Protein Map2k3

URN urn:agi-llid:5606
Total Entities 0
Connectivity 330
Name Map2k3
Description mitogen activated protein kinase kinase 3
Notes The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Ariadne Ontology MKK3-6
Secreted proteins

GO Molecular Function protein kinase binding
nucleotide binding
ATP binding
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein serine-threonine kinase activity
protein tyrosine kinase activity
MAP kinase kinase activity

GO Cellular Component nucleoplasm
cytosol

GO Biological Process activation of MAPK activity
signal transduction
MAPK cascade
stress-activated MAPK cascade
toll-like receptor signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
toll-like receptor 1 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
Toll signaling pathway
positive regulation of transcription, DNA-dependent
positive regulation of protein kinase activity
regulation of cytokine biosynthetic process
protein phosphorylation
phosphorylation
innate immune response
inflammatory response
cardiac muscle contraction

Pathway FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling
PDGFR -> AP-1/MYC signaling
VEGFR -> AP-1/CREB/MYC signaling
HGFR -> AP-1/CREB/MYC signaling
AngiopoietinR -> AP-1 signaling
ErythropoietinR -> AP-1/CREB/MYC signaling
ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling
EGFR -> AP-1/CREB/ELK-SRF/MYC signaling
EctodysplasinR -> NF-kB signaling
NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling
TNFRSF5/6 -> RB1/E2F signaling
TNFR -> CREB/ELK-SRF signaling
TNFR -> NF-kB signaling
NGFR -> MEF signaling
TNFRSF6 -> DDIT3 signaling
NGFR -> NF-kB signaling
TNFR -> AP-1/ATF/TP53 signaling
TNFRSF1A -> AP-1/ATF/TP53 signaling
TNFRSF1A -> CREB/ELK-SRF signaling
Notch -> TCF3 signaling
T-cell receptor -> ATF/CREB signaling
TGFBR -> ATF/GADD/MAX/TP53 signaling
TGFBR -> CREB/ELK-SRF signaling
TGFBR -> MEF/MYOD/MYOG signaling
TGFBR -> AP-1 signaling
IL1R -> NF-kB signaling
TLR -> AP-1 signaling
EGFR -> AP-1/ATF2 signaling
EGFR/ERBB2 -> TP53 signaling
EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling
VEGFR -> NFATC signaling
VEGFR -> ATF/CREB/ELK-SRF signaling
IGF1R -> MEF/MYOD/MYOG signaling
NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling
ICAM1 -> AP-1/CREB/ELK-SRF signaling
FibronectinR -> NF-kB signaling
FibronectinR -> AP-1/ELK-SRF/SREBF signaling
CholinergicRm -> CREB/ELK-SRF signaling
CannabinoidR -> AP-1/EGR signaling
DopamineR2 -> AP-1/CREB/ELK-SRF signaling
SerotoninR1 -> FOS signaling
PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling
VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling
PTAFR -> NF-kB signaling
VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling
GRM1/5 -> CREB signaling
EDG3/5 -> AP-1/ELK-SRF signaling
EndothelinRb -> AP-1/CREB/ELK-SRF signaling
VIPR -> CREB/CEBP signaling
EndothelinRa -> AP-1/CREB signaling
VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling
VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling
ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling
EphrinB -> JUN signaling
Clozapine-Induced Granulocytopenia
ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy
TGFB3-TGFBR2 Expression Targets
TGFB2-TGFBR2 Expression Targets
TGFB1-TGFBR2 Expression Targets
TLR5 Expression Targets
TLR7 Expression Targets
TLR9 Expression Targets
TLR1/2/6 Expression Targets
FASLG Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets
TNFSF13 Expression Targets
TNFSF13B Expression Targets
EDA Expression Targets
TNFSF10 Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
TNF/CREB Expression Targets
