| URN | urn:agi-llid:5754 |
|---|---|
| Total Entities | 0 |
| Connectivity | 68 |
| Name | Ptk7 |
| Description | PTK7 protein tyrosine kinase 7 |
| Notes | Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene. |
| Ariadne Ontology | Receptors |
|---|---|
| Secreted proteins |
| GO Molecular Function | ATP binding |
|---|---|
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| transmembrane receptor protein tyrosine kinase activity |
| GO Cellular Component | cell junction |
|---|---|
| membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| cell-cell junction |
| GO Biological Process | metabolic process |
|---|---|
| cell adhesion | |
| cellular response to retinoic acid | |
| signal transduction | |
| Wnt receptor signaling pathway | |
| canonical Wnt receptor signaling pathway | |
| planar cell polarity pathway involved in neural tube closure | |
| positive regulation of neuron projection development | |
| establishment of epithelial cell apical-basal polarity | |
| protein phosphorylation | |
| cell migration | |
| actin cytoskeleton reorganization | |
| wound healing | |
| establishment of planar polarity | |
| cochlea morphogenesis | |
| axis elongation | |
| neural tube closure | |
| lung-associated mesenchyme development | |
| convergent extension |
| Pathway | the planar cell polarity Wnt signaling pathway |
|---|---|
| Wnt signaling, the planar cell polarity pathway |
| Group | Receptors |
|---|---|
| metabolic process | |
| cell adhesion | |
| cellular response to retinoic acid | |
| signal transduction | |
| Wnt receptor signaling pathway | |
| canonical Wnt receptor signaling pathway | |
| planar cell polarity pathway involved in neural tube closure | |
| positive regulation of neuron projection development | |
| establishment of epithelial cell apical-basal polarity | |
| protein phosphorylation | |
| cell migration | |
| actin cytoskeleton reorganization | |
| wound healing | |
| establishment of planar polarity | |
| cochlea morphogenesis | |
| axis elongation | |
| neural tube closure | |
| lung-associated mesenchyme development | |
| convergent extension | |
| ATP binding | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| transmembrane receptor protein tyrosine kinase activity | |
| cell junction | |
| membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| cell-cell junction | |
| Secreted proteins |
| MedScan ID | 5754 |
|---|
| Hugo ID | 9618 |
|---|
| Human chromosome position | 6p21.1-p12.2 |
|---|
| LocusLink ID | 5754 |
|---|---|
| 71461 | |
| 301242 |
| Alias | CCK4 |
|---|---|
| CCK-4 | |
| inactive tyrosine-protein kinase 7 | |
| colon carcinoma kinase 4 | |
| tyrosine-protein kinase-like 7 | |
| pseudo tyrosine kinase receptor 7 | |
| chz | |
| mPTK7/CCK4 | |
| 8430404F20Rik | |
| protein chuzhoi | |
| protein-tyrosine kinase 7 | |
| receptor tyrosine kinase-like protein | |
| PTK7/CCK4 | |
| PTK7 III | |
| PTK7 protein tyrosine kinase | |
| PTK7 protein tyrosine kinase 7 | |
| PTK7 protein tyrosine kinase VII | |
| PTK7-1 | |
| PTK7-2 | |
| PTK7-3 | |
| PTK7-4 | |
| PTK7 II | |
| receptor CCK4 | |
| CCK4 protein | |
| PTK7 IV | |
| PTK7 I | |
| CCK4 gene | |
| CCK4/PTK7 | |
| Colon carcinoma kinase IV | |
| Colon carcinoma kinase-4 | |
| OTTHUMP00000039809 | |
| OTTHUMP00000217016 | |
| protein-tyrosine kinase PTK7 | |
| PTK7 | |
| Srf | |
| serum response factor | |
| 8430404F20 | |
| Tyrosine-protein kinase-like 7 precursor | |
| RIKEN cDNA 8430404F20 gene | |
| PTK7-3s | |
| PTK7 Is | |
| PTK7-1s | |
| PTK7-4s | |
| PTK7-2s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601890 |
|---|
| Unigene ID | Hs.90572 |
|---|---|
| Mm.181833 | |
| Rn.198822 |
| KEGG ID | hsa:5754 |
|---|---|
| mmu:71461 | |
| rno:301242 |
| Swiss-Prot Accession | B7Z477 |
|---|---|
| E9PFZ5 | |
| Q13308 | |
| Q8BKG3 | |
| Q3V422 | |
| Q6W8S9 | |
| Q8CHK5 | |
| Q8K178 | |
| A8K974 | |
| Q13417 | |
| Q5T650 | |
| Q6IQ54 | |
| Q8NFA5 | |
| Q8NFA6 | |
| Q8NFA7 | |
| Q8NFA8 | |
| Q59FV9 | |
| Q86X91 | |
| Q9NSQ6 | |
| Q3V2W2 |
| EC Number | 2.7.10.1 |
|---|
| GO ID | 0005524 |
|---|---|
| 0004714 | |
| 0031532 | |
| 0003401 | |
| 0060070 | |
| 0007155 | |
| 0016477 | |
| 0071300 | |
| 0090103 | |
| 0060026 | |
| 0045198 | |
| 0001736 | |
| 0060484 | |
| 0001843 | |
| 0090179 | |
| 0010976 | |
| 0007165 | |
| 0042060 | |
| 0005911 | |
| 0005887 | |
| 0016301 | |
| 0004672 | |
| 0004713 | |
| 0016772 | |
| 0016055 | |
| 0008152 | |
| 0006468 | |
| 0030054 | |
| 0016021 | |
| 0016020 | |
| 0004872 | |
| 0005515 | |
| 0005737 | |
| 0007169 | |
| 0005021 | |
| 0005886 |
| PIR ID | JC4593 |
|---|
| Swiss-Prot ID | PTK7_MOUSE |
|---|---|
| PTK7_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Cell junction | |
| Plasma membrane |
| IPI ID | IPI00222589 |
|---|---|
| IPI00168813 | |
| IPI00170814 | |
| IPI00174794 | |
| IPI00298292 | |
| IPI00478565 | |
| IPI00555762 | |
| IPI00743413 | |
| IPI00186793 | |
| IPI00745552 | |
| IPI00373753 | |
| IPI00782502 | |
| IPI00781688 | |
| IPI00777643 |
| Mouse chromosome position | 17 |
|---|---|
| 17 C |
| Rat chromosome position | 9q12 |
|---|
| Homologene ID | 43672 |
|---|
| MGI ID | 1918711 |
|---|
| RGD ID | 1310472 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|