| URN | urn:agi-llid:387 |
|---|---|
| Total Entities | 0 |
| Connectivity | 2363 |
| Name | Rhoa |
| Description | ras homolog gene family, member A |
| Notes | results provide first evidence that RhoA in vivo acts downstream of Wnt5 and Wnt11 to effect, without affecting cell fates, the convergence and extension movements in zebrafish embryos; it elicits such effect via both effectors, Rho kinase and Dia Results provide first evidence that RhoA in vivo acts downstream of Wnt5 and Wnt11 to effect, without affecting cell fates, the convergence and extension movements in zebrafish embryos; it elicits such effect via both effectors, Rho kinase and Dia. |
| Ariadne Ontology | Rho |
|---|---|
| Oncogenes | |
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | protein domain specific binding |
|---|---|
| myosin binding | |
| nucleotide binding | |
| GTP binding | |
| GTPase activity | |
| signal transducer activity |
| GO Cellular Component | cell junction |
|---|---|
| membrane | |
| ruffle membrane | |
| midbody | |
| plasma membrane | |
| intracellular | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| cell cortex | |
| cytoskeleton | |
| nucleus | |
| cleavage furrow | |
| lamellipodium | |
| axon | |
| apical junction complex |
| GO Biological Process | virus-host interaction |
|---|---|
| cell division | |
| cell adhesion | |
| cell cycle | |
| spindle assembly involved in mitosis | |
| cell cycle cytokinesis | |
| positive regulation of cell cycle cytokinesis | |
| regulation of small GTPase mediated signal transduction | |
| negative regulation of intracellular steroid hormone receptor signaling pathway | |
| negative regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of NF-kappaB import into nucleus | |
| cleavage furrow formation | |
| androgen receptor signaling pathway | |
| small GTPase mediated signal transduction | |
| stress-activated protein kinase signaling cascade | |
| Rho protein signal transduction | |
| phosphatidylinositol-mediated signaling | |
| integrin-mediated signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| positive regulation of cell growth | |
| positive regulation of translation | |
| regulation of transcription from RNA polymerase II promoter | |
| negative regulation of neuron differentiation | |
| negative regulation of axonogenesis | |
| negative regulation of neuron apoptotic process | |
| positive regulation of cell adhesion | |
| positive regulation of cell migration | |
| positive regulation of neuron differentiation | |
| positive regulation of axonogenesis | |
| positive regulation of actin filament polymerization | |
| positive regulation of stress fiber assembly | |
| positive regulation of neuron apoptotic process | |
| regulation of actin polymerization or depolymerization | |
| regulation of osteoblast proliferation | |
| regulation of axonogenesis | |
| regulation of dendrite development | |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| regulation of cell migration | |
| cell differentiation | |
| cell morphogenesis | |
| neuron projection morphogenesis | |
| platelet activation | |
| GTP catabolic process | |
| cell-matrix adhesion | |
| cellular response to progesterone stimulus | |
| actin cytoskeleton organization | |
| stress fiber assembly | |
| apical junction assembly | |
| response to drug | |
| response to amino acid stimulus | |
| response to glucocorticoid stimulus | |
| response to glucose stimulus | |
| response to ethanol | |
| axon guidance | |
| response to hypoxia | |
| response to mechanical stimulus | |
| positive regulation of podosome assembly | |
| positive regulation of vasoconstriction | |
| positive regulation of smooth muscle contraction | |
| regulation of calcium ion transport | |
| skeletal muscle tissue development | |
| trabecula morphogenesis | |
| ossification involved in bone maturation | |
| blood coagulation |
| Pathway | Tight Junction Assembly (JAMs) |
|---|---|
| Adherens Junction Assembly (Cadherins) | |
| FrizzledR -> JUN/PAX2 signaling | |
| EphrinR -> actin signaling | |
| CholinergicRm -> CREB/ELK-SRF signaling | |
| CannabinoidR -> AP-1/EGR signaling | |
| SerotoninR1 -> FOS signaling | |
| EDG3/5 -> AP-1/ELK-SRF signaling | |
| EndothelinRb -> AP-1/CREB/ELK-SRF signaling | |
