Protein SHC1

URN urn:agi-llid:6464
Total Entities 0
Connectivity 1401
Name SHC1
Description src homology 2 domain-containing transforming protein C1
Notes mouse homolog interacts with growth factor receptors; involved in transformation and differentiation in a Ras-dependent fashion [RGD]

GO Molecular Function transmembrane receptor protein tyrosine kinase adaptor activity
protein tyrosine kinase activity
protein complex binding
phosphoprotein binding
insulin receptor binding
insulin-like growth factor receptor binding
ephrin receptor binding
receptor tyrosine kinase binding
neurotrophin TRKA receptor binding
epidermal growth factor receptor binding
phosphotyrosine binding
phospholipid binding

GO Cellular Component Shc-EGFR complex
endosome membrane
mitochondrial matrix
plasma membrane
cytoplasm
cytosol
mitochondrion
nucleus

GO Biological Process leukocyte migration
innate immune response
Fc-epsilon receptor signaling pathway
MAPK cascade
activation of MAPK activity
positive regulation of vasoconstriction
blood coagulation
platelet activation
angiogenesis
organ regeneration
heart development
neuron differentiation
neuron projection development
aging
actin cytoskeleton organization
actin cytoskeleton reorganization
intracellular signal transduction
Ras protein signal transduction
regulation of epidermal growth factor-activated receptor activity
neurotrophin TRK receptor signaling pathway
insulin receptor signaling pathway
fibroblast growth factor receptor signaling pathway
epidermal growth factor receptor signaling pathway
endoplasmic reticulum unfolded protein response
activation of signaling protein activity involved in unfolded protein response
cell-cell adhesion
positive regulation of cell proliferation
positive regulation of smooth muscle cell proliferation
response to toxic substance
response to hydrogen peroxide
response to insulin
response to organic cyclic compound
response to glucocorticoid
response to nicotine
response to hypoxia
positive regulation of DNA replication
regulation of growth
cellular protein metabolic process
peptidyl-tyrosine phosphorylation

