Protein GRB2

URN urn:agi-llid:2885
Total Entities 0
Connectivity 1053
Name GRB2
Description growth factor receptor bound protein 2
Notes acts as a link between tyrosine kinase receptors and Ras signaling [RGD]

GO Molecular Function SH3-SH2 adaptor activity
phosphoprotein binding
protein domain specific binding
insulin receptor substrate binding
ephrin receptor binding
neurotrophin TRKA receptor binding
epidermal growth factor receptor binding
protein kinase binding
protein phosphatase binding
SH3 domain binding
phosphotyrosine binding

GO Cellular Component membrane
Grb2-EGFR complex
vesicle membrane
COP9 signalosome
protein complex
intracellular
plasma membrane
cytoplasm
Golgi apparatus
cytosol
endosome
nucleus

GO Biological Process leukocyte migration
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
Fc-epsilon receptor signaling pathway
T cell costimulation
receptor internalization
regulation of MAPK cascade
branching involved in labyrinthine layer morphogenesis
blood coagulation
platelet activation
axon guidance
aging
cell differentiation
positive regulation of actin filament polymerization
cell-cell signaling
positive regulation of signal transduction
signal transduction in response to DNA damage
Ras protein signal transduction
phosphatidylinositol-mediated signaling
negative regulation of epidermal growth factor receptor signaling pathway
neurotrophin TRK receptor signaling pathway
insulin receptor signaling pathway
fibroblast growth factor receptor signaling pathway
epidermal growth factor receptor signaling pathway
cellular response to ionizing radiation
positive regulation of reactive oxygen species metabolic process
anatomical structure formation involved in morphogenesis
modulation by virus of host morphology or physiology
protein heterooligomerization

