| URN | urn:agi-llid:23513 |
|---|---|
| Total Entities | 0 |
| Connectivity | 214 |
| Name | Scrib |
| Description | similar to PDZ-domain protein scribble (predicted) |
| Notes | Degradation by human papilloma virus E6 may cause progressive decrease of hScrib expression during disease progression from low-grade squamous intraepithelial lesions (SIL) to high-grade SIL Degradation by human papilloma virus E6 may cause progressive decrease of hScrib expression during disease progression from low-grade squamous intraepithelial lesions (SIL) to high-grade SIL. Down-regulation of scrib is associated with colon cancer progression. E6AP is extensively involved in the ubiquitin-mediated degradation of SCRIB (an HPV E6-dependent substrate) as a cellular E3 ubiquitin-protein ligase. Human scribble accumulates in colorectal neoplasia in association with an altered distribution of beta-catenin. KIAA0147 encodes the human homolog of Drosophila Scribble. hScrib is targeted for ubiquitin-mediated degradation by the HPV E6 oncoprotein, and mutations in Dros. scrib result in loss of polarity and growth control of epithelial cells. Knockdown of hScrib expression by RNAi disrupts localization of adenomatous polyposis coli(APC) at the adherens junction. These data suggest hScrib may participate in the hDlg-APC complex through PDZ domains and regulate cell cycle and neural function. LPP and Scrib proteins localize in cell-cell contacts. This interaction links Scrib to a communication pathway between cell-cell contacts and the nucleus, and implicates LPP in Scrib-associated functions. May act as a tumor suppressor. The direct interaction between hScrib and ZO-2, a junction-associated protein, was reported. These results suggest that Scrib stabilizes the coupling between E-cadherin and the catenins and are consistent with the idea that mammalian Scrib could behave as a tumor suppressor by regulating epithelial cell adhesion and migration. Data establishs a potential link between the E-cadherin and hScrib tumor suppressors. Essential role for mammalian Scribble in the regulation of the polarity specifically involved in directed epithelial migration. HScrib directly binds to the G protein-coupled thyroid stimulating hormone receptor (TSHR), inhibits basal receptor endocytosis and promotes recycling, and thus TSHR signalling, at the cell membrane. HScrib is a functional homologue of DmScrib and therefore predict an important role for hScrib in the suppression of mammalian tumorigenesis. Interacts with TRIP6; binding between two of zyxin's family members and Scrib links Scrib to a communication pathway between cell-cell contacts and the nucleus, and implicates these zyxin family members in Scrib-associated functions. Mapped the binding site of E6 on hScrib and shown that the interaction of E6 with hScrib is distinct from its interactions with other PDZ domain-containing targets. |
| Ariadne Ontology | Biofluids assayable substances |
|---|
| GO Cellular Component | cell junction |
|---|---|
| membrane | |
| basolateral plasma membrane | |
| Scrib-APC-beta-catenin complex | |
| plasma membrane | |
| myelin sheath abaxonal region | |
| cell leading edge | |
| cytoplasm | |
| presynaptic membrane | |
| postsynaptic membrane | |
| cell-cell junction | |
| cell-cell adherens junction |
| GO Biological Process | cell proliferation |
|---|---|
| virus-host interaction | |
| negative regulation of mitotic cell cycle | |
| activation of Rac GTPase activity | |
| positive regulation of receptor recycling | |
| positive regulation of apoptotic process | |
| cell differentiation | |
| apoptotic process involved in morphogenesis | |
| cell-cell adhesion | |
| synaptic vesicle targeting | |
| cell migration | |
| astrocyte cell migration | |
| establishment of apical-basal cell polarity | |
| positive chemotaxis | |
| wound healing | |
| multicellular organismal development | |
| mammary gland duct morphogenesis | |
| neural tube closure | |
| morphogenesis of embryonic epithelium | |
| synaptic vesicle endocytosis | |
| asymmetric protein localization | |
| protein localization to adherens junction |
| Pathway | the planar cell polarity Wnt signaling pathway |
|---|---|
| Wnt signaling, the planar cell polarity pathway |
