| URN | urn:agi-llid:3630 |
|---|---|
| Connectivity | 4336 |
| Name | Ins2 |
| Description | preproinsulin |
| Notes | Our results indicate that in adult tilapia insulin expression is not restricted to the endocrine pancreatic cells, but also occurs in endocrine cells of the pituitary gland and in the neuronal cells of the brain. Our results indicate that in adult tilapia insulin expression is not restricted to the endocrine pancreatic cells, but also occurs in endocrine cells of the pituitary gland and in the neuronal cells of the brain. |
| Pathway | InsulinR -> STAT signaling |
|---|---|
| InsulinR -> CTNNB/FOXA/FOXO signaling | |
| IGF1R -> CEBPA/FOXO1A signaling | |
| InsulinR -> ELK-SRF/SREBF signaling | |
| IGF1R -> MEF/MYOD/MYOG signaling | |
| IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling | |
| IGF1R -> STAT signaling | |
| insulin signaling pathway | |
| insulin signaling pathway | |
| type 2 diabetes mellitus pathway | |
| altered insulin signaling pathway | |
| insulin signaling pathway |
| GO Molecular Function | protein complex binding |
|---|---|
| insulin receptor binding | |
| protease binding | |
| insulin-like growth factor receptor binding | |
| hormone activity |
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space | |
| soluble fraction | |
| cytoplasm | |
| small nucleolar ribonucleoprotein complex | |
| stored secretory granule | |
| nucleus |
| GO Biological Process | cell death |
|---|---|
| positive regulation of cell proliferation | |
| respiratory burst | |
| cell-cell signaling | |
| positive regulation of cell differentiation | |
| negative regulation of respiratory burst involved in inflammatory response | |
| positive regulation of vasodilation | |
| negative regulation of vasodilation | |
| positive regulation of cytokine secretion | |
| positive regulation of cell growth | |
| negative regulation of protein secretion | |
| positive regulation of mitosis | |
| positive regulation of phosphoinositide 3-kinase cascade | |
| positive regulation of protein kinase B signaling cascade | |
| positive regulation of MAPKKK cascade | |
| activation of JUN kinase activity | |
| activation of MAPK activity | |
| positive regulation of insulin receptor signaling pathway | |
| regulation of protein secretion | |
| regulation of transmembrane transporter activity | |
| MAPKKK cascade | |
| regulation of cellular amino acid metabolic process | |
| negative regulation of fatty acid metabolic process | |
| positive regulation of cellular protein metabolic process | |
| negative regulation of glycogen catabolic process | |
| positive regulation of glycolysis | |
| negative regulation of gluconeogenesis | |
| negative regulation of proteolysis | |
| negative regulation of transcription from RNA polymerase II promoter | |
| positive regulation of DNA replication | |
| positive regulation of glycogen biosynthetic process | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of protein amino acid autophosphorylation | |
| regulation of gene-specific transcription | |
| positive regulation of NF-kappaB transcription factor activity | |
| regulation of phosphorylation | |
| negative regulation of protein kinase activity | |
| activation of protein kinase B activity | |
| positive regulation of cell migration | |
| negative regulation of apoptosis | |
| regulation of apoptosis | |
| alpha-beta T cell activation | |
| glucose metabolic process | |
| ER overload response | |
| insulin receptor signaling pathway | |
| wound healing | |
| negative regulation of acute inflammatory response | |
| acute-phase response | |
| regulation of protein localization | |
| negative regulation of lipid catabolic process | |
| negative regulation of protein catabolic process | |
| positive regulation of respiratory burst | |
| positive regulation of lipid biosynthetic process | |
| positive regulation of glucose import | |
| carbohydrate metabolic process | |
| lipid catabolic process | |
| glucose transport | |
| G-protein coupled receptor protein signaling pathway | |
| fatty acid homeostasis | |
| glucose homeostasis | |
| positive regulation of nitric-oxide synthase activity | |
| negative regulation of NAD(P)H oxidase activity |
| Ariadne Ontology | INS |
|---|
| Group | INS |
|---|---|
| extracellular region | |
| cell death | |
| positive regulation of cell proliferation | |
