Elsevier Inc. Wls Csnk1g1 Wnt_ligands_secreted Sostdc1 Ndp Sost Crebbp translocated Ctnnb1 palmitate Wnt_ligands Rnf43 ---| Fzd_receptors Rnf43 ---| Fzd_receptors Znrf3 ---| Fzd_receptors Znrf3 ---| Fzd_receptors sFRPs ---| Wnt_ligands_secreted Wif1 ---| Wnt_ligands_secreted Znrf3 ---| Lrp6 Csnk1g1 --+> Lrp6 Gsk3b --+> Lrp6 Btrc ---| Ctnnb1 RSPOs ---> Wnt signal potentiation Ndp ---> Wnt signal potentiation Gsk3b Lrp6 Kremen2 Kremen1 Wif1 Porcn Lef1 Smarca4 Csnk1a1 Rnf43 Znrf3 Lgr4 Lgr5 RSPOs Btrc Axin1 Dvls Wnt signal potentiation Dkk members Axin1 ---- Lrp6 Dvls ---- Fzd_receptors Lrp5 sFRPs sFRPs ---- Wnt_ligands_secreted sFRPs ---> Fzd_receptors Fzd_receptors Fzd_receptors ---- sFRPs Apc Apc ---- Axin1 Axin1 ---- Gsk3b Apc ---- Ctnnb1 Lgr4 ---- Ndp RSPOs ---> Znrf3 Lrp6 ---- Sost Lrp5 ---- Sost Lrp6 ---- Sostdc1 Dkk members ---- Lrp5 Dkk members ---> Lrp5 Dkk members ---> Lrp6 Dkk members ---- Lrp6 Lrp5 ---- Ndp Lgr4 ---- RSPOs Lgr5 ---- RSPOs Fzd_receptors ---- Wnt_ligands_secreted Lrp5 ---- Wnt_ligands_secreted Wnt target genes Kremen2 ---> Dkk members Kremen1 ---> Dkk members Dkk members ---- Kremen1 Dkk members ---- Kremen2 Lrp6 ---- Wnt_ligands_secreted Axin1 ---- Ctnnb1 Csnk1a1 ---| Ctnnb1 Gsk3b ---| Ctnnb1 Ctnnb1 ---> translocated Ctnnb1 Wif1 ---- Wnt_ligands_secreted translocated Ctnnb1 ---> Wnt target genes Porcn ---> Wnt_ligands Wls ---- Wnt_ligands Wnt_ligands ---> Wnt_ligands_secreted Fzd_receptors ---- Ndp Axin2 Axin1 ---- Csnk1a1 Tcf_factors Csnk1a1 ---> Axin1 Ctnnb1 Gsk3b ---> Axin1