| Group | cell proliferation |
|---|---|
| virus-host interaction | |
| negative regulation of mitotic cell cycle | |
| activation of Rac GTPase activity | |
| positive regulation of receptor recycling | |
| positive regulation of apoptotic process | |
| cell differentiation | |
| apoptotic process involved in morphogenesis | |
| cell-cell adhesion | |
| synaptic vesicle targeting | |
| cell migration | |
| astrocyte cell migration | |
| establishment of apical-basal cell polarity | |
| positive chemotaxis | |
| wound healing | |
| multicellular organismal development | |
| mammary gland duct morphogenesis | |
| neural tube closure | |
| morphogenesis of embryonic epithelium | |
| synaptic vesicle endocytosis | |
| asymmetric protein localization | |
| protein localization to adherens junction | |
| cell junction | |
| membrane | |
| basolateral plasma membrane | |
| Scrib-APC-beta-catenin complex | |
| plasma membrane | |
| myelin sheath abaxonal region | |
| cell leading edge | |
| cytoplasm | |
| presynaptic membrane | |
| postsynaptic membrane | |
| cell-cell junction | |
| cell-cell adherens junction | |
| Biofluids assayable substances |
| Source | Curated |
|---|---|
| GO component |
| MedScan ID | 23513 |
|---|
| Hugo ID | 30377 |
|---|
| Human chromosome position | 8q24.3 |
|---|
| LocusLink ID | 23513 |
|---|---|
| 105782 | |
| 362938 | |
| 54559 | |
| 103976 | |
| 789825 | |
| 368473 |
| Alias | CRIB1 |
|---|---|
| SCRB1 | |
| SCRIB1 | |
| Vartul | |
| protein scribble homolog | |
| Crc | |
| CRIB | |
| AI118201 | |
| mKIAA0147 | |
| circletail | |
| scribble homolog 1 | |
| PDZ-domain protein scribble | |
| RGD1565055 | |
| scribble | |
| OTTMUSP00000023093 | |
| SCRIB | |
| scribble homolog I | |
| scribbled homolog | |
| OTTMUSP00000023091 | |
| scribbled homolog (Drosophila) | |
| mScrib | |
| A430093J20Rik | |
| AU016091 | |
| D030059I21 | |
| hScrib | |
| A430093J20 | |
| KIAA0147 | |
| RIKEN cDNA A430093J20 gene | |
| SCRIB1s | |
| expressed sequence AI118201 | |
| scribble homolog 1 (Drosophila) | |
| similar to PDZ-domain protein scribble (predicted) | |
| chromosome | |
| landlocked | |
| llk | |
| scaffold | |
| scribble1 | |
| si:ch211-12p8.1 | |
| si:zc12p8.1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 607733 |
|---|
| Unigene ID | Hs.436329 |
|---|---|
| Mm.25568 | |
| Rn.138068 | |
| Bt.72370 | |
| Dr.95482 |
| KEGG ID | hsa:23513 |
|---|---|
| mmu:105782 | |
| rno:362938 |
| Swiss-Prot Accession | Q14160 |
|---|---|
| A0PJK8 | |
| Q80U72 | |
| D3ZWS0 | |
| Q6P496 | |
| Q7Z5D1 | |
| Q8WWV8 | |
| Q96C69 | |
| Q96GG1 | |
| Q6P5H7 | |
| Q7TPH8 | |
| Q80VB1 | |
| Q8CI48 | |
| Q8VII1 | |
| Q922S3 | |
| Q8WYU8 | |
| Q6P9N3 |
| GO ID | 0032863 |
|---|---|
| 0060561 | |
| 0008105 | |
| 0016477 | |
| 0008283 | |
| 0016337 | |
| 0035089 | |
| 0060603 | |
| 0045930 | |
| 0001843 | |
| 0050918 | |
| 0043065 | |
| 0001921 | |
| 0071896 | |
| 0048488 | |
| 0016080 | |
| 0019048 | |
| 0042060 | |
| 0034750 | |
| 0016323 | |
| 0031252 | |
| 0005913 | |
| 0005911 | |
| 0035748 | |
| 0005886 | |
| 0045211 | |
| 0042734 | |
| 0043615 | |
| 0030154 | |
| 0016331 | |
| 0007275 | |
| 0030054 | |
| 0005737 | |
| 0016020 | |
| 0005515 | |
| 0007242 | |
| 0001764 |
| Swiss-Prot ID | SCRIB_HUMAN |
|---|---|
| SCRIB_MOUSE | |
| A0PJK8_HUMAN | |
| LAP4_HUMAN | |
| LAP4_MOUSE |
| Cell Localization | Cell membrane |
|---|---|
| Cell junction | |
| adherens junction | |
| Cytoplasm | |
| Plasma membrane |
| IPI ID | IPI00410666 |
|---|---|
| IPI00425560 | |
| IPI00425562 | |
| IPI00129388 | |
| IPI00454104 | |
| IPI00454106 | |
| IPI00474285 | |
| IPI00425566 | |
| IPI00395630 | |
| IPI00830775 | |
| IPI00830262 | |
| IPI00366277 | |
| IPI00564915 | |
| IPI00566729 |
| Mouse chromosome position | 15 43.8 cM |
|---|
| Rat chromosome position | 7q34 |
|---|
| Homologene ID | 44228 |
|---|
| MGI ID | 2145950 |
|---|---|
| 1859564 |
| RGD ID | 1565055 |
|---|
| Homo sapiens Chromosome position | 8q24.3 |
|---|
| Microarray ID | 1427064_a_at |
|---|
| FunctionalClass | protein binding |
|---|
| Mus musculus Chromosome position | 15 43.8 cM |
|---|
| Rattus norvegicus Chromosome position | 7q34 |
|---|
| Bos taurus Chromosome position | 14 |
|---|