| URN | urn:agi-Binding:inout-urn:agi-llid:6464:inout-urn:agi-llid:2885::unknown |
|---|---|
| References | 1191 |
| Connectivity | 2 |
| Effect | unknown |
| TextRef | info:pmid/10891441 |
|---|---|
| MedLine Reference | 10891441 |
| Sentence | Grb2 interacts with Shc |
| Source | Curated |
| TextRef | info:pmid/8524290 |
|---|---|
| MedLine Reference | 8524290 |
| Sentence | Shc interacts with Grb2 |
| Source | Curated |
| TextRef | info:pmid/9566877 |
|---|---|
| MedLine Reference | 9566877 |
| Sentence | Shc interacts with Grb2 |
| Source | Curated |
| TextRef | info:pmid/9774338 |
|---|---|
| MedLine Reference | 9774338 |
| Sentence | Grb2 interacts with Shc |
| Source | Curated |
| TextRef | info:pmid/12486127 |
|---|---|
| MedLine Reference | 12486127 |
| Sentence | Grb2 interacts with phosphorylated Shc |
| Source | Curated |
| TextRef | info:pmid/9148935 |
|---|---|
| MedLine Reference | 9148935 |
| Sentence | An unspecified isoform of Grb2 interacts with the p52 isoform of Shc |
| Source | Curated |
| TextRef | info:pmid/7898932#abs:8 |
|---|---|
| MedLine Reference | 7898932:7 |
| Sentence | These effects require the association of Shc with Grb2. |
| TextRef | info:pmid/8752899#abs:6 |
|---|---|
| MedLine Reference | 8752899:5 |
| Sentence | Y577 is also required for association of Shc with GRB2. |
| Organism | Mus musculus |
| TextRef | info:pmid/9446569#abs:11 |
|---|---|
| MedLine Reference | 9446569:10 |
| Sentence | UTP also promoted the association of Shc with Grb2. |
| Organism | Rattus norvegicus |
| TextRef | info:pmid/8084588 |
|---|---|
| MedLine Reference | 8084588 |
| Sentence | Shc interacts with Grb2. This interaction was modelled on a demonstrated interaction between Shc from human and Grb2 from rat and an unspecified species |
| Source | Curated |
| TextRef | info:pmid/16990343#abs:9 |
|---|---|
| MedLine Reference | 16990343:8 |
| Sentence | EGF treatment caused the association of SHC with Grb2 and Gab2 with phospho-SHC, phospho-Gab1, Grb2, and p85. |
| TextRef | info:pmid/18093973#abs:4 |
|---|---|
| MedLine Reference | 18093973:3 |
| Sentence | PTPepsilon binds and dephosphorylates Shc in vivo, reducing the association of Shc with Grb2 and inhibiting downstream ERK activation. |
| TextRef | info:pmid/17129375#abs:9 |
|---|---|
| MedLine Reference | 17129375:8 |
| Sentence | In addition, the PI3K pathway was activated similarly in normal and OA Obs while that for p42/44 MAPK was higher in OA Obs compared to normal. p42/44 MAPK can be triggered via an IRS-1/Syp or Grb2/Shc interaction. |
| TextRef | info:pmid/17607710#abs:6 |
|---|---|
| MedLine Reference | 17607710:5 |
| Sentence | In addition, there was enhanced IGF-I-stimulated Shc association with SHPS-1, Shc tyrosine phosphorylation, Shc and Grb2 association, and MAP kinase activation leading to increased cell proliferation. |
| TextRef | info:pmid/10477741#body:96 |
|---|---|
| MedLine Reference | 10477741:1095 |
| Sentence | We next assessed the kinetics of the Shc interaction with Grb2. |
| CellLineName | U937IF |
| Journal | Blood |
| Journal Reference | v94 i6 p2112 (1999) |
| Journal Link | http://www.bloodjournal.org/cgi/content/full/94/6/2112 |
| Source | Curated |
| TextRef | info:pmid/10891441#body:115 |
|---|---|
| MedLine Reference | 10891441:1114 |
| Sentence | Wild-type Shc coprecipitated with both SHIP and Grb2 after IL-3 stimulation. |
| Organism | mouse |
| CellType | MAST |
| Journal | Blood |
| Journal Reference | v96 i1 p132 (2000) |
| Journal Link | http://www.bloodjournal.org/cgi/content/full/96/1/132 |
| Source | Curated |
| TextRef | info:pmid/10477722#body:33 |
|---|---|
| MedLine Reference | 10477722:1032 |
| Sentence | The bound SHC recruits grb2 into the complex and grb2 binds sos, which then activates p21 ras nucleotide exchange. |
| Organism | mouse |
| Tissue | hematological |
| Journal | Blood |
| Journal Reference | v94 i6 p1933 (1999) |
| Journal Link | http://www.bloodjournal.org/cgi/content/full/94/6/1933 |
