| URN | urn:agi-llid:7189 |
|---|---|
| Total Entities | 0 |
| Connectivity | 659 |
| Name | Traf6 |
| Description | TNF receptor-associated factor 6 |
| Notes | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq] |
| Ariadne Ontology | TNFRAP |
|---|---|
| Secreted proteins |
| GO Molecular Function | protein N-terminus binding |
|---|---|
| histone deacetylase binding | |
| thioesterase binding | |
| protein kinase binding | |
| protein kinase B binding | |
| mitogen-activated protein kinase kinase kinase binding | |
| ubiquitin protein ligase binding | |
| metal ion binding | |
| zinc ion binding | |
| ligase activity | |
| ubiquitin-protein ligase activity | |
| signal transducer activity |
| GO Cellular Component | nuclear membrane |
|---|---|
| endosome membrane | |
| nucleolus | |
| CD40 receptor complex | |
| internal side of plasma membrane | |
| protein complex | |
| plasma membrane | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| lipid particle | |
| cytosol | |
| cell cortex | |
| nucleus |
| GO Biological Process | positive regulation of lipopolysaccharide-mediated signaling pathway |
|---|---|
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| activation of NF-kappaB-inducing kinase activity | |
| positive regulation of JUN kinase activity | |
| activation of MAPK activity | |
| signal transduction | |
| apoptotic signaling pathway | |
| nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | |
| nucleotide-binding oligomerization domain containing signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| stress-activated MAPK cascade | |
| JNK cascade | |
| T cell receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| cytokine-mediated signaling pathway | |
| Toll signaling pathway | |
| interleukin-1-mediated signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| positive regulation of interleukin-6 biosynthetic process | |
| positive regulation of interleukin-12 biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| activation of protein kinase activity | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of apoptotic process | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of T cell proliferation | |
| positive regulation of T cell activation | |
| positive regulation of osteoclast differentiation | |
| regulation of immunoglobulin secretion | |
| regulation of apoptotic process | |
| cell development | |
| osteoclast differentiation | |
| myeloid dendritic cell differentiation | |
| protein ubiquitination | |
| protein polyubiquitination | |
| protein autoubiquitination | |
| protein K63-linked ubiquitination | |
| apoptotic process | |
| immune response | |
| positive regulation of T cell cytokine production | |
| innate immune response | |
| T-helper 1 type immune response | |
| antigen processing and presentation of exogenous peptide antigen via MHC class II | |
| response to interleukin-1 | |
| positive regulation of interleukin-2 production | |
| neural tube closure | |
| organ morphogenesis | |
| odontogenesis of dentin-containing tooth | |
| ossification | |
| bone remodeling | |
| membrane protein intracellular domain proteolysis | |
| protein complex assembly | |
| bone resorption | |
| positive regulation of transcription regulatory region DNA binding |
| Pathway | EctodysplasinR -> NF-kB signaling |
|---|---|
| EctodysplasinR -> AP-1 signaling | |
| TNFRSF5/13B -> NFATC1 signaling | |
| NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling | |
| TNFRSF5/6 -> RB1/E2F signaling | |
| TNFR -> CREB/ELK-SRF signaling | |
| TNFR -> NF-kB signaling | |
| NGFR -> MEF signaling | |
| NGFR -> NF-kB signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| EctodysplasinR -> LEF1 signaling | |
| T-cell receptor -> NF-kB signaling | |
| TLR4/5/7/9 -> NF-kB signaling | |