Pathway NURD Chromatin Remodeling
Prostate Cancer Overview
Metastatic Colorectal Cancer Overview
Mechanism of Cetuximab Resistance in Colorectal Cancer
RARA Signaling Pathway in Acute Myeloid Leukemia (M3)
FLT3 and KIT Signaling to MLL Pathway in Acute Myeloid Leukemia (M5)
Block of Apoptosis in Acute Myeloid Leukemia
Block of Differentiation in Acute Myeloid Leukemia
Acute Myeloid Leukemia Overview
Alzheimer's Disease Overview
IL-6/IGF-1/VEGFA in Multiple Myeloma
Multiple Myeloma Overview
T-cell Acute Lymphoblastic Leukemia Overview
B-cell Chronic Lymphocytic Leukemia Overview
APP and Glutamate Signaling-Related Neuronal Dysfunction in Alzheimer's Disease
Follicular Lymphoma Overview
Cowden Syndrome
Proteins Involved in Pathogenesis of Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
Proteins Involved in Pathogenesis of Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer Related to ERBB/VEGFR/Akt Signaling Pathway
Proteins Involved in Pathogenesis of Breast Cancer Related to ESR1 Signaling Pathway
ESR1/ERBB-positive Luminal Breast Cancer
Basal Breast Cancer
Insulin Influence on Glycogenesis
Insulin Influence on Protein Synthesis
Impaired Adiponectin Synthesis in Insulin Resistance
Clear Cell Ovarian Carcinoma
Mucinous Ovarian Carcinoma
High-grade Serous Ovarian Carcinoma
Endometrioid Ovarian Carcinoma
Ovarian Cancer Overview
Low-grade Serous Ovarian Carcinoma
Type I Endometrial Cancer (Endometrioid Endometrial Cancer)
Type II Endometrial Cancer (Clear-cell Endometrial Cancer and Papillary Serous Endometrial Cancer)
Endometrial Cancer Overview
Melanoma Overview
Model of T-cell Maturation
Cancer Overview
CFTR Up-regulates the Oxidative Stress in Airway Epithelium in Cystic Fibrosis
Mucin Production in Goblet Airway Epithelial Cells in Cystic Fibrosis
Smooth Muscle Cell Dysfunction in Pulmonary Arterial Hypertension
Primary Glioblastoma
Secondary Glioblastoma
Glioma Invasion Signaling
Astrocytoma
Osteoarthritis Overview
Steroid-Induced Cataract
Impairment of EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
Growth Factor Signaling in Neuroblastoma
Neuroblastoma Overview
Growth Factor Signaling in Pancreatic Cancer
TGFBR Signaling in Pancreatic Cancer
Pancreatic Ductal Carcinoma
Pancreatic Neuroendocrine Tumors
Impaired Steroidogenesis in Polycystic Ovary Syndrome
Polycystic Ovary Syndrome Overview
Growth Factor Signaling in Hepatocellular Carcinoma
Proteins Involved in Pathogenesis of Hepatocellular Carcinoma
Hepatocellular Carcinoma Overview
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Mechanism of Skin Fibrosis in Systemic Scleroderma
Myocardial Remodeling in Myocardial Ischemia
Role of Scavenger Receptor OLR1 in Inflammation-Related Endothelial Dysfunction in Atherosclerosis
Nociception-related DRD2 expression targets
CHRM1 -> IL2 production
Nociception-related NTSR1 expression targets
NTRK1/2/3 -> acetylcholine production
Summarized nociception-related expression targets
Regulation of calcium flux
FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling
PDGFR -> AP-1/MYC signaling
VEGFR -> AP-1/CREB/MYC signaling
HGFR -> AP-1/CREB/MYC signaling
ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling
EGFR -> AP-1/CREB/ELK-SRF/MYC signaling
EGFR -> NCOR2 signaling
FcIgER -> ELK-SRF signaling
EGFR/ERBB2 -> HIF1A signaling
EGFR -> AP-1/ATF2 signaling
EGFR/ERBB2 -> TP53 signaling
EGFR -> CTNND signaling
EGFR/ERBB2 -> CTNNB signaling
ERBB2/3 -> EP300/ETS/ETV/SP1 signaling
EGFR -> SMAD1 signaling
EGFR/ERBB -> STAT signaling
FGFR -> RUNX2 signaling
KIT -> MITF signaling
VEGFR -> NFATC signaling
VEGFR -> ATF/CREB/ELK-SRF signaling
IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling
InsulinR -> ELK-SRF/SREBF signaling
GDNF -> HSF1 signaling
NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling
DDR1 -> NF-kB signaling
UrokinaseR -> ELK-SRF signaling
FibronectinR -> AP-1/ELK-SRF/SREBF signaling
IL4R -> ELK-SRF/HMGY signaling
IL2R -> ELK-SRF/MYC signaling
ErythropoietinR -> ELK-SRF/FOS signaling
ThrombopoietinR -> SPI1 signaling
ThrombopoietinR -> SP1 signaling
GHR -> ELK-SRF/MYC signaling
EDG2 -> ELK-SRF signaling
CholinergicRm -> CREB/ELK-SRF signaling
DopamineR2 -> AP-1/CREB/ELK-SRF signaling
NeurotensinR -> ELK-SRF/AP-1/EGR signaling
VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling
GRM1/5 -> CREB signaling
VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling
ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling
ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy
NGF/FOXO/MYCN/ELK-SRF Expression Targets
NGF/AP-1/TP53/MYC Expression Targets
NGF/CREB/CEBPB/MEF2A Expression Targets
NGF/SMAD3/NF-kB Expression Targets
Fibronectin Expression Targets
CD247 Expression Targets
FCGR3A Expression Targets
PLAU/ELK-SRF/AP-1 Expression Targets
IL2 Expression Targets
IL4 Expression Targets
Thrombopoietin/SPI1 Expression Targets
Thrombopoietin/SP1 Expression Targets
Erythropoietin/ELK-SRF Expression Targets
GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets
PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets
CSH1-GHR Expression Targets
Dopamine/Gi Expression Targets
Acetylcholine Expression Targets
AREG/SMAD1 Expression Target
AREG/STAT Expression Targets
AREG/AP-1 Expression Targets
AREG/HIF1A Expression Targets
BTC/STAT Expression Targets
BTC/EP300/ETS/ETV/SP1 Expression Targets
EGF/HIF1A Expression Targets
EGF/TP53 Expression Targets
EREG/CTNNB/CTNND Expression Target
EREG/STAT Expression Targets
EREG/AP-1/ATF Expression Targets
EREG/EP300/SP1 Expression Targets
EREG/HIF1A Expression Target
HBEGF/STAT Expression Targets
HBEGF/AP-1/ATF Expression Targets
HBEGF/EP300/ETS/ETV/SP1 Expression Targets
HBEGF/HIF1A Expression Targets
HBEGF/TP53 Expression Targets
NRG1/Catenin Expression Targets
NRG1/STAT Expression Targets
NRG1/AP-1/ATF Expression Targets
NRG1/EP300/ETS/ETV/SP1 Expression Targets
NRG1/HIF1A Expression Target
NRG1/TP53 Expression Target
TGFA/CTNNB/CTNND Expression Targets
TGFA/STAT Expression Targets
TGFA/HIF1A Expression Targets
TGFA/TP53 Expression Targets
FGF2/RUNX Expression Targets
VEGFA/NFATC Expression Targets
VEGFA/ATF/CREB/ELK-SRF Expression Targets
VEGFC/ATF Expression Target
Collagen/NF-kB Expression Targets
GDNF/HSF1 Expression Targets
IGF2/HIF1A/MYC Expression Targets
CTGF/AP-1/CREB/MYC Expression Targets
CTGF/NCOR2 Expression Target
PGF/AP-1/CREB/CREBBP/MYC Expression Targets
Thrombopoietin/AP-1/CREB/CREBBP/MYC Expression Targets
AREG/CREB/CREBBP Expression Targets
AREG/FOXO3A Expression Target
AREG/NCOR2 Expression Targets
EGF/FOXO3A Expression Targets
EGF/NCOR2 Expression Target
EREG/CREB Expression Target
EREG/FOXO3A Expression Target
HBEGF/CREB/MYC Expression Targets
HBEGF/FOXO3A Expression Target
NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets
NRG1/FOXO3A Expression Targets
TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets
TGFA/FOXO3A Expression Targets
FGF1/AP-1/CREB/ELK-SRF/MYC Expression Targets
FGF1/NCOR2 Expression Target
FGF2/FOXO3A Expression Targets
FGF2/NCOR2 Expression Targets
FGF4/AP-1/MYC Expression Targets
FGF10/AP-1/CREB/CREBBP/MYC Expression Targets
FGF10/FOXO3A Expression Target
CSF1/AP-1/CREB/CREBBP/MYC Expression Targets
PDGFB/AP-1/CREB/MYC Expression Target
PDGFC/CREB Expression Target
PDGFD/AP-1 Expression Targets
VEGFA/NCOR2 Expression Target
FIGF/AP-1 Expression Target
FIGF/NCOR2 Expression Target
F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets
PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets
Glutamate/Gq Expression Targets
AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets
NTS Expression Targets
AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets
FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets
Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets
EGF/AP-1/ATF Expression Targets
EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets
EGF/STAT Expression Targets
HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets
IGF1/ELK-SRF/HIF1A/MYC/SREBF Expression Targets
KITLG/AP-1/CREB/CREBBP/MYC Expression Targets
LPA Expression Targets
PDGF/AP-1/CREB/CREBBP/MYC Expression Targets
TGFA/AP-1/ATF Expression Targets
VEGFA/AP-1/CREBBP/MYC Expression Targets
AREG/CTNN Expression Targets
BTC/AP-1/ATF/CREB Expression Targets
BTC/CTNN Expression Targets
EGF/CTNN Expression Targets
FGF1/RUNX Expression Targets
insulin signaling pathway
scatter factor-hepatocyte growth factor signaling pathway
insulin signaling pathway
altered insulin signaling pathway
epidermal growth factor/neuregulin signaling pathway

