| URN | urn:agi-llid:7249 |
|---|---|
| Total Entities | 0 |
| Connectivity | 906 |
| Name | Tsc2 |
| Description | tuberous sclerosis 2 |
| Notes | acts as a tumor suppressor; may play a role in cell cycle regulation; acute phase response, and negative regulation of cell proliferation [RGD] |
| GO Molecular Function | GTPase activator activity |
|---|---|
| Rab GTPase activator activity | |
| 14-3-3 protein binding | |
| phosphatase binding | |
| protein homodimerization activity | |
| protein heterodimerization activity |
| GO Cellular Component | membrane |
|---|---|
| cell | |
| membrane raft | |
| caveola | |
| protein complex | |
| TSC1-TSC2 complex | |
| intracellular | |
| cytoplasm | |
| Golgi apparatus | |
| cytosol | |
| perinuclear region of cytoplasm | |
| intracellular membrane-bounded organelle | |
| cytoskeleton | |
| nucleus | |
| growth cone | |
| neuron projection | |
| dendrite | |
| neuronal cell body |
| GO Biological Process | innate immune response |
|---|---|
| Fc-epsilon receptor signaling pathway | |
| negative regulation of MAP kinase activity | |
| positive regulation of GTPase activity | |
| positive regulation of Rab GTPase activity | |
| heart development | |
| neural tube closure | |
| cell projection organization | |
| cell cycle arrest | |
| regulation of cell cycle | |
| signal transduction | |
| protein kinase B signaling | |
| regulation of small GTPase mediated signal transduction | |
| negative regulation of protein kinase B signaling | |
| negative regulation of TOR signaling | |
| negative regulation of phosphatidylinositol 3-kinase signaling | |
| phosphatidylinositol-mediated signaling | |
| phosphatidylinositol 3-kinase signaling | |
| regulation of insulin receptor signaling pathway | |
| negative regulation of Wnt signaling pathway | |
| neurotrophin TRK receptor signaling pathway | |
| insulin receptor signaling pathway | |
| insulin-like growth factor receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| negative regulation of cell size | |
| negative regulation of cell proliferation | |
| negative regulation of epithelial cell proliferation | |
| protein import into nucleus | |
| positive chemotaxis | |
| response to hypoxia | |
| acute-phase response | |
| negative regulation of protein kinase activity | |
| regulation of endocytosis | |
| establishment of protein localization | |
| vesicle-mediated transport | |
| endocytosis | |
| protein heterooligomerization | |
| protein homooligomerization | |
| protein localization |
| Pathway | Androgen Receptor to SGK1 Signaling in Prostate Cancer |
|---|---|
| Insulin Influence on Protein Synthesis | |
| Proteins Involved in Pathogenesis of Diabetes Mellitus Type 2 | |
| Proteins Involved in Pathogenesis of Pancreatic Cancer | |
| Proteins Involved in Pathogenesis of Peutz-Jeghers Syndrome | |
| Peutz-Jeghers Syndrome Overview | |
| Proteins Involved in Pathogenesis of Epilepsy | |
| Epilepsies Associated with Blood-Brain Barrier Disruption | |
| mTOR Hyperactivation after Status Epilepticus | |
| Proposed Mechanisms of Antiepileptic Effects of a Ketogenic Diet | |
| Preconditioning Ischemia | |
| EGFR/ERBB2 -> HIF1A signaling | |
| AREG/HIF1A Expression Targets | |
