| URN | urn:agi-llid:1432 |
|---|---|
| Total Entities | 0 |
| Connectivity | 4237 |
| Name | Mapk14 |
| Description | mitogen activated protein kinase 14 |
| Notes | mitogen-activated protein kinase; involved in intracellular signalling, inhibition of apoptosis and gene activation [RGD] |
| Ariadne Ontology | p38 |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | protein C-terminus binding |
|---|---|
| NFAT protein binding | |
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase activity | |
| MAP kinase kinase activity |
| GO Cellular Component | cell |
|---|---|
| nucleoplasm | |
| spindle pole | |
| cytoplasm | |
| mitochondrion | |
| cytosolic part | |
| cytosol | |
| nucleus |
| GO Biological Process | cellular component movement |
|---|---|
| DNA damage checkpoint | |
| activation of MAPK activity | |
| stress-induced premature senescence | |
| signal transduction | |
| cell surface receptor signaling pathway | |
| signal transduction by phosphorylation | |
| signal transduction in response to DNA damage | |
| intracellular protein kinase cascade | |
| stress-activated MAPK cascade | |
| Ras protein signal transduction | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| lipopolysaccharide-mediated signaling pathway | |
| Toll signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| vascular endothelial growth factor receptor signaling pathway | |
| positive regulation of reactive oxygen species metabolic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| regulation of sequence-specific DNA binding transcription factor activity | |
| positive regulation of muscle cell differentiation | |
| positive regulation of erythrocyte differentiation | |
| positive regulation of protein import into nucleus | |
| cell morphogenesis | |
| muscle cell differentiation | |
| chondrocyte differentiation | |
| osteoclast differentiation | |
| striated muscle cell differentiation | |
| platelet activation | |
| transcription, DNA-dependent | |
| RNA metabolic process | |
| mRNA metabolic process | |
| fatty acid oxidation | |
| protein phosphorylation | |
| peptidyl-serine phosphorylation | |
| protein autophosphorylation | |
| phosphorylation | |
| cellular response to growth factor stimulus | |
| response to DNA damage stimulus | |
| cellular response to ionizing radiation | |
| apoptotic process | |
| innate immune response | |
| response to stress | |
| chemotaxis | |
| response to lipopolysaccharide | |
| response to muramyl dipeptide | |
| response to glucose stimulus | |
| 3'-UTR-mediated mRNA stabilization | |
| angiogenesis | |
| skeletal muscle tissue development | |
| blood coagulation | |
| glucose metabolic process | |
| gene expression |
| Pathway | FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling |
|---|---|
| PDGFR -> AP-1/MYC signaling | |
| VEGFR -> AP-1/CREB/MYC signaling | |
| HGFR -> AP-1/CREB/MYC signaling | |
| AngiopoietinR -> AP-1 signaling | |
| ErythropoietinR -> AP-1/CREB/MYC signaling | |
| ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EctodysplasinR -> NF-kB signaling | |
| NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling | |
| TNFRSF5/6 -> RB1/E2F signaling | |
| TNFR -> CREB/ELK-SRF signaling | |
| TNFR -> NF-kB signaling | |
| NGFR -> MEF signaling | |
| TNFRSF6 -> DDIT3 signaling | |
| NGFR -> NF-kB signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> CREB/ELK-SRF signaling | |
| Notch -> TCF3 signaling | |