| Source | Curated |
| TextRef | info:pmid/9448048#body:169 |
|---|---|
| MedLine Reference | 9448048:1168 |
| Sentence | To determine if Shc associates with Grb2 following IL-5 treatment, eosinophil anti-Shc immunoprecipitates were immunoblotted with anti-Grb2 antisera. |
| CellType | eosinophil |
| Journal | AJRCMB |
| Journal Reference | v18 i1 p75 (1998) |
| Journal Link | http://ajrcmb.atsjournals.org/cgi/content/full/18/1/75 |
| Source | Curated |
| TextRef | info:pmid/10979966#body:25 |
|---|---|
| MedLine Reference | 10979966:1024 |
| Sentence | We have recently examined the events upstream of ERK1/2 phosphorylation in human basophils and found tyrosine kinase (presumably syk)-dependent phosphorylation of shc, association of shc with Grb2-Sos2 complex, and activation of ras-MEK1-ERK1/2. |
| CellType | basophil |
| Journal | Blood |
| Journal Reference | v96 i6 p2199 (2000) |
| Journal Link | http://www.bloodjournal.org/cgi/content/full/96/6/2199 |
| Source | Curated |
| TextRef | info:pmid/9539773#cont:164 |
|---|---|
| MedLine Reference | 9539773:10163 |
| Journal | PNAS |
| Journal Reference | v95 i8 p4538 |
| Journal Link | http://www.pnas.org/cgi/content/full/95/8/4538 |
| TextRef | info:pmid/9389692#cont:92 |
|---|---|
| MedLine Reference | 9389692:10091 |
| Organism | Mus musculus |
| Journal | Blood |
| Journal Reference | v90 i12 p4759 |
| Journal Link | http://www.bloodjournal.org/cgi/content/full/90/12/4759 |
| TextRef | info:pmid/9490675#cont:130 |
|---|---|
| MedLine Reference | 9490675:10129 |
| Journal | Blood |
| Journal Reference | v91 i6 p1924 |
| Journal Link | http://www.bloodjournal.org/cgi/content/full/91/6/1924 |
| TextRef | info:pmid/14983012#cont:145 |
|---|---|
| MedLine Reference | 14983012:10144 |
| Organism | Mus musculus |
| Journal | PNAS |
| Journal Reference | v101 i8 p2345 |
| Journal Link | http://www.pnas.org/cgi/content/full/101/8/2345 |
| TextRef | info:pmid/9473212#cont:275 |
|---|---|
| MedLine Reference | 9473212:10274 |
| Organism | Mus musculus |
| Journal | Blood |
| Journal Reference | v91 i5 p1496 |
| Journal Link | http://www.bloodjournal.org/cgi/content/full/91/5/1496 |
| TextRef | info:pmid/10216087#cont:22 |
|---|---|
| MedLine Reference | 10216087:10021 |
| Organism | Mus musculus |
| Journal | Blood |
| Journal Reference | v93 i9 p2928 |
| Journal Link | http://www.bloodjournal.org/cgi/content/full/93/9/2928 |
| TextRef | info:pmid/10764780#cont:26 |
|---|---|
| MedLine Reference | 10764780:10025 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v275 i24 p18114 |
| Journal Link | http://www.jbc.org/cgi/content/full/275/24/18114 |
| TextRef | info:pmid/10477583#cont:32 |
|---|---|
| MedLine Reference | 10477583:10031 |
| Organism | Mus musculus |
| Journal | J. Immunol |
| Journal Reference | v163 i6 p3160 |
| Journal Link | http://www.jimmunol.org/cgi/content/full/163/6/3160 |
| TextRef | info:pmid/11498013#abs:2 |
|---|---|
| MedLine Reference | 11498013:1 |
| Source | Curated |
| TextRef | info:pmid/9040941#abs:6 |
|---|---|
| MedLine Reference | 9040941:5 |
| Source | Curated |
| TextRef | info:pmid/7641883#abs:3 |
|---|---|
| MedLine Reference | 7641883:2 |
| Source | Curated |
| TextRef | info:pmid/8909796#abs:5 |
|---|---|
| MedLine Reference | 8909796:4 |
| Source | Curated |
| TextRef | info:pmid/9121430#abs:2 |
|---|---|
| MedLine Reference | 9121430:1 |
| Source | Curated |
| TextRef | info:pmid/8621453#body:188 |
|---|---|
| MedLine Reference | 8621453:1187 |
| Organism | mouse |
| Journal | J. Biol. Chem |
| Journal Reference | v271 i10 p5832 (1996) |
| Journal Link | http://www.jbc.org/cgi/content/full/271/10/5832 |
| Source | Curated |
| TextRef | info:pmid/8621469#body:25 |
|---|---|
| MedLine Reference | 8621469:1024 |
| Organism | mouse |
| Tissue | Lymph |
| Journal | J. Biol. Chem |
| Journal Reference | v271 i10 p5947 (1996) |
| Journal Link | http://www.jbc.org/cgi/content/full/271/10/5947 |
| Source | Curated |
