Protein Spag9

URN	urn:agi-llid:9043
Total Entities	0
Connectivity	60
Name	Spag9
Description	sperm associated antigen 9
Notes	Extracellular signals are transduced into cells through mitogen-activated protein kinases. The structural organization of these kinases into specific signaling domains is facilitated by scaffolding proteins involved in closely tethering different kinases so that successive phosphorylation events can occur. The protein encoded by this gene is a scaffolding protein that brings together mitogen-activated protein kinases and their transcription factor targets for the activation of specific signaling pathways. This gene which is abundantly expressed in testicular haploid germ cells encodes a protein that is recognized by sperm-agglutinating antibodies and implicated in infertility. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Ariadne Ontology	Oncogenes
	Biofluids assayable substances

GO Molecular Function	phosphatidylinositol 3-kinase binding
	JUN kinase binding
	mitogen-activated protein kinase p38 binding
	kinesin binding

GO Cellular Component	integral to membrane
	cytoplasm
	perinuclear region of cytoplasm
	cytosol
	acrosomal vesicle

GO Biological Process	positive regulation of MAPK cascade
	activation of JUN kinase activity
	activation of MAPK activity
	positive regulation of cell migration
	positive regulation of muscle cell differentiation
	positive regulation of neuron differentiation
	muscle cell differentiation
	striated muscle cell differentiation
	spermatogenesis
	retrograde transport, endosome to Golgi
	protein homooligomerization
	negative regulation of protein homodimerization activity

Pathway	p38 MAPK signaling pathway
	p38 MAPK signaling pathway

Group	Oncogenes
	positive regulation of MAPK cascade
	activation of JUN kinase activity
	activation of MAPK activity
	positive regulation of cell migration
	positive regulation of muscle cell differentiation
	positive regulation of neuron differentiation
	muscle cell differentiation
	striated muscle cell differentiation
	spermatogenesis
	retrograde transport, endosome to Golgi
	protein homooligomerization
	negative regulation of protein homodimerization activity
	phosphatidylinositol 3-kinase binding
	JUN kinase binding
	mitogen-activated protein kinase p38 binding
	kinesin binding
	integral to membrane
	cytoplasm
	perinuclear region of cytoplasm
	cytosol
	acrosomal vesicle
	Biofluids assayable substances

MedScan ID	9043

Hugo ID	14524

Human chromosome position	17q21.33

Alias	JLP
	CT89
	HLC4
	HLC6
	JIP4
	PHET
	PIG6
	HLC-6
	JIP-4
	C-Jun-amino-terminal kinase-interacting protein 4
	sunday driver 1
	Max-binding protein
	sperm surface protein
	lung cancer oncogene 4
	JNK interacting protein
	cancer/testis antigen 89
	JNK/SAPK-associated protein
	proliferation-inducing gene 6
	protein highly expressed in testis
	human lung cancer oncogene 6 protein
	mitogen-activated protein kinase 8-interacting protein 4
	c-Jun NH2-terminal kinase-associated leucine zipper protein
	syd1
	JSAP2
	JSAP2a
	AW552012
	Mapk8ip4
	3110018C07Rik
	4733401I23Rik
	4831406C20Rik
	RP23-378I13.3
	JNK-interacting protein 4
	sperm-associated antigen 9
	JNK/SAPK-associated protein 2
	JNK-interacting leucine zipper
	JNK-associated leucine-zipper protein
	KIAA0516
	MGC74461
	MGC14967
	MGC117291
	lung cancer oncogene IV
	LOC264894
	OTTMUSP00000001565
	SPAG9
	OTTMUSP00000001568
	OTTMUSP00000001569
	jnk-interacting protein IV
	sperm associated antigen 9
	SYD I
	proliferation-inducing gene VI
	3110018C07
	4733401I23
	JNK-associated leucine-zipper
	FLJ13450
	FLJ14006
	FLJ26141
	JNK/SAPK associated protein
	4831406C20
	FLJ34602
	JNK interactive leucine-zipper protein
	JNK interacting leucine-zipper protein
	hlc-4

OMIM ID	605430

PIR ID	JC5958

Mouse chromosome position	11

Rat chromosome position	10q26

Homologene ID	2954

MGI ID	1918084

RGD ID	1311289