| URN | urn:agi-llid:867 |
|---|---|
| Connectivity | 498 |
| Name | Cbl |
| Description | similar to CBL E3 ubiquitin protein ligase (Signal transduction protein CBL) (predicted) |
| Notes | The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. |
| Pathway | MacrophageR -> CEBPB/NF-kB signaling |
|---|---|
| TNFRSF5/13B -> NFATC1 signaling | |
| scatter factor-hepatocyte growth factor signaling pathway | |
| epidermal growth factor/neuregulin signaling pathway | |
| epidermal growth factor-neuregulin signaling pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| ligase activity | |
| transcription factor activity | |
| SH3 domain binding | |
| metal ion binding | |
| calcium ion binding | |
| zinc ion binding | |
| ubiquitin-protein ligase activity |
| GO Cellular Component | plasma membrane |
|---|---|
| cytoplasm | |
| cytosol | |
| nucleus | |
| flotillin complex |
| GO Biological Process | positive regulation of receptor-mediated endocytosis |
|---|---|
| protein ubiquitination | |
| modification-dependent protein catabolic process | |
| cell surface receptor linked signaling pathway | |
| epidermal growth factor receptor signaling pathway |
| Ariadne Ontology | Ubiquitin-dependent protein degradation |
|---|---|
| CBL | |
| Oncogenes |
| Group | Ubiquitin-dependent protein degradation |
|---|---|
| CBL | |
| Oncogenes | |
| positive regulation of receptor-mediated endocytosis | |
| protein ubiquitination | |
| modification-dependent protein catabolic process | |
| cell surface receptor linked signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| signal transducer activity | |
| ligase activity | |
| transcription factor activity | |
| SH3 domain binding | |
| metal ion binding | |
| calcium ion binding | |
| zinc ion binding | |
| ubiquitin-protein ligase activity | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| flotillin complex |
| MedScan ID | 867 |
|---|
| Hugo ID | 1541 |
|---|
| Human chromosome position | 11q23.3 |
|---|
| LocusLink ID | 867 |
|---|---|
| 12402 | |
| 500985 |
| Alias | CBL2 |
|---|---|
| C-CBL | |
| RNF55 | |
| E3 ubiquitin-protein ligase CBL | |
| oncogene CBL2 | |
| proto-oncogene c-Cbl | |
| RING finger protein 55 | |
| signal transduction protein CBL | |
| casitas B-lineage lymphoma proto-oncogene | |
| cbl | |
| Cbl-2 | |
| 4732447J05Rik | |
| RGD1561386 | |
| Cas-Br-M (murine) ecotropic retroviral transforming sequence | |
| Casitas B-lineage lymphoma | |
| 4732447J05 | |
| Cas-Br-M ecotropic retroviral transforming sequence | |
| CBL_HUMAN | |
| cCBL | |
| LOC283153 | |
| Signal transduction protein CBL (Proto-oncogene c-CBL) | |
| transforming protein (cbl) | |
| hypothetical protein LOC283153 | |
| similar to CBL E3 ubiquitin protein ligase (Signal transduction protein CBL) (predicted) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 165360 |
|---|
| Mouse chromosome position | 9 26.0 cM |
|---|
| GO ID | 0017124 |
|---|---|
| 0005509 | |
| 0016874 | |
| 0004871 | |
| 0003700 | |
| 0004842 | |
| 0008270 | |
| 0007166 | |
| 0007173 | |
| 0048260 | |
| 0016567 | |
| 0005737 | |
| 0005829 | |
| 0016600 | |
| 0005634 | |
| 0005886 | |
| 0046872 | |
| 0019941 | |
| 0005515 | |
| 0006512 | |
| 0007242 |
| Rat chromosome position | 8q22 |
|---|
| Swiss-Prot Accession | P22681 |
|---|---|
| Q3U527 | |
| P22682 | |
| Q2M4H7 | |
| A3KMP8 | |
| Q8NAQ6 |
| PIR ID | A43817 |
|---|
| Unigene ID | Hs.504096 |
|---|---|
| Mm.266871 | |
| Rn.35589 |
| KEGG ID | hsa:867 |
|---|---|
| mmu:12402 | |
| rno:500985 |
| EC Number | 6.3.2.- |
|---|
| Swiss-Prot ID | CBL_HUMAN |
|---|---|
| Q3U527_MOUSE | |
| A3KMP8_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| IPI ID | IPI00027269 |
|---|---|
| IPI00652341 | |
| IPI00884054 | |
| IPI00323590 | |
| IPI00896033 | |
| IPI00196823 |
| Homologene ID | 3802 |
|---|
| RGD ID | 1561386 |
|---|
| MGI ID | 88279 |
|---|
| Source | Curated |
|---|