Pathway Prostate Cancer Overview
Metastatic Colorectal Cancer Overview
Dystrophin Glycoprotein Complex Signaling in Duchenne Muscular Dystrophy
Duchenne Muscular Dystrophy Overview
IL6 Promotes Inflammation
Mechanism of Cetuximab Resistance in Colorectal Cancer
RARA Signaling Pathway in Acute Myeloid Leukemia (M3)
FLT3 and KIT Signaling to MLL Pathway in Acute Myeloid Leukemia (M5)
Block of Apoptosis in Acute Myeloid Leukemia
Block of Differentiation in Acute Myeloid Leukemia
Acute Myeloid Leukemia Overview
Alzheimer's Disease Overview
IL-6/IGF-1/VEGFA in Multiple Myeloma
Multiple Myeloma Overview
Chronic Myeloid Leukemia Overview
B-cell Acute Lymphoblastic Leukemia Overview
T-cell Acute Lymphoblastic Leukemia Overview
B-cell Chronic Lymphocytic Leukemia Overview
APP and Glutamate Signaling-Related Neuronal Dysfunction in Alzheimer's Disease
Follicular Lymphoma Overview
Cowden Syndrome
Interleukin-22 Induced Keratinocyte Proliferation in Psoriasis
Proteins Involved in Pathogenesis of Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
Proteins Involved in Pathogenesis of Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer Related to ERBB/VEGFR/Akt Signaling Pathway
ESR1/ERBB-positive Luminal Breast Cancer
Basal Breast Cancer
Insulin Influence on Glycogenesis
Insulin Resistance in Hepatocytes
CD8+ T-cell Response to Self-Determinants in Diabetes Mellitus Type 1
Impaired Peripheral Tolerance to Autoantigens in Diabetes Mellitus Type 1
Insulin Influence on Protein Synthesis
Impaired Adiponectin Synthesis in Insulin Resistance
Cardiovascular Effects of Hyperthyroidism
Common Non-genomic Effects of Thyroid Hormones
Clear Cell Ovarian Carcinoma
Mucinous Ovarian Carcinoma
High-grade Serous Ovarian Carcinoma
Endometrioid Ovarian Carcinoma
Ovarian Cancer Overview
Low-grade Serous Ovarian Carcinoma
Type I Endometrial Cancer (Endometrioid Endometrial Cancer)
Type II Endometrial Cancer (Clear-cell Endometrial Cancer and Papillary Serous Endometrial Cancer)
Endometrial Cancer Overview
Th1 Cell Function in Systemic Lupus Erythematosus
Th2 Cell Function in Systemic Lupus Erythematosus
Th0 Cell Aberrant Activation in Systemic Lupus Erythematosus
T-cell-Dependent B-cell Activation
Natural Killer Cell Activation through C-type Lectin-like Receptors
Natural Killer Cell Activation through ITAM-Containing Receptors
Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors
Central T-cell Tolerance
Peripheral T-cell Tolerance Overview
Model of T-cell Maturation
T-cell Positive Selection and Neglect-Induced Death
CD8+ T-cell Activation
Natural Killer Cell Activation
Th17 Cell Differentiation
Th1 Cell Differentiation
T-cell Receptor Signaling
Regulatory T-cell Differentiation
Th2 Cell Differentiation
Cancer Overview
CFTR Up-regulates the Oxidative Stress in Airway Epithelium in Cystic Fibrosis
Mucin Production in Goblet Airway Epithelial Cells in Cystic Fibrosis
Activation and Proliferation of Th1 Cells in Atherosclerosis
Onset of Atopic Dermatitis
Mast Cells in Atopic Dermatitis
Smooth Muscle Cell Dysfunction in Pulmonary Arterial Hypertension
Primary Glioblastoma
Secondary Glioblastoma
Glioma Invasion Signaling
Astrocytoma
Impairment of CD8+ T-cell Action in HIV Type 1 Infection
Block of CD4+ T-cell Signaling in HIV Type 1 Infection
CD4+ T-cell Death in HIV Type 1 Infection
TNF and IL1B Induce Metalloproteinase Synthesis
Osteoarthritis Overview
Steroid-Induced Cataract
Impairment of EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
Growth Factor Signaling in Neuroblastoma
ALK-Associated Neuroblastoma
Neuroblastoma Overview
Growth Factor Signaling in Pancreatic Cancer
TGFBR Signaling in Pancreatic Cancer
Pancreatic Ductal Carcinoma
Pancreatic Neuroendocrine Tumors
Impaired Steroidogenesis in Polycystic Ovary Syndrome
Polycystic Ovary Syndrome Overview
Growth Factor Signaling in Hepatocellular Carcinoma
Hepatocellular Carcinoma Overview
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
PTPN22 Involvement in Rheumatoid Arthritis
Mechanism of Skin Fibrosis in Systemic Scleroderma
B-cells Function in Systemic Scleroderma
Role of Th2 cells in Systemic Scleroderma
Myocardial Remodeling in Myocardial Ischemia
DRD2 -> TRPC1 transcription
Nociception-related DRD2 expression targets
CHRM1 -> IL2 production
CHRNA7 -> NOS1 production
Nociception-related NTSR1 expression targets
Nociception-related IL6 expression targets
Summarized nociception-related expression targets
FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling
PDGFR -> AP-1/MYC signaling
VEGFR -> AP-1/CREB/MYC signaling
HGFR -> AP-1/CREB/MYC signaling
ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling
EGFR -> AP-1/CREB/ELK-SRF/MYC signaling
EGFR -> NCOR2 signaling
TNFRSF1A -> AP-1/ATF/TP53 signaling
TNFRSF1A -> CREB/ELK-SRF signaling
PTPRC -> BCL6 signaling
T-cell receptor -> AP-1 signaling
FcIgER -> ELK-SRF signaling
EGFR/ERBB2 -> HIF1A signaling
EGFR -> AP-1/ATF2 signaling
EGFR/ERBB2 -> TP53 signaling
EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling
ERBB2/3 -> EP300/ETS/ETV/SP1 signaling
EGFR -> SMAD1 signaling
FGFR -> RUNX2 signaling
KIT -> MITF signaling
VEGFR -> NFATC signaling
VEGFR -> ATF/CREB/ELK-SRF signaling
IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling
InsulinR -> ELK-SRF/SREBF signaling
GDNF -> HSF1 signaling
NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling
UrokinaseR -> ELK-SRF signaling
NCAM1 -> CREB/ELK-SRF/MYC signaling
PECAM -> SP1 signaling
FibronectinR -> AP-1/ELK-SRF/SREBF signaling
SELE -> ELK-SRF signaling
IL4R -> ELK-SRF/HMGY signaling
IL6R -> CEBP/ELK-SRF signaling
IL2R -> ELK-SRF/MYC signaling
ErythropoietinR -> ELK-SRF/FOS signaling
ThrombopoietinR -> SPI1 signaling
LeptinR -> ELK-SRF signaling
ThrombopoietinR -> SP1 signaling
