| URN | urn:agi-llid:6198 |
|---|---|
| Connectivity | 732 |
| Name | Rps6kb1 |
| Description | ribosomal protein S6 kinase, 70kDa, polypeptide 1 |
| Notes | This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized. |
| Pathway | mTOR signaling pathway |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| peptide binding | |
| transferase activity | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| ribosomal protein S6 kinase activity |
| GO Cellular Component | synapse |
|---|---|
| cell surface | |
| membrane | |
| soluble fraction | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| cytosol | |
| mitochondrion | |
| mitochondrial outer membrane | |
| nucleus | |
| synaptosome | |
| cell junction |
| GO Biological Process | cell cycle |
|---|---|
| aging | |
| germ cell development | |
| positive regulation of skeletal muscle tissue growth | |
| long-term memory | |
| skeletal muscle atrophy | |
| skeletal muscle contraction | |
| signal transduction | |
| G1-S transition of mitotic cell cycle | |
| positive regulation of translational initiation | |
| positive regulation of mitotic cell cycle | |
| negative regulation of insulin receptor signaling pathway | |
| TOR signaling pathway | |
| protein kinase B signaling cascade | |
| phosphoinositide-mediated signaling | |
| regulation of translation | |
| positive regulation of translation | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of smooth muscle cell migration | |
| negative regulation of apoptosis | |
| cell migration | |
| protein amino acid phosphorylation | |
| cellular response to hormone stimulus | |
| apoptosis | |
| response to electrical stimulus involved in regulation of muscle adaptation | |
| response to mechanical stimulus | |
| response to organic substance | |
| response to drug | |
| response to toxin | |
| response to nutrient | |
| response to heat | |
| response to wounding | |
| response to organic nitrogen | |
| response to amino acid stimulus | |
| response to organic cyclic substance | |
| response to ethanol | |
| response to leucine | |
| response to lipopolysaccharide | |
| response to tumor necrosis factor | |
| response to peptide hormone stimulus | |
| response to insulin stimulus | |
| response to glucagon stimulus | |
| response to testosterone stimulus | |
| response to glucocorticoid stimulus | |
| response to glucose stimulus | |
| regulation of glucose import |
| Ariadne Ontology | p70S6K |
|---|
| Group | p70S6K |
|---|---|
| synapse | |
| cell cycle | |
| aging | |
| germ cell development | |
| positive regulation of skeletal muscle tissue growth | |
| long-term memory | |
| skeletal muscle atrophy | |
| skeletal muscle contraction | |
| signal transduction | |
| G1-S transition of mitotic cell cycle | |
| positive regulation of translational initiation | |
| positive regulation of mitotic cell cycle | |
| negative regulation of insulin receptor signaling pathway | |
| TOR signaling pathway | |
| protein kinase B signaling cascade | |
| phosphoinositide-mediated signaling | |
| regulation of translation | |
| positive regulation of translation | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of smooth muscle cell migration | |
| negative regulation of apoptosis | |
| cell migration | |
| protein amino acid phosphorylation | |
| cellular response to hormone stimulus | |
| apoptosis | |
| response to electrical stimulus involved in regulation of muscle adaptation | |
| response to mechanical stimulus | |
| response to organic substance | |
| response to drug | |
| response to toxin | |
| response to nutrient | |
| response to heat | |
| response to wounding | |
| response to organic nitrogen | |
| response to amino acid stimulus | |
| response to organic cyclic substance | |
| response to ethanol | |
| response to leucine | |
| response to lipopolysaccharide | |
| response to tumor necrosis factor | |
