| URN | urn:agi-llid:6464 |
|---|---|
| Connectivity | 599 |
| Name | Shc1 |
| Description | src homology 2 domain-containing transforming protein C1 |
| Notes | mouse homolog interacts with growth factor receptors; involved in transformation and differentiation in a Ras-dependent fashion [RGD] |
| Pathway | FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling |
|---|---|
| PDGFR -> AP-1/MYC signaling | |
| VEGFR -> AP-1/CREB/MYC signaling | |
| HGFR -> AP-1/CREB/MYC signaling | |
| ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> NCOR2 signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| DDR1 -> NF-kB signaling | |
| GDNF -> HSF1 signaling | |
| InsulinR -> ELK-SRF/SREBF signaling | |
| IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| ThrombopoietinR -> SPI1 signaling | |
| ThrombopoietinR -> SP1 signaling | |
| ErythropoietinR -> ELK-SRF/FOS signaling | |
| GHR -> ELK-SRF/MYC signaling | |
| EGFR -> CTNND signaling | |
| EGFR -> SMAD1 signaling | |
| EGFR/ERBB -> STAT signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| EGFR/ERBB2 -> CTNNB signaling | |
| ERBB2/3 -> EP300/ETS/ETV/SP1 signaling | |
| EGFR/ERBB2 -> HIF1A signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| FGFR -> RUNX2 signaling | |
| KIT -> MITF signaling | |
| VEGFR -> NFATC signaling | |
| VEGFR -> ATF/CREB/ELK-SRF signaling | |
| IL2R -> ELK-SRF/MYC signaling | |
| IL4R -> ELK-SRF/HMGY signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| CholinergicRm -> CREB/ELK-SRF signaling | |
| DopamineR2 -> AP-1/CREB/ELK-SRF signaling | |
| EDG2 -> ELK-SRF signaling | |
| GRM1/5 -> CREB signaling | |
| NeurotensinR -> ELK-SRF/AP-1/EGR signaling | |
| VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| FcIgER -> ELK-SRF signaling | |
| UrokinaseR -> ELK-SRF signaling | |
| insulin signaling pathway | |
| scatter factor-hepatocyte growth factor signaling pathway | |
| insulin signaling pathway | |
| altered insulin signaling pathway | |
| epidermal growth factor/neuregulin signaling pathway | |
| epidermal growth factor-neuregulin signaling pathway |
| GO Molecular Function | phosphoprotein binding |
|---|---|
| protein complex binding | |
| transmembrane receptor protein tyrosine kinase adaptor protein activity | |
| phospholipid binding | |
| insulin receptor binding | |
| insulin-like growth factor receptor binding | |
| epidermal growth factor receptor binding | |
| phosphotyrosine binding |
| GO Cellular Component | plasma membrane |
|---|---|
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| endosome membrane | |
| mitochondrial matrix | |
| nucleus | |
| Shc-EGFR complex |
| GO Biological Process | positive regulation of cell proliferation |
|---|---|
| aging | |
| regulation of growth | |
| angiogenesis | |
| heart development | |
| neuron differentiation | |
| organ regeneration | |
| positive regulation of vasoconstriction | |
| cell-cell adhesion | |
| actin cytoskeleton organization | |
| neuron projection development | |
| regulation of epidermal growth factor receptor activity | |
| activation of MAPK activity | |
| MAPKKK cascade | |
| Ras protein signal transduction | |
| positive regulation of DNA replication | |
| positive regulation of smooth muscle cell proliferation | |
| actin cytoskeleton reorganization | |
| insulin receptor signaling pathway | |
| response to toxin | |
| response to hypoxia | |
| response to organic cyclic substance | |
| response to hydrogen peroxide | |
| response to nicotine | |
| response to insulin stimulus | |
| response to glucocorticoid stimulus | |
| intracellular signaling pathway | |
| epidermal growth factor receptor signaling pathway |
| Ariadne Ontology | Shc |
|---|
| Group | Shc |
|---|---|
| positive regulation of cell proliferation | |
| aging | |
| regulation of growth | |
| angiogenesis | |
| heart development | |
| neuron differentiation | |
| organ regeneration | |
| positive regulation of vasoconstriction | |
| cell-cell adhesion | |
| actin cytoskeleton organization | |
| neuron projection development | |
| regulation of epidermal growth factor receptor activity | |
| activation of MAPK activity | |
| MAPKKK cascade | |
| Ras protein signal transduction | |
| positive regulation of DNA replication | |
| positive regulation of smooth muscle cell proliferation | |
| actin cytoskeleton reorganization | |
| insulin receptor signaling pathway | |
| response to toxin | |
| response to hypoxia | |
| response to organic cyclic substance | |