| TextRef | info:pmid/8621475#body:97 |
|---|---|
| MedLine Reference | 8621475:1096 |
| CellLineName | SVK14 |
| Journal | J. Biol. Chem |
| Journal Reference | v271 i15 p8529 (1996) |
| Journal Link | http://www.jbc.org/cgi/content/full/271/15/8529 |
| Source | Curated |
| TextRef | info:pmid/11278982#cont:147 |
|---|---|
| MedLine Reference | 11278982:10146 |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i19 p16045 |
| Journal Link | http://www.jbc.org/cgi/content/full/276/19/16045 |
| TextRef | info:pmid/12917446#cont:233 |
|---|---|
| MedLine Reference | 12917446:10232 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i43 p41646 |
| Journal Link | http://www.jbc.org/cgi/content/full/278/43/41646 |
| TextRef | info:pmid/10777525#cont:265 |
|---|---|
| MedLine Reference | 10777525:10264 |
| Journal | J. Biol. Chem |
| Journal Reference | v275 i17 p12416 |
| Journal Link | http://www.jbc.org/cgi/content/full/275/17/12416 |
| TextRef | info:pmid/10465268#cont:113 |
|---|---|
| MedLine Reference | 10465268:10112 |
| Organism | Mus musculus |
| Journal | Endocrinology |
| Journal Reference | v140 i9 p3992 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/140/9/3992 |
| TextRef | info:pmid/15210794#cont:399 |
|---|---|
| MedLine Reference | 15210794:10398 |
| Organism | Mus musculus |
| Journal | J. Immunol |
| Journal Reference | v173 i1 p360 |
| Journal Link | http://www.jimmunol.org/cgi/content/full/173/1/360 |
| TextRef | info:pmid/8978277#cont:98 |
|---|---|
| MedLine Reference | 8978277:10097 |
| Organism | Mus musculus |
| Journal | Blood |
| Journal Reference | v89 i1 p55 |
| Journal Link | http://www.bloodjournal.org/cgi/content/full/89/1/55 |
| TextRef | info:pmid/7642641#cont:124 |
|---|---|
| MedLine Reference | 7642641:10123 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v270 i33 p19557 |
| Journal Link | http://www.jbc.org/cgi/content/full/270/33/19557 |
| TextRef | info:pmid/14557262#cont:55 |
|---|---|
| MedLine Reference | 14557262:10054 |
| Journal | J. Biol. Chem |
| Journal Reference | v279 i1 p326 |
| Journal Link | http://www.jbc.org/cgi/content/full/279/1/326 |
| TextRef | info:pmid/14660677#cont:38 |
|---|---|
| MedLine Reference | 14660677:10037 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v279 i7 p5520 |
| Journal Link | http://www.jbc.org/cgi/content/full/279/7/5520 |
| TextRef | info:pmid/7744881#cont:347 |
|---|---|
| MedLine Reference | 7744881:10346 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v270 i20 p12286 |
| Journal Link | http://www.jbc.org/cgi/content/full/270/20/12286 |
| TextRef | info:pmid/9171350#cont:52 |
|---|---|
| MedLine Reference | 9171350:10051 |
| Organism | Mus musculus |
| Journal | EMBO |
| Journal Reference | v16 i9 p2365 |
| Journal Link | http://emboj.oupjournals.org/cgi/content/full/16/9/2365 |
| TextRef | info:pmid/9786938#body:169 |
|---|---|
| MedLine Reference | 9786938:1168 |
| Organism | pig |
| Journal | J. Biol. Chem |
| Journal Reference | v273 i44 p29254 (1998) |
| Journal Link | http://www.jbc.org/cgi/content/full/273/44/29254 |
| Source | Curated |
| TextRef | info:pmid/9813041#body:26 |
|---|---|
| MedLine Reference | 9813041:1025 |
| Organism | mouse |
| Journal | J. Biol. Chem |
| Journal Reference | v273 i47 p31327 (1998) |
| Journal Link | http://www.jbc.org/cgi/content/full/273/47/31327 |
| Source | Curated |
| TextRef | info:pmid/10564100#body:186 |
|---|---|
| MedLine Reference | 10564100:1185 |
| Organ | Pancreas |
| Organism | rat |
| Journal | Gastr. Liver Phys |
| Journal Reference | v277 i5 pG953.html (1999) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/277/5/G953.h |
| Source | Curated |
| TextRef | info:pmid/10716940#body:267 |
|---|---|
| MedLine Reference | 10716940:1266 |
| Journal | Genes & Dev |
| Journal Reference | v14 i5 p505 (2000) |
| Journal Link | http://www.genesdev.org/cgi/content/full/14/5/505 |
| Source | Curated |
| TextRef | info:pmid/10809671#body:247 |
|---|---|