| response to peptide hormone stimulus | |
| response to insulin stimulus | |
| response to glucagon stimulus | |
| response to testosterone stimulus | |
| response to glucocorticoid stimulus | |
| response to glucose stimulus | |
| regulation of glucose import | |
| nucleotide binding | |
| peptide binding | |
| transferase activity | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| ribosomal protein S6 kinase activity | |
| cell surface | |
| membrane | |
| soluble fraction | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| cytosol | |
| mitochondrion | |
| mitochondrial outer membrane | |
| nucleus | |
| synaptosome | |
| cell junction |
| MedScan ID | 6198 |
|---|
| Hugo ID | 10436 |
|---|
| Human chromosome position | 17q23.1 |
|---|
| LocusLink ID | 6198 |
|---|---|
| 83840 |
| Alias | S6K |
|---|---|
| PS6K | |
| S6K1 | |
| STK14A | |
| p70-S6K | |
| p70-alpha | |
| p70(S6K)-alpha | |
| ribosomal protein S6 kinase beta-1 | |
| P70S6K1 | |
| p70 S6KA | |
| p70-S6K 1 | |
| S6K-beta-1 | |
| p70 S6K-alpha | |
| p70 S6 kinase alpha | |
| p70 S6 kinase, alpha 1 | |
| p70 S6 kinase, alpha 2 | |
| p70 ribosomal S6 kinase alpha | |
| ribosomal protein S6 kinase I | |
| serine/threonine kinase 14 alpha | |
| serine/threonine-protein kinase 14A | |
| 70 kDa ribosomal protein S6 kinase 1 | |
| P70S6K | |
| S6 kinase | |
| ribosomal protein S6 kinase, polypeptide 1 | |
| 2610318I15 | |
| 2610318I15Rik | |
| 70 kDa ribosomal protein S6 kinase, polypeptide 1 | |
| 70 kDa ribosomal protein S6 kinase, polypeptide I | |
| p70 ribosomal S6 kinase | |
| p70 S6 kinase | |
| p70 s6k, p85 s6k | |
| p70/85s6k | |
| ribosomal protein S6 kinase, 70kD, polypeptide 1 | |
| ribosomal protein S6 kinase, 70kD, polypeptide I | |
| ribosomal protein S6 kinase, 70kDa, polypeptide 1 | |
| ribosomal protein S6 kinase, 70kDa, polypeptide I | |
| ribosomal S6 kinase, 70kD, polypeptide | |
| ribosomal S6 kinase, 70kDa, polypeptide | |
| Rps6kb I | |
| Rps6kb1 | |
| S6K I | |
| serine/threonine kinase 14 | |
| RIKEN cDNA 2610318I15 gene | |
| 70 kDa ribosomal protein S6 kinase, , polypeptide 1 | |
| 70 kDa ribosomal protein S6 kinase, , polypeptide I |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus |
| OMIM ID | 608938 |
|---|
| GO ID | 0005524 |
|---|---|
| 0016301 | |
| 0000166 | |
| 0042277 | |
| 0004672 | |
| 0004711 | |
| 0016740 | |
| 0000082 | |
| 0031929 | |
| 0007568 | |
| 0007049 | |
| 0016477 | |
| 0032870 | |
| 0007281 | |
| 0007616 | |
| 0043066 | |
| 0048015 | |
| 0045931 | |
| 0048633 | |
| 0014911 | |
| 0048661 | |
| 0045727 | |
| 0045948 | |
| 0006468 | |
| 0043491 | |
| 0042493 | |
| 0014878 | |
| 0045471 | |
| 0033762 | |
| 0051384 | |
| 0009749 | |
| 0009408 | |
| 0032868 | |
| 0043201 | |
| 0032496 | |
| 0009612 | |
| 0007584 | |
| 0014070 | |
| 0033574 | |
| 0009636 | |
| 0009611 | |
| 0007165 | |
| 0014732 | |
| 0003009 | |
| 0030054 | |
| 0009986 | |
| 0005737 | |
| 0005829 | |
| 0016020 | |
| 0005741 | |
| 0005739 | |
| 0005634 | |
| 0048471 | |
| 0005625 | |
| 0045202 | |
| 0019717 | |
| 0006915 | |
| 0046627 | |
| 0046324 | |
| 0006417 | |
| 0043200 | |
| 0010243 | |
| 0010033 | |
| 0043434 | |
| 0034612 | |
| 0004674 | |
| 0005840 |
| Rat chromosome position | 10q26 |
|---|
| Swiss-Prot Accession | P23443 |
|---|---|
| Q4G0X7 | |
| Q7Z721 | |
| P67999 | |
| P21425 |
| PIR ID | A36484 |
|---|---|
| A41687 |
| Unigene ID | Hs.463642 |
|---|---|
| Rn.4042 |
| KEGG ID | hsa:6198 |
|---|---|
| rno:83840 |
| EC Number | 2.7.11.1 |
|---|
| Swiss-Prot ID | KS6B1_RAT |
|---|---|
| KS6B1_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Cell junction | |
| synapse | |
| synaptosome |
| IPI ID | IPI00471630 |
|---|---|
| IPI00760127 | |
| IPI00216132 | |
| IPI00759649 | |
| IPI00647496 | |
| IPI00795216 | |
| IPI00392901 |
| Homologene ID | 81703 |
|---|
| RGD ID | 620683 |
|---|