| TLR1/2/6 -> NF-kB signaling | |
| IL1R -> STAT3 signaling | |
| IL1R -> NF-kB signaling | |
| TLR -> AP-1 signaling | |
| DDR1 -> NF-kB signaling | |
| B-cell receptor -> NF-kB signaling | |
| CD38 -> NF-kB signaling | |
| TLR4/NF-kB/IRF Expression Targets | |
| TLR5 Expression Targets | |
| TLR7 Expression Targets | |
| TLR9 Expression Targets | |
| TLR1/2/6 Expression Targets | |
| NGF/FOXO/MYCN/ELK-SRF Expression Targets | |
| BDNF Expression Targets | |
| NTF3 Expression Targets | |
| NTF4 Expression Targets | |
| CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets | |
| TNFSF13 Expression Targets | |
| TNFSF13B Expression Targets | |
| EDA Expression Targets | |
| NGF/AP-1/TP53/MYC Expression Targets | |
| NGF/CREB/CEBPB/MEF2A Expression Targets | |
| NGF/SMAD3/NF-kB Expression Targets | |
| CD40LG/ATF2/AP-1/TP53/E2F Expression Targets | |
| Gamma Globulins Expression Targets | |
| PECAM1 Expression Targets | |
| Collagen/NF-kB Expression Targets | |
| IL16/NF-kB Expression Targets | |
| CD8/NF-kB Expression Targets | |
| CD80/NF-kB Expression Targets | |
| CD86/NF-kB Expression Targets | |
| CD22/NF-kB Expression Targets | |
| CD72/NF-kB Expression Targets | |
| PDCD1/NF-kB Expression Targets | |
| TCR/NF-kB Expression Targets | |
| IL1A Expression Targets | |
| TLR4/AP-1 Expression Targets | |
| TLR4/AP-1/EGR1/HIF1A Expression Targets | |
| IL1B Expression Targets | |
| interleukin-1 signaling pathway | |
| Toll-like receptor signaling pathway | |
| p38 MAPK signaling pathway | |
| p38 MAPK signaling pathway | |
| p38 MAPK signaling pathway |
| Group | TNFRAP |
|---|---|
| positive regulation of lipopolysaccharide-mediated signaling pathway | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| activation of NF-kappaB-inducing kinase activity | |
| positive regulation of JUN kinase activity | |
| activation of MAPK activity | |
| signal transduction | |
| apoptotic signaling pathway | |
| nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | |
| nucleotide-binding oligomerization domain containing signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| stress-activated MAPK cascade | |
| JNK cascade | |
| T cell receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| cytokine-mediated signaling pathway | |
| Toll signaling pathway | |
| interleukin-1-mediated signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| positive regulation of interleukin-6 biosynthetic process | |
| positive regulation of interleukin-12 biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| activation of protein kinase activity | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of apoptotic process | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of T cell proliferation | |
| positive regulation of T cell activation | |
| positive regulation of osteoclast differentiation | |
| regulation of immunoglobulin secretion | |
| regulation of apoptotic process | |
| cell development | |
| osteoclast differentiation | |
| myeloid dendritic cell differentiation | |
| protein ubiquitination | |
| protein polyubiquitination | |
| protein autoubiquitination | |
| protein K63-linked ubiquitination | |
| apoptotic process | |
| immune response | |
| positive regulation of T cell cytokine production | |
| innate immune response | |
| T-helper 1 type immune response | |
| antigen processing and presentation of exogenous peptide antigen via MHC class II | |
| response to interleukin-1 | |
| positive regulation of interleukin-2 production | |
| neural tube closure | |
| organ morphogenesis | |
| odontogenesis of dentin-containing tooth | |
| ossification | |
| bone remodeling | |
| membrane protein intracellular domain proteolysis | |
| protein complex assembly | |
| bone resorption | |
| positive regulation of transcription regulatory region DNA binding | |