| EndothelinRa -> AP-1/CREB signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| Clozapine-Induced Granulocytopenia | |
| ROS and RNS in Regulation of Vasoconstriction and Vasodilation | |
| WNT7A Expression Targets | |
| WNT1 Expression Targets | |
| WNT4 Expression Targets | |
| WNT3A Expression Targets | |
| Dronabinol/Anandamide Expression Targets | |
| Acetylcholine Expression Targets | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| S1P Expression Targets | |
| EDN1 Expression Targets | |
| EDN3 Expression Targets | |
| IL1B/PGE2 Expression Targets | |
| WNT5A Expression Targets | |
| calcium signaling pathway via the calcium-sensing receptor | |
| the planar cell polarity Wnt signaling pathway | |
| Wnt signaling, the planar cell polarity pathway |
| Group | Rho |
|---|---|
| Oncogenes | |
| virus-host interaction | |
| cell division | |
| cell adhesion | |
| cell cycle | |
| spindle assembly involved in mitosis | |
| cell cycle cytokinesis | |
| positive regulation of cell cycle cytokinesis | |
| regulation of small GTPase mediated signal transduction | |
| negative regulation of intracellular steroid hormone receptor signaling pathway | |
| negative regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of NF-kappaB import into nucleus | |
| cleavage furrow formation | |
| androgen receptor signaling pathway | |
| small GTPase mediated signal transduction | |
| stress-activated protein kinase signaling cascade | |
| Rho protein signal transduction | |
| phosphatidylinositol-mediated signaling | |
| integrin-mediated signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| positive regulation of cell growth | |
| positive regulation of translation | |
| regulation of transcription from RNA polymerase II promoter | |
| negative regulation of neuron differentiation | |
| negative regulation of axonogenesis | |
| negative regulation of neuron apoptotic process | |
| positive regulation of cell adhesion | |
| positive regulation of cell migration | |
| positive regulation of neuron differentiation | |
| positive regulation of axonogenesis | |
| positive regulation of actin filament polymerization | |
| positive regulation of stress fiber assembly | |
| positive regulation of neuron apoptotic process | |
| regulation of actin polymerization or depolymerization | |
| regulation of osteoblast proliferation | |
| regulation of axonogenesis | |
| regulation of dendrite development | |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| regulation of cell migration | |
| cell differentiation | |
| cell morphogenesis | |
| neuron projection morphogenesis | |
| platelet activation | |
| GTP catabolic process | |
| cell-matrix adhesion | |
| cellular response to progesterone stimulus | |
| actin cytoskeleton organization | |
| stress fiber assembly | |
| apical junction assembly | |
| response to drug | |
| response to amino acid stimulus | |
| response to glucocorticoid stimulus | |
| response to glucose stimulus | |
| response to ethanol | |
| axon guidance | |
| response to hypoxia | |
| response to mechanical stimulus | |
| positive regulation of podosome assembly | |
| positive regulation of vasoconstriction | |
| positive regulation of smooth muscle contraction | |
| regulation of calcium ion transport | |
| skeletal muscle tissue development | |
| trabecula morphogenesis | |
| ossification involved in bone maturation | |
| blood coagulation | |
| protein domain specific binding | |
| myosin binding | |
| nucleotide binding | |
| GTP binding | |
| GTPase activity | |
| signal transducer activity | |
| cell junction | |
| membrane | |
| ruffle membrane | |
| midbody | |
| plasma membrane | |
| intracellular | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| cell cortex | |
| cytoskeleton | |
| nucleus | |
| cleavage furrow | |
| lamellipodium | |
| axon | |
| apical junction complex | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|---|
| GO component |
| MedScan ID | 387 |
|---|
| Hugo ID | 667 |
|---|
| Human chromosome position | 3p21.3 |
|---|
| LocusLink ID | 387 |
|---|---|
| 11848 | |
| 117273 | |
| 50886 | |
| 51787 | |
| 107443 | |
| 297173 | |
| 338049 | |
| 336001 |
| Alias | ARHA |
|---|---|
| ARH12 | |
| RHO12 | |
| RHOH12 | |
| transforming protein RhoA | |
| h12 | |
| oncogene RHO H12 | |
| rho cDNA clone 12 | |
