Elsevier Inc. Egfr/Erbb4 ligands ERBB4 ERBB3 SOS2 Sos1 Adams ---> Nrg ligands Adams ---> Egfr/Erbb4 ligands Adams ---> Egfr ligands ERBB4 ---- Nrg ligands ERBB3 ---- Nrg ligands Egfr/Erbb4 ligands ---- ERBB4 EGFR ---- Egfr/Erbb4 ligands EGFR ---- Egfr ligands the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> differentiation phosphatidylinositol 3-kinase-Akt signaling pathway ---> cell proliferation phosphatidylinositol 3-kinase-Akt signaling pathway ---> cell growth the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> cell growth the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> cell proliferation cell growth phosphatidylinositol 3-kinase-Akt signaling pathway cell proliferation phosphatidylinositol 3-kinase-Akt signaling pathway ---> cell survival the extracellular signal-regulated Raf/Mek/Erk signaling pathway EGFR ---- SHC1 ERBB4 ---- GRB2 ERBB2 ---- SHC1 EGFR ---- GRB2 GRB2 ---- SHC1 GRB2 ---- SOS2 GRB2 GRB2 ---- Sos1 PIK3R1 PTPRJ SHC1 ERBB4 ---- SHC1 SOS2 ---> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Sos1 ---> the extracellular signal-regulated Raf/Mek/Erk signaling pathway EGFR differentiation cell survival ERBB2 ERBB3 ---> phosphatidylinositol 3-kinase-Akt signaling pathway ERBB3 ---- PIK3R1 Egfr ligands Adams Nrg ligands PTPRJ ---| EGFR CBL CBL ---| EGFR