GHR -> ELK-SRF/MYC signaling
EDG2 -> ELK-SRF signaling
CholinergicRm -> CREB/ELK-SRF signaling
DopamineR2 -> AP-1/CREB/ELK-SRF signaling
DopamineR2 -> NF-kB signaling
VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling
NeurotensinR -> ELK-SRF/AP-1/EGR signaling
AdrenergicRa -> ELK-SRF signaling
VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling
GRM1/5 -> CREB signaling
AdrenergicRa -> STAT3 signaling
AngiotensinR -> CREB/ELK-SRF/TP53 signaling
VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling
VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling
ThrombinR -> NF-kB signaling
ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling
CholinergicRn -> CREB signaling
Tamoxifen-Induced Endometrial Cancer
ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy
NGF/FOXO/MYCN/ELK-SRF Expression Targets
LTA Expression Targets
TNF/CREB Expression Targets
TNF/TP53/ATF Expression Targets
TNF/ELK-SRF Expression Targets
NGF/AP-1/TP53/MYC Expression Targets
NGF/CREB/CEBPB/MEF2A Expression Targets
NGF/SMAD3/NF-kB Expression Targets
Fibronectin Expression Targets
NCAM1 Expression Targets
CD247 Expression Targets
FCGR3A Expression Targets
PECAM1 Expression Targets
PLAU/ELK-SRF/AP-1 Expression Targets
IL6 Expression Targets
IL2 Expression Targets
IL4 Expression Targets
Thrombopoietin/SPI1 Expression Targets
Thrombopoietin/SP1 Expression Targets
Erythropoietin/ELK-SRF Expression Targets
GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets
PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets
CSH1-GHR Expression Targets
Leptin/ELK-SRF Expression Targets
Dopamine/Gi Expression Targets
Acetylcholine Expression Targets
PTPRC/BCL6 Expression Targets
AREG/SMAD1 Expression Target
AREG/AP-1 Expression Targets
AREG/HIF1A Expression Targets
AREG/NFATC Expression Target
BTC/EP300/ETS/ETV/SP1 Expression Targets
BTC/NFATC Expression Targets
EGF/HIF1A Expression Targets
EGF/TP53 Expression Targets
EREG/AP-1/ATF Expression Targets
EREG/EP300/SP1 Expression Targets
EREG/HIF1A Expression Target
HBEGF/AP-1/ATF Expression Targets
HBEGF/EP300/ETS/ETV/SP1 Expression Targets
HBEGF/HIF1A Expression Targets
HBEGF/MEF/MYOD Expression Target
HBEGF/TP53 Expression Targets
NRG1/AP-1/ATF Expression Targets
NRG1/EP300/ETS/ETV/SP1 Expression Targets
NRG1/HIF1A Expression Target
NRG1/MEF/MYOD Expression Targets
NRG1/TP53 Expression Target
TGFA/HIF1A Expression Targets
TGFA/MEF/MYOD/NFATC Expression Targets
TGFA/TP53 Expression Targets
FGF2/RUNX Expression Targets
FGF7/RUNX Expression Targets
FGF8/RUNX Expression Targets
FGF9/RUNX Expression Targets
VEGFA/NFATC Expression Targets
VEGFA/ATF/CREB/ELK-SRF Expression Targets
VEGFC/ATF Expression Target
GDNF/HSF1 Expression Targets
IGF2/HIF1A/MYC Expression Targets
CTGF/AP-1/CREB/MYC Expression Targets
CTGF/NCOR2 Expression Target
FLT3LG/AP-1/CREB/CREBBP Expression Targets
GAS6/AP-1/CREB Expression Targets
PGF/AP-1/CREB/CREBBP/MYC Expression Targets
Thrombopoietin/AP-1/CREB/CREBBP/MYC Expression Targets
AREG/CREB/CREBBP Expression Targets
AREG/FOXO3A Expression Target
AREG/NCOR2 Expression Targets
EGF/FOXO3A Expression Targets
EGF/NCOR2 Expression Target
EREG/CREB Expression Target
EREG/FOXO3A Expression Target
HBEGF/CREB/MYC Expression Targets
HBEGF/FOXO3A Expression Target
NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets
NRG1/FOXO3A Expression Targets
TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets
TGFA/FOXO3A Expression Targets
FGF1/AP-1/CREB/ELK-SRF/MYC Expression Targets
FGF1/NCOR2 Expression Target
FGF2/FOXO3A Expression Targets
FGF2/NCOR2 Expression Targets
FGF4/AP-1/MYC Expression Targets
FGF7/AP-1/CREB/CREBBP/MYC Expression Targets
FGF7/FOXO3A Expression Target
FGF8/AP-1/CREB/MYC Expression Targets
FGF9/AP-1/CREB/MYC Expression Targets
FGF10/AP-1/CREB/CREBBP/MYC Expression Targets
FGF10/FOXO3A Expression Target
FGF18/AP-1/CREB Expression Targets
FGF23/NCOR2 Expression Targets
CSF1/AP-1/CREB/CREBBP/MYC Expression Targets
PDGFB/AP-1/CREB/MYC Expression Target
PDGFC/CREB Expression Target
PDGFD/AP-1 Expression Targets
VEGFA/NCOR2 Expression Target
FIGF/AP-1 Expression Target
FIGF/NCOR2 Expression Target
F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets
PLG -> STAT1/NF-kB Expression Targets
Epinephrine/Gq Expression Targets
Glutamate/Gq Expression Targets
AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets
AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets
NTS Expression Targets
AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets
AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets
Noreadrenaline/Gq Expression Targets
IL16/AP-1 Expression Targets
CD8/AP-1 Expression Targets
CD80/AP-1 Expression Targets
CD86/AP-1 Expression Targets
CD72/AP-1 Expression Targets
PDCD1/AP-1 Expression Targets
TCR/AP-1 Expression Targets
AGT/TP53 Expression Targets
AGT/ELK-SRF Expression Targets
FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets
Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets
NOTCH Expression Targets
AGT/CREB Expression Targets
EGF/AP-1/ATF Expression Targets
EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets
EGF/MEF/MYOD/NFATC Expression Targets
HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets
IGF1/ELK-SRF/HIF1A/MYC/SREBF Expression Targets
KITLG/AP-1/CREB/CREBBP/MYC Expression Targets
LPA Expression Targets
PDGF/AP-1/CREB/CREBBP/MYC Expression Targets
TGFA/AP-1/ATF Expression Targets
TNF/AP-1 Expression Targets
VEGFA/AP-1/CREBBP/MYC Expression Targets
BTC/AP-1/ATF/CREB Expression Targets
FGF1/RUNX Expression Targets
interleukin-6 signaling pathway
insulin signaling pathway
scatter factor-hepatocyte growth factor signaling pathway
insulin signaling pathway
altered insulin signaling pathway
epidermal growth factor/neuregulin signaling pathway

