| URN | urn:agi-llid:5795 |
|---|---|
| Total Entities | 0 |
| Connectivity | 275 |
| Name | PTPRJ |
| Description | protein tyrosine phosphatase, receptor type, J |
| Notes | protein tyrosine phosphatase expressed in smooth muscle cells; may be involved in cell adhesion or cell-cell signaling [RGD] |
| GO Molecular Function | hydrolase activity |
|---|---|
| phosphatase activity | |
| phosphoprotein phosphatase activity | |
| protein tyrosine phosphatase activity | |
| beta-catenin binding | |
| delta-catenin binding | |
| gamma-catenin binding | |
| platelet-derived growth factor receptor binding | |
| protein kinase binding | |
| mitogen-activated protein kinase binding |
| GO Cellular Component | membrane |
|---|---|
| cell junction | |
| integral component of membrane | |
| immunological synapse | |
| integral component of plasma membrane | |
| ruffle membrane | |
| cell surface | |
| plasma membrane | |
| cell projection | |
| cell-cell junction |
| GO Biological Process | negative regulation of T cell receptor signaling pathway |
|---|---|
| positive regulation of macrophage chemotaxis | |
| negative regulation of MAP kinase activity | |
| blood coagulation | |
| positive regulation of platelet activation | |
| negative regulation of vascular permeability | |
| vasculogenesis | |
| heart development | |
| contact inhibition | |
| positive regulation of protein kinase B signaling | |
| negative regulation of protein kinase B signaling | |
| negative regulation of platelet-derived growth factor receptor signaling pathway | |
| negative regulation of epidermal growth factor receptor signaling pathway | |
| negative regulation of receptor activity | |
| platelet-derived growth factor receptor signaling pathway | |
| negative regulation of cell growth | |
| regulation of cell adhesion | |
| positive regulation of cell adhesion | |
| positive regulation of cell-matrix adhesion | |
| positive regulation of focal adhesion assembly | |
| negative regulation of cell migration | |
| negative regulation of cell proliferation | |
| positive chemotaxis | |
| protein dephosphorylation | |
| peptidyl-tyrosine dephosphorylation | |
| dephosphorylation |
| Pathway | PTPRJ -> CTNND signaling |
|---|---|
| PTPRJ Expression Targets | |
| epidermal growth factor/neuregulin signaling pathway |
| Group | RPTP |
|---|---|
| Phosphatases | |
| negative regulation of T cell receptor signaling pathway | |
| positive regulation of macrophage chemotaxis | |
| negative regulation of MAP kinase activity | |
| blood coagulation | |
| positive regulation of platelet activation | |
| negative regulation of vascular permeability | |
| vasculogenesis | |
| heart development | |
| contact inhibition | |
| positive regulation of protein kinase B signaling | |
| negative regulation of protein kinase B signaling | |
| negative regulation of platelet-derived growth factor receptor signaling pathway | |
| negative regulation of epidermal growth factor receptor signaling pathway | |
| negative regulation of receptor activity | |
| platelet-derived growth factor receptor signaling pathway | |
| negative regulation of cell growth | |
| regulation of cell adhesion | |
| positive regulation of cell adhesion | |
| positive regulation of cell-matrix adhesion | |
| positive regulation of focal adhesion assembly | |
| negative regulation of cell migration | |
| negative regulation of cell proliferation | |
| positive chemotaxis | |
| hydrolase activity | |
| phosphatase activity | |
| phosphoprotein phosphatase activity | |
| protein tyrosine phosphatase activity | |
| protein dephosphorylation | |
| peptidyl-tyrosine dephosphorylation | |
| dephosphorylation | |
| beta-catenin binding | |
| delta-catenin binding | |
| gamma-catenin binding | |
