Protein Celsr1

URN	urn:agi-llid:9620
Total Entities	0
Connectivity	44
Name	Celsr1
Description	cadherin EGF LAG seven-pass G-type receptor 1
Notes	The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis.

Ariadne Ontology	GPCR-Other

GO Molecular Function	calcium ion binding
	transmembrane signaling receptor activity
	G-protein coupled receptor activity
	signal transducer activity

GO Biological Process	cell adhesion
	cell-cell signaling
	regulation of neurotransmitter secretion
	signal transduction
	cell surface receptor signaling pathway
	Rho protein signal transduction
	G-protein coupled receptor signaling pathway
	neuropeptide signaling pathway
	planar cell polarity pathway involved in neural tube closure
	regulation of actin cytoskeleton organization
	homophilic cell adhesion
	neuron migration
	protein localization involved in establishment of planar polarity
	wound healing
	locomotory behavior
	multicellular organismal development
	establishment of planar polarity
	inner ear morphogenesis
	establishment of planar polarity of embryonic epithelium
	establishment of body hair planar orientation
	neural tube closure
	orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
	planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
	lateral sprouting involved in lung morphogenesis
	central nervous system development
	hair follicle development
	anterior-posterior pattern specification
	gastrulation with mouth forming second
	apical protein localization

Pathway	the planar cell polarity Wnt signaling pathway
	Wnt signaling, the planar cell polarity pathway

Group	GPCR-Other
	cell adhesion
	cell-cell signaling
	regulation of neurotransmitter secretion
	signal transduction
	cell surface receptor signaling pathway
	Rho protein signal transduction
	G-protein coupled receptor signaling pathway
	neuropeptide signaling pathway
	planar cell polarity pathway involved in neural tube closure
	regulation of actin cytoskeleton organization
	homophilic cell adhesion
	neuron migration
	protein localization involved in establishment of planar polarity
	wound healing
	locomotory behavior
	multicellular organismal development
	establishment of planar polarity
	inner ear morphogenesis
	establishment of planar polarity of embryonic epithelium
	establishment of body hair planar orientation
	neural tube closure
	orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
	planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
	lateral sprouting involved in lung morphogenesis
	central nervous system development
	hair follicle development
	anterior-posterior pattern specification
	gastrulation with mouth forming second
	apical protein localization
	calcium ion binding
	transmembrane signaling receptor activity
	G-protein coupled receptor activity
	signal transducer activity
	membrane
	integral to plasma membrane
	integral to membrane
	plasma membrane

MedScan ID	9620

Hugo ID	1850

Human chromosome position	22q13.3

Alias	ME2
	FMI2
	CDHF9
	HFMI2
	RP5-1163J1.5
	cadherin EGF LAG seven-pass G-type receptor 1
	flamingo homolog 2
	cadherin family member 9
	protocadherin flamingo 2
	Scy
	Crsh
	crash
	seven-pass transmembrane receptor
	flamingo-like protein celsr1
	spin cycle mutant
	OTTHUMP00000028852
	protocadherin flamingo II
	LOC300128
	cadherin EGF LAG seven-pass G-type receptor I
	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
	Celsr I
	Celsr1
	DKFZp434p0729
	cadherin, EGF LAG seven-pass G-type receptor 1
	Celsr1s
	Celsr Is
	spin cycle
	fb15b11
	wu:fb15b11
	CELSR
	EGF
	LAG
	bZ22E02.1
	cadherin EGF LAG seven-pass G-type receptor 1a
	celsr1a
	chromosome
	flamingo 1a
	fmi1a
	scaffold
	si:bz6l08.1
	zfmi1a
	EGF LAG seven-pass G-type receptor
	EGF LAG seven-pass G-type receptor (CELSR))
	LOC558628
	similar to SI:bZ6L08.1 (novel protein similar to human cadherin
	similar to SI:bZ6L08.1 (novel protein similar to human cadherin, EGF LAG seven-pass G-type receptor (CELSR))
	similar to Cadherin EGF LAG seven-pass G-type receptor 1 precursor
	similar to Cadherin EGF LAG seven-pass G-type receptor 1 precursor (Flamingo homolog 2) (hFmi2)

OMIM ID	604523

PIR ID	T14119

Swiss-Prot ID	CELR1_MOUSE
	CELR1_HUMAN

Cell Localization	Cell membrane
	Plasma membrane

Mouse chromosome position	15 49.0 cM

Rat chromosome position	7q34

Homologene ID	7665

MGI ID	1100883
	1861995

RGD ID	1560078

Primary Cell Localization	Plasma membrane

Homo sapiens Chromosome position	22q13.3

Microarray ID	103516_at

FunctionalClass	G-protein coupled receptor
	calcium ion binding
	protein dimerization
	receptor
	signal transducer
	structural molecule
	brain-specific angiogenesis inhibitor
	protein binding

Mus musculus Chromosome position	15 49.0 cM
	Y

Rattus norvegicus Chromosome position	7q34

Danio rerio Chromosome position	LG 4

Bos taurus Chromosome position	5