KU03_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00125319 |
|---|---|
| IPI00028570 | |
| IPI00216190 | |
| IPI00324168 | |
| IPI00750061 |
| Homologene ID | 55629 |
|---|
| RGD ID | 70982 |
|---|
| MGI ID | 1861437 |
|---|---|
| 1914056 | |
| 1925394 | |
| 2146721 |
| Source | Curated |
|---|