Group Grb
leukocyte migration
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
Fc-epsilon receptor signaling pathway
T cell costimulation
receptor internalization
regulation of MAPK cascade
branching involved in labyrinthine layer morphogenesis
blood coagulation
platelet activation
axon guidance
aging
cell differentiation
positive regulation of actin filament polymerization
cell-cell signaling
positive regulation of signal transduction
signal transduction in response to DNA damage
Ras protein signal transduction
phosphatidylinositol-mediated signaling
SH3-SH2 adaptor activity
negative regulation of epidermal growth factor receptor signaling pathway
neurotrophin TRK receptor signaling pathway
insulin receptor signaling pathway
fibroblast growth factor receptor signaling pathway
epidermal growth factor receptor signaling pathway
cellular response to ionizing radiation
positive regulation of reactive oxygen species metabolic process
anatomical structure formation involved in morphogenesis
modulation by virus of host morphology or physiology
protein heterooligomerization
phosphoprotein binding
protein domain specific binding
insulin receptor substrate binding
ephrin receptor binding
neurotrophin TRKA receptor binding
epidermal growth factor receptor binding
protein kinase binding
protein phosphatase binding
SH3 domain binding
phosphotyrosine binding
membrane
Grb2-EGFR complex
vesicle membrane
COP9 signalosome
protein complex
intracellular
plasma membrane
cytoplasm
Golgi apparatus
cytosol
endosome
nucleus
Proteins Involved in Pathogenesis of Cowden Syndrome
Biofluids assayable substances

