Protein Map2k6

URN urn:agi-llid:5608
Total Entities 0
Connectivity 432
Name Map2k6
Description mitogen-activated protein kinase kinase 6
Notes activator of p38 MAPK; may play a role in cardiac hypertrophic and failure conditions [RGD]

Ariadne Ontology MKK3-6
Secreted proteins

GO Molecular Function protein kinase binding
nucleotide binding
ATP binding
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein serine-threonine kinase activity
protein tyrosine kinase activity
MAP kinase kinase activity

GO Cellular Component nucleoplasm
cytoplasm
cytosol
cytoskeleton
nucleus

GO Biological Process cell cycle arrest
activation of MAPK activity
signal transduction
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
nucleotide-binding oligomerization domain containing signaling pathway
MAPK cascade
stress-activated MAPK cascade
toll-like receptor signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
toll-like receptor 1 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
Toll signaling pathway
regulation of transcription, DNA-dependent
positive regulation of muscle cell differentiation
positive regulation of apoptotic process
muscle cell differentiation
transcription, DNA-dependent
protein phosphorylation
DNA damage induced protein phosphorylation
phosphorylation
apoptotic process
innate immune response
response to stress
response to drug
cardiac muscle contraction

Pathway FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling
PDGFR -> AP-1/MYC signaling
VEGFR -> AP-1/CREB/MYC signaling
HGFR -> AP-1/CREB/MYC signaling
AngiopoietinR -> AP-1 signaling
ErythropoietinR -> AP-1/CREB/MYC signaling
ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling
EGFR -> AP-1/CREB/ELK-SRF/MYC signaling
EctodysplasinR -> NF-kB signaling
NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling
TNFRSF5/6 -> RB1/E2F signaling
TNFR -> CREB/ELK-SRF signaling
TNFR -> NF-kB signaling
NGFR -> MEF signaling
TNFRSF6 -> DDIT3 signaling
NGFR -> NF-kB signaling
TNFR -> AP-1/ATF/TP53 signaling
TNFRSF1A -> AP-1/ATF/TP53 signaling
TNFRSF1A -> CREB/ELK-SRF signaling
Notch -> TCF3 signaling
T-cell receptor -> ATF/CREB signaling
TGFBR -> ATF/GADD/MAX/TP53 signaling
TGFBR -> CREB/ELK-SRF signaling
TGFBR -> MEF/MYOD/MYOG signaling
TGFBR -> AP-1 signaling
IL1R -> NF-kB signaling
TLR -> AP-1 signaling
EGFR -> AP-1/ATF2 signaling
EGFR/ERBB2 -> TP53 signaling
EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling
VEGFR -> NFATC signaling
VEGFR -> ATF/CREB/ELK-SRF signaling
IGF1R -> MEF/MYOD/MYOG signaling
NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling
ICAM1 -> AP-1/CREB/ELK-SRF signaling
FibronectinR -> NF-kB signaling
FibronectinR -> AP-1/ELK-SRF/SREBF signaling
CholinergicRm -> CREB/ELK-SRF signaling
CannabinoidR -> AP-1/EGR signaling
DopamineR2 -> AP-1/CREB/ELK-SRF signaling
SerotoninR1 -> FOS signaling
PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling
VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling
PTAFR -> NF-kB signaling
VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling
GRM1/5 -> CREB signaling
EDG3/5 -> AP-1/ELK-SRF signaling
EndothelinRb -> AP-1/CREB/ELK-SRF signaling
VIPR -> CREB/CEBP signaling
EndothelinRa -> AP-1/CREB signaling
VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling
VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling
ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling
EphrinB -> JUN signaling
Clozapine-Induced Granulocytopenia
ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy
TGFB3-TGFBR2 Expression Targets
TGFB2-TGFBR2 Expression Targets
TGFB1-TGFBR2 Expression Targets
TLR5 Expression Targets
TLR7 Expression Targets
TLR9 Expression Targets
TLR1/2/6 Expression Targets
FASLG Expression Targets
NGF/FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets
TNFSF13 Expression Targets
TNFSF13B Expression Targets
EDA Expression Targets
TNFSF10 Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
TNF/CREB Expression Targets
TNF/TP53/ATF Expression Targets
TNF/ELK-SRF Expression Targets
NGF/AP-1/TP53/MYC Expression Targets
NGF/CREB/CEBPB/MEF2A Expression Targets
NGF/SMAD3/NF-kB Expression Targets
CD40LG/ATF2/AP-1/TP53/E2F Expression Targets
ICAM1 Expression Targets
Fibronectin Expression Targets
Dopamine/Gi Expression Targets
Dronabinol/Anandamide Expression Targets