Group Shc
leukocyte migration
innate immune response
Fc-epsilon receptor signaling pathway
MAPK cascade
activation of MAPK activity
positive regulation of vasoconstriction
blood coagulation
platelet activation
angiogenesis
organ regeneration
heart development
neuron differentiation
neuron projection development
aging
actin cytoskeleton organization
actin cytoskeleton reorganization
intracellular signal transduction
Ras protein signal transduction
regulation of epidermal growth factor-activated receptor activity
transmembrane receptor protein tyrosine kinase adaptor activity
neurotrophin TRK receptor signaling pathway
insulin receptor signaling pathway
fibroblast growth factor receptor signaling pathway
epidermal growth factor receptor signaling pathway
endoplasmic reticulum unfolded protein response
activation of signaling protein activity involved in unfolded protein response
cell-cell adhesion
positive regulation of cell proliferation
positive regulation of smooth muscle cell proliferation
response to toxic substance
response to hydrogen peroxide
response to insulin
response to organic cyclic compound
response to glucocorticoid
response to nicotine
response to hypoxia
positive regulation of DNA replication
regulation of growth
protein tyrosine kinase activity
cellular protein metabolic process
peptidyl-tyrosine phosphorylation
protein complex binding
phosphoprotein binding
insulin receptor binding
insulin-like growth factor receptor binding
ephrin receptor binding
receptor tyrosine kinase binding
neurotrophin TRKA receptor binding
epidermal growth factor receptor binding
phosphotyrosine binding
phospholipid binding
Shc-EGFR complex
endosome membrane
mitochondrial matrix
plasma membrane
cytoplasm
cytosol
mitochondrion
nucleus
Proteins Involved in Pathogenesis of Cowden Syndrome
Secreted proteins