| respiratory burst | |
| cell-cell signaling | |
| positive regulation of cell differentiation | |
| negative regulation of respiratory burst involved in inflammatory response | |
| positive regulation of vasodilation | |
| negative regulation of vasodilation | |
| positive regulation of cytokine secretion | |
| positive regulation of cell growth | |
| negative regulation of protein secretion | |
| positive regulation of mitosis | |
| positive regulation of phosphoinositide 3-kinase cascade | |
| positive regulation of protein kinase B signaling cascade | |
| positive regulation of MAPKKK cascade | |
| activation of JUN kinase activity | |
| activation of MAPK activity | |
| positive regulation of insulin receptor signaling pathway | |
| regulation of protein secretion | |
| regulation of transmembrane transporter activity | |
| MAPKKK cascade | |
| regulation of cellular amino acid metabolic process | |
| negative regulation of fatty acid metabolic process | |
| positive regulation of cellular protein metabolic process | |
| negative regulation of glycogen catabolic process | |
| positive regulation of glycolysis | |
| negative regulation of gluconeogenesis | |
| negative regulation of proteolysis | |
| negative regulation of transcription from RNA polymerase II promoter | |
| positive regulation of DNA replication | |
| positive regulation of glycogen biosynthetic process | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of protein amino acid autophosphorylation | |
| regulation of gene-specific transcription | |
| positive regulation of NF-kappaB transcription factor activity | |
| regulation of phosphorylation | |
| negative regulation of protein kinase activity | |
| activation of protein kinase B activity | |
| positive regulation of cell migration | |
| negative regulation of apoptosis | |
| regulation of apoptosis | |
| alpha-beta T cell activation | |
| glucose metabolic process | |
| ER overload response | |
| insulin receptor signaling pathway | |
| wound healing | |
| negative regulation of acute inflammatory response | |
| acute-phase response | |
| regulation of protein localization | |
| negative regulation of lipid catabolic process | |
| negative regulation of protein catabolic process | |
| positive regulation of respiratory burst | |
| positive regulation of lipid biosynthetic process | |
| positive regulation of glucose import | |
| carbohydrate metabolic process | |
| lipid catabolic process | |
| glucose transport | |
| G-protein coupled receptor protein signaling pathway | |
| fatty acid homeostasis | |
| glucose homeostasis | |
| positive regulation of nitric-oxide synthase activity | |
| negative regulation of NAD(P)H oxidase activity | |
| protein complex binding | |
| insulin receptor binding | |
| protease binding | |
| insulin-like growth factor receptor binding | |
| hormone activity | |
| extracellular space | |
| soluble fraction | |
| cytoplasm | |
| small nucleolar ribonucleoprotein complex | |
| stored secretory granule | |
| nucleus |
| MedScan ID | 3630 |
|---|
| Hugo ID | 6081 |
|---|
| Human chromosome position | 11p15.5 |
|---|
| LocusLink ID | 3630 |
|---|---|
| 16334 | |
| 24506 | |
| 101480 | |
| 280829 | |
| 30262 | |
| 16333 |
| Alias | ILPR |
|---|---|
| IRDN | |
| IDDM2 | |
| MODY10 | |
| insulin | |
| proinsulin | |
| OTTHUMP00000196036 | |
| OTTHUMP00000196038 | |
| Mody | |
| Ins-2 | |
| InsII | |
| Mody4 | |
| AA986540 | |
| insulin-2 | |
| OTTMUSP00000020351 | |
| OTTMUSP00000020352 | |
| OTTMUSP00000020353 | |
| OTTMUSP00000020355 | |
| OTTMUSP00000020356 | |
| OTTMUSP00000037477 | |
| INS_HUMAN | |
| Ins2 | |
| Ins2-rs I | |
| Ins2-rs1 | |
| insulin 1 | |
| insulin 2 | |
| insulin I | |
| insulin II | |
| insulins | |
| OTTHUMP00000011161 | |
| OTTHUMP00000011162 | |
| expressed sequence AA986540 | |
| proinsulin precursor | |
| insulin precursor | |
| Ins1 | |
| Ins-1 | |
| CH211-139A5.9 | |
| chromosome | |
| ins | |
| insa | |
| preproinsulin | |
| scaffold | |
| zgc:109842 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio | |
| Human |
| OMIM ID | 176730 |
|---|---|
| 125852 | |
| 606176 | |
| 147510 | |
| 613370 | |
| 125850 | |
| OMIM:176730 | |
| OMIM:125850 |
| Mouse chromosome position | 7 69.1 cM |
|---|
| GO ID | 0005179 |
|---|---|
| 0005158 | |
| 0005159 | |
| 0007186 | |
| 0000165 | |
| 0032148 | |
