| URN | urn:agi-llid:8493 |
|---|---|
| Total Entities | 0 |
| Connectivity | 188 |
| Name | Ppm1d |
| Description | protein phosphatase, Mg2+/Mn2+ dependent, 1D |
| Notes | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq] |
| Ariadne Ontology | Phosphatases |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| metal ion binding | |
| hydrolase activity | |
| phosphoprotein phosphatase activity | |
| protein serine-threonine phosphatase activity | |
| magnesium-dependent protein serine-threonine phosphatase activity |
| GO Cellular Component | nucleus |
|---|
| GO Biological Process | response to bacterium |
|---|---|
| cell cycle | |
| G2-M transition of mitotic cell cycle | |
| negative regulation of cell proliferation | |
| protein dephosphorylation | |
| peptidyl-threonine dephosphorylation | |
| dephosphorylation | |
| response to radiation |
| Pathway | p38 MAPK signaling pathway |
|---|---|
| p38 MAPK signaling pathway |
| Group | Phosphatases |
|---|---|
| response to bacterium | |
| cell cycle | |
| G2-M transition of mitotic cell cycle | |
| negative regulation of cell proliferation | |
| protein dephosphorylation | |
| peptidyl-threonine dephosphorylation | |
| dephosphorylation | |
| response to radiation | |
| catalytic activity | |
| metal ion binding | |
| hydrolase activity | |
| phosphoprotein phosphatase activity | |
| protein serine-threonine phosphatase activity | |
| magnesium-dependent protein serine-threonine phosphatase activity | |
| nucleus |
| MedScan ID | 8493 |
|---|
| Hugo ID | 9277 |
|---|
| Human chromosome position | 17q23.2 |
|---|
| LocusLink ID | 8493 |
|---|---|
| 53892 | |
| 287585 |
| Alias | WIP1 |
|---|---|
| PP2C-DELTA | |
| protein phosphatase 1D | |
| protein phosphatase Wip1 | |
| wild-type p53-induced phosphatase 1 | |
| protein phosphatase 2C delta isoform | |
| protein phosphatase magnesium-dependent 1 delta | |
| protein phosphatase 1D magnesium-dependent, delta isoform | |
| AV338790 | |
| RP24-95F14.1 | |
| p53-induced protein phosphatase 1 | |
| protein phosphatase 2C isoform delta | |
| protein phosphatase Wip I | |
| protein phosphatase 2c, delta isozyme | |
| Wip I | |
| Protein phosphatase magnesium- dependent 1 delta | |
| Ppm1d | |
| p53- induced protein phosphatase I | |
| p53- induced protein phosphatase 1 | |
| OTTMUSP00000000998 | |
| protein phosphatase, Mg2+/Mn2+ dependent, 1D |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605100 |
|---|---|
| 114480 |
| Unigene ID | Hs.286073 |
|---|---|
| Mm.45609 | |
| Rn.15540 | |
| Hs.591184 |
| KEGG ID | hsa:8493 |
|---|---|
| mmu:53892 | |
| rno:287585 |
| Swiss-Prot Accession | O15297 |
|---|---|
| Q6P991 | |
| Q3TZJ9 | |
| Q80WV2 | |
| Q9QZ67 | |
| B1WCA0 | |
| Q53XP4 | |
| B1B0B0 | |
| Q8IVR6 | |
| Q8NEA7 | |
| Q3TAP1 | |
| Q78S82 | |
| Q8R1N9 | |
| Q9CW02 |
| EC Number | 3.1.3.16 |
|---|
| GO ID | 0046872 |
|---|---|
| 0004722 | |
| 0000086 | |
| 0008285 | |
| 0035970 | |
| 0006470 | |
| 0009617 | |
| 0009314 | |
| 0005634 | |
| 0003824 | |
| 0016787 | |
| 0004724 | |
| 0004721 | |
| 0007049 | |
| 0016311 | |
| 0008287 | |
| 0000287 | |
| 0030145 |
| Swiss-Prot ID | PPM1D_HUMAN |
|---|---|
| PPM1D_MOUSE | |
| Q80WV2_MOUSE | |
| B1B0B0_MOUSE | |
| Q3TZJ9_MOUSE | |
| Q53XP4_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00005782 |
|---|---|
| IPI00330666 | |
| IPI00387225 | |
| IPI00791057 | |
| IPI00474877 | |
| IPI00648112 | |
| IPI00201900 |
| Mouse chromosome position | 11 47.0 cM |
|---|
| Rat chromosome position | 10q26 |
|---|
| Homologene ID | 31185 |
|---|
| MGI ID | 1858214 |
|---|
| RGD ID | 1305460 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|