Protein Eif4ebp1

URN	urn:agi-llid:1978
Total Entities	0
Connectivity	873
Name	Eif4ebp1
Description	eukaryotic translation initiation factor 4E binding protein 1
Notes	This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

GO Molecular Function	translation repressor activity
	translation initiation factor binding
	eukaryotic initiation factor 4E binding

GO Biological Process	lung development
	G1-S transition of mitotic cell cycle
	positive regulation of mitotic cell cycle
	TOR signaling
	insulin receptor signaling pathway
	response to ethanol
	response to ischemia
	negative regulation of protein complex assembly
	negative regulation of translation
	negative regulation of translational initiation
	regulation of translation
	regulation of translational initiation
	translational initiation
	cellular protein metabolic process
	translation
	gene expression

Pathway	Myostatin-IGF1 Crosstalk in Skeletal Muscles
	IGF1 in Muscle Hypertrophy
	Mechanism of Cetuximab Resistance in Colorectal Cancer
	Acute Myeloid Leukemia Overview
	IL-6/IGF-1/VEGFA in Multiple Myeloma
	Multiple Myeloma Overview
	Chronic Myeloid Leukemia Overview
	B-cell Acute Lymphoblastic Leukemia Overview
	T-cell Acute Lymphoblastic Leukemia Overview
	Mantle Cell Lymphoma Overview
	PI3K/AKT/MTOR, NF-kB and BCR Signaling Deregulation in Mantle Cell Lymphoma
	Insulin Influence on Protein Synthesis
	Cardiovascular Effects of Hyperthyroidism
	Deregulation of Cell Cycle in Melanoma
	Mechanisms of Cardiomyocyte Hypertrophy in Hypertrophic Cardiomyopathy
	Hypertrophic Cardiomyopathy Overview
	Epilepsies Associated with Blood-Brain Barrier Disruption
	mTOR Hyperactivation after Status Epilepticus
	Proposed Mechanisms of Antiepileptic Effects of a Ketogenic Diet
	Preconditioning Ischemia
	ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy
	mTOR signaling pathway
	mTOR signaling pathway

Group	Translation
	lung development
	G1-S transition of mitotic cell cycle
	positive regulation of mitotic cell cycle
	TOR signaling
	insulin receptor signaling pathway
	response to ethanol
	response to ischemia
	negative regulation of protein complex assembly
	negative regulation of translation
	negative regulation of translational initiation
	translation repressor activity
	regulation of translation
	regulation of translational initiation
	translational initiation
	cellular protein metabolic process
	translation
	gene expression
	translation initiation factor binding
	eukaryotic initiation factor 4E binding
	nucleolus
	protein complex
	cytoplasm
	cytosol
	nucleus

Cell Localization	Cytoplasm

Alias	BP-1
	4EBP1
	4E-BP1
	PHAS-I
	eukaryotic translation initiation factor 4E-binding protein 1
	eIF4E-binding protein 1
	phosphorylated heat- and acid-stable protein regulated by insulin 1
	AA959816
	PIR:A55258
	insulin-stimulated phosphoprotein PHAS-I
	MGC4316
	P/OKCL6
	PHAS-1
	eukaryotic initiation factor 4E binding protein 1
	initiation factor 4E binding protein 1
	translational respressor-4E-binding protein
	translational respressor 4E-binding protein
	Eukaryotic translation initiation factor 4Ebinding protein I
	eukaryotic translation initiation factor 4E binding protein 1
	translational respressor 4E binding protein
	4E-BP I
	4E-binding protein 1
	Eukaryotic translation initiation factor 4Ebinding protein 1
	4EBP I
	eukaryotic translation initiation factor 4E binding protein I
	eIF4E -binding protein I
	Eif4ebp1
	eukaryotic translation initiating factor 4E binding protein 1
	eukaryotic translation initiating factor 4E binding protein I
	Eukaryotic translation initiating factor 4Ebinding protein 1
	Eukaryotic translation initiating factor 4Ebinding protein I
	Eif4ebp I
	4E-binding protein I
	4EBP Is
	eIF4E -binding protein 1

Mouse chromosome position	8 15.95 cM
	8 8.0 cM

OMIM ID	602223

Rat chromosome position	16q12.3

Hugo ID	3288

Human chromosome position	8p12

Homologene ID	3021

MGI ID	103267

RGD ID	620259

MedScan ID	1978