| URN | urn:agi-llid:2888 |
|---|---|
| Connectivity | 47 |
| Name | Grb14 |
| Description | growth factor receptor bound protein 14 |
| Notes | member of the Grb7 subfamily of adapters; functions as inhibitor in insulin-mediated pathways [RGD] |
| Pathway | insulin signaling pathway |
|---|---|
| insulin signaling pathway | |
| altered insulin signaling pathway | |
| insulin signaling pathway |
| GO Molecular Function | phosphoprotein binding |
|---|---|
| SH3-SH2 adaptor activity | |
| insulin receptor binding | |
| receptor activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| cytoplasm | |
| endosome | |
| Golgi