| platelet-derived growth factor receptor binding | |
| protein kinase binding | |
| mitogen-activated protein kinase binding | |
| membrane | |
| cell junction | |
| integral component of membrane | |
| immunological synapse | |
| integral component of plasma membrane | |
| ruffle membrane | |
| cell surface | |
| plasma membrane | |
| cell projection | |
| cell-cell junction | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 5795 |
|---|---|
| 19271 | |
| 29645 |
| Cell Localization | Plasma membrane |
|---|---|
| Cytoplasm | |
| Cell membrane | |
| Cell projection | |
| Ruffle membrane | |
| Cell junction |
| GO ID | 0008013 |
|---|---|
| 0070097 | |
| 0045295 | |
| 0051019 | |
| 0016791 | |
| 0005161 | |
| 0019901 | |
| 0004725 | |
| 0007596 | |
| 0060242 | |
| 0007507 | |
| 0043407 | |
| 0050860 | |
| 0030308 | |
| 0030336 | |
| 0008285 | |
| 0042059 | |
| 0010642 | |
| 0051898 | |
| 2000272 | |
| 0043116 | |
| 0035335 | |
| 0048008 | |
| 0050918 | |
| 0045785 | |
| 0051894 | |
| 0010759 | |
| 0010572 | |
| 0051897 | |
| 0030155 | |
| 0001570 | |
| 0009986 | |
| 0005911 | |
| 0001772 | |
| 0005887 | |
| 0005886 | |
| 0032587 | |
| 0016787 | |
| 0004721 | |
| 0016311 | |
| 0001954 | |
| 0006470 | |
| 0030054 | |
| 0042995 | |
| 0016021 | |
| 0016020 | |
| 0004872 | |
| 0005001 | |
| 0007267 | |
| 0007169 | |
| 0007185 |
| Alias | DEP1 |
|---|---|
| SCC1 | |
| CD148 | |
| HPTPeta | |
| R-PTP-ETA | |
| receptor-type tyrosine-protein phosphatase eta | |
| DEP-1 | |
| R-PTP-J | |
| HPTP eta | |
| CD148 antigen | |
| density-enhanced phosphatase 1 | |
| protein-tyrosine phosphatase eta | |
| human density enhanced phosphatase-1 | |
| protein-tyrosine phosphatase receptor type J | |
| susceptibility to colon cancer 1, mouse, homolog of | |
| protein tyrosine phosphatase, receptor type, J polypeptide | |
| BET | |
| Byp | |
| Ptpb2 | |
| RPTPJ | |
| Scc-1 | |
| AI450271 | |
| PTPbeta2 | |
| RP24-113P16.2 | |
| colon tumor susceptibility 1 | |
| susceptibility to colon cancer 1 | |
| HPTP beta-like tyrosine phosphatase | |
| rCG_26744 | |
| density enhanced phosphatase-1 | |
| Ptprj | |
| receptor tyrosine phosphatase eta | |
| OTTMUSP00000015048 | |
| protein tyrosine phosphatase, receptor type, J | |
| RIKEN cDNA 2310003N02 gene | |
| human density enhanced phosphatase I | |
| BET receptor | |
| HPTPETAs | |
| BET protein | |
| 2310003N02 | |
| colon tumor susceptibility I | |
| BET receptors | |
| colon tumour susceptibility 1 | |
| DEP I | |
| Density enhanced phosphatase I | |
| colon tumour susceptibility I | |
| 2310003N02Rik | |
| Protein-tyrosine phosphatase eta precursor |
| Mouse chromosome position | 2 50.19 cM |
|---|---|
| 2 49.5 cM |
| OMIM ID | 600925 |
|---|---|
| 114500 |
| Rat chromosome position | 3q32-q33 |
|---|
| Hugo ID | 9673 |
|---|
| Human chromosome position | 11p11.2 |
|---|
| Swiss-Prot Accession | Q12913 |
|---|---|
| Q9NPR5 | |
| A2AWF9 | |
| E9Q4S7 | |
| Q64455 | |
| Q15255 | |
| Q6P4H4 | |
| Q8NHM2 | |
| Q9UDA9 | |
| Q3UH64 | |
| Q3UHL5 | |
| Q541R5 | |
| Q8CIW9 | |
| Q8K3Q2 | |
| Q61373 | |
| Q62884 |
| PIR ID | I38670 |
|---|---|
| S68700 |
| Unigene ID | Hs.318547 |
|---|---|
| Mm.330393 | |
| Rn.10278 |
| KEGG ID | hsa:5795 |
|---|---|
| mmu:19271 | |
| rno:29645 |
| Swiss-Prot ID | PTPRJ_HUMAN |
|---|---|
| PTPRJ_MOUSE |
| EC Number | 3.1.3.48 |
|---|
| Ensembl ID | ENSG00000149177 |
|---|---|
| ENSP00000409733 | |
| ENST00000440289 | |
| ENSMUSG00000025314 | |
| ENSMUSP00000107121 | |
| ENSMUST00000111495 | |
| ENSMUSP00000129592 | |
| ENSMUST00000168621 | |
| ENSMUSP00000107119 | |
| ENSMUST00000111493 |
| Homologene ID | 2130 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 104574 |
|---|
| RGD ID | 3454 |
|---|
| MedScan ID | 5795 |
|---|