| URN | urn:agi-llid:6300 |
|---|---|
| Total Entities | 0 |
| Connectivity | 203 |
| Name | Mapk12 |
| Description | mitogen-activated protein kinase 12 |
| Notes | kinse activated by cellular stresses, bacterial endotoxin and inflammatory cytokines [RGD] |
| Ariadne Ontology | p38 |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| ATP binding | |
| metal ion binding | |
| magnesium ion binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase activity |
| GO Cellular Component | nucleoplasm |
|---|---|
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| nucleus |
| GO Biological Process | cell cycle |
|---|---|
| cell cycle arrest | |
| negative regulation of cell cycle | |
| signal transduction | |
| signal transduction by phosphorylation | |
| MAPK cascade | |
| Ras protein signal transduction | |
| nerve growth factor receptor signaling pathway | |
| regulation of transcription, DNA-dependent | |
| positive regulation of muscle cell differentiation | |
| muscle cell differentiation | |
| myoblast differentiation | |
| transcription, DNA-dependent | |
| protein phosphorylation | |
| peptidyl-serine phosphorylation | |
| DNA damage induced protein phosphorylation | |
| phosphorylation | |
| response to stress | |
| muscle organ development |
| Pathway | NGFR -> MEF signaling |
|---|---|
| EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling | |
| IGF1R -> MEF/MYOD/MYOG signaling | |
| VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling | |
| VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling | |
| BDNF Expression Targets | |
| NTF3 Expression Targets | |
| HBEGF/MEF/MYOD Expression Target | |
| NRG1/MEF/MYOD Expression Targets | |
| TGFA/MEF/MYOD/NFATC Expression Targets | |
| IGF2/MEF/MYOD Expression Targets | |
| AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets | |
| AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets | |
| IGF1/MEF/MYOD/MYOG Expression Targets | |
| Insulin/MEF/MYOD Expression Targets | |
| p38 MAPK signaling pathway | |
| p38 MAPK signaling pathway | |
| p38 MAPK signaling pathway |
| Group | p38 |
|---|---|
| cell cycle | |
| cell cycle arrest | |
| negative regulation of cell cycle | |
| signal transduction | |
| signal transduction by phosphorylation | |
| MAPK cascade | |
| Ras protein signal transduction | |
| nerve growth factor receptor signaling pathway | |
| regulation of transcription, DNA-dependent | |
| positive regulation of muscle cell differentiation | |
| muscle cell differentiation | |
| myoblast differentiation | |
| transcription, DNA-dependent | |
| protein phosphorylation | |
| peptidyl-serine phosphorylation | |
| DNA damage induced protein phosphorylation | |
| phosphorylation | |
| response to stress | |
| muscle organ development | |
| nucleotide binding | |
| ATP binding | |
| metal ion binding | |
| magnesium ion binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase activity | |
| nucleoplasm | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| nucleus |
| Source | Curated |
|---|
| MedScan ID | 6300 |
|---|---|
| 663255 |
| Hugo ID | 6874 |
|---|
| Human chromosome position | 22q13.33 |
|---|
| LocusLink ID | 6300 |
|---|---|
| 29857 | |
| 60352 | |
| 114707 | |
| 106028 |
| Alias | ERK3 |
|---|---|
| ERK6 | |
| SAPK3 | |
| PRKM12 | |
| SAPK-3 | |
| P38GAMMA | |
| mitogen-activated protein kinase 12 | |
| ERK-6 | |
| MAPK 12 | |
| MAP kinase 12 | |
| MAP kinase p38 gamma | |
| stress-activated protein kinase 3 | |
| mitogen-activated protein kinase 3 | |
| extracellular signal-regulated kinase 6 | |
| mitogen-activated protein kinase p38 gamma | |
| AW123708 | |
| stress activated protein kinase 3 | |
| mitogen activated protein kinase 12 | |
| SAP kinase-3 | |
| OTTHUMP00000196671 | |
| p38gamma mitogen-activated protein kinase | |
| SAP kinase III | |
| SAPK III | |
| Stress-activated protein kinase III | |
| ERK VI | |
| Extracellular signal- regulated kinase 6 | |
| MAPK p38 gamma | |
| MGC156834 | |
| Extracellular signal- regulated kinase VI | |
| MAPK12 | |
| MAP kinase p38 gamma | |
| Stress-activated protein kinase-3 | |
| Stress-activated protein kinase III | |
| MAPK12s | |
| PRKM12s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602399 |
|---|---|
| OMIM:602399 |
| Unigene ID | Hs.432642 |
|---|---|
| Mm.38343 | |
| Rn.162968 | |
| Rn.42944 |
| KEGG ID | hsa:6300 |
|---|---|
| mmu:29857 | |
| rno:60352 |
| Swiss-Prot Accession | P53778 |
|---|---|
| O08911 | |
| Q63538 | |
| Q9D0M4 | |
| Q14260 | |
| Q99588 | |
| Q99672 | |
| Q6IC53 | |
| Q6N076 | |
| Q99M09 | |
| Q66HA3 |
| EC Number | 2.7.11.24 |
|---|---|
| 2.7.1.37 |
| GO ID | 0005524 |
|---|---|
| 0004707 | |
| 0000287 | |
| 0004674 | |
| 0006975 | |
| 0000165 | |
| 0007265 | |
| 0007050 | |
| 0042692 | |
| 0007517 | |
| 0045445 | |
| 0048011 | |
| 0018105 | |
| 0051149 | |
| 0006355 | |
| 0007165 | |
| 0006351 | |
| 0005829 | |
| 0005739 | |
| 0005654 | |
| 0016301 | |
| 0046872 | |
| 0000166 | |
| 0004672 | |
| 0016740 | |
| 0016772 | |
| 0007049 | |
| 0045786 | |
| 0016310 | |
| 0006468 | |
| 0006950 | |
| 0023014 | |
| 0005737 | |
| 0005634 | |
| 0005625 | |
| 0005515 | |
| 0007242 | |
| 0004713 | |
| 0004682 | |
| 0004691 |
| PIR ID | S68680 |
|---|---|
| JC5252 | |
| JC6138 |
| Swiss-Prot ID | MK12_RAT |
|---|---|
| MK12_MOUSE | |
| MK12_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Mitochondrion |
| IPI ID | IPI00210037 |
|---|---|
| IPI00117172 | |
| IPI00296283 | |
| IPI00853109 | |
| IPI00853317 | |
| IPI00471830 |
| Mouse chromosome position | 15 |
|---|---|
| 15 E3 |
| Rat chromosome position | 7q34 |
|---|
| Homologene ID | 55705 |
|---|
| MGI ID | 1353438 |
|---|---|
| 2146196 |
| RGD ID | 70975 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|