| URN | urn:agi-llid:23002 |
|---|---|
| Total Entities | 0 |
| Connectivity | 73 |
| Name | Daam1 |
| Description | dishevelled associated activator of morphogenesis 1 (predicted) |
| Notes | Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined. |
| Ariadne Ontology | DAAM |
|---|---|
| Secreted proteins |
| GO Molecular Function | Rho GTPase binding |
|---|---|
| actin binding |
| GO Cellular Component | stress fiber |
|---|---|
| plasma membrane | |
| cytoplasm |
| GO Biological Process | actin cytoskeleton organization |
|---|---|
| cellular component organization |
| Pathway | FrizzledR -> JUN/PAX2 signaling |
|---|---|
| WNT7A Expression Targets | |
| WNT1 Expression Targets | |
| WNT4 Expression Targets | |
| WNT3A Expression Targets | |
| WNT5A Expression Targets | |
| the planar cell polarity Wnt signaling pathway | |
| Wnt signaling, the planar cell polarity pathway |
| Group | DAAM |
|---|---|
| actin cytoskeleton organization | |
| cellular component organization | |
| Rho GTPase binding | |
| actin binding | |
| stress fiber | |
| plasma membrane | |
| cytoplasm | |
| Secreted proteins |
| Source | Curated |
|---|
| MedScan ID | 23002 |
|---|
| Hugo ID | 18142 |
|---|
| Human chromosome position | 14q23.1 |
|---|
| LocusLink ID | 23002 |
|---|---|
| 208846 | |
| 314212 | |
| 67346 | |
| 69600 | |
| 104845 | |
| 513742 | |
| 560060 | |
| 325487 | |
| 378457 |
| Alias | disheveled-associated activator of morphogenesis 1 |
|---|---|
| AI503486 | |
| mKIAA0666 | |
| E130308H01 | |
| 1700066F09Rik | |
| 2310028E21Rik | |
| KIAA0666 | |
| Daam1 | |
| dishevelled-associated activator of morphogenesis I | |
| OTTHUMP00000179033 | |
| FLJ41657 | |
| 1700066F09 | |
| Daam I | |
| 2310028E21 | |
| dishevelled associated activator of morphogenesis 1 | |
| dishevelled-associated activator of morphogenesis 1 | |
| RIKEN cDNA 2310028E21 gene | |
| hypothetical protein E130308H01 | |
| dishevelled associated activator of morphogenesis 1 (predicted) | |
| fc83b10 | |
| si:ch211-87i20.1 | |
| wu:fc83b10 | |
| CH211-87I20.1 | |
| chromosome | |
| daam1l | |
| dishevelled associated activator of morphogenesis 1 like | |
| dishevelled associated activator of morphogenesis 1, like | |
| scaffold |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 606626 |
|---|
| Unigene ID | Hs.19156 |
|---|---|
| Mm.87417 | |
| Mm.474935 | |
| Rn.92012 | |
| Hs.654934 | |
| Mm.471127 | |
| Hs.574538 | |
| Mm.431210 | |
| Mm.436199 | |
| Bt.8208 | |
| Dr.133393 | |
| Dr.74015 | |
| Mm.462561 |
| KEGG ID | hsa:23002 |
|---|---|
| mmu:208846 | |
| rno:314212 |
| Swiss-Prot Accession | Q9Y4D1 |
|---|---|
| Q8BPM0 | |
| Q8BTF1 | |
| D4ABM3 | |
| Q3UHB4 | |
| Q6DFY0 | |
| Q6TAB8 | |
| Q80Y68 | |
| Q9CQQ2 | |
| Q86U34 | |
| Q8N1Z8 | |
| Q8TB39 | |
| Q6ZQ74 |
| GO ID | 0017048 |
|---|---|
| 0003779 | |
| 0030036 | |
| 0005737 | |
| 0005886 | |
| 0001725 | |
| 0016043 | |
| 0005488 | |
| 0015629 | |
| 0060026 |
| Swiss-Prot ID | DAAM1_MOUSE |
|---|---|
| DAAM1_HUMAN | |
| Q8BTF1_MOUSE | |
| Q6DFY0_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00621301 |
|---|---|
| IPI00857742 | |
| IPI01008183 | |
| IPI00337800 | |
| IPI00337801 | |
| IPI00337802 | |
| IPI00223511 | |
| IPI00567578 | |
| IPI00367408 | |
| IPI00779214 |
| Mouse chromosome position | 12 |
|---|---|
| 12 C3 |
| Rat chromosome position | 6q24 |
|---|
| Homologene ID | 36635 |
|---|
| MGI ID | 1914596 |
|---|---|
| 1916850 | |
| 2144851 |
| RGD ID | 1305119 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| Homo sapiens Chromosome position | 14q23.1 |
|---|
| FunctionalClass | Rho GTPase binding |
|---|---|
| actin binding | |
| binding |
| Mus musculus Chromosome position | 12 C3 |
|---|---|
| 12 |
| KEGG pathway | Wnt signaling pathway |
|---|
| Rattus norvegicus Chromosome position | 6q24 |
|---|
| Bos taurus Chromosome position | 10 |
|---|