Ariadne Genomics Inc. Erbb3 --+> phosphatidylinositol 3-kinase-Akt signaling pathway Sos2 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Sos1 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Erbb4 Erbb3 Sos1 Adams ---> Nrg ligands Adams ---> Egfr/Erbb4 ligands Adams ---> Egfr ligands Erbb4 ---- Nrg ligands Erbb3 ---- Nrg ligands Egfr/Erbb4 ligands ---- Erbb4 Egfr ---- Egfr/Erbb4 ligands Egfr ---- Egfr ligands the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> cell differentiation phosphatidylinositol 3-kinase-Akt signaling pathway ---> cell proliferation phosphatidylinositol 3-kinase-Akt signaling pathway ---> pro-growth the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> pro-growth the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> cell proliferation pro-growth phosphatidylinositol 3-kinase-Akt signaling pathway cell proliferation phosphatidylinositol 3-kinase-Akt signaling pathway ---> cell survival the extracellular signal-regulated Raf/Mek/Erk signaling pathway Egfr ---- Shc1 Erbb4 ---- Grb2 Erbb2 ---- Shc1 Egfr ---- Grb2 Grb2 ---- Shc1 Grb2 ---- Sos2 Grb2 Grb2 ---- Sos1 Pik3r1 Shc1 Erbb4 ---- Shc1 Egfr cell differentiation cell survival Erbb2 Erbb3 ---- Pik3r1 Ptprj ---| Egfr Cbl Cbl ---| Egfr Egfr ligands Egfr/Erbb4 ligands Adams Ptprj Sos2 Nrg ligands