| URN | urn:agi-llid:3667 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1656 |
| Name | Irs1 |
| Description | insulin receptor substrate 1 |
| Notes | a docking protein; may act to link the insulin receptor kinase with enzymes regulating cellular growth and metabolism [RGD] |
| GO Molecular Function | signal transducer activity |
|---|---|
| transmembrane receptor protein tyrosine kinase adaptor activity | |
| phosphatidylinositol 3-kinase binding | |
| protein domain specific binding | |
| insulin receptor binding | |
| insulin-like growth factor receptor binding | |
| protein kinase binding | |
| protein kinase C binding | |
| SH2 domain binding |
| GO Cellular Component | insulin receptor complex |
|---|---|
| caveola | |
| intracellular | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| intracellular membrane-bounded organelle | |
| nucleus |
| GO Biological Process | innate immune response |
|---|---|
| Fc-epsilon receptor signaling pathway | |
| positive regulation of glycogen biosynthetic process | |
| lipid catabolic process | |
| positive regulation of fatty acid beta-oxidation | |
| positive regulation of glucose metabolic process | |
| positive regulation of phosphatidylinositol 3-kinase activity | |
| mammary gland development | |
| signal transduction | |
| protein kinase B signaling | |
| JAK-STAT cascade involved in growth hormone signaling pathway | |
| phosphatidylinositol-mediated signaling | |
| phosphatidylinositol 3-kinase signaling | |
| positive regulation of insulin receptor signaling pathway | |
| negative regulation of insulin receptor signaling pathway | |
| neurotrophin TRK receptor signaling pathway | |
| insulin receptor signaling pathway | |
| insulin-like growth factor receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| positive regulation of glucagon secretion | |
| negative regulation of somatostatin secretion | |
| negative regulation of insulin secretion | |
| insulin secretion | |
| positive regulation of cell migration | |
| positive regulation of glucose import in response to insulin stimulus | |
| positive regulation of cell proliferation | |
| positive regulation of mesenchymal cell proliferation | |
| positive regulation of glucose import | |
| response to peptide hormone | |
| response to insulin | |
| cellular response to insulin stimulus | |
| response to caffeine | |
| positive regulation of phosphorylation | |
| regulation of gene expression | |
| protein heterooligomerization | |
| protein localization to nucleus | |
| glucose homeostasis |
| Pathway | Prostate Cancer Overview |
|---|---|
| Myostatin-IGF1 Crosstalk in Skeletal Muscles | |
| IL6 in Insulin Resistance | |
| Duchenne Muscular Dystrophy Overview | |
| IGF1 in Muscle Hypertrophy | |
| IL-6/IGF-1/VEGFA in Multiple Myeloma | |
| Multiple Myeloma Overview | |
| T-cell Acute Lymphoblastic Leukemia Overview | |
| Proteins Involved in Pathogenesis of Breast Cancer Related to IGF1R/Akt Signaling Pathway | |
| Breast Cancer Related to IGF1R/Akt Signaling Pathway | |
| Breast Cancer Related to ERBB/VEGFR/Akt Signaling Pathway | |
| ESR1/ERBB-positive Luminal Breast Cancer | |
| Insulin Influence on Glycogenesis | |
| Insulin Resistance in Hepatocytes | |
| Insulin Influence on Lipogenesis | |
| Insulin Influence on Protein Synthesis | |
| Proteins Involved in Pathogenesis of Insulin Resistance | |
| Impaired Adiponectin Synthesis in Insulin Resistance | |
| Proteins Involved in Pathogenesis of Diabetes Mellitus Type 2 | |
| Graves Ophthalmopathy | |
| Thyroid Hormones in Adipose Tissue Metabolism | |
| Ovarian Cancer Overview | |
| Type I Endometrial Cancer (Endometrioid Endometrial Cancer) | |
| Endometrial Cancer Overview | |
| Deregulation of Cell Cycle in Melanoma | |
| Melanoma Overview | |
| Mechanisms of Cardiomyocyte Hypertrophy in Hypertrophic Cardiomyopathy | |
| Hypertrophic Cardiomyopathy Overview | |
| Smooth Muscle Cell Dysfunction in Pulmonary Arterial Hypertension | |
| Proteins Involved in Pathogenesis of Medulloblastoma | |
