| URN | urn:agi-llid:5295 |
|---|---|
| Connectivity | 198 |
| Name | Pik3r1 |
| Description | phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) |
| Notes | It has recently been shown that Akt activation is associated with a worse outcome among endocrine treated breast cancer patients and that it also inhibits the progesterone receptor (PR) expression via the PI3K/Akt pathway in breast cancer cells. It has recently been shown that Akt activation is associated with a worse outcome among endocrine treated breast cancer patients and that it also inhibits the progesterone receptor (PR) expression via the PI3K/Akt pathway in breast cancer cells. PI3K regulates cell cycle progression and cell proliferation in human gastric tumor cells via Rb-mediated pathway; effect mediated through direct association with Rb via N-terminal end of its p55 kDa regulatory subunits and modulating Rb-E2F interactions. Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in three transcript variants encoding different isoforms. RhoG protects cells from apoptosis caused by the loss of anchorage through a PI3K-dependent mechanism, independent of its activation of Rac1. These results support a model in which phagosomal PI3K generates PI(3,4,5)P(3) necessary for later stages of phagocytosis, PTEN determines whether those late stages can occur, and SHIP-1 regulates when and where they occur. Constitutively active Stat5 mutant forms a complex with the p85 subunit of phosphatidylinositol 3-kinase and the scaffolding adapter Gab2 in leukemic bone marrow cells, resulting in the activation of Akt/PKB, a crucial downstream target of PI3-K. Direct interactions between native Syk and PI3K proteins are differentially regulated during FcgammaR phagocytosis and endocytosis. Protein whose expression is deregulated in the epidermis of the elderly. |
| Pathway | phosphatidylinositol 3-kinase-Akt signaling pathway |
|---|---|
| scatter factor-hepatocyte growth factor signaling pathway | |
| reelin signaling pathway | |
| Reelin signaling pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| epidermal growth factor/neuregulin signaling pathway | |
| Reelin signaling pathway | |
| epidermal growth factor-neuregulin signaling pathway |
| GO Molecular Function | protein C-terminus binding |
|---|---|
| phosphoprotein binding | |
| protein domain specific binding | |
| insulin receptor substrate binding | |
| receptor binding | |
| insulin receptor binding | |
| insulin-like growth factor receptor binding | |
| ErbB-3 class receptor binding | |
| protein kinase binding | |
| protein phosphatase binding | |
| insulin binding | |
| phosphatidylinositol binding | |
| kinase activity | |
| 1-phosphatidylinositol-3-kinase activity | |
| phosphoinositide 3-kinase regulator activity |
| GO Cellular Component | protein complex |
|---|---|
| membrane | |
| intracellular | |
| soluble fraction | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| phosphoinositide 3-kinase complex | |
| 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex |
| GO Biological Process | aging |
|---|---|
| interspecies interaction between organisms | |
| positive regulation of anti-apoptosis | |
| positive regulation of myoblast differentiation | |
| negative regulation of osteoclast differentiation | |
| B cell differentiation | |
| signal transduction | |
| positive regulation of establishment of protein localization in plasma membrane | |
| phosphoinositide 3-kinase cascade | |
| negative regulation of proteolysis | |
| positive regulation of cell migration | |
| negative regulation of cell-cell adhesion | |
| negative regulation of cell-matrix adhesion | |
| negative regulation of apoptosis | |
| glucose metabolic process | |
| protein amino acid phosphorylation | |
| phosphoinositide phosphorylation | |