Source Curated
ResNet
GO component

LocusLink ID 6464
20416
85385
507196

Cell Localization Cytoplasm
Mitochondrion matrix
Mitochondrion

GO ID 0046875
0005154
0005158
0005159
0005168
0005543
0004713
0005068
0038095
0000165
0007265
0031532
0000187
0006987
0001525
0007596
0016337
0044267
0030968
0007173
0008543
0007507
0045087
0008286
0050900
0048011
0018108
0030168
0045740
0008284
0007176
0040008
0070435
0005829
0005759
0005886
0051219
0001784
0032403
0030971
0030036
0007568
0035556
0030182
0031175
0048661
0045907
0005737
0010008
0005739
0005634
0031100
0051384
0042542
0001666
0032868
0035094
0014070
0009636
0005515
0007242
0045840
0001558

Alias SHC
SHCA
RP11-307C12.1
SHC-transforming protein 1
SH2 domain protein C1
SHC-transforming protein 3
SHC-transforming protein A
SHC (Src homology 2 domain-containing) transforming protein 1
p66
p66shc
src homology 2 domain-containing-transforming protein C1
src homology 2 domain-containing transforming protein C1
SHC (Src homology 2 domain containing) transforming protein 1
SHC (Src homology 2 domain-containing) transforming protein I
Shc I
SHC transforming protein
Shc1
Shc-P
src homology 2 domain-containing transforming protein C
Shc adaptor protein
Shc adaptor proteins
Shc signaling adaptor protein
Shc signaling adaptor proteins
OTTMUSP00000024847
OTTHUMP00000035471
(Src homology 2 domain-containing) transforming I
6720466E06
OTTHUMP00000035409
OTTHUMP00000035472
OTTMUSP00000024853
OTTMUSP00000024849
p52Shc
Sck (Rattus rattus)
(Src homology 2 domain-containing) transforming 1
FLJ26504
hypothetical protein 6720466E06
P(66)