| Steroid-Induced Cataract | |
| Proteins Involved in Pathogenesis of Cataract | |
| Growth Factor Signaling in Neuroblastoma | |
| Neuroblastoma Overview | |
| Growth Factor Signaling in Pancreatic Cancer | |
| Pancreatic Ductal Carcinoma | |
| Pancreatic Neuroendocrine Tumors | |
| Proteins Involved in Pathogenesis of Polycystic Ovary Syndrome | |
| Impaired SHBG and IGFBP1 Synthesis in Polycystic Ovary Syndrome | |
| Impaired Steroidogenesis in Polycystic Ovary Syndrome | |
| Block of Ovulation in Polycystic Ovary Syndrome | |
| Polycystic Ovary Syndrome Overview | |
| Growth Factor Signaling in Hepatocellular Carcinoma | |
| Proteins Involved in Pathogenesis of Hepatocellular Carcinoma | |
| Hepatocellular Carcinoma Overview | |
| Effects of BDNF Upregulation Induced by Seizures | |
| Proposed Mechanisms of Antiepileptic Effects of a Ketogenic Diet | |
| EPHB -> NMDA receptor activation | |
| NTRK1/2/3 -> acetylcholine production | |
| GFs/TNF -> ion channels | |
| Regulation of calcium flux | |
| IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling | |
| InsulinR -> CTNNB/FOXA/FOXO signaling | |
| InsulinR -> ELK-SRF/SREBF signaling | |
| IGF1R -> CEBPA/FOXO1A signaling | |
| IGF1R -> MEF/MYOD/MYOG signaling | |
| NTRK -> FOXO/MYCN signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| IL4R -> ELK-SRF/HMGY signaling | |
| Dexamethasone-Induced Diabetes | |
| Ritonavir-Induced Diabetes | |
| NGF/FOXO/MYCN/ELK-SRF Expression Targets | |
| NGF/AP-1/TP53/MYC Expression Targets | |
| NGF/CREB/CEBPB/MEF2A Expression Targets | |
| NGF/SMAD3/NF-kB Expression Targets | |
| IL4 Expression Targets | |
| IGF2/CEBPA/FOXO1A Expression Targets | |
| IGF2/MEF/MYOD Expression Targets | |
| IGF2/HIF1A/MYC Expression Targets | |
| IGF1/CEBPA/FOXO1A Expression Targets | |
| Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| IGF1/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| IGF1/MEF/MYOD/MYOG Expression Targets | |
| Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
| Insulin/MEF/MYOD Expression Targets | |
| insulin signaling pathway | |
| insulin signaling pathway | |
| mTOR signaling pathway | |
| altered insulin signaling pathway | |
| mTOR signaling pathway |
| Group | IRS |
|---|---|
| innate immune response | |
| Fc-epsilon receptor signaling pathway | |
| positive regulation of glycogen biosynthetic process | |
| lipid catabolic process | |
| positive regulation of fatty acid beta-oxidation | |
| positive regulation of glucose metabolic process | |
| positive regulation of phosphatidylinositol 3-kinase activity | |
| mammary gland development | |
| signal transduction | |
| signal transducer activity | |
| protein kinase B signaling | |
| JAK-STAT cascade involved in growth hormone signaling pathway | |
| phosphatidylinositol-mediated signaling | |
| phosphatidylinositol 3-kinase signaling | |
| positive regulation of insulin receptor signaling pathway | |
| transmembrane receptor protein tyrosine kinase adaptor activity | |
| negative regulation of insulin receptor signaling pathway | |
| neurotrophin TRK receptor signaling pathway | |
| insulin receptor signaling pathway | |
| insulin-like growth factor receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| positive regulation of glucagon secretion | |
| negative regulation of somatostatin secretion | |
| negative regulation of insulin secretion | |
| insulin secretion | |
| positive regulation of cell migration | |
| positive regulation of glucose import in response to insulin stimulus | |
| positive regulation of cell proliferation | |
| positive regulation of mesenchymal cell proliferation | |
| positive regulation of glucose import | |
| response to peptide hormone | |
| response to insulin | |
| cellular response to insulin stimulus | |
| response to caffeine | |
| positive regulation of phosphorylation | |
| regulation of gene expression | |
| protein heterooligomerization | |
| protein localization to nucleus | |
| glucose homeostasis | |