| MedLine Reference | 10809671:1246 |
| Organism | mouse |
| Tissue | vasculature |
| Journal | Genes & Dev |
| Journal Reference | v14 i9 p1132 (2000) |
| Journal Link | http://www.genesdev.org/cgi/content/full/14/9/1132 |
| Source | Curated |
| TextRef | info:pmid/7642641#body:123 |
|---|---|
| MedLine Reference | 7642641:1122 |
| Organism | mouse |
| CellLineName | NIH 3T3 |
| Journal | J. Biol. Chem |
| Journal Reference | v270 i33 p19557 (1995) |
| Journal Link | http://www.jbc.org/cgi/content/full/270/33/19557 |
| Source | Curated |
| TextRef | info:pmid/7759503#body:83 |
|---|---|
| MedLine Reference | 7759503:1082 |
| Organism | rat |
| CellLineName | rasmc |
| Journal | J. Biol. Chem |
| Journal Reference | v270 i21 p12563 (1995) |
| Journal Link | http://www.jbc.org/cgi/content/full/270/21/12563 |
| Source | Curated |
| TextRef | info:pmid/7983051#abs:6 |
|---|---|
| MedLine Reference | 7983051:5 |
| Source | Curated |
| TextRef | info:pmid/9607818#body:6 |
|---|---|
| MedLine Reference | 9607818:1005 |
| Organism | rat |
| Tissue | endocrine |
| Journal | Endocrinology |
| Journal Reference | v139 i6 p3034 (1998) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/139/6/3034 |
| Source | Curated |
| TextRef | info:pmid/9886807#body:124 |
|---|---|
| MedLine Reference | 9886807:1123 |
| Organism | rat |
| CellType | fibroblast |
| CellLineName | GH |
| Journal | Endocrinology |
| Journal Reference | v140 i1 p55 (1999) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/140/1/55 |
| Source | Curated |
| TextRef | info:pmid/10465268#body:14 |
|---|---|
| MedLine Reference | 10465268:1013 |
| Organism | drosophila |
| Journal | Endocrinology |
| Journal Reference | v140 i9 p3992 (1999) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/140/9/3992 |
| Source | Curated |
| TextRef | info:pmid/11517161#body:235 |
|---|---|
| MedLine Reference | 11517161:1234 |
| Organ | renal |
| Organism | mouse |
| Journal | Endocrinology |
| Journal Reference | v142 i9 p3842 (2001) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/142/9/3842 |
| Source | Curated |
| TextRef | info:pmid/9528944#body:41 |
|---|---|
| MedLine Reference | 9528944:1040 |
| Organism | mouse |
| Journal | Endocrinology |
| Journal Reference | v139 i4 p1638 (1998) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/139/4/1638 |
| Source | Curated |
| TextRef | info:pmid/9832424#body:179 |
|---|---|
| MedLine Reference | 9832424:1178 |
| Journal | Endocrinology |
| Journal Reference | v139 i12 p4881 (1998) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/139/12/4881 |
| Source | Curated |
| TextRef | info:pmid/10469123#body:106 |
|---|---|
| MedLine Reference | 10469123:1105 |
| Journal | Eur. J. Biochem |
| Journal Reference | v263 i3 p605 (1999) |
| Journal Link | http://www.ejbiochem.org/cgi/content/full/263/3/605 |
| Source | Curated |
| TextRef | info:pmid/10362652#body:163 |
|---|---|
| MedLine Reference | 10362652:1162 |
| Organism | dog |
| Journal | Gastr. Liver Phys |
| Journal Reference | v276 i6 pG1484.htm (1999) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/276/6/G1484. |
| Source | Curated |
| TextRef | info:pmid/8530511#body:9 |
|---|---|
| MedLine Reference | 8530511:1008 |
| Organism | mouse |
| CellLineName | NIH 3T3 |
| Journal | J. Biol. Chem |
| Journal Reference | v270 i51 p30717 (1995) |
| Journal Link | http://www.jbc.org/cgi/content/full/270/51/30717 |
| Source | Curated |
| TextRef | info:pmid/8621421#body:71 |
|---|---|
| MedLine Reference | 8621421:1070 |
| Organism | mouse |
| Journal | J. Biol. Chem |
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| Journal Link | http://www.jbc.org/cgi/content/full/271/10/5603 |
| Source | Curated |
| TextRef | info:pmid/8621459#body:75 |
|---|---|
| MedLine Reference | 8621459:1074 |
| Organism | mouse |
| Journal | J. Biol. Chem |
| Journal Reference | v271 i10 p5871 (1996) |
| Journal Link | http://www.jbc.org/cgi/content/full/271/10/5871 |
| Source | Curated |
