Elsevier Inc. translation initiation pathway TSC complex Akt1s1 Gatsl3 insulin signaling pathway mTORC1 complex GF leucine ribosome biogenesis pathway translation pathway nuclear factor, erythroid 2 like 2 signaling pathway autophagy pathway phosphatidylinositol 3-kinase-Akt signaling pathway the extracellular signal-regulated Raf/Mek/Erk signaling pathway adenosine monophosphate-activated protein kinase (AMPK) signaling pathway Irs1 Rheb Rrag members rapamycin Flcn-Flip mTORC2 complex Gator2 complex Ragulator complex Gator1 complex Rrag members ---> mTORC1 complex phosphatidylinositol 3-kinase-Akt signaling pathway ---| Tsc2 the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---| Tsc2 Tsc1 Tsc2 Rheb --+> mTORC1 complex insulin signaling pathway --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway insulin signaling pathway --+> phosphatidylinositol 3-kinase-Akt signaling pathway environmental cues Rrag members --+> mTORC1 complex mTORC2 complex --+> cytoskeletal rearrangements cytoskeletal rearrangements Flcn-Flip --+> Rrag members Gator2 complex ---| Gator1 complex Ragulator complex --+> Rrag members Gator2 complex ---- Sesn2 Sesn2 ---| Gator2 complex Gator2 complex ---- Gatsl2 Gator2 complex ---- Gatsl3 Gatsl3 ---| Gator2 complex Gatsl2 ---| Gator2 complex Rps6kb1 ---| Irs1 leucine ---- Sesn2 Rps6kb1 Rps6kb1 --+> translation initiation pathway Eif4ebp1 ---| translation initiation pathway mTORC1 complex --+> Rps6kb1 translation initiation pathway ---> ribosome biogenesis pathway Eif4ebp1 mTORC1 complex ---| Eif4ebp1 mTORC1 complex ---| autophagy pathway mTORC1 complex --+> nuclear factor, erythroid 2 like 2 signaling pathway Sesn2 leucine ---| Sesn2 arginine ---| Gatsl3 environmental cues --+> adenosine monophosphate-activated protein kinase (AMPK) signaling pathway GF --+> mTORC2 complex mTORC2 complex --+> phosphatidylinositol 3-kinase-Akt signaling pathway Gator1 complex ---| Rrag members phosphatidylinositol 3-kinase-Akt signaling pathway ---| Akt1s1 adenosine monophosphate-activated protein kinase (AMPK) signaling pathway --+> Tsc2 Tsc2 ---| Rheb Akt1s1 ---| mTORC1 complex adenosine monophosphate-activated protein kinase (AMPK) signaling pathway ---| mTORC1 complex Fkbp1a ---- rapamycin rapamycin ---| mTORC1 complex arginine arginine ---- Gatsl3 Gatsl2 Gatsl2 ---- Gatsl3 Fkbp1a