| protein N-terminus binding | |
| histone deacetylase binding | |
| thioesterase binding | |
| protein kinase binding | |
| protein kinase B binding | |
| mitogen-activated protein kinase kinase kinase binding | |
| ubiquitin protein ligase binding | |
| metal ion binding | |
| zinc ion binding | |
| ligase activity | |
| ubiquitin-protein ligase activity | |
| signal transducer activity | |
| nuclear membrane | |
| endosome membrane | |
| nucleolus | |
| CD40 receptor complex | |
| internal side of plasma membrane | |
| protein complex | |
| plasma membrane | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| lipid particle | |
| cytosol | |
| cell cortex | |
| nucleus | |
| Secreted proteins |
| MedScan ID | 7189 |
|---|
| Hugo ID | 12036 |
|---|
| Human chromosome position | 11p12 |
|---|
| LocusLink ID | 7189 |
|---|---|
| 22034 | |
| 311245 |
| Alias | RNF85 |
|---|---|
| MGC:3310 | |
| TNF receptor-associated factor 6 | |
| RING finger protein 85 | |
| interleukin-1 signal transducer | |
| E3 ubiquitin-protein ligase TRAF6 | |
| AI851288 | |
| 2310003F17Rik | |
| C630032O20Rik | |
| RP23-313G3.1 | |
| 2310003F17 | |
| tumour necrosis factor (TNF) receptor-associated factor 6 | |
| tumour necrosis factor receptor associated factor 6 | |
| Tumor necrosis factor receptor associated factor 6 | |
| tumor necrosis factor (TNF) receptor-associated factor 6 | |
| TRAF6 | |
| TNF receptor-associated factor VI | |
| OTTMUSP00000015480 | |
| LOC100048242 | |
| LOC100042930 | |
| C630032O20 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602355 |
|---|
| Unigene ID | Hs.444172 |
|---|---|
| Hs.591983 | |
| Mm.292729 | |
| Rn.220435 |
| KEGG ID | hsa:7189 |
|---|---|
| mmu:22034 | |
| rno:311245 |
| Swiss-Prot Accession | Q9Y4K3 |
|---|---|
| P70196 | |
| B5DF45 | |
| A6NKI7 | |
| A8KAB3 | |
| D3DR16 | |
| Q8NEH5 | |
| Q6P9M0 | |
| Q8BLV2 |
| EC Number | 6.3.2.- |
|---|
| GO ID | 0042826 |
|---|---|
| 0031435 | |
| 0047485 | |
| 0043422 | |
| 0019901 | |
| 0031996 | |
| 0031625 | |
| 0004842 | |
| 0008270 | |
| 0007249 | |
| 0007254 | |
| 0002755 | |
| 0002756 | |
| 0050852 | |
| 0042088 | |
| 0035666 | |
| 0008063 | |
| 0000187 | |
| 0007250 | |
| 0032147 | |
| 0019886 | |
| 0006915 | |
| 0045453 | |
| 0048468 | |
| 0045087 | |
| 0070498 | |
| 0031293 | |
| 0043011 | |
| 0000122 | |
| 0045892 | |
| 0048011 | |
| 0001843 | |
| 0035872 | |
| 0070423 | |
| 0042475 | |
| 0001503 | |
| 0030316 | |
| 0043123 | |
| 0043507 | |
| 0051092 | |
| 0050870 | |
| 0002726 | |
| 0042102 | |
| 0045084 | |
| 0032743 | |
| 0045410 | |
| 0031666 | |
| 0045672 | |
| 0051091 | |
| 0048661 | |
| 0045944 | |
| 2000679 | |
| 0070534 | |
| 0051865 | |
| 0000209 | |
| 0042981 | |
| 0051023 | |
| 0070555 | |
| 0051403 | |
| 0034130 | |
| 0034134 | |
| 0034138 | |
| 0034142 | |
| 0002224 | |
| 0035631 | |
| 0005938 | |
| 0005737 | |
| 0005829 | |
| 0010008 | |
| 0009898 | |
| 0005811 | |
| 0031965 | |
| 0005730 | |
| 0005634 | |
| 0048471 | |
| 0005886 | |
| 0016874 | |
| 0046872 | |
| 0004871 | |
| 0046849 | |
| 0019221 | |
| 0006955 | |
| 0009887 | |
| 0006461 | |
| 0016567 | |
| 0007165 | |
| 0043234 | |
| 0006916 | |
| 0008624 | |
| 0016564 | |
| 0005624 | |
| 0019941 | |
| 0004872 |
| PIR ID | S71821 |
|---|
| Swiss-Prot ID | TRAF6_RAT |
|---|---|
| TRAF6_HUMAN | |
| TRAF6_MOUSE | |
| D3DR16_HUMAN | |
| B5DF45_RAT | |
| Q6P9M0_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| cell cortex | |
| Nucleus | |
| Lipid droplet |
| IPI ID | IPI00363697 |
|---|---|
| IPI00743663 | |
| IPI00136488 | |
| IPI00222919 | |
| IPI00420463 |
| Mouse chromosome position | 2 |
|---|
| Rat chromosome position | 3q31 |
|---|
| Homologene ID | 3395 |
|---|
| MGI ID | 108072 |
|---|
| RGD ID | 1306853 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|