| EGF/HIF1A Expression Targets | |
| EREG/HIF1A Expression Target | |
| HBEGF/HIF1A Expression Targets | |
| NRG1/HIF1A Expression Target | |
| TGFA/HIF1A Expression Targets | |
| mTOR signaling pathway | |
| mTOR signaling pathway |
| Group | PSC |
|---|---|
| DNA repair | |
| innate immune response | |
| Fc-epsilon receptor signaling pathway | |
| negative regulation of MAP kinase activity | |
| positive regulation of GTPase activity | |
| GTPase activator activity | |
| Rab GTPase activator activity | |
| positive regulation of Rab GTPase activity | |
| heart development | |
| neural tube closure | |
| cell projection organization | |
| cell cycle arrest | |
| regulation of cell cycle | |
| signal transduction | |
| protein kinase B signaling | |
| regulation of small GTPase mediated signal transduction | |
| negative regulation of protein kinase B signaling | |
| negative regulation of TOR signaling | |
| negative regulation of phosphatidylinositol 3-kinase signaling | |
| phosphatidylinositol-mediated signaling | |
| phosphatidylinositol 3-kinase signaling | |
| regulation of insulin receptor signaling pathway | |
| negative regulation of Wnt signaling pathway | |
| neurotrophin TRK receptor signaling pathway | |
| insulin receptor signaling pathway | |
| insulin-like growth factor receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| negative regulation of cell size | |
| negative regulation of cell proliferation | |
| negative regulation of epithelial cell proliferation | |
| protein import into nucleus | |
| positive chemotaxis | |
| response to hypoxia | |
| acute-phase response | |
| negative regulation of protein kinase activity | |
| regulation of endocytosis | |
| establishment of protein localization | |
| vesicle-mediated transport | |
| endocytosis | |
| protein heterooligomerization | |
| protein homooligomerization | |
| protein localization | |
| 14-3-3 protein binding | |
| phosphatase binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| membrane | |
| cell | |
| membrane raft | |
| caveola | |
| protein complex | |
| TSC1-TSC2 complex | |
| intracellular | |
| cytoplasm | |
| Golgi apparatus | |
| cytosol | |
| perinuclear region of cytoplasm | |
| intracellular membrane-bounded organelle | |
| cytoskeleton | |
| nucleus | |
| growth cone | |
| neuron projection | |
| dendrite | |
| neuronal cell body | |
| Proteins Involved in Pathogenesis of Cowden Syndrome | |
| Disease Genes Identified in Syndromic Epilepsy | |
| Disease Genes Identified in Epilepsy with Mental Retardation and Brain Malformations | |
| Genes with Mutations Associated with Pancreatic Cancer | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 7249 |
|---|---|
| 22084 | |
| 24855 |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm | |
| Membrane |
| GO ID | 0071889 |
|---|---|
| 0005096 | |
| 0019902 | |
| 0046982 | |
| 0042803 | |
| 0038095 | |
| 0006953 | |
| 0007050 | |
| 0030030 | |
| 0006897 | |
| 0007173 | |
| 0008543 | |
| 0007507 | |
| 0045087 | |
| 0008286 | |
| 0048009 | |
| 0043407 | |
| 0032007 | |
| 0030178 | |
| 0008285 | |
| 0045792 | |
| 0050680 | |
| 0014067 | |
| 0051898 | |
| 0006469 | |
| 0001843 | |
| 0048011 | |
| 0014065 | |