| T-cell receptor -> ATF/CREB signaling | |
| TGFBR -> ATF/GADD/MAX/TP53 signaling | |
| TGFBR -> CREB/ELK-SRF signaling | |
| TGFBR -> MEF/MYOD/MYOG signaling | |
| TGFBR -> AP-1 signaling | |
| IL1R -> NF-kB signaling | |
| TLR -> AP-1 signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling | |
| VEGFR -> NFATC signaling | |
| VEGFR -> ATF/CREB/ELK-SRF signaling | |
| IGF1R -> MEF/MYOD/MYOG signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| DDR1 -> NF-kB signaling | |
| ICAM1 -> AP-1/CREB/ELK-SRF signaling | |
| FibronectinR -> NF-kB signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| CholinergicRm -> CREB/ELK-SRF signaling | |
| CannabinoidR -> AP-1/EGR signaling | |
| DopamineR2 -> AP-1/CREB/ELK-SRF signaling | |
| SerotoninR1 -> FOS signaling | |
| CCR5 -> TP53 signaling | |
| PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling | |
| VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling | |
| PTAFR -> NF-kB signaling | |
| VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| GRM1/5 -> CREB signaling | |
| EDG3/5 -> AP-1/ELK-SRF signaling | |
| EndothelinRb -> AP-1/CREB/ELK-SRF signaling | |
| VIPR -> CREB/CEBP signaling | |
| EndothelinRa -> AP-1/CREB signaling | |
| AngiotensinR -> CREB/ELK-SRF/TP53 signaling | |
| VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| EphrinB -> JUN signaling | |
| Cyclosporine-Induced Nephrotoxicity | |
| Unfolded Protein Response | |
| Doxorubicin-Induced Cardiotoxicity | |
| Clozapine-Induced Granulocytopenia | |
| ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy | |
| TGFB3-TGFBR2 Expression Targets | |
| TGFB2-TGFBR2 Expression Targets | |
| TGFB1-TGFBR2 Expression Targets | |
| TLR5 Expression Targets | |
| TLR7 Expression Targets | |
| TLR9 Expression Targets | |
| TLR1/2/6 Expression Targets | |
| FASLG Expression Targets | |
| NGF/FOXO/MYCN/ELK-SRF Expression Targets | |
| BDNF Expression Targets | |
| NTF3 Expression Targets | |
| NTF4 Expression Targets | |
| CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets | |
| TNFSF13 Expression Targets | |
| TNFSF13B Expression Targets | |
| EDA Expression Targets | |
| TNFSF10 Expression Targets | |
| LTA Expression Targets | |
| TNFSF14 Expression Targets | |
| TNF/CREB Expression Targets | |
| TNF/TP53/ATF Expression Targets | |
| TNF/ELK-SRF Expression Targets | |
| NGF/AP-1/TP53/MYC Expression Targets | |
| NGF/CREB/CEBPB/MEF2A Expression Targets | |
| NGF/SMAD3/NF-kB Expression Targets | |
| CD40LG/ATF2/AP-1/TP53/E2F Expression Targets | |
| ICAM1 Expression Targets | |
| Fibronectin Expression Targets | |
| CCL2 Expression Targets | |
| CCL5 Expression Targets | |
| IL8 Expression Targets | |
| Dopamine/Gi Expression Targets | |
| Dronabinol/Anandamide Expression Targets | |
| Acetylcholine Expression Targets | |
| AREG/AP-1 Expression Targets | |
| AREG/NFATC Expression Target | |
| BTC/NFATC Expression Targets | |
| EGF/TP53 Expression Targets | |
| EREG/AP-1/ATF Expression Targets | |
| HBEGF/AP-1/ATF Expression Targets | |
| HBEGF/MEF/MYOD Expression Target | |
| HBEGF/TP53 Expression Targets | |
| NRG1/AP-1/ATF Expression Targets | |
| NRG1/MEF/MYOD Expression Targets | |
| NRG1/TP53 Expression Target | |
| TGFA/MEF/MYOD/NFATC Expression Targets | |
| TGFA/TP53 Expression Targets | |
| VEGFA/NFATC Expression Targets | |
| VEGFA/ATF/CREB/ELK-SRF Expression Targets | |
| VEGFC/ATF Expression Target | |