TNF/TP53/ATF Expression Targets
TNF/ELK-SRF Expression Targets
NGF/AP-1/TP53/MYC Expression Targets
NGF/CREB/CEBPB/MEF2A Expression Targets
NGF/SMAD3/NF-kB Expression Targets
CD40LG/ATF2/AP-1/TP53/E2F Expression Targets
ICAM1 Expression Targets
Fibronectin Expression Targets
Dopamine/Gi Expression Targets
Dronabinol/Anandamide Expression Targets
Acetylcholine Expression Targets
AREG/AP-1 Expression Targets
AREG/NFATC Expression Target
BTC/NFATC Expression Targets
EGF/TP53 Expression Targets
EREG/AP-1/ATF Expression Targets
HBEGF/AP-1/ATF Expression Targets
HBEGF/MEF/MYOD Expression Target
HBEGF/TP53 Expression Targets
NRG1/AP-1/ATF Expression Targets
NRG1/MEF/MYOD Expression Targets
NRG1/TP53 Expression Target
TGFA/MEF/MYOD/NFATC Expression Targets
TGFA/TP53 Expression Targets
VEGFA/NFATC Expression Targets
VEGFA/ATF/CREB/ELK-SRF Expression Targets
VEGFC/ATF Expression Target
IGF2/MEF/MYOD Expression Targets
CTGF/AP-1/CREB/MYC Expression Targets
Erythropoietin/AP-1/MYC/CREB Expression Targets
FLT3LG/AP-1/CREB/CREBBP Expression Targets
GAS6/AP-1/CREB Expression Targets
PGF/AP-1/CREB/CREBBP/MYC Expression Targets
Thrombopoietin/AP-1/CREB/CREBBP/MYC Expression Targets
AREG/CREB/CREBBP Expression Targets
EREG/CREB Expression Target
HBEGF/CREB/MYC Expression Targets
NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets
TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets
FGF1/AP-1/CREB/ELK-SRF/MYC Expression Targets
FGF4/AP-1/MYC Expression Targets
FGF7/AP-1/CREB/CREBBP/MYC Expression Targets
FGF8/AP-1/CREB/MYC Expression Targets
FGF9/AP-1/CREB/MYC Expression Targets
FGF10/AP-1/CREB/CREBBP/MYC Expression Targets
FGF18/AP-1/CREB Expression Targets
CSF1/AP-1/CREB/CREBBP/MYC Expression Targets
PDGFB/AP-1/CREB/MYC Expression Target
PDGFC/CREB Expression Target
PDGFD/AP-1 Expression Targets
ANGPT1/CREB/CREBBP Expression Targets
ANGPT2/AP-1/CREBBP/MYC Expression Targets
FIGF/AP-1 Expression Target
F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets
PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets
Glutamate/Gq Expression Targets
AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets
AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets
PAF/Gq -> NF-kB Expression Targets
S1P Expression Targets
VIP Expression Targets
AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets
AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets
EDN1 Expression Targets
EDN3 Expression Targets
ADCYAP1 Expression Targets
IL16/ATF/CREB/CREBBP Expression Target
CD8/ATF/CREB/CREBBP Expression Targets
CD80/ATF/CREB/CREBBP Expression Targets
CD86/ATF/CREB/CREBBP Expression Targets
CD72/CREB/CREBBP Expression Targets
PDCD1/ATF/CREB/CREBBP Expression Targets
TCR/CREB/CREBBP/ATF Expression Targets
FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets
IL1A Expression Targets
NOTCH Expression Targets
TNF/NF-kB Expression Targets
EGF/AP-1/ATF Expression Targets
EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets
EGF/MEF/MYOD/NFATC Expression Targets
HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets
IGF1/MEF/MYOD/MYOG Expression Targets
Insulin/MEF/MYOD Expression Targets
KITLG/AP-1/CREB/CREBBP/MYC Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets
PDGF/AP-1/CREB/CREBBP/MYC Expression Targets
TGFA/AP-1/ATF Expression Targets
TLR4/AP-1 Expression Targets
TLR4/AP-1/EGR1/HIF1A Expression Targets
TNF/AP-1 Expression Targets
VEGFA/AP-1/CREBBP/MYC Expression Targets
IL1B Expression Targets
BTC/AP-1/ATF/CREB Expression Targets
p38 MAPK signaling pathway
p38 MAPK signaling pathway
p38 MAPK signaling pathway