| growth hormone receptor signaling pathway | |
| insulin receptor signaling pathway | |
| response to cAMP | |
| response to insulin stimulus | |
| response to estrogen stimulus | |
| response to glucocorticoid stimulus | |
| positive regulation of glucose import | |
| insulin-like growth factor receptor signaling pathway |
| Ariadne Ontology | PI3K |
|---|
| Group | PI3K |
|---|---|
| aging | |
| interspecies interaction between organisms | |
| positive regulation of anti-apoptosis | |
| positive regulation of myoblast differentiation | |
| negative regulation of osteoclast differentiation | |
| B cell differentiation | |
| signal transduction | |
| positive regulation of establishment of protein localization in plasma membrane | |
| phosphoinositide 3-kinase cascade | |
| negative regulation of proteolysis | |
| positive regulation of cell migration | |
| negative regulation of cell-cell adhesion | |
| negative regulation of cell-matrix adhesion | |
| negative regulation of apoptosis | |
| glucose metabolic process | |
| protein amino acid phosphorylation | |
| phosphoinositide phosphorylation | |
| growth hormone receptor signaling pathway | |
| insulin receptor signaling pathway | |
| response to cAMP | |
| response to insulin stimulus | |
| response to estrogen stimulus | |
| response to glucocorticoid stimulus | |
| positive regulation of glucose import | |
| insulin-like growth factor receptor signaling pathway | |
| protein C-terminus binding | |
| phosphoprotein binding | |
| protein domain specific binding | |
| insulin receptor substrate binding | |
| receptor binding | |
| insulin receptor binding | |
| insulin-like growth factor receptor binding | |
| ErbB-3 class receptor binding | |
| protein kinase binding | |
| protein phosphatase binding | |
| insulin binding | |
| phosphatidylinositol binding | |
| kinase activity | |
| 1-phosphatidylinositol-3-kinase activity | |
| phosphoinositide 3-kinase regulator activity | |
| protein complex | |
| membrane | |
| intracellular | |
| soluble fraction | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| phosphoinositide 3-kinase complex | |
| 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex |
| MedScan ID | 5295 |
|---|
| Hugo ID | 8979 |
|---|
| Human chromosome position | 5q13.1 |
|---|
| LocusLink ID | 5295 |
|---|---|
| 18708 | |
| 25513 | |
| 153387 | |
| 105088 | |
| 328326 | |
| 360334 | |
| 282307 | |
| 557176 |
| Alias | p85 |
|---|---|
| GRB1 | |
| p85-ALPHA | |
| phosphatidylinositol 3-kinase regulatory subunit alpha | |
| PI3-kinase subunit p85-alpha | |
| PI3K regulatory subunit alpha | |
| PI3-kinase regulatory subunit alpha | |
| ptdIns-3-kinase regulatory subunit alpha | |
| phosphatidylinositol 3-kinase, regulatory, 1 | |
| ptdIns-3-kinase regulatory subunit p85-alpha | |
| phosphatidylinositol 3-kinase-associated p-85 alpha | |
| phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha | |
| phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) | |
| PI3K | |
| AA414921 | |
| p50alpha | |
| p55alpha | |
| p85alpha | |
| C530050K14 | |
| PI3KA | |
| ptdIns-3-kinase p85-alpha | |
| PI3-kinase p85 subunit alpha | |
| Phosphoinositide 3-kinase p85 (other splicing variants: p55 and p50) | |
| Phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) | |
| 3-phosphatidylinositol kinase 85K chain | |
| AK049798 | |
| GRB I | |
| LOC153387 | |
| LOC360334 | |
| LOC497750 | |
| P 85A | |
| P(85)A | |
| P85a | |
| P-85A | |
| P85-A | |
| P85A_HUMAN | |
| p85alpha regulatory subunit of phosphoinositide 3-kinase | |
| Phosphatidylinositol 3-kinase regulatory alpha subunit | |
| phosphatidylinositol 3-kinase, regulatory subunit 1 | |
| phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha | |
| phosphatidylinositol 3-kinase, regulatory subunit, polypeptide I | |