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|---|---|
| MedLine Reference | 8621483:1045 |
| Organism | yeast |
| CellType | b cell |
| Journal | J. Biol. Chem |
| Journal Reference | v271 i15 p8564 (1996) |
| Journal Link | http://www.jbc.org/cgi/content/full/271/15/8564 |
| Source | Curated |
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|---|---|
| MedLine Reference | 8626723:1109 |
| Organism | mouse |
| CellType | fibroblast |
| CellLineName | 3T3 L1 |
| Journal | J. Biol. Chem |
| Journal Reference | v271 i8 p3959 (1996) |
| Journal Link | http://www.jbc.org/cgi/content/full/271/8/3959 |
| Source | Curated |
| TextRef | info:pmid/11444425#abs:2 |
|---|---|
| MedLine Reference | 11444425:1 |
| Organism | rat |
| Source | Curated |
| TextRef | info:pmid/11825879#body:201 |
|---|---|
| MedLine Reference | 11825879:1200 |
| Organism | drosophila |
| Journal | Genes & Dev |
| Journal Reference | v16 i3 p388 (2002) |
| Journal Link | http://www.genesdev.org/cgi/content/full/16/3/388 |
| Source | Curated |
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|---|---|
| MedLine Reference | 10484435:1268 |
| Organism | pig |
| Journal | Heart Circul |
| Journal Reference | v277 i3 pH1113 (1999) |
| Journal Link | http://ajpheart.physiology.org/cgi/content/full/277/3/H1113 |
| Source | Curated |
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|---|---|
| MedLine Reference | 9856979:1057 |
| CellLineName | RTE |
| Journal | Hypertension |
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| Journal Link | http://hyper.ahajournals.org/cgi/content/full/32/6/1089 |
| Source | Curated |
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|---|---|
| MedLine Reference | 10085099:1185 |
| Organism | mouse |
| CellLineName | T47D |
| Journal | J. Biol. Chem |
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| Journal Link | http://www.jbc.org/cgi/content/full/274/13/8624 |
| Source | Curated |
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|---|---|
| MedLine Reference | 10092665:1072 |
| Organism | rat |
| Journal | J. Biol. Chem |
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| Journal Link | http://www.jbc.org/cgi/content/full/274/14/9760 |
| Source | Curated |
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|---|---|
| MedLine Reference | 10187852:1017 |
| CellLineName | COS-7 |
| Journal | J. Biol. Chem |
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| Journal Link | http://www.jbc.org/cgi/content/full/274/15/10571 |
| Source | Curated |
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|---|---|
| MedLine Reference | 10207047:1031 |
| Organism | mouse |
| CellType | b cell |
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| Source | Curated |
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| MedLine Reference | 9099730:10147 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v272 i16 p10777 |
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|---|---|
| MedLine Reference | 7499278:10069 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
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| Journal Link | http://www.jbc.org/cgi/content/full/270/47/27991 |
| TextRef | info:pmid/7721878#body:205 |
|---|---|
| MedLine Reference | 7721878:1204 |
| Organism | rat |
| CellLineName | H3 |
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| Journal Link | http://www.jbc.org/cgi/content/full/270/16/9500 |
| Source | Curated |
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|---|---|
| MedLine Reference | 7744881:1346 |
| Organism | mouse |
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|---|---|
| MedLine Reference | 7896829:1067 |
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|---|---|
| MedLine Reference | 8537333:1024 |
| CellType | macrophage |
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|---|---|
| MedLine Reference | 8576169:1278 |
| Organism | rat |
| Journal | J. Biol. Chem |
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