| URN | urn:agi-ProtModification:inout-urn:agi-llid:8945:out-urn:agi-llid:1499::unknown |
|---|---|
| References | 7 |
| Connectivity | 2 |
| Effect | unknown |
| TextRef | info:pmid/18806787#abs:4 |
|---|---|
| MedLine Reference | 18806787:3 |
| Sentence | Whereas the well-established beta-catenin E3 ubiquitin ligase component beta-TrCP ubiquitylates only phosphorylated beta-catenin, Jade-1 ubiquitylates both phosphorylated and non-phosphorylated beta-catenin and therefore regulates canonical Wnt signalling in both Wnt-off and Wnt-on phases. |
| TextRef | info:pmid/16809773#cont:319 |
|---|---|
| MedLine Reference | 16809773:10318 |
| Sentence | The F-box protein beta-TrCP associateswith phosphorylated beta-catenin and regulates its activity in thecell. |
| Journal | Mol. Cell. Biol |
| Journal Reference | v26 i14 p5373 |
| Journal Link | http://mcb.asm.org/cgi/content/full/26/14/5373 |
| TextRef | info:pmid/10228155#cont:122 |
|---|---|
| MedLine Reference | 10228155:10121 |
| Sentence | Facilitation of eta-catenin ubiquitination in vivo . ( A ) Promotion of eta-catenin ubiquitination by FWD1. |
| CellLineName | 293T |
| Journal | EMBO |
| Journal Reference | v18 i9 p2401 |
| Journal Link | http://emboj.oupjournals.org/cgi/content/full/18/9/2401 |
| TextRef | info:pmid/16510874#cont:22 |
|---|---|
| MedLine Reference | 16510874:10021 |
| Sentence | The phosphorylated ß-cat is then ubiquitinated by ßTrCP and destroyed by proteasome-mediated proteolysis. |
| Tissue | epithelia |
| CellType | Hematopoietic Stem |
| Organ | gastric |
| Journal | Genes & Dev |
| Journal Reference | v20 i5 p586 |
| Journal Link | http://www.genesdev.org/cgi/content/full/20/5/586 |
| TextRef | info:pmid/16177058#cont:23 |
|---|---|
| MedLine Reference | 16177058:10022 |
| Sentence | Substrate phospho-I?B-a and phospho-ß-catenin are normally ubiquitinated by a specific ubiquitin ligase complex designated E3-SCF ß-TrCP ( 2 , 3 ). |
| Tissue | epithelia |
| Organism | Homo sapiens |
| Journal | J. Immunol |
| Journal Reference | v175 i7 p4194 |
| Journal Link | http://www.jimmunol.org/cgi/content/full/175/7/4194 |
| TextRef | info:pmid/17855653#cont:101 |
|---|---|
| MedLine Reference | 17855653:10100 |
| Sentence | Because the phosphorylation of ß-catenin by GSK-3ß and its subsequent association with ß-TrCP leads to ß-catenin degradation (Winston et al., 1999 ), we examined whether decursin-mediated inhibition of the Wnt/ß-catenin pathway requires GSK-3ß activity. |
| Journal | Mol. Pharm |
| Journal Reference | v72 i6 p1599 |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/72/6/1599 |
| MedLine Reference | 160100062:10070 |
|---|---|
| Sentence | Thus, the identification of SCF ß-Trcp as the enzyme that ubiquitinates ß-catenin is expected to have a significant impact on both cancer biology and clinical oncology. |
| Journal | Oncogene |
| Journal Reference | v18 i4 p1202653 |
| Journal Link | http://www.nature.com/onc/journal/v18/n4/full/1202653a.html |