| Phosphatidylinositol 3-kinase, regulatory, I | |
| Phosphoinositide 3-kinase p85 | |
| phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 | |
| phosphoinositide 3-kinase, regulatory subunit, polypeptide I | |
| phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | |
| phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) | |
| PI3-kinase P85- alpha subunit | |
| Pik3r I | |
| Pik3r1 | |
| phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | |
| phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 | |
| Phosphatidylinositol 3-kinase, regulatory | |
| 3-phosphatidylinositol kinase 85K chain | |
| phosphoinositide-3-kinase, regulatory subunit 1 | |
| hypothetical gene supported by AK049798 | |
| expressed sequence AA414921 | |
| phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 | |
| LOC557176 | |
| chromosome | |
| polypeptide 1 | |
| regulatory subunit | |
| scaffold | |
| similar to phosphoinositide-3-kinase | |
| similar to phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 171833 |
|---|
| Mouse chromosome position | 13 50.0 cM |
|---|
| GO ID | 0043125 |
|---|---|
| 0043559 | |
| 0005158 | |
| 0043560 | |
| 0005159 | |
| 0005545 | |
| 0035014 | |
| 0019903 | |
| 0060396 | |
| 0008286 | |
| 0048009 | |
| 0044419 | |
| 0014065 | |
| 0046854 | |
| 0090004 | |
| 0046326 | |
| 0007165 | |
| 0005943 | |
| 0005829 | |
| 0005622 | |
| 0016303 | |
| 0016301 | |
| 0051219 | |
| 0008022 | |
| 0019904 | |
| 0019901 | |
| 0005102 | |
| 0030183 | |
| 0006006 | |
| 0043066 | |
| 0022408 | |
| 0001953 | |
| 0045671 | |
| 0045861 | |
| 0045768 | |
| 0030335 | |
| 0045663 | |
| 0006468 | |
| 0051591 | |
| 0043627 | |
| 0051384 | |
| 0032868 | |
| 0005737 | |
| 0016020 | |
| 0005942 | |
| 0005886 | |
| 0043234 | |
| 0005625 | |
| 0007568 | |
| 0070201 | |
| 0005515 | |
| 0007242 | |
| 0035030 | |
| 0005096 |
| Rat chromosome position | 2q12 |
|---|
| Swiss-Prot Accession | P27986 |
|---|---|
| P70304 | |
| Q80UI5 | |
| Q8K3B3 | |
| P26450 | |
| P70305 | |
| Q3TP23 | |
| Q8C7P2 | |
| Q99LY6 | |
| Q63787 | |
| O55168 | |
| Q15747 | |
| Q4VBZ7 | |
| Q53EM6 | |
| Q8IXA2 | |
| Q8N1C5 | |
| O55085 | |
| P70544 | |
| Q63790 | |
| D3DWA0 |
| PIR ID | A38748 |
|---|---|
| A38747 |
| Unigene ID | Hs.132225 |
|---|---|
| Hs.604502 | |
| Mm.259333 | |
| Rn.10599 | |
| Bt.91714 | |
| Dr.77293 |
| KEGG ID | hsa:5295 |
|---|---|
| mmu:18708 | |
| rno:25513 |
| Swiss-Prot ID | P85A_HUMAN |
|---|---|
| P85A_RAT | |
| D3DWA0_HUMAN | |
| Q80UI5_MOUSE | |
| P70304_MOUSE | |
| Q8K3B3_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00021448 |
|---|---|
| IPI00295788 | |
| IPI00333040 | |
| IPI00807573 | |
| IPI00211946 | |
| IPI00231820 | |
| IPI00231821 | |
| IPI00403425 | |
| IPI00322466 | |
| IPI00263878 | |
| IPI00226772 | |
| IPI00474314 |
| Homologene ID | 7889 |
|---|
| RGD ID | 3329 |
|---|
| MGI ID | 97583 |
|---|---|
| 2145159 |
| Microarray ID | 96592_at |
|---|---|
| 244181_at | |
| 212239_at | |
| 212240_s_at | |
| 1425514_at | |
| 1425515_at | |
| 1438682_at |
| FunctionalClass | ErbB-3 class receptor binding |
|---|---|
| insulin binding | |
| insulin receptor binding | |
| insulin receptor substrate binding | |
| insulin-like growth factor receptor binding | |
| phosphatidylinositol binding | |
| phosphoinositide 3-kinase regulator | |
| protein phosphatase binding | |
| kinase | |
| phosphatidylinositol 3-kinase | |
| protein binding | |
| protein C-terminus binding | |
| receptor binding | |
| 1-phosphatidylinositol-3-kinase |
| Mus musculus Chromosome position | 13 50.0 cM |
|---|---|
| 13 | |
| 13 D1 |
| Source | Curated |
|---|---|
| GO component |
| Homo sapiens Chromosome position | 5q13.1 |
|---|
| Bos taurus Chromosome position | 20 |
|---|
| Rattus norvegicus Chromosome position | 2q12 |
|---|