| Aplysia ras-related homolog 12 | |
| small GTP binding protein RhoA | |
| ras homolog gene family, member A | |
| Arha1 | |
| Arha2 | |
| ras homolog A1 | |
| ras homolog A2 | |
| Rho family GTPase | |
| aplysia ras-related homolog A | |
| aplysia ras-related homolog A1 | |
| aplysia ras-related homolog A2 | |
| ras homolog gene family, member A1 | |
| ras homolog gene family, member A2 | |
| plysia ras-related homolog A2 | |
| rho A | |
| rhoA | |
| Rho family GTPase A | |
| RHO H12 | |
| Rho-A | |
| RhoA small GTPase | |
| RSA-14-44 | |
| RhoA activity | |
| Arha I | |
| MGC72339 | |
| MGC94489 | |
| OTTHUMP00000210783 | |
| OTTHUMP00000210785 | |
| RHOH12s | |
| 4930544G11Rik | |
| Transforming protein RhoA (H12) | |
| RIKEN cDNA 4930544G11 gene | |
| Ras homolog gene family, member A (oncogene RHO H12) | |
| Aplysia ras-related homolog XII | |
| MGC114074 | |
| chromosome | |
| fj42e08 | |
| ras homolog gene family, member Ab | |
| rhoab | |
| scaffold | |
| small GTPase RhoA | |
| wu:fj42e08 | |
| zgc:92206 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 165390 |
|---|
| Unigene ID | Hs.247077 |
|---|---|
| Mm.757 | |
| Rn.107401 | |
| Mm.471622 | |
| Hs.709788 | |
| Rn.47032 | |
| Bt.49678 | |
| Dr.25812 | |
| Hs.657976 |
| KEGG ID | hsa:387 |
|---|---|
| mmu:11848 | |
| rno:117273 |
| Swiss-Prot Accession | P61586 |
|---|---|
| Q9BVT0 | |
| Q4VAE6 | |
| Q9QUI0 | |
| P61589 | |
| P06749 | |
| Q53HM4 | |
| Q5U024 | |
| Q9UDJ0 | |
| Q9UEJ4 | |
| O88336 | |
| Q3TN61 | |
| O35791 | |
| RHOA_HUMAN |
| GO ID | 0005525 |
|---|---|
| 0003924 | |
| 0017022 | |
| 0007266 | |
| 0030036 | |
| 0030521 | |
| 0043297 | |
| 0007411 | |
| 0007596 | |
| 0007160 | |
| 0036089 | |
| 0050771 | |
| 0033144 | |
| 0043524 | |
| 0048011 | |
| 0043931 | |
| 0048015 | |
| 0030168 | |
| 0043123 | |
| 0042346 | |
| 0050772 | |
| 0071777 | |
| 0045666 | |
| 0051496 | |
| 0050770 | |
| 0030334 | |
| 0033688 | |
| 0051056 | |
| 0006357 | |
| 0007519 | |
| 0007264 | |
| 0090307 | |
| 0043149 | |
| 0061383 | |
| 0007179 | |
| 0019048 | |
| 0043296 | |
| 0005938 | |
| 0030054 | |
| 0032154 | |
| 0005856 | |
| 0005829 | |
| 0030027 | |
| 0030496 | |
| 0005739 | |
| 0005634 | |
| 0005886 | |
| 0032587 | |
| 0000166 | |
| 0019904 | |
| 0006184 | |
| 0007155 | |
| 0007049 | |
| 0030154 | |
| 0051301 | |
| 0000902 | |
| 0007229 | |
| 0043124 | |
| 0045665 | |
| 0030838 | |
| 0030307 | |
| 0043280 | |
| 0043525 | |
| 0071803 | |
| 0051924 | |
| 0050773 | |
| 0042493 | |
| 0031098 | |
| 0030424 | |
| 0005737 | |
| 0005622 | |
| 0016020 | |
| 0004871 | |
| 0033205 | |
| 0071393 | |
| 0048812 | |
| 0045785 | |
| 0030335 | |
| 0045987 | |
| 0045727 | |
| 0045907 | |
| 0008064 | |
| 0043200 | |
| 0045471 | |
| 0051384 | |
| 0009749 | |
| 0001666 | |
| 0009612 | |
| 0044419 | |
| 0051927 | |
| 0005624 | |
| 0005625 | |
| 0000287 | |
| 0005515 | |
| 0015031 | |
| 0005579 | |
| 0016055 | |
| 0035121 | |
| 0042074 | |
| 0048840 |
| PIR ID | A26675 |
|---|
| Swiss-Prot ID | RHOA_HUMAN |
|---|---|
| RHOA_MOUSE | |
| RHOA_RAT | |
| Q4VAE6_MOUSE | |
| Q9BVT0_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Cytoplasm | |
| cytoskeleton | |
| Cleavage furrow | |
| cell cortex | |
| Midbody |
| IPI ID | IPI00478231 |
|---|---|
| IPI00315100 | |
| IPI00201699 | |
| IPI00789934 |
| Mouse chromosome position | 9 |
|---|---|
| 9 F2 |
| Rat chromosome position | 16q12.5 |
|---|
| Homologene ID | 1257 |
|---|
| MGI ID | 1096342 |
|---|---|
| 1355308 |
| RGD ID | 619921 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| Homo sapiens Chromosome position | 3p21.3 |
|---|
| Microarray ID | 101111_at |
|---|---|
| 101112_g_at | |
| 101113_at | |
| 200059_s_at | |
| 1437628_s_at |
| FunctionalClass | GTP binding |
|---|---|
| GTPase | |
| magnesium ion binding | |
| nucleotide binding | |
| protein binding | |
| signal transducer |
| Mus musculus Chromosome position | 9 F2 |
|---|---|
| 9 | |
| 2 |
| KEGG pathway | Adherens junction |
|---|---|
| Axon guidance | |
| Focal adhesion | |
| Leukocyte transendothelial migration | |
| Regulation of actin cytoskeleton | |
| T cell receptor signaling pathway | |
| TGF-beta signaling pathway | |
| Tight junction | |
| Wnt signaling pathway |
| Rattus norvegicus Chromosome position | 16q12.5 |
|---|---|
| 4q31 |
| Bos taurus Chromosome position | 22 |
|---|