| URN | urn:agi-llid:7298 |
|---|---|
| Connectivity | 172 |
| Name | Tyms |
| Description | thymidylate synthetase |
| Notes | Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq] |
| Pathway | de novo pyrimidine biosynthetic pathway |
|---|---|
| salvage pyrimidine biosynthetic pathway2 | |
| de novo pyrimidine biosynthetic pathwayl | |
| folated mediated one carbon metabolic pathway | |
| folated mediated one-carbon metabolic pathway | |
| folated mediated one-carbon metabolic pathway | |
| folated mediated one carbon metabolic pathway | |
| folate mediated one-carbon metabolic pathway |
| GO Molecular Function | cofactor binding |
|---|---|
| nucleotide binding | |
| transferase activity | |
| folic acid binding | |
| methyltransferase activity | |
| thymidylate synthase activity |
| GO Cellular Component | soluble fraction |
|---|---|
| cytosol |
| GO Biological Process | developmental growth |
|---|---|
| aging | |
| immortalization of host cell by virus | |
| cartilage development | |
| intestinal epithelial cell maturation | |
| organ regeneration | |
| phosphoinositide-mediated signaling | |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | |
| dTMP biosynthetic process | |
| dUMP metabolic process | |
| DNA replication | |
| nucleotide biosynthetic process | |
| deoxyribonucleoside monophosphate biosynthetic process | |
| DNA repair | |
| response to drug | |
| response to glucocorticoid stimulus | |
| response to organophosphorus |
| Ariadne Ontology | Pyrimidine metabolism |
|---|
| Group | Pyrimidine metabolism |
|---|---|
| developmental growth | |
| aging | |
| immortalization of host cell by virus | |
| cartilage development | |
| intestinal epithelial cell maturation | |
| organ regeneration | |
| phosphoinositide-mediated signaling | |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | |
| dTMP biosynthetic process | |
| dUMP metabolic process | |
| DNA replication | |
| nucleotide biosynthetic process | |
| deoxyribonucleoside monophosphate biosynthetic process | |
| DNA repair | |
| response to drug | |
| response to glucocorticoid stimulus | |
| response to organophosphorus | |
| cofactor binding | |
| nucleotide binding | |
| transferase activity | |
| folic acid binding | |
| methyltransferase activity | |
| thymidylate synthase activity | |
| soluble fraction | |
| cytosol |
| MedScan ID | 7298 |
|---|
| Hugo ID | 12441 |
|---|
| Human chromosome position | 18p11.32 |
|---|
| LocusLink ID | 7298 |
|---|---|
| 22171 | |
| 29261 |
| Alias | TS |
|---|---|
| TMS | |
| HST422 | |
| MGC88736 | |
| OK/SW-cl.29 | |
| thymidylate synthase | |
| TSase | |
| OTTMUSP00000029744 | |
| MGC156654 | |
| dTMP synthase | |
| dTMP synthases | |
| dTMP synthetase | |
| dTMP synthetases | |
| LOC115567 | |
| methylenetetrahydrofolate:dUMP C-methyltransferase | |
| methylenetetrahydrofolate:dUMP C-methyltransferases | |
| thymidylate synthase (EC 2.1.1.45) | |
| thymidylate synthetase | |
| thymidylate synthetase (EC 2.1.1.45) | |
| TMP synthase | |
| TMP synthases | |
| TMP synthetase | |
| TMP synthetases | |
| TYMS |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 188350 |
|---|
| Mouse chromosome position | 5 18.2 cM |
|---|
| GO ID | 0048037 |
|---|---|
| 0008168 | |
| 0000166 | |
| 0004799 | |
| 0016740 | |
| 0006281 | |
| 0006260 | |
| 0006231 | |
| 0046078 | |
| 0009157 | |
| 0006139 | |
| 0009165 | |
| 0048015 | |
| 0046683 | |
| 0005542 | |
| 0005625 | |
| 0007568 | |
| 0051216 | |
| 0048589 | |
| 0019088 | |
| 0060574 | |
| 0031100 | |
| 0042493 | |
| 0051384 | |
| 0005829 |
| Rat chromosome position | 9q38 |
|---|
| Swiss-Prot Accession | P04818 |
|---|---|
| Q53Y97 | |
| Q53FB7 | |
| Q8WYK3 | |
| Q8WYK4 | |
| P07607 | |
| Q544L2 | |
| Q8C2H6 | |
| Q8C2R3 | |
| Q8K1U2 | |
| Q8VDV6 | |
| Q9D0H1 | |
| P45352 | |
| A0JN23 |
| PIR ID | A26323 |
|---|---|
| S53715 | |
| A23047 |
| Unigene ID | Hs.592338 |
|---|---|
| Mm.268395 | |
| Rn.162284 |
| KEGG ID | hsa:7298 |
|---|---|
| mmu:22171 | |
| rno:29261 |
| EC Number | 2.1.1.45 |
|---|
| Swiss-Prot ID | TYSY_MOUSE |
|---|---|
| TYSY_RAT | |
| TYSY_HUMAN | |
| Q53Y97_HUMAN | |
| Q544L2_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00130734 |
|---|---|
| IPI00207230 | |
| IPI00221108 | |
| IPI00103732 | |
| IPI00103733 | |
| IPI00643685 | |
| IPI00642342 | |
| IPI00857689 |
| Homologene ID | 834 |
|---|
| RGD ID | 3921 |
|---|
| MGI ID | 98878 |
|---|