Mouse chromosome position 3 39.11 cM
3 45.0 cM

OMIM ID 600560

Rat chromosome position 2q34

Hugo ID 10840

Human chromosome position 1q21

Swiss-Prot Accession P29353
P98083
G3V8S2
F1LN14
Q5M824
B5BU19
D3DV78
O15290
Q5T180
Q5T183
Q5T184
Q5T185
Q5T186
Q8N4K5
Q96CL1
Q3U2Q7
Q8BFY3
Q8K4C6
Q8K4C7
Q5T187
Q5T188
Q59HB0
Q9Z1I0
Q8NFT1
Q8NFT0
Q5T182
Q5T181

PIR ID S25776
A55484

GenBank ID NC_000001
NM_001130041
NP_001123513
NM_001202859
NP_001189788
NM_003029
NP_003020
XM_005245452
XP_005245509
NM_183001
NP_892113
NM_001130040
NP_001123512
XM_005245450
XP_005245507
XM_005245449
XP_005245506
XM_005245451
XP_005245508
NG_029028
NC_018912
AC_000133
ABBA01016724
AF455141
AAM61859
AAM61860
AL451085
AMYH02001935
CH471121
EAW53167
EAW53168
EAW53169
EAW53170
EAW53171
Y09847
CAA70977
AB208849
BAD92086
AB451255
BAG70069
AB451379
BAG70193
AK096169
AK130014
AK225332
AK292143
BAF84832
AK296786
BAG59364
AK315842
BAF98733
BC011813
BC014158
AAH14158
BC017283
BC033925
AAH33925
BX647136
BX647149
U73377
AAB49972
X68148
CAA48251
P29353
HQ448284
ADQ32764
NC_000069
XM_006501212
XP_006501275
NM_011368
NP_035498
XM_006501211
XP_006501274
NM_001113331
NP_001106802
XM_006501213
XP_006501276
AC_000025
AAHY01028958
AC171273
AF455140
CH466547
EDL15195
EDL15196
U46956
AAA91777
AK036980
AK049357
BAC33706
AK155158
BAE33083
AK182226
AK184070
AK191292
AK194449
AK195313
AK198488
AK199216
AK203451
AK205229
AK205263
AK210297
AK211173
BB458154
BB656759
BC036172
AAH36172
BQ031241
BY341731
U15784
AAC52146
P98083
DQ721914
NC_005101
NM_053517
NP_445969
NM_001164060
NP_001157532
AC_000070
AABR06018822
AAHX01018601
CH473976
EDM00626
EDM00627
EDM00628
BC088298
AAH88298
CB813924
D83015
BAA74950
Q5M824
NT_004487
NW_001838531
NW_925683
AC_000044
CAI13246
CAI13247
CAI13248
CAI13249
CAI13250
CAI13251
CAI13252
CAI13253
CAI13254
Q59HB0
Q5T181
Q5T182
Q5T187
Q5T188
Q8NFT0
Q8NFT1
NT_039240
NW_001030721
NW_047626
NW_001084805
Q9Z1I0
AI050321
NW_000191
XM_342282
BB753533
BG070010
BG082870
BG088317
Q5T180
Q5T186
Q5T185
Q5T184
Q5T183
NT_039234
119573555
119573556
15559595
17380299
1834515
1899055
21541500
21541501
21706900
36454
55960108
55960109
55960110
55960111
55960112
55960113
55960114
55960115
55960116
62087278
74707598
74730298
74730299
74744423
74744424
74744425
74744426
74744427
74744428
74744429
74744430
74744431
14211984
21264509
23273601
26340086
558999
74196394
4249548
56789497
81870081
81883074
NT_086596
XP_342283
113912120
122143183
122144089
71725061
AAI22689
AAZ38953
BC122688
DQ125497
NC_007301
NM_001075305
NP_001068773
NW_001494724
Q0IIE2
Q45KX9
119573552
119573553
119573554
148683248
148683249
149048050
149048051
149048052