Source Curated
ResNet
GO component

LocusLink ID 2885
14784
81504
80299
103536
80715
281211
535298
406308
321539
321785

Cell Localization Cytoplasm
Nucleus
Endosome
Golgi apparatus

GO ID 0017124
0005070
0046875
0005154
0043560
0005168
0001784
0019901
0019903
0038095
0038096
0007265
0031295
0007568
0048646
0007411
0007596
0060670
0007267
0071479
0007173
0008543
0045087
0008286
0050900
0019048
0042059
0048011
0048015
0030168
0030838
2000379
0051291
0031623
0043408
0042770
0008180
0005794
0070436
0005737
0005829
0005768
0005634
0005886
0012506
0051219
0019904
0030154
0009967
0005622
0016020
0043234
0044419
0004872
0005515
0000165
0007242

Alias ASH
Grb3-3
MST084
NCKAP2
MSTP084
EGFRBP-GRB2
growth factor receptor-bound protein 2
HT027
protein Ash
SH2/SH3 adapter GRB2
abundant SRC homology
growth factor receptor-bound protein 3
epidermal growth factor receptor-binding protein GRB2
AA408164
RP23-28I4.1
adapter protein GRB2
OTTMUSP00000003663
OTTHUMP00000166096
OTTHUMP00000166097
OTTHUMP00000166098
OTTMUSP00000003660
OTTMUSP00000003662
adaptor protein GRB2
GRB2 adaptor protein
MGC108668
OTTMUSP00000003661
FLJ20886
Grb2
GRB2 adapter protein
HT(027)
Grb3 III
growth factor receptor bound protein 2
Growth factor receptor-bound protein II
GRB2_HUMAN
SH2/SH3 adapter GRB2
Grb3-3s
hypothetical protein FLJ20886
HT 027
HT-027
fb18e12
wu:fb18e12
fb34e06
wu:fb34e06
chromosome
scaffold
zgc:73077

Mouse chromosome position 11 80.91 cM
11 75.0 cM

OMIM ID 108355

Rat chromosome position 10q32.3

Hugo ID 4566

Human chromosome position 17q24-q25

Swiss-Prot Accession B0LPF3
P62993
Q3U5I5
Q60631
P62994
Q61240
P29354
Q14450
Q5BKA7
Q63057
Q63059
Q6ICN0
Q3U1Q4
Q63058
Q7Z4F5
Q9H2Q4
Q9H7G8
Q9HAU2

PIR ID A54688
S26050
A43321

GenBank ID NC_000017
NM_203506
NP_987102
NM_002086
NP_002077
NG_029556
NC_018928
AC_000149
ABBA01028798
ABBA01028799
ABBA01028800
ABBA01028801
AC011933
AF063618
AAC72075
AMYH02033991
AMYH02033992
AMYH02033993
AMYH02033994
AMYH02033995
CH471099
EAW89270
EAW89271
EAW89272
EU332843
ABY87532
JX512444
AGC09591
AA452034
AF171699
AAQ13606
AF246238
AAG44485
AF302079
AAG27442
AF498925
AAM21073
AK024539
BAB14923
AK091010
BAG52262
AK315565
BAG37940
BC000631
AAH00631
BC019082
BC033644
BC039827
BC043007
BI459414
BQ073225
BQ962129
CR450363
CAG29359
CR541942
CAG46740
DA458680
L29511
AAC37549
M96995
AAA58448
X62852
CAA44664
P62993
DQ891830
ABM82756
DQ894923
ABM85849
NC_000077
NM_008163
NP_032189
AC_000033
AAHY01096670
AAHY01096671
AAHY01096672
AL645852
AL732491
CH466558
EDL34515
EDL34516
EDL34517
AK077750
AK079087
AK148148
BAE28376
AK153557
BAE32093
AK155800
BAE33439
AK166142
BAE38595
AK170845
BAE42068
AK172002
AK177056
AK180406
AK181485
AK184348
AK192421
AK192819
AK194267
AK195178
AK195957
AK196023
AK196107
AK196759
AK202005
AK208766
AK211391
AK212651
AK215138
AK216513
AK217191
AK217799
BC052377
AAH52377
BC085254
AAH85254
D85748
BAA12862
U07617
AAB40022
Q60631
NC_005109
XM_006247767
XP_006247829
NM_030846
NP_110473
AC_000078
AABR06066174
AABR06066175
AABR06066176
AABR06066177
AABR06066215
AAHX01066734
AAHX01066735
AAHX01066736
CH473948
EDM06604
EDM06605
EDM06606
EDM06607
EDM06608
EDM06609
EDM06610
AA926364
BC091144
AAH91144
D49846
BAA08645
D49847
BAA08646
D49848
BAA08647
FQ220840
X62853
CAA44665
P62994
CAM21965
CAM21966
CAM21967
CAM21968
CAM19836
CAM19837
CAM19838
CAM19839
XM_003750955
XP_003751003
XM_003750956
XP_003751004
NT_010783
NW_001838454
NW_926918
AC_000060
BC009417
Q6ICN0
NT_165773
NW_001030434
Q3U1Q4
Q3U5I5
NW_047343
NW_001084656
Q63058
NT_010641
Q7Z4F5
Q9H2Q4
Q9H7G8
Q9HAU2
AI323718
Q5BKA7
NT_096135
BG078047
BG064712
NT_086886
NW_000040
10436844
11036973
119609676
119609677
12005511
123996495
12653693
181976
20379026
28876
33337968
3850302
47496673
49456839
498178
51702266
74713500
74718116
74718671
74718692
74748763
31455236
AAH09417
123787434
123796999
1375041
2498425
30851533
464005
55154544
74141681
74152124
74195307
74214845
74221133
AA408164
51702260
55763
60552087
81890319
914957
914959
914961
122145087
74354609
AAI02412
BC102411
NC_007317
NM_001034630
NP_001029802
NW_001493695
Q3T0F9
AI416149
AI522340
AI415824
AI436912
37590325
82237673
AAH59450
BC059450
BX465842
NC_007114
NM_213035
NP_998200
NW_001513105
Q6PC73
119609678
123981854
123228035
123228036
123228037
123267549
123267550
123267551
123267552
148702568
148702569
148702570
149054787
149054788
54261768
126007508
42558029
54261769
ZDB-GENE-030131-258
ZDB-GENE-030131-504
406308
Dr.114331
Dr.74564
ZDB-GENE-040426-1975
dre:406308

