| URN | urn:agi-llid:84335 |
|---|---|
| Connectivity | 38 |
| Name | Akt1s1 |
| Description | AKT1 substrate 1 (proline-rich) |
| Notes | AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM] |
| Pathway | mTOR signaling pathway |
|---|
| GO Cellular Component | protein complex |
|---|---|
| soluble fraction | |
| cytoplasm | |
| TORC1 complex | |
| cytosol | |
| cytosolic part | |
| nucleus |
| GO Biological Process | negative regulation of TOR signaling pathway |
|---|---|
| negative regulation of protein kinase activity | |
| regulation of survival gene product expression | |
| neuroprotection | |
| Notch signaling pathway | |
| negative regulation of cell size |
| Group | negative regulation of TOR signaling pathway |
|---|---|
| negative regulation of protein kinase activity | |
| regulation of survival gene product expression | |
| neuroprotection | |
| Notch signaling pathway | |
| negative regulation of cell size | |
| protein complex | |
| soluble fraction | |
| cytoplasm | |
| TORC1 complex | |
| cytosol | |
| cytosolic part | |
| nucleus |
| MedScan ID | 84335 |
|---|
| Hugo ID | 28426 |
|---|
| Human chromosome position | 19q13.33 |
|---|
| LocusLink ID | 84335 |
|---|---|
| 67605 | |
| 292887 |
| Alias | Lobe |
|---|---|
| PRAS40 | |
| MGC2865 | |
| proline-rich AKT1 substrate 1 | |
| OTTHUMP00000196756 | |
| OTTHUMP00000196760 | |
| 40 kDa proline-rich AKT substrate | |
| proline-rich Akt substrate, 40 kDa | |
| Lobel | |
| AI227026 | |
| 1110012J22Rik | |
| lobe-like | |
| OTTMUSP00000026761 | |
| OTTMUSP00000026762 | |
| OTTMUSP00000026763 | |
| OTTMUSP00000026768 | |
| proline-rich AKT substrate | |
| AKT1 substrate 1 (proline-rich) | |
| PKB/Akt substrate 40 | |
| Pras | |
| 1110012J22 | |
| AI430011 | |
| akt1 substrate 1 | |
| akt1 substrate I | |
| AKT1S1 | |
| lobe homolog | |
| lobe homolog-like | |
| LOC292887 | |
| OTTHUMP00000196757 | |
| OTTHUMP00000196758 | |
| OTTHUMP00000196759 | |
| RIKEN cDNA 1110012J22 | |
| PRAS40s | |
| expressed sequence AI430011 | |
| hypothetical protein MGC2865 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 610221 |
|---|
| Mouse chromosome position | 7 |
|---|---|
| 7 B2 |
| GO ID | 0032007 |
|---|---|
| 0045792 | |
| 0006469 | |
| 0043526 | |
| 0045884 | |
| 0031931 | |
| 0005737 | |
| 0005829 | |
| 0044445 | |
| 0007219 | |
| 0005634 | |
| 0043234 | |
| 0005625 | |
| 0003674 | |
| 0005575 |
| Rat chromosome position | 1q22 |
|---|
| Swiss-Prot Accession | Q96B36 |
|---|---|
| Q9D1F4 | |
| A8MTQ1 | |
| B2RE93 | |
| Q96BI4 | |
| Q96IK7 | |
| Q96NG2 | |
| Q9BWR5 | |
| A2RT52 |
| Unigene ID | Hs.515542 |
|---|---|
| Mm.148007 | |
| Rn.102669 | |
| Rn.220328 | |
| Mm.431538 | |
| Rn.218941 |
| KEGG ID | hsa:84335 |
|---|---|
| mmu:67605 | |
| rno:292887 |
| Swiss-Prot ID | AKTS1_HUMAN |
|---|---|
| AKTS1_MOUSE | |
| B2RE93_HUMAN | |
| A2RT52_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| cytosol |
| IPI ID | IPI00306195 |
|---|---|
| IPI00549786 | |
| IPI00133685 | |
| IPI00853601 | |
| IPI00857957 | |
| IPI00857073 | |
| IPI00857218 | |
| IPI00857311 | |
| IPI00857434 | |
| IPI00856137 | |
| IPI00856261 | |
| IPI00869848 |
| Homologene ID | 12162 |
|---|
| RGD ID | 1312049 |
|---|
| MGI ID | 1914855 |
|---|