| response to hydrogen peroxide | |
| response to nicotine | |
| response to insulin stimulus | |
| response to glucocorticoid stimulus | |
| intracellular signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| phosphoprotein binding | |
| protein complex binding | |
| transmembrane receptor protein tyrosine kinase adaptor protein activity | |
| phospholipid binding | |
| insulin receptor binding | |
| insulin-like growth factor receptor binding | |
| epidermal growth factor receptor binding | |
| phosphotyrosine binding | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| endosome membrane | |
| mitochondrial matrix | |
| nucleus | |
| Shc-EGFR complex |
| MedScan ID | 6464 |
|---|
| Hugo ID | 10840 |
|---|
| Human chromosome position | 1q21 |
|---|
| LocusLink ID | 6464 |
|---|---|
| 20416 | |
| 85385 | |
| 507196 |
| Alias | SHC |
|---|---|
| SHCA | |
| FLJ26504 | |
| RP11-307C12.1 | |
| SHC-transforming protein 1 | |
| OTTHUMP00000035472 | |
| SH2 domain protein C1 | |
| SHC-transforming protein 3 | |
| SHC-transforming protein A | |
| src homology 2 domain-containing-transforming protein C1 | |
| SHC (Src homology 2 domain-containing) transforming protein 1 | |
| p66 | |
| p66shc | |
| OTTMUSP00000024847 | |
| OTTMUSP00000024849 | |
| OTTMUSP00000024853 | |
| src homology 2 domain-containing transforming protein C1 | |
| (Src homology 2 domain-containing) transforming 1 | |
| (Src homology 2 domain-containing) transforming I | |
| 6720466E06 | |
| OTTHUMP00000035409 | |
| OTTHUMP00000035471 | |
| p52Shc | |
| Sck (Rattus rattus) | |
| SHC (Src homology 2 domain containing) transforming protein 1 | |
| SHC (Src homology 2 domain-containing) transforming protein I | |
| Shc I | |
| SHC transforming protein | |
| Shc1 | |
| Shc-P | |
| src homology 2 domain-containing transforming protein C | |
| hypothetical protein 6720466E06 | |
| P(66) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus |
| OMIM ID | 600560 |
|---|
| Mouse chromosome position | 3 45.0 cM |
|---|
| GO ID | 0005154 |
|---|---|
| 0005158 | |
| 0005159 | |
| 0005543 | |
| 0005068 | |
| 0000165 | |
| 0007265 | |
| 0000187 | |
| 0007173 | |
| 0008286 | |
| 0045740 | |
| 0008284 | |
| 0007176 | |
| 0040008 | |
| 0070435 | |
| 0005737 | |
| 0005829 | |
| 0005759 | |
| 0005739 | |
| 0005886 | |
| 0051219 | |
| 0001784 | |
| 0032403 | |
| 0030036 | |
| 0031532 | |
| 0007568 | |
| 0001525 | |
| 0016337 | |
| 0007507 | |
| 0023034 | |
| 0030182 | |
| 0031175 | |
| 0048661 | |
| 0045907 | |
| 0010008 | |
| 0005634 | |
| 0031100 | |
| 0051384 | |
| 0042542 | |
| 0001666 | |
| 0032868 | |
| 0035094 | |
| 0014070 | |
| 0009636 | |
| 0005515 | |
| 0007242 | |
| 0045840 | |
| 0001558 |
| Rat chromosome position | 2q34 |
|---|
| Swiss-Prot Accession | P29353 |
|---|---|
| Q59HB0 | |
| Q5T181 | |
| Q5T182 | |
| Q5T187 | |
| Q5T188 | |
| Q8NFT0 | |
| Q8NFT1 | |
| P98083 | |
| Q5M824 | |
| Q9Z1I0 | |
| O15290 | |
| Q5T180 | |
| Q5T183 | |
| Q5T184 | |
| Q5T185 | |
| Q5T186 | |
| Q8N4K5 | |
| Q96CL1 | |
| Q3U2Q7 | |
| Q8BFY3 | |
| Q8K4C6 | |
| Q8K4C7 | |
| D3DV78 |
| PIR ID | S25776 |
|---|---|
| A55484 |
| Unigene ID | Hs.433795 |
|---|---|
| Mm.86595 | |
| Mm.478270 | |
| Rn.138818 | |
| Bt.4279 |
| KEGG ID | hsa:6464 |
|---|---|
| mmu:20416 | |
| rno:85385 |
| Swiss-Prot ID | SHC1_HUMAN |
|---|---|
| SHC1_RAT | |
| SHC1_MOUSE | |
| D3DV78_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Mitochondrion matrix |
| IPI ID | IPI00165135 |
|---|---|
| IPI00643176 | |
| IPI00643863 | |
| IPI00943132 | |
| IPI00777105 | |
| IPI00125298 | |
| IPI00759853 | |
| IPI00759982 | |
| IPI00645103 | |
| IPI00513796 | |
| IPI00021326 | |
| IPI00641285 | |
| IPI00645940 | |
| IPI00647867 | |
| IPI00640190 | |
| IPI00831713 | |
| IPI00831035 | |
| IPI00830982 | |
| IPI00831084 | |
| IPI00373231 |
| Homologene ID | 7934 |
|---|
| RGD ID | 620446 |
|---|
| MGI ID | 98296 |
|---|
| Microarray ID | 104350_at |
|---|---|
| 93713_at | |
| 201469_s_at |
| FunctionalClass | insulin receptor binding |
|---|---|
| insulin-like growth factor receptor binding | |
| phospholipid binding | |
| protein binding | |
| transmembrane receptor protein tyrosine kinase adaptor protein | |
| phosphotyrosine binding | |
| phosphoprotein binding |
| Mus musculus Chromosome position | 3 45.0 cM |
|---|
| Source | Curated |
|---|---|
| ResNet | |
| GO component |
| Homo sapiens Chromosome position | 1q21 |
|---|
| Bos taurus Chromosome position | 3 |
|---|
| Rattus norvegicus Chromosome position | 2q34 |
|---|