Unigene ID Hs.444356
Mm.439649
Mm.490413
Rn.3360
Hs.708119
Mm.472452
Mm.6900
Hs.633064
Rn.163461
Mm.383426
Hs.651330
Bt.8815
Dr.114331
Dr.74564
Hs.699367

KEGG ID hsa:2885
mmu:14784
rno:81504

Swiss-Prot ID GRB2_MOUSE
GRB2_RAT
GRB2_HUMAN
B0LPF3_HUMAN
Q3U5I5_MOUSE

Ensembl ID ENSG00000177885
ENSP00000339007
ENST00000316804
ENSP00000317360
ENST00000316615
ENSMUSG00000059923
ENSMUSP00000021090
ENSMUST00000021090
ENSRNOG00000003990
ENSRNOP00000005347
ENSRNOT00000005347

Homologene ID 1576

Organism Homo sapiens
Mus musculus
Rattus norvegicus
Bos taurus
Danio rerio

MGI ID 95805
2143976

RGD ID 619758

MedLine Reference 10022833
10051406
10068651
10077576
10080542
10086340
10087612
10224664
10319320
10329689
10330178
10339567
10354709
10359574
10377264
10386953
10455176
10467411
10469124
10477741
10488157
10490839
10521483
10559276
10602027
10636929
10660596
10706702
10747847
10748052
10781580
10781592
10790433
10820378
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MedScan ID 2885

Primary Cell Localization Cytoplasm

IPI ID IPI00021327
IPI00218070
IPI00203630
IPI00231574
IPI00382077
IPI00119058
IPI00230539
IPI00018782
IPI00790124
IPI00792746
IPI00648993
IPI00649256
IPI00204921
IPI00567134

KEGG pathway Chronic myeloid leukemia
Colorectal cancer
Dorso-ventral axis formation
Endometrial cancer
ErbB signaling pathway
Fc epsilon RI signaling pathway
Focal adhesion
Gap junction
Glioma
GnRH signaling pathway
Huntington's disease
Insulin signaling pathway
Jak-STAT signaling pathway
MAPK signaling pathway
Natural killer cell mediated cytotoxicity
Neurodegenerative Disorders
Non-small cell lung cancer
Renal cell carcinoma
T cell receptor signaling pathway

Homo sapiens Chromosome position 17q24-q25
17q25.3

Microarray ID 101034_at

FunctionalClass SH3/SH2 adaptor
epidermal growth factor receptor binding
insulin receptor substrate binding
protein binding
receptor
phosphotyrosine binding
phosphoprotein binding

Bos taurus Chromosome position 19

Mus musculus Chromosome position 11 75.0 cM
11

Rattus norvegicus Chromosome position 10q32.3

Danio rerio Chromosome position LG 3