| 0048015 | |
| 0050918 | |
| 0051291 | |
| 0051260 | |
| 0006606 | |
| 0043491 | |
| 0008104 | |
| 0051726 | |
| 0030100 | |
| 0046626 | |
| 0051056 | |
| 0001666 | |
| 0016192 | |
| 0005794 | |
| 0033596 | |
| 0005901 | |
| 0005737 | |
| 0005829 | |
| 0030425 | |
| 0030426 | |
| 0016020 | |
| 0043025 | |
| 0005634 | |
| 0048471 | |
| 0045184 | |
| 0043547 | |
| 0007165 | |
| 0005623 | |
| 0005856 | |
| 0005622 | |
| 0043231 | |
| 0045121 | |
| 0043005 | |
| 0043234 | |
| 0005097 | |
| 0032851 | |
| 0005488 | |
| 0005515 | |
| 0045786 | |
| 0005624 | |
| 0005102 | |
| 0007049 | |
| 0030695 | |
| 0032956 | |
| 0051893 | |
| 0051492 | |
| 0044430 | |
| 0005792 | |
| 0016599 | |
| 0006457 | |
| 0051082 | |
| 0005886 | |
| 0000074 |
| Alias | LAM |
|---|---|
| TSC4 | |
| tuberin | |
| tuberous sclerosis 2 protein | |
| Tcs2 | |
| Nafld | |
| tuberous sclerosis 2 protein homolog | |
| Rc | |
| Tsc2 | |
| renal carcinoma | |
| tuberous sclerosis 2 homolog protein | |
| tuberin isoform 2 | |
| tuberin isoform II | |
| tuberous sclerosis complex 2 protein | |
| tuberous sclerosis II | |
| Tuberous sclerosis 2, (renal carcinoma) | |
| Tuberins | |
| tuberin isoform III | |
| tuberous sclerosis 2 | |
| OTTHUMP00000198394 | |
| FLJ43106 | |
| tuberin isoform I | |
| LOC124054 | |
| tuberin isoform 1 | |
| tuberin isoform 3 | |
| uberin | |
| Tuberous sclerosis 2 (renal carcinoma) | |
| Tsc2 gene |
| Mouse chromosome position | 17 12.41 cM |
|---|---|
| 17 10.3 cM |
| OMIM ID | 191092 |
|---|---|
| 606690 | |
| 613254 | |
| 191100 |
| Rat chromosome position | 10q12 |
|---|
| Hugo ID | 12363 |
|---|
| Human chromosome position | 16p13.3 |
|---|
| Swiss-Prot Accession | P49815 |
|---|---|
| Q7TT21 | |
| Q3UGI8 | |
| Q61037 | |
| P49816 | |
| A7E2E2 | |
| B4DIQ7 | |
| B4DRN2 | |
| C9J378 | |
| O75275 | |
| Q4LE71 | |
| Q8TAZ1 | |
| Q5HYF7 | |
| Q3TBX9 | |
| Q3TCQ7 | |
| Q3TP98 | |
| Q3TQ10 | |
| Q3UG84 | |
| Q3UG88 | |
| Q3UHB2 | |
| Q3UI96 | |
| Q925J1 |
| PIR ID | S57329 |
|---|---|
| A49420 |
| Unigene ID | Hs.90303 |
|---|---|
| Mm.30435 | |
| Rn.5875 |
| KEGG ID | hsa:7249 |
|---|---|
| mmu:22084 | |
| rno:24855 |
| Swiss-Prot ID | TSC2_RAT |
|---|---|
| TSC2_HUMAN | |
| Q3UGI8_MOUSE | |
| Q7TT21_MOUSE | |
| A7E2E2_HUMAN | |
| Q4LE71_HUMAN |
| Ensembl ID | ENSG00000103197 |
|---|---|
| ENSP00000219476 | |
| ENST00000219476 | |
| ENSP00000384468 | |
| ENST00000401874 | |
| ENSP00000344383 | |
| ENST00000350773 | |
| ENSP00000371978 | |
| ENST00000382538 | |
| ENSMUSG00000002496 | |
| ENSMUSP00000094986 | |
| ENSMUST00000097373 | |
| ENSRNOG00000011375 | |
| ENSRNOP00000016221 | |
| ENSRNOT00000016221 |
| Homologene ID | 462 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 102548 |
|---|
| RGD ID | 3908 |
|---|
| MedScan ID | 7249 |
|---|
| IPI ID | IPI00230778 |
|---|---|
| IPI00230779 | |
| IPI00230780 | |
| IPI00323980 | |
| IPI00028493 | |
| IPI00218881 | |
| IPI00218883 | |
| IPI00879496 | |
| IPI00952929 | |
| IPI00954095 | |
| IPI00230482 | |
| IPI00468568 | |
| IPI00218882 | |
| IPI00552156 | |
| IPI00877641 | |
| IPI00877797 | |
| IPI00620969 | |
| IPI00230478 | |
| IPI00230479 | |
| IPI00230480 | |
| IPI00230481 | |
| IPI00875520 | |
| IPI00874661 |