Protein Map3k3

URN	urn:agi-llid:4215
Total Entities	0
Connectivity	216
Name	Map3k3
Description	mitogen activated protein kinase kinase kinase 3 (predicted)
Notes	This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Ariadne Ontology	MAP3K

GO Molecular Function	nucleotide binding
	ATP binding
	metal ion binding
	transferase activity
	transferase activity, transferring phosphorus-containing groups
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	MAP kinase kinase kinase activity

GO Cellular Component	cytosol

GO Biological Process	positive regulation of I-kappaB kinase-NF-kappaB cascade
	activation of MAPKK activity
	intracellular protein kinase cascade
	MAPK cascade
	protein phosphorylation
	protein autophosphorylation
	phosphorylation

Pathway	NGFR -> MEF signaling
	TGFBR -> MEF/MYOD/MYOG signaling
	EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling
	IGF1R -> MEF/MYOD/MYOG signaling
	VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling
	VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling
	NTF3 Expression Targets
	NGF/CREB/CEBPB/MEF2A Expression Targets
	HBEGF/MEF/MYOD Expression Target
	NRG1/MEF/MYOD Expression Targets
	TGFA/MEF/MYOD/NFATC Expression Targets
	IGF2/MEF/MYOD Expression Targets
	AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets
	AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets
	EGF/MEF/MYOD/NFATC Expression Targets
	IGF1/MEF/MYOD/MYOG Expression Targets
	Insulin/MEF/MYOD Expression Targets
	p38 MAPK signaling pathway
	Erk5 MAPK signaling pathway
	p38 MAPK signaling pathway
	p38 MAPK signaling pathway

Group	MAP3K
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	activation of MAPKK activity
	intracellular protein kinase cascade
	MAPK cascade
	protein phosphorylation
	protein autophosphorylation
	phosphorylation
	nucleotide binding
	ATP binding
	metal ion binding
	transferase activity
	transferase activity, transferring phosphorus-containing groups
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	MAP kinase kinase kinase activity
	cytosol

Source	Curated

MedScan ID	4215

Hugo ID	6855

Human chromosome position	17q23.3

Alias	MEKK3
	MAPKKK3
	mitogen-activated protein kinase kinase kinase 3
	MEKK 3
	MEK kinase 3
	MAP/ERK kinase kinase 3
	MAPK/ERK kinase kinase 3
	AW548911
	mKIAA4031
	RP23-81G14.5
	mitogen activated protein kinase kinase kinase 3
	MEK kinase III
	mitogen-activated protein kinase kinase kinase III
	OTTMUSP00000002980
	KIAA4031
	MAPK/ ERK kinase kinase III
	MAPK/ ERK kinase kinase 3
	Map3k3
	MAP/ERK kinase kinase III
	MAP kinase kinase kinase MEKK3
	Map3k3_predicted
	expressed sequence AW548911
	mitogen activated protein kinase kinase kinase 3 (predicted)

OMIM ID	602539
	OMIM:602539

EC Number	2.7.11.25
	2.7.1.-

Cell Localization	Cytoplasm

Mouse chromosome position	11
	11 E1

Rat chromosome position	10q32.1

Homologene ID	69110

RGD ID	1304575

Primary Cell Localization	Cytoplasm