| 0006953 | |
| 0046631 | |
| 0005975 | |
| 0007267 | |
| 0055089 | |
| 0042593 | |
| 0006006 | |
| 0015758 | |
| 0033861 | |
| 0002674 | |
| 0043066 | |
| 0045922 | |
| 0045721 | |
| 0045818 | |
| 0050995 | |
| 0042177 | |
| 0050709 | |
| 0045861 | |
| 0060266 | |
| 0045908 | |
| 0045740 | |
| 0043410 | |
| 0051092 | |
| 0045597 | |
| 0030307 | |
| 0030335 | |
| 0008284 | |
| 0032270 | |
| 0050715 | |
| 0046326 | |
| 0045725 | |
| 0045821 | |
| 0046628 | |
| 0046889 | |
| 0045840 | |
| 0045429 | |
| 0051000 | |
| 0050731 | |
| 0014068 | |
| 0031954 | |
| 0051897 | |
| 0060267 | |
| 0045909 | |
| 0006521 | |
| 0032583 | |
| 0032880 | |
| 0050708 | |
| 0022898 | |
| 0042060 | |
| 0005576 | |
| 0005615 | |
| 0002020 | |
| 0032403 | |
| 0006983 | |
| 0007257 | |
| 0000187 | |
| 0008286 | |
| 0016042 | |
| 0000122 | |
| 0042981 | |
| 0042325 | |
| 0005737 | |
| 0005634 | |
| 0005732 | |
| 0005625 | |
| 0030141 | |
| 0008219 | |
| 0006469 | |
| 0045730 | |
| 0005520 | |
| 0005515 | |
| 0014065 | |
| 0070201 | |
| 0005813 | |
| 0007166 | |
| 0006091 | |
| 0003674 | |
| 0008150 | |
| 0005575 | |
| 0007582 | |
| 0005786 | |
| 0009968 | |
| 0032114 | |
| 0006629 |
| Rat chromosome position | 1q41 |
|---|
| Swiss-Prot Accession | P01308 |
|---|---|
| P01326 | |
| Q5EEX1 | |
| P01323 | |
| Q5EEX2 |
| PIR ID | A93222 |
|---|---|
| A26342 | |
| B90789 |
| Unigene ID | Hs.272259 |
|---|---|
| Mm.4946 | |
| Rn.989 | |
| Hs.523414 | |
| Hs.89832 | |
| Bt.453 | |
| Dr.75811 | |
| Hs.654579 | |
| Mm.46269 |
| KEGG ID | hsa:3630 |
|---|---|
| mmu:16334 | |
| rno:24506 |
| Swiss-Prot ID | INS_HUMAN |
|---|---|
| INS2_MOUSE | |
| INS2_RAT | |
| Q5EEX1_MOUSE |
| Cell Localization | Secreted |
|---|---|
| Extracellular |
| IPI ID | IPI00001508 |
|---|---|
| IPI00134311 | |
| IPI00212593 | |
| IPI00853573 | |
| IPI00853225 | |
| IPI00894133 | |
| IPI00831556 | |
| IPI00831448 | |
| IPI00881334 |
| Homologene ID | 173 |
|---|
| RGD ID | 2916 |
|---|
| MGI ID | 96573 |
|---|---|
| 2141856 |
| Microarray ID | 100150_f_at |
|---|---|
| 161849_r_at | |
| 1370077_at | |
| rc_AA852056_at | |
| rc_AI014020_f_at | |
| j04807mrna_f_at | |
| 1422446_x_at | |
| 98271_f_at | |
| Msa.2391.0_at | |
| X04724_s_at | |
| A_51_P389597 | |
| NM_008387 | |
| J00268 | |
| L15440 | |
| 206598_at | |
| 225312_at | |
| 65808_at | |
| AA203738_at | |
| C06270_at | |
| V00565_s_at | |
| 160038_s_at | |
| j00268_s_at | |
| L15440_at | |
| 1429_AT | |
| A_32_P916628 | |
| I_3244259 | |
| A_23_P1981 | |
| I_931130 | |
| 165489_f_at | |
| 131499_f_at | |
| 97658_f_at | |
| 97659_r_at | |
| Msa.2390.0_at | |
| 1387815_at | |
| M25584_at | |
| rc_C07167_f_at | |
| C07167_at | |
| 1422447_at | |
| A_52_P407060 | |
| A_14_P111696 |
| FunctionalClass | hormone |
|---|---|
| insulin receptor binding | |
| insulin-like growth factor binding | |
| protein binding | |
| molecular_function | |
| protease binding |
| Mus musculus Chromosome position | 7 69.1 cM |
|---|---|
| 7 |
| Source | Curated |
|---|---|
| GO component | |
| ResNet |
| KEGG pathway | Insulin signaling pathway |
|---|---|
| Type II diabetes mellitus | |
| Type I diabetes mellitus | |
| Dentatorubropallidoluysian atrophy (DRPLA) | |
| Regulation of actin cytoskeleton | |
| Maturity onset diabetes of the young | |
| Regulation of autophagy | |
| mTOR signaling pathway | |
| Prostate cancer |
| Homo sapiens Chromosome position | 11p15.5 |
|---|
| Bos taurus Chromosome position | 29 |
|---|
| LocatorString | pmquery:egfr+transactivation |
|---|
| Rattus norvegicus Chromosome position | 1q41 |
|---|
| Keyword | HDL |
|---|---|
| protein serine/threonine kinase | |
| granule | |
| hormone | |
| growth factor | |
| sh-2 domain | |
| Glycogen synthase | |
| tyrosine kinase receptor | |
| 6-phosphofructo-2-kinase | |
| 2.7.1.112 | |
| microsome | |
| receptor protein tyrosine kinase | |
| desmoplakin | |
| peptide hormone | |
| cyclase | |
| toxin | |
| [glycogen-synthase-D] phosphatase | |
| golgi apparatus | |
| glycogen synthase | |
| amylase | |
| alkaline phosphatase | |
| insulin family | |
| casein kinase I | |
| synthase | |
| ectoprotein kinase | |
| acute phase | |
| cyclase activity | |
| insulin-like growth factor | |
| apolipoprotein | |
| anti-antioxidant | |
| vasodilator | |
| secretory granule | |
| RNA | |
| Golgi | |
| ATPase | |
| DNA binding activity | |
| antioxidant |