| phosphatidylinositol 3-kinase binding | |
| protein domain specific binding | |
| insulin receptor binding | |
| insulin-like growth factor receptor binding | |
| protein kinase binding | |
| protein kinase C binding | |
| SH2 domain binding | |
| insulin receptor complex | |
| caveola | |
| intracellular | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| intracellular membrane-bounded organelle | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|---|
| GO component |
| LocusLink ID | 3667 |
|---|---|
| 16367 | |
| 25467 | |
| 538598 | |
| 559281 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| GO ID | 0042169 |
|---|---|
| 0005158 | |
| 0005159 | |
| 0043548 | |
| 0005080 | |
| 0004871 | |
| 0005068 | |
| 0038095 | |
| 0060397 | |
| 0032869 | |
| 0007173 | |
| 0008543 | |
| 0042593 | |
| 0045087 | |
| 0008286 | |
| 0048009 | |
| 0016042 | |
| 0030879 | |
| 0046627 | |
| 0046676 | |
| 0048011 | |
| 0014065 | |
| 0048015 | |
| 0030335 | |
| 0008284 | |
| 0032000 | |
| 0046326 | |
| 2001275 | |
| 0010907 | |
| 0045725 | |
| 0046628 | |
| 0002053 | |
| 0043552 | |
| 0043491 | |
| 0034504 | |
| 0010468 | |
| 0032868 | |
| 0043434 | |
| 0007165 | |
| 0005901 | |
| 0005737 | |
| 0005829 | |
| 0005899 | |
| 0043231 | |
| 0005634 | |
| 0005886 | |
| 0019904 | |
| 0019901 | |
| 0030073 | |
| 0090275 | |
| 0070094 | |
| 0042327 | |
| 0051291 | |
| 0031000 | |
| 0005622 | |
| 0005515 | |
| 0005069 | |
| 0005792 | |
| 0004872 | |
| 0005010 | |
| 0009749 | |
| 0042301 | |
| 0006006 |
| Alias | HIRS-1 |
|---|---|
| insulin receptor substrate 1 | |
| IRS-1 | |
| G972R | |
| IRS1IRM | |
| pp185 | |
| insulin receptor substrate 3 | |
| insulin receptor substrate I | |
| insulin receptor substrate III | |
| Irs3 | |
| OTTMUSP00000017705 | |
| IRS I | |
| INS receptor substrate III | |
| INS receptor substrate I | |
| ENSMUSG00000022591 | |
| INS receptor substrate 3 | |
| IRS1_HUMAN | |
| INS receptor substrate 1 | |
| HIRS I | |
| LOC559281 | |
| XIRS-L | |
| chromosome | |
| scaffold | |
| similar to Insulin receptor substrate 1-B (IRS1-B) | |
| similar to Insulin receptor substrate 1-B (IRS1-B) (xIRS-1-B) | |
| similar to Insulin receptor substrate 1-B (IRS1-B) (xIRS-1-B) (XIRS-L) |
| Mouse chromosome position | 1 42.0 cM |
|---|---|
| 1 57.0 cM |
| OMIM ID | 147545 |
|---|---|
| 125853 |
| Rat chromosome position | 9q34 |
|---|
| Hugo ID | 6125 |
|---|
| Human chromosome position | 2q36 |
|---|
| Swiss-Prot Accession | P35568 |
|---|---|
| P35569 | |
| Q543V3 | |
| P35570 | |
| Q810H1 |
| PIR ID | S30185 |
|---|---|
| I53160 | |
| S16948 |
| Unigene ID | Hs.471508 |
|---|---|
| Mm.4952 | |
| Rn.10476 | |
| Mm.472689 | |
| Mm.395683 | |
| Mm.385530 | |
| Dr.3152 | |
| Mm.458267 | |
| Mm.476433 | |
| Hs.716618 |
| KEGG ID | hsa:3667 |
|---|---|
| mmu:16367 | |
| rno:25467 |
| Swiss-Prot ID | IRS1_MOUSE |
|---|---|
| IRS1_HUMAN | |
| IRS1_RAT | |
| Q543V3_MOUSE |
| Ensembl ID | ENSG00000169047 |
|---|---|
| ENSP00000304895 | |
| ENST00000305123 | |
| ENSMUSG00000055980 | |
| ENSMUSP00000063795 | |
| ENSMUST00000069799 | |
| ENSRNOG00000014597 | |
| ENSRNOP00000019579 | |
| ENSRNOT00000019579 |
| Homologene ID | 4049 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| MGI ID | 99454 |
|---|
| RGD ID | 2922 |
|---|
| MedScan ID | 3667 |
|---|
| IPI ID | IPI00019471 |
|---|---|
| IPI00119627 | |
| IPI00199662 | |
| IPI00605223 |
| Homo sapiens Chromosome position | 2q36 |
|---|
| Microarray ID | 98824_at |
|---|
| FunctionalClass | SH2 domain binding |
|---|---|
| insulin receptor binding | |
| insulin-like growth factor receptor binding | |
| phosphoinositide 3-kinase binding | |
| protein binding | |
| protein kinase binding | |
| signal transducer | |
| transmembrane receptor protein tyrosine kinase docking protein | |
| receptor | |
| insulin-like growth factor receptor | |
| protein domain specific binding |
| Bos taurus Chromosome position | 2 |
|---|
| Mus musculus Chromosome position | 1 57.0 cM |
|---|
| Rattus norvegicus Chromosome position | 9q34 |
|---|