| URN | urn:agi-llid:1978 |
|---|---|
| Connectivity | 257 |
| Name | Eif4ebp1 |
| Description | eukaryotic translation initiation factor 4E binding protein 1 |
| Notes | This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. |
| Pathway | mTOR signaling pathway |
|---|
| GO Molecular Function | translation repressor activity |
|---|---|
| translation initiation factor binding | |
| eukaryotic initiation factor 4E binding |
| GO Cellular Component | protein complex |
|---|---|
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | G1-S transition of mitotic cell cycle |
|---|---|
| regulation of translational initiation | |
| negative regulation of translational initiation | |
| positive regulation of mitotic cell cycle | |
| TOR signaling pathway | |
| regulation of translation | |
| negative regulation of translation | |
| insulin receptor signaling pathway | |
| negative regulation of protein complex assembly |
| Ariadne Ontology | Translation |
|---|
| Group | Translation |
|---|---|
| G1-S transition of mitotic cell cycle | |
| regulation of translational initiation | |
| negative regulation of translational initiation | |
| positive regulation of mitotic cell cycle | |
| TOR signaling pathway | |
| regulation of translation | |
| negative regulation of translation | |
| insulin receptor signaling pathway | |
| negative regulation of protein complex assembly | |
| translation repressor activity | |
| translation initiation factor binding | |
| eukaryotic initiation factor 4E binding | |
| protein complex | |
| cytoplasm | |
| cytosol | |
| nucleus |
| MedScan ID | 1978 |
|---|
| Hugo ID | 3288 |
|---|
| Human chromosome position | 8p12 |
|---|
| LocusLink ID | 1978 |
|---|---|
| 13685 | |
| 116636 |
| Alias | BP-1 |
|---|---|
| 4EBP1 | |
| 4E-BP1 | |
| PHAS-I | |
| MGC4316 | |
| eukaryotic translation initiation factor 4E-binding protein 1 | |
| eIF4E-binding protein 1 | |
| phosphorylated heat- and acid-stable protein regulated by insulin 1 | |
| AA959816 | |
| 4E-binding protein 1 | |
| 4E-binding protein I | |
| 4EBP I | |
| 4E-BP I | |
| eIF4E -binding protein 1 | |
| eIF4E -binding protein I | |
| Eif4ebp I | |
| Eif4ebp1 | |
| eukaryotic translation initiating factor 4E binding protein 1 | |
| eukaryotic translation initiating factor 4E binding protein I | |
| Eukaryotic translation initiating factor 4Ebinding protein 1 | |
| Eukaryotic translation initiating factor 4Ebinding protein I | |
| eukaryotic translation initiation factor 4E binding protein 1 | |
| eukaryotic translation initiation factor 4E binding protein I | |
| Eukaryotic translation initiation factor 4Ebinding protein 1 | |
| Eukaryotic translation initiation factor 4Ebinding protein I | |
| insulin-stimulated phosphoprotein PHAS-I | |
| P/OKCL6 | |
| PHAS-1 | |
| PIR:A55258 | |
| 4EBP Is |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602223 |
|---|
| Mouse chromosome position | 8 8.0 cM |
|---|
| GO ID | 0008190 |
|---|---|
| 0000082 | |
| 0031929 | |
| 0008286 | |
| 0031333 | |
| 0045947 | |
| 0045931 | |
| 0005737 | |
| 0005829 | |
| 0005634 | |
| 0043234 | |
| 0031369 | |
| 0030371 | |
| 0017148 | |
| 0006417 | |
| 0006446 | |
| 0005515 | |
| 0003743 |
| Rat chromosome position | 16q12.3 |
|---|
| Swiss-Prot Accession | Q13541 |
|---|---|
| Q60876 | |
| Q3TII9 | |
| Q62622 | |
| Q3TDS8 | |
| Q9CZ40 | |
| B2R502 | |
| Q6IBN3 | |
| D3DSW8 |
| PIR ID | A57396 |
|---|---|
| A55258 | |
| S50866 |
| Unigene ID | Hs.411641 |
|---|---|
| Mm.6700 | |
| Rn.11161 |
| KEGG ID | hsa:1978 |
|---|---|
| mmu:13685 | |
| rno:116636 |
| Swiss-Prot ID | 4EBP1_MOUSE |
|---|---|
| 4EBP1_RAT | |
| 4EBP1_HUMAN | |
| D3DSW8_HUMAN | |
| B2R502_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00318938 |
|---|---|
| IPI00207037 | |
| IPI00002569 |
| Homologene ID | 3021 |
|---|
| RGD ID | 620259 |
|---|
| MGI ID | 103267 |
|---|