| URN | urn:agi-llid:5600 |
|---|---|
| Total Entities | 0 |
| Connectivity | 381 |
| Name | Mapk11 |
| Description | similar to mitogen-activated protein kinase 11 |
| Notes | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. |
| Ariadne Ontology | p38 |
|---|---|
| Biofluids assayable substances |
| GO Molecular Function | nucleotide binding |
|---|---|
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase activity |
| GO Cellular Component | nucleoplasm |
|---|---|
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | activation of MAPK activity |
|---|---|
| signal transduction | |
| signal transduction by phosphorylation | |
| intracellular protein kinase cascade | |
| MAPK cascade | |
| stress-activated MAPK cascade | |
| Ras protein signal transduction | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| regulation of transcription, DNA-dependent | |
| regulation of sequence-specific DNA binding transcription factor activity | |
| positive regulation of muscle cell differentiation | |
| muscle cell differentiation | |
| transcription, DNA-dependent | |
| RNA metabolic process | |
| mRNA metabolic process | |
| protein phosphorylation | |
| phosphorylation | |
| innate immune response | |
| response to stress | |
| gene expression |
| Pathway | p38 MAPK signaling pathway |
|---|---|
| p38 MAPK signaling pathway | |
| p38 MAPK signaling pathway |
| Group | p38 |
|---|---|
| activation of MAPK activity | |
| signal transduction | |
| signal transduction by phosphorylation | |
| intracellular protein kinase cascade | |
| MAPK cascade | |
| stress-activated MAPK cascade | |
| Ras protein signal transduction | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| regulation of transcription, DNA-dependent | |
| regulation of sequence-specific DNA binding transcription factor activity | |
| positive regulation of muscle cell differentiation | |
| muscle cell differentiation | |
| transcription, DNA-dependent | |
| RNA metabolic process | |
| mRNA metabolic process | |
| protein phosphorylation | |
| phosphorylation | |
| innate immune response | |
| response to stress | |
| gene expression | |
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase activity | |
| nucleoplasm | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| Biofluids assayable substances |
| Source | Curated |
|---|
| MedScan ID | 5600 |
|---|
| Hugo ID | 6873 |
|---|
| Human chromosome position | 22q13.33 |
|---|
| LocusLink ID | 5600 |
|---|---|
| 19094 | |
| 689314 |
| Alias | P38B |
|---|---|
| SAPK2 | |
| p38-2 | |
| PRKM11 | |
| SAPK2B | |
| p38Beta | |
| P38BETA2 | |
| mitogen-activated protein kinase 11 | |
| MAPK 11 | |
| MAP kinase 11 | |
| MAP kinase p38 beta | |
| stress-activated protein kinase 2 | |
| stress-activated protein kinase-2 | |
| stress-activated protein kinase 2b | |
| stress-activated protein kinase-2b | |
| mitogen-activated protein kinase p38-2 | |
| mitogen-activated protein kinase p38 beta | |
| mitogen activated protein kinase 11 | |
| protein kinase, mitogen activated kinase, 11, p38beta | |
| p38b MAPK | |
| p38beta mitogen-activated protein kinase | |
| protein kinase mitogen- activated 11 | |
| Stress-activated protein kinase II | |
| mitogen-activated protein kinase p38 II | |
| OTTHUMP00000196655 | |
| p38 Mitogen-activated protein kinase beta | |
| DKFZp586C1322 | |
| LOC679007 | |
| MAPK p38 beta | |
| p38 II | |
| MGC187942 | |
| MAPK11 | |
| kinase, mitogen activated kinase, 11, p38beta | |
| p38 IIs | |
| Mitogen-activated protein kinase p38 beta | |
| protein kinase mitogen- activated 11 | |
| p38 Mitogen-activated protein kinase beta | |
| MAPK11s | |
| PRKM11s | |
| LOC689314 | |
| hypothetical protein LOC689314 | |
| similar to mitogen-activated protein kinase 11 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602898 |
|---|
| Unigene ID | Hs.57732 |
|---|---|
| Mm.91969 | |
| Rn.45869 |
| KEGG ID | hsa:5600 |
|---|---|
| mmu:19094 | |
| rno:689314 |
| Swiss-Prot Accession | Q15759 |
|---|---|
| Q9WUI1 | |
| D4A3U7 | |
| Q569F1 | |
| B0LPG1 | |
| O00284 | |
| O15472 | |
| Q2XNF2 | |
| Q3TT60 | |
| Q6P243 | |
| Q6PG57 |
| EC Number | 2.7.11.24 |
|---|---|
| 2.7.11.1 | |
| 2.7.1.37 |
| GO ID | 0005524 |
|---|---|
| 0004707 | |
| 0004674 | |
| 0002755 | |
| 0002756 | |
| 0016070 | |
| 0007265 | |
| 0035666 | |
| 0008063 | |
| 0000187 | |
| 0010467 | |
| 0045087 | |
| 0007243 | |
| 0016071 | |
| 0042692 | |
| 0048011 | |
| 0051149 | |
| 0051090 | |
| 0006950 | |
| 0007165 | |
| 0051403 | |
| 0034130 | |
| 0034134 | |
| 0034138 | |
| 0034142 | |
| 0002224 | |
| 0006351 | |
| 0005829 | |
| 0005654 | |
| 0016301 | |
| 0000166 | |
| 0004672 | |
| 0016740 | |
| 0016772 | |
| 0000165 | |
| 0016310 | |
| 0006468 | |
| 0006355 | |
| 0023014 | |
| 0005737 | |
| 0005634 | |
| 0008339 | |
| 0005625 | |
| 0005515 | |
| 0005575 | |
| 0019735 | |
| 0008372 | |
| 0004713 |
| PIR ID | G02524 |
|---|---|
| JC5529 |
| Swiss-Prot ID | MK11_MOUSE |
|---|---|
| MK11_HUMAN | |
| Q569F1_MOUSE | |
| B0LPG1_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| IPI ID | IPI00556722 |
|---|---|
| IPI00019473 | |
| IPI00622322 | |
| IPI00853117 | |
| IPI00190306 |
| Mouse chromosome position | 15 |
|---|
| Rat chromosome position | 7q34 |
|---|
| Homologene ID | 55684 |
|---|
| MGI ID | 1338024 |
|---|
| RGD ID | 1309340 |
|---|---|
| 1593550 |
| Primary Cell Localization | Cytoplasm |
|---|