| URN | urn:agi-llid:4217 |
|---|---|
| Total Entities | 0 |
| Connectivity | 735 |
| Name | Map3k5 |
| Description | mitogen activated protein kinase kinase kinase 5 |
| Notes | Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. |
| Ariadne Ontology | MAP3K |
|---|---|
| Secreted proteins |
| GO Molecular Function | protein kinase binding |
|---|---|
| protein phosphatase binding | |
| protein homodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| metal ion binding | |
| magnesium ion binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase kinase kinase activity | |
| cysteine-type endopeptidase activator activity involved in apoptotic process |
| GO Cellular Component | cytoplasm |
|---|---|
| endoplasmic reticulum |
| GO Biological Process | virus-host interaction |
|---|---|
| activation of MAPKK activity | |
| activation of JUN kinase activity | |
| activation of MAPK activity | |
| regulation of cell death | |
| apoptotic signaling pathway | |
| MAPK cascade | |
| JNK cascade | |
| intrinsic apoptotic signaling pathway in response to oxidative stress | |
| positive regulation of apoptotic process | |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| protein phosphorylation | |
| phosphorylation | |
| cellular response to hydrogen peroxide | |
| apoptotic process | |
| hydrogen peroxide-mediated programmed cell death | |
| innate immune response | |
| response to stress |
| Pathway | Apoptosis |
|---|---|
| EctodysplasinR -> NF-kB signaling | |
| EctodysplasinR -> AP-1 signaling | |
| TNFRSF6 -> HSF1 signaling | |
| NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling | |
| TNFRSF5/6 -> RB1/E2F signaling | |
| TNFR -> CREB/ELK-SRF signaling | |
| TNFR -> NF-kB signaling | |
| NGFR -> MEF signaling | |
| TNFRSF6 -> DDIT3 signaling | |
| NGFR -> NF-kB signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> CREB/ELK-SRF signaling | |
| TGFBR -> ATF/GADD/MAX/TP53 signaling | |
| TGFBR -> CREB/ELK-SRF signaling | |
| TGFBR -> MEF/MYOD/MYOG signaling | |
| TGFBR -> AP-1 signaling | |
| IL1R -> NF-kB signaling | |
| Unfolded Protein Response | |
| ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy | |
| TGFB3-TGFBR2 Expression Targets | |
| TGFB2-TGFBR2 Expression Targets | |
| TGFB1-TGFBR2 Expression Targets | |
| FASLG Expression Targets | |
| NGF/FOXO/MYCN/ELK-SRF Expression Targets | |
| BDNF Expression Targets | |
| NTF3 Expression Targets | |
| NTF4 Expression Targets | |
| CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets | |
| TNFSF13 Expression Targets | |
| TNFSF13B Expression Targets | |
| EDA Expression Targets | |
| TNFSF10 Expression Targets | |
| LTA Expression Targets | |
| TNFSF14 Expression Targets | |
| TNF/CREB Expression Targets | |
| TNF/TP53/ATF Expression Targets | |
| TNF/ELK-SRF Expression Targets | |
| NGF/AP-1/TP53/MYC Expression Targets | |
| NGF/CREB/CEBPB/MEF2A Expression Targets | |
| NGF/SMAD3/NF-kB Expression Targets | |
| CD40LG/ATF2/AP-1/TP53/E2F Expression Targets | |
| IL1A Expression Targets | |
| TNF/NF-kB Expression Targets | |
| TNF/AP-1 Expression Targets | |
| IL1B Expression Targets | |
| p38 MAPK signaling pathway | |
| c-Jun N-terminal kinases MAPK signaling pathway | |
| p38 MAPK signaling pathway | |
| p38 MAPK signaling pathway | |
| c-Jun N-terminal kinases MAPK signaling pathway |
| Group | MAP3K |
|---|---|
| virus-host interaction | |
| activation of MAPKK activity | |
| activation of JUN kinase activity | |
| activation of MAPK activity | |
| regulation of cell death | |
| apoptotic signaling pathway | |
| MAPK cascade | |
| JNK cascade | |
| intrinsic apoptotic signaling pathway in response to oxidative stress | |
| positive regulation of apoptotic process | |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| protein phosphorylation | |
| phosphorylation | |
| cellular response to hydrogen peroxide | |
| apoptotic process | |
| hydrogen peroxide-mediated programmed cell death | |
| innate immune response | |
| response to stress | |
| protein kinase binding | |
| protein phosphatase binding | |
| protein homodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| metal ion binding | |