Group MKK3-6
activation of MAPK activity
signal transduction
MAPK cascade
stress-activated MAPK cascade
toll-like receptor signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
toll-like receptor 1 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
Toll signaling pathway
positive regulation of transcription, DNA-dependent
positive regulation of protein kinase activity
regulation of cytokine biosynthetic process
protein phosphorylation
phosphorylation
innate immune response
inflammatory response
cardiac muscle contraction
protein kinase binding
nucleotide binding
ATP binding
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein serine-threonine kinase activity
protein tyrosine kinase activity
MAP kinase kinase activity
nucleoplasm
cytosol
Secreted proteins

Source Curated

MedScan ID 5606

Hugo ID 6843

Human chromosome position 17q11.2

GenBank ID NC_000017
NM_145109
NP_659731
NM_002756
NP_002747
NG_028256
NC_018928
AC_000149
AC087294
CH879350
EAW50386
U66840
AAB40653
AB451226
BAG70040
AB451349
BAG70163
AI758302
AK093838
BAG52769
AK223490
BAD97210
AK315505
BAG37889
BC032478
AAH32478
BM836867
CR536514
CAG38752
CR541793
CAG46592
D87116
BAA13248
DA131175
DA987047
GQ225578
ACT33197
L36719
AAC41718
U66839
AAB40652
P46734
DQ894188
ABM85114
NC_000077
NM_008928
NP_032954
AC_000033
AL603830
CAI25794
CH466675
EDL38689
EDL38690
EDL38691
AK008141
BAB25489
AK011002
BAB27321
AK053378
AK150067
BAE29279
AK159379
BAE35034
AK166255
BAE38665
AK166507
BAE38817
AK167209
BAE39336
AK167442
BAE39528
AK168710
BAE40552
AK176968
AK179609
AK181928
AK185191
AK197832
AK219340
BC007467
AAH07467
D87115
BAA13247
X93150
CAA63649
O09110
NC_005109
NM_001100674
NP_001094144
AC_000078
CH473948
EDM04672
EDM04673
BC100095
AAI00096
BC160839
AAI60839
DY311082
FQ228252
FQ231052
FQ234879
FQ235160
FQ235176
NT_010718
NW_001838428
NW_921423
CR597835
Q53EZ9
Q6FHG1
Q6FI23
NT_096135
NW_001030465
Q3TJG7
Q3TLX7
Q3TX82
Q3UDI2
Q5SWN9
NW_047334
NW_001084656
Q498S1
XM_239239
XP_239239
XM_001077724
XP_001077724
Q8BPT2
BG077180
AC_000060
NW_926672
AI481780
NP_659732
XM_944206
XP_949299
NM_145110
NW_000039

LocusLink ID 5606
26397
303200
19103
104607

Alias MEK3
MKK3
MAPKK3
PRKMK3
SAPKK2
SAPKK-2
dual specificity mitogen-activated protein kinase kinase 3
MEK 3
MAPKK 3
SAPK kinase 2
MAPK/ERK kinase 3
MAP kinase kinase 3
stress-activated protein kinase kinase 2
mMKK3b
AW212142
RP23-467E19.1
mitogen activated protein kinase kinase 3
protein kinase, mitogen-activated, kinase 3
SKK2
mitogen-activated protein kinase kinase III
OTTHUMP00000166044
OTTMUSP00000006687
MAPK/ERK kinase III
Dual specificity mitogen-activated protein kinase kinase III
dual specificity mitogen activated protein kinase kinase 3
LOC303200
LOC82070
LOC92079
Map2k3
MAPK kinase 3
MAPK kinase III
MAP kinase kinase III
mitogen-activated protein kinase kinase 3
MAPKK3s
PRKMK3s
protein kinase, mitogen-activated, kinase III
kinase, mitogen-activated, kinase

Organism Homo sapiens
Mus musculus
Rattus norvegicus

OMIM ID 602315
OMIM:602315

Unigene ID Hs.514012
Mm.18494
Rn.100064
Hs.180533

KEGG ID hsa:5606
mmu:26397
rno:303200

Swiss-Prot Accession P46734
Q6FI23
O09110
Q5SWN9
B1H230
Q498S1
P97293
Q91VX1
B3KSK7
Q99441
Q9UE71
Q9UE72
Q53EZ9
Q6FHG1
Q3TJG7
Q3TLX7
Q3TX82
Q3UDI2

EC Number 2.7.12.2
2.7.1.-

GO ID 0005524
0004708
0019901
0004674
0004713
0002755
0002756
0035666
0008063
0000187
0060048
0006954
0045087
0045860
0045893
0042035
0007165
0051403
0034130
0034134
0034138
0034142
0002224
0005829
0005654
0016301
0000166
0004672
0016740
0016772
0000165
0016310
0006468
0005515
0003674
0005575

Swiss-Prot ID MP2K3_MOUSE
MP2K3_HUMAN
Q5SWN9_MOUSE
Q6FI23_HUMAN
B1H230_RAT
Q498S1_RAT

Cell Localization Cytoplasm

IPI ID IPI00114245
IPI00230052
IPI00218857
IPI00218858
IPI00220438
IPI00911212
IPI00886178

Mouse chromosome position 11
11 B2

Rat chromosome position 10q22

Homologene ID 56430

MGI ID 1346868
1328353
2144511

RGD ID 1306620

Primary Cell Localization Cytoplasm

KEGG pathway Toll-like receptor signaling pathway
MAPK signaling pathway