Unigene ID Hs.433795
Mm.86595
Rn.138818
Bt.4279

KEGG ID hsa:6464
mmu:20416
rno:85385

Swiss-Prot ID SHC1_HUMAN
SHC1_RAT
SHC1_MOUSE

Ensembl ID ENSG00000160691
ENSP00000401303
ENST00000448116
ENSP00000357435
ENST00000368450
ENSP00000475850
ENST00000606391
ENSP00000357438
ENST00000368453
ENSP00000357430
ENST00000368445
ENSMUSG00000042626
ENSMUSP00000035361
ENSMUST00000039110
ENSRNOG00000020657
ENSRNOP00000028038
ENSRNOT00000028038
ENSRNOP00000053490
ENSRNOT00000056652

Homologene ID 7934

Organism Homo sapiens
Mus musculus
Rattus norvegicus
Bos taurus

MGI ID 98296

RGD ID 620446

MedLine Reference 10037694
10086341
10382761
10457218
10477722
10482988
10559276
10570290
10602027
10623845
10650943
10652211
10662798
10704825
10748054
10749680
10764799
10783152
10790433
10816433
10896916
10921922
10971656
10996427
11027663
11044453
11075717
11094073
11302736
11505033
11607835
11694516
11707390
11707404
11707405
11714803
11724572
11773443
11855827
11877420
11884411
11884620
11896612
11903040
11948181
11950700
11980671
12009895
12024011
12048194
12069755
12237775
12400011
12446583
12477932
12577067
12586295
12589038
12789267
14530863
14665640
14676841
14702039
14749389
14764897
14983012
14990987
15094067
15226408
15308584
15316024
15485499
15562031
15688026
15705774
15753984
15888547
15992607
16170380
16186108
1623525
16257509
16481327
16487929
16519809
16756945
16825188
16934220
17081113
7499194
7514169
7524086
7535773
7537849
7541035
7541045
7544443
7556090
7559478
7635484
7650013
7675451
7731718
7791787
7806213
7929214
7933095
7961936
8035825
8183561
8195171
8226808
8294403
8400282
8491186
8557643
8617812
8628261
8643566
8656061
8662748
8662998
8761298
8776723
8918464
8940017
9045663
9047384
9049300
9058724
9083103
9096689
9121430
9126968
9174053
9209414
9223670
9325171
9344843
9346925
9373149
9378963
9388490
9446569
9544989
9614102
9632636
9659899
9660833
9685404
9694850
9710204
9710588
9741627
9824671
9872323
9927207
10349636
10580504
10797480
10809671
10922068
11042159
11076861
11088019
11163269
11217851
11409899
11756549
11831027
11884717
12032825
12052829
12101399
12466851
12571362
12808090
12842895
14502564
14576154
14698815
14698816
15102471
15121188
15173034
15505103
15621204
15716419
15782199
15837797
15899871
15998704
16141072
16141073
16251354
16400024
16517240
16520382
16614081
16731826
16829231
16870734
16972253
17272725
7798194
8887653
9346957
12837289
12882334
15262993
9271418
9920808
12522270
14573619
15489334
15592455
15951569
17081983
17158237
17167775
17380301
7473762
7544002
8125298
8524391
8939605
9192859
9233773
16763167
16809014
16963224
16982683
17077388
17219406
17360381
17417601
17626887
9165038
13679576
1409579
17274988
8910399
9748281

MedScan ID 6464

Homo sapiens Chromosome position 1q21

Microarray ID 104350_at
93713_at
201469_s_at

FunctionalClass insulin receptor binding
insulin-like growth factor receptor binding
phospholipid binding
protein binding
transmembrane receptor protein tyrosine kinase adaptor protein
phosphotyrosine binding
phosphoprotein binding

Bos taurus Chromosome position 3

Mus musculus Chromosome position 3 45.0 cM

Rattus norvegicus Chromosome position 2q34