| Collagen/NF-kB Expression Targets | |
| IGF2/MEF/MYOD Expression Targets | |
| CTGF/AP-1/CREB/MYC Expression Targets | |
| Erythropoietin/AP-1/MYC/CREB Expression Targets | |
| FLT3LG/AP-1/CREB/CREBBP Expression Targets | |
| GAS6/AP-1/CREB Expression Targets | |
| PGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| Thrombopoietin/AP-1/CREB/CREBBP/MYC Expression Targets | |
| AREG/CREB/CREBBP Expression Targets | |
| EREG/CREB Expression Target | |
| HBEGF/CREB/MYC Expression Targets | |
| NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| FGF1/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| FGF4/AP-1/MYC Expression Targets | |
| FGF7/AP-1/CREB/CREBBP/MYC Expression Targets | |
| FGF8/AP-1/CREB/MYC Expression Targets | |
| FGF9/AP-1/CREB/MYC Expression Targets | |
| FGF10/AP-1/CREB/CREBBP/MYC Expression Targets | |
| FGF18/AP-1/CREB Expression Targets | |
| CSF1/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGFB/AP-1/CREB/MYC Expression Target | |
| PDGFC/CREB Expression Target | |
| PDGFD/AP-1 Expression Targets | |
| ANGPT1/CREB/CREBBP Expression Targets | |
| ANGPT2/AP-1/CREBBP/MYC Expression Targets | |
| FIGF/AP-1 Expression Target | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| Glutamate/Gq Expression Targets | |
| AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets | |
| AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| PAF/Gq -> NF-kB Expression Targets | |
| S1P Expression Targets | |
| VIP Expression Targets | |
| AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets | |
| AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| EDN1 Expression Targets | |
| EDN3 Expression Targets | |
| ADCYAP1 Expression Targets | |
| IL16/ATF/CREB/CREBBP Expression Target | |
| CD8/ATF/CREB/CREBBP Expression Targets | |
| CD80/ATF/CREB/CREBBP Expression Targets | |
| CD86/ATF/CREB/CREBBP Expression Targets | |
| CD72/CREB/CREBBP Expression Targets | |
| PDCD1/ATF/CREB/CREBBP Expression Targets | |
| TCR/CREB/CREBBP/ATF Expression Targets | |
| AGT/TP53 Expression Targets | |
| AGT/ELK-SRF Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| IL1A Expression Targets | |
| NOTCH Expression Targets | |
| TNF/NF-kB Expression Targets | |
| AGT/CREB Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| EGF/MEF/MYOD/NFATC Expression Targets | |
| HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| IGF1/MEF/MYOD/MYOG Expression Targets | |
| Insulin/MEF/MYOD Expression Targets | |
| KITLG/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| TGFA/AP-1/ATF Expression Targets | |
| TLR4/AP-1 Expression Targets | |
| TLR4/AP-1/EGR1/HIF1A Expression Targets | |
| TNF/AP-1 Expression Targets | |
| VEGFA/AP-1/CREBBP/MYC Expression Targets | |
| IL1B Expression Targets | |
| BTC/AP-1/ATF/CREB Expression Targets | |
| p38 MAPK signaling pathway | |
| p38 MAPK signaling pathway | |
| p38 MAPK signaling pathway |
| Group | p38 |
|---|---|
| cellular component movement | |
| DNA damage checkpoint | |
| activation of MAPK activity | |
| stress-induced premature senescence | |
| signal transduction | |
| cell surface receptor signaling pathway | |
| signal transduction by phosphorylation | |
| signal transduction in response to DNA damage | |
| intracellular protein kinase cascade | |
| stress-activated MAPK cascade | |
| Ras protein signal transduction | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| lipopolysaccharide-mediated signaling pathway | |
| Toll signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| vascular endothelial growth factor receptor signaling pathway | |
| positive regulation of reactive oxygen species metabolic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| regulation of sequence-specific DNA binding transcription factor activity | |
| positive regulation of muscle cell differentiation | |
| positive regulation of erythrocyte differentiation | |
| positive regulation of protein import into nucleus | |
| cell morphogenesis | |
| muscle cell differentiation | |
| chondrocyte differentiation | |
| osteoclast differentiation | |
| striated muscle cell differentiation | |
| platelet activation | |
| transcription, DNA-dependent | |
| RNA metabolic process | |
| mRNA metabolic process | |
| fatty acid oxidation | |
| protein phosphorylation | |
| peptidyl-serine phosphorylation | |
| protein autophosphorylation | |
| phosphorylation | |
| cellular response to growth factor stimulus | |
| response to DNA damage stimulus | |
| cellular response to ionizing radiation | |
| apoptotic process | |
| innate immune response | |
| response to stress | |
| chemotaxis | |
| response to lipopolysaccharide | |
| response to muramyl dipeptide | |
| response to glucose stimulus | |
| 3'-UTR-mediated mRNA stabilization | |
| angiogenesis | |
| skeletal muscle tissue development | |
| blood coagulation | |
| glucose metabolic process | |
| gene expression | |
| protein C-terminus binding | |
| NFAT protein binding | |
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase activity | |
| MAP kinase kinase activity | |
| cell | |
| nucleoplasm | |
| spindle pole | |
| cytoplasm | |
| mitochondrion | |
| cytosolic part | |
| cytosol | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|
| MedScan ID | 1432 |
|---|
| Hugo ID | 6876 |
|---|
| Human chromosome position | 6p21.3-p21.2 |
|---|
| LocusLink ID | 1432 |
|---|---|
| 26416 | |
| 81649 | |
| 12975 | |
| 326416 |
| Alias | RK |
|---|---|
| p38 | |
| CSBP | |
| EXIP | |
| Mxi2 | |
| CSBP1 | |
| CSBP2 | |
| CSPB1 | |
| PRKM14 | |
| PRKM15 | |
| SAPK2A | |
| p38ALPHA | |
| RP1-179N16.5 | |
| mitogen-activated protein kinase 14 | |
| MAP kinase 14 | |
| p38alpha Exip | |
| p38 MAP kinase | |
| MAP kinase Mxi2 | |
| MAP kinase p38 alpha | |
| CSAID-binding protein | |
| Csaids binding protein | |
| MAX-interacting protein 2 | |
| stress-activated protein kinase 2A | |
| p38 mitogen activated protein kinase | |
| mitogen-activated protein kinase p38 alpha | |
| cytokine suppressive anti-inflammatory drug binding protein | |
| cytokine suppressive anti-inflammatory drug-binding protein | |
| Crk1 | |
| p38a | |
| p38MAPK | |
| p38-alpha | |
| RP24-137E7.1 | |
| MAPK 14 | |
| p38 MAPK | |
| p38 alpha | |
| p38 MAP kinase alpha | |
| tRNA synthetase cofactor p38 | |
| mitogen activated protein kinase 14 | |
| cytokine suppressive anti-inflammatory drug binding protein 1 | |
| Hog | |
| p38Hog | |
| MAP kinase 2 | |
| reactive kinase | |
| mitogen-activated protein kinase 14A | |
| cytokine-supressive anti-inflammatory drug binding protein | |
| p38 kinase | |
| OTTMUSP00000021709 | |
| OTTMUSP00000021708 | |
| OTTMUSP00000021707 | |
| OTTMUSP00000021706 | |
| OTTHUMP00000216563 | |
| p38alpha mitogen-activated protein kinase | |
| Mitogen-activated protein kinase p38 | |
| OTTHUMP00000216566 | |
| trna synthase cofactor p38 | |
| CSPB I | |
| MGC105413 | |
| CSAID binding protein | |
| Csaids-binding protein | |
| CSBP I | |
| CSBP/p38 kinase | |
| CSBP/p38 MAPK | |
| MGC102436 | |
| cytokine suppressive anti-inflammatory drug binding protein I | |
| MAPK14 | |
| MAPK p38 | |
| CSBP/p38 MAP kinase | |
| MAP kinase p38 | |
| MAX-interacting protein II | |
| MAX-interactive protein 2 | |
| cytokine-supressive anti-inflammatory drug-binding protein | |
| MAX-interactive protein II | |
| Mitogen-activated protein kinase p38 | |
| PRKM14s | |
| PRKM15s | |
| MAPK14s | |
| Lil I | |
| Serum cholesterol level QTL XII | |
| Serum cholesterol level QTL 12 | |
| P-38 | |
| Lil1 | |
| Lipid Level QTL 1 | |
| Scl12 | |
| Lipid Level QTL I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600289 |
|---|---|
| 61407 | |
| OMIM:600289 |
| Unigene ID | Hs.485233 |
|---|---|
| Mm.311337 | |
| Rn.88085 | |
| Hs.719314 | |
| Hs.722031 | |
| Hs.588289 | |
| Mm.4437 | |
| Mm.347796 | |
| Hs.79107 |
| KEGG ID | hsa:1432 |
|---|---|
| mmu:26416 | |
| rno:81649 |
| Swiss-Prot Accession | Q16539 |
|---|---|
| P47811 | |
| Q5U421 | |
| Q56A33 | |
| P70618 | |
| B2KF37 | |
| B2KF38 | |
| O08666 | |
| Q3U6R5 | |
| Q3UZS3 | |
| Q8C289 | |
| Q9JLV8 | |
| Q9QZ80 | |
| A6ZJ92 | |
| A8K6P4 | |
| B0LPH0 | |
| O60776 | |
| Q13083 | |
| Q14084 | |
| Q8TDX0 | |
| Q15454 |
| EC Number | 2.7.11.24 |
|---|---|
| 2.7.1.37 | |
| 2.7.1.- |
| GO ID | 0005524 |
|---|---|
| 0004707 | |
| 0004708 | |
| 0051525 | |
| 0008022 | |
| 0004674 | |
| 0070935 | |
| 0000077 | |
| 0002755 | |
| 0002756 | |
| 0016070 | |
| 0007265 | |
| 0035666 | |
| 0008063 | |
| 0000187 | |
| 0001525 | |
| 0006915 | |
| 0007596 | |
| 0000902 | |
| 0007166 | |
| 0006928 | |
| 0071363 | |
| 0071479 | |
| 0006935 | |
| 0002062 | |
| 0019395 | |
| 0010467 | |
| 0006006 | |
| 0045087 | |
| 0007243 | |
| 0031663 | |
| 0016071 | |
| 0042692 | |
| 0048011 | |
| 0030316 | |
| 0018105 | |
| 0030168 | |
| 0045648 | |
| 0051149 | |
| 2000379 | |
| 0045944 | |
| 0046777 | |
| 0051090 | |
| 0009749 | |
| 0032495 | |
| 0006950 | |
| 0007165 | |
| 0042770 | |
| 0007519 | |
| 0051403 | |
| 0090400 | |
| 0051146 | |
| 0034130 | |
| 0034134 | |
| 0034138 | |
| 0034142 | |
| 0002224 | |
| 0006351 | |
| 0048010 | |
| 0005737 | |
| 0005829 | |
| 0044445 | |
| 0005739 | |
| 0005654 | |
| 0005634 | |
| 0000922 | |
| 0016301 | |
| 0000166 | |
| 0004672 | |
| 0016740 | |
| 0016772 | |
| 0016310 | |
| 0042307 | |
| 0006468 | |
| 0006355 | |
| 0006974 | |
| 0032496 | |
| 0023014 | |
| 0005623 | |
| 0008339 | |
| 0005625 | |
| 0005515 | |
| 0004682 | |
| 0006960 | |
| 0004713 | |
| 0019735 | |
| 0004691 |
| PIR ID | I49066 |
|---|---|
| S53536 |
| Swiss-Prot ID | MK14_MOUSE |
|---|---|
| MK14_HUMAN | |
| Q5U421_MOUSE | |
| Q56A33_RAT | |
| B2KF37_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| IPI ID | IPI00112346 |
|---|---|
| IPI00331732 | |
| IPI00816843 | |
| IPI00828805 | |
| IPI00002857 | |
| IPI00221141 | |
| IPI00221142 | |
| IPI00221143 | |
| IPI00230807 | |
| IPI00830415 | |
| IPI00190530 | |
| IPI00829435 | |
| IPI00558535 |
| Mouse chromosome position | 17 13.5 cM |
|---|
| Rat chromosome position | 20p12 |
|---|
| Homologene ID | 31777 |
|---|
| MGI ID | 1346865 |
|---|---|
| 1338028 |
| RGD ID | 70496 |
|---|---|
| 61407 |
| Primary Cell Localization | Cytoplasm |
|---|
| KEGG pathway | Toll-like receptor signaling pathway |
|---|---|
| MAPK signaling pathway |
| Hugo Symbol | MAPK14 |
|---|