| magnesium ion binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase kinase kinase activity | |
| cysteine-type endopeptidase activator activity involved in apoptotic process | |
| cytoplasm | |
| endoplasmic reticulum | |
| Secreted proteins |
| Source | Curated |
|---|---|
| RGD modified | |
| ResNet |
| MedScan ID | 4217 |
|---|---|
| 365057 |
| Hugo ID | 6857 |
|---|
| Human chromosome position | 6q22.33 |
|---|
| LocusLink ID | 4217 |
|---|---|
| 26408 | |
| 365057 | |
| 293015 | |
| 17273 | |
| 320994 | |
| 537380 | |
| 555703 | |
| 336299 | |
| 373122 | |
| 555773 |
| Alias | ASK1 |
|---|---|
| MEKK5 | |
| MAPKKK5 | |
| RP3-325F22.4 | |
| mitogen-activated protein kinase kinase kinase 5 | |
| ASK-1 | |
| MEKK 5 | |
| MEK kinase 5 | |
| MAP/ERK kinase kinase 5 | |
| MAPK/ERK kinase kinase 5 | |
| apoptosis signal regulating kinase 1 | |
| apoptosis signal-regulating kinase 1 | |
| ASK | |
| 7420452D20Rik | |
| mitogen activated protein kinase kinase kinase 5 | |
| OTTMUSP00000040576 | |
| MEK kinase V | |
| MGC141518 | |
| MGC141519 | |
| OTTHUMP00000017275 | |
| mitogen-activated protein kinase kinase kinase V | |
| 7420452D20 | |
| MAPK/ ERK kinase kinase V | |
| apoptosis signal regulating kinase | |
| Apoptosis signal- regulating kinase 1 | |
| Apoptosis signal- regulating kinase I | |
| ASK I | |
| LOC270672 | |
| MAP/ERK kinase kinase V | |
| Map3k5 | |
| MAPK/ ERK kinase kinase 5 | |
| RGD1306565 | |
| RIKEN cDNA 7420452D20 gene | |
| hypothetical protein LOC270672 | |
| similar to ASK I | |
| similar to ASK1 | |
| fj62c10 | |
| wu:fj62c10 | |
| chromosome | |
| scaffold | |
| LOC555773 | |
| similar to mitogen-activated protein kinase kinase kinase 5 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 602448 |
|---|---|
| OMIM:602448 |
| Unigene ID | Hs.186486 |
|---|---|
| Mm.6595 | |
| Rn.232064 | |
| Rn.108921 | |
| Hs.151988 | |
| Bt.31917 | |
| Dr.122363 | |
| Dr.16458 | |
| Dr.27055 |
| KEGG ID | hsa:4217 |
|---|---|
| mmu:26408 | |
| rno:365057 |
| Swiss-Prot Accession | Q99683 |
|---|---|
| O35099 | |
| Q5THN3 | |
| Q99461 | |
| Q14AY5 | |
| Q59GL6 | |
| Q14AY4 | |
| Q8CC79 |
| EC Number | 2.7.11.25 |
|---|---|
| 2.7.1.- |
| GO ID | 0005524 |
|---|---|
| 0004709 | |
| 0008656 | |
| 0000287 | |
| 0042803 | |
| 0004672 | |
| 0019901 | |
| 0019903 | |
| 0007254 | |
| 0000165 | |
| 0007257 | |
| 0000186 | |
| 0006919 | |
| 0070301 | |
| 0010421 | |
| 0045087 | |
| 0008631 | |
| 0043065 | |
| 0043280 | |
| 0019048 | |
| 0005783 | |
| 0016301 | |
| 0046872 | |
| 0000166 | |
| 0004674 | |
| 0016740 | |
| 0016772 | |
| 0000187 | |
| 0006915 | |
| 0016310 | |
| 0006468 | |
| 0010941 | |
| 0006950 | |
| 0005737 | |
| 0008624 | |
| 0044419 | |
| 0005515 | |
| 0042802 | |
| 0005575 |
| PIR ID | JC5778 |
|---|
| Swiss-Prot ID | M3K5_HUMAN |
|---|---|
| M3K5_MOUSE | |
| Q14AY5_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Endoplasmic reticulum |
| IPI ID | IPI00412433 |
|---|---|
| IPI00126589 | |
| IPI00890883 | |
| IPI00479216 | |
| IPI00748581 | |
| IPI00894869 | |
| IPI00895076 | |
| IPI00894925 |
| Mouse chromosome position | 10 |
|---|---|
| 10 A3 |
| Rat chromosome position | 1p12 |
|---|
| Homologene ID | 38114 |
|---|
| MGI ID | 1346876 |
|---|---|
| 1101761 | |
| 2445207 |
| RGD ID | 1306565 |
|---|---|
| 1306431 |
| Primary Cell Localization | Cytoplasm |
|---|
| Homo sapiens Chromosome position | 6q22.33 |
|---|
| Microarray ID | 99855_at |
|---|---|
| 203837_at |
| FunctionalClass | ATP binding |
|---|---|
| MAP kinase kinase kinase | |
| caspase activator | |
| magnesium ion binding | |
| nucleotide binding | |
| protein self binding | |
| protein serine/threonine kinase | |
| transferase | |
| kinase | |
| metal ion binding | |
| protein binding | |
| protein kinase | |
| identical protein binding | |
| protein homodimerization |
| Mus musculus Chromosome position | 10 A3 |
|---|
| KEGG pathway | MAPK signaling pathway |
|---|
| Rattus norvegicus Chromosome position | 1p12 |
|---|
| Danio rerio Chromosome position | LG 25 |
|---|
| Bos taurus Chromosome position | 9 |
|---|