Acetylcholine Expression Targets
AREG/AP-1 Expression Targets
AREG/NFATC Expression Target
BTC/NFATC Expression Targets
EGF/TP53 Expression Targets
EREG/AP-1/ATF Expression Targets
HBEGF/AP-1/ATF Expression Targets
HBEGF/MEF/MYOD Expression Target
HBEGF/TP53 Expression Targets
NRG1/AP-1/ATF Expression Targets
NRG1/MEF/MYOD Expression Targets
NRG1/TP53 Expression Target
TGFA/MEF/MYOD/NFATC Expression Targets
TGFA/TP53 Expression Targets
VEGFA/NFATC Expression Targets
VEGFA/ATF/CREB/ELK-SRF Expression Targets
VEGFC/ATF Expression Target
IGF2/MEF/MYOD Expression Targets
CTGF/AP-1/CREB/MYC Expression Targets
Erythropoietin/AP-1/MYC/CREB Expression Targets
FLT3LG/AP-1/CREB/CREBBP Expression Targets
GAS6/AP-1/CREB Expression Targets
PGF/AP-1/CREB/CREBBP/MYC Expression Targets
Thrombopoietin/AP-1/CREB/CREBBP/MYC Expression Targets
AREG/CREB/CREBBP Expression Targets
EREG/CREB Expression Target
HBEGF/CREB/MYC Expression Targets
NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets
TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets
FGF1/AP-1/CREB/ELK-SRF/MYC Expression Targets
FGF4/AP-1/MYC Expression Targets
FGF7/AP-1/CREB/CREBBP/MYC Expression Targets
FGF8/AP-1/CREB/MYC Expression Targets
FGF9/AP-1/CREB/MYC Expression Targets
FGF10/AP-1/CREB/CREBBP/MYC Expression Targets
FGF18/AP-1/CREB Expression Targets
CSF1/AP-1/CREB/CREBBP/MYC Expression Targets
PDGFB/AP-1/CREB/MYC Expression Target
PDGFC/CREB Expression Target
PDGFD/AP-1 Expression Targets
ANGPT1/CREB/CREBBP Expression Targets
ANGPT2/AP-1/CREBBP/MYC Expression Targets
FIGF/AP-1 Expression Target
F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets
PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets
Glutamate/Gq Expression Targets
AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets
AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets
PAF/Gq -> NF-kB Expression Targets
S1P Expression Targets
VIP Expression Targets
AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets
AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets
EDN1 Expression Targets
EDN3 Expression Targets
ADCYAP1 Expression Targets
IL16/ATF/CREB/CREBBP Expression Target
CD8/ATF/CREB/CREBBP Expression Targets
CD80/ATF/CREB/CREBBP Expression Targets
CD86/ATF/CREB/CREBBP Expression Targets
CD72/CREB/CREBBP Expression Targets
PDCD1/ATF/CREB/CREBBP Expression Targets
TCR/CREB/CREBBP/ATF Expression Targets
FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets
IL1A Expression Targets
NOTCH Expression Targets
TNF/NF-kB Expression Targets
EGF/AP-1/ATF Expression Targets
EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets
EGF/MEF/MYOD/NFATC Expression Targets
HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets
IGF1/MEF/MYOD/MYOG Expression Targets
Insulin/MEF/MYOD Expression Targets
KITLG/AP-1/CREB/CREBBP/MYC Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets
PDGF/AP-1/CREB/CREBBP/MYC Expression Targets
TGFA/AP-1/ATF Expression Targets
TLR4/AP-1 Expression Targets
TLR4/AP-1/EGR1/HIF1A Expression Targets
TNF/AP-1 Expression Targets
VEGFA/AP-1/CREBBP/MYC Expression Targets
IL1B Expression Targets
BTC/AP-1/ATF/CREB Expression Targets
p38 MAPK signaling pathway
p38 MAPK signaling pathway
p38 MAPK signaling pathway

Group MKK3-6
cell cycle arrest
activation of MAPK activity
signal transduction
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
nucleotide-binding oligomerization domain containing signaling pathway
MAPK cascade
stress-activated MAPK cascade
toll-like receptor signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
toll-like receptor 1 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
Toll signaling pathway
regulation of transcription, DNA-dependent
positive regulation of muscle cell differentiation
positive regulation of apoptotic process
muscle cell differentiation
transcription, DNA-dependent
protein phosphorylation
DNA damage induced protein phosphorylation
phosphorylation
apoptotic process
innate immune response
response to stress
response to drug
cardiac muscle contraction
protein kinase binding
nucleotide binding
ATP binding
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein serine-threonine kinase activity
protein tyrosine kinase activity
MAP kinase kinase activity
nucleoplasm
cytoplasm
cytosol
cytoskeleton
nucleus
Secreted proteins

Source Curated

MedScan ID 5608

Hugo ID 6846

Human chromosome position 17q24.3

GenBank ID NC_000017
NM_002758
NP_002749
NG_029437
NC_018928
AC_000149
AC002546
AC015920
CH471099
EAW89084
EAW89085
EAW89086
EU332850
ABY87539
AA932919
AB451252
BAG70066
AB451376
BAG70190
AK225719
AK290747
BAF83436
BC012009
AAH12009
BX641121
CAE46056
D87905
BAA13496
DB111443
U39064
AAB03708
U39065
AAB03705
U39656
AAC50388
U39657
AAC50389
U49732
AAB05035
X96757
CAA65532
P52564
DQ891488
ABM82414
DQ894673
ABM85599
NC_000077
NM_011943
NP_036073
AC_000033
AL603826
CAM17458
AL691461
CAM15928
CAM15929
CH466558
EDL34384
EDL34385
EDL34386
EDL34387
AK043482
BAC31556
AK077712
BAC36972
AK086722
BAC39729
AK138757
BAE23771
AK140289
AK141708
BAE24808
AK162671
BAE37014
BC075652
AAH75652
U39066
AAB03709
X97052
CAA65764
X98067
CAA66670
P70236
NC_005109
NM_053703
NP_446155
AC_000078
CH473948
EDM06489
EDM06490
EDM06491
AF369384
AAK53428
BC087004
AAH87004
NT_010783
NW_001838454
NW_926918
AC_000060
CR604345
CR616398
CR624804
CR625265
Q6MZH7
NT_165773
NW_001030434
P70273
Q3UU57
Q543Z5
Q60521
Q8BP44
Q8C371
NW_047343
NW_001084656
Q925D6
NT_010641
NM_031988
NT_096135
BG065128
NP_114365
NW_000040
BB261602
BG078419

LocusLink ID 5608
26399
114495
19104

Alias MEK6
MKK6
MAPKK6
PRKMK6
SAPKK3
SAPKK-3
dual specificity mitogen-activated protein kinase kinase 6
MEK 6
MAPKK 6
SAPK kinase 3
MAPK/ERK kinase 6
stress-activated protein kinase kinase 3
protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)
RP23-162E10.1
MAP kinase kinase 6
mitogen activated protein kinase kinase 6
protein kinase, mitogen activated, kinase 6
SKK3
mitogen-activated protein kinase kinase VI
OTTMUSP00000003317
OTTMUSP00000003318
protein kinase, mitogen-activated, kinase VI
MGC93287
ERK kinase VI
Map2k6
ERK kinase 6
MAP kinase kinase VI
MAPK/ERK kinase VI
MAPK kinase VI
MAPK kinase 6
Dual specificity mitogen-activated protein kinase kinase VI
mitogen-activated protein kinase kinase 6
protein kinase, mitogen-activated, kinase 6
PRKMK6s
MAPKK6s
SAPKK3s
kinase 6

Organism Homo sapiens
Mus musculus
Rattus norvegicus

OMIM ID 601254
OMIM:601254

Unigene ID Hs.463978
Mm.14487
Rn.17256
Hs.256924

KEGG ID hsa:5608
mmu:26399
rno:114495

Swiss-Prot Accession A8K3Y2
P52564
P70236
Q543Z5
Q925D6
Q6MZH7
P70273
Q3UU57
Q60521
Q8BP44
Q8C371

EC Number 2.7.12.2
2.7.1.-

GO ID 0005524
0004708
0019901
0004674
0004713
0006975
0002755
0002756
0035666
0008063
0000187
0006915
0007050
0045087
0042692
0035872
0070423
0051149
0006355
0007165
0051403
0034130
0034134
0034138
0034142
0002224
0006351
0005856
0005829
0005654
0016301
0000166
0004672
0016740
0016772
0000165
0060048
0016310
0043065
0006468
0006950
0005737
0005634
0042493
0005515

PIR ID S71631
S71632

Swiss-Prot ID MP2K6_HUMAN
MP2K6_MOUSE
Q925D6_RAT
Q543Z5_MOUSE
A8K3Y2_HUMAN

Cell Localization Nucleus
Cytoplasm
cytoskeleton

IPI ID IPI00003814
IPI00219569
IPI00137439
IPI00205537
IPI00425919
IPI00796408
IPI00648735
IPI00781935

Mouse chromosome position 11
11 E1

Rat chromosome position 10q32.1

Homologene ID 55686

MGI ID 1346870
108032

RGD ID 620666

Primary Cell Localization Cytoplasm

KEGG pathway Toll-like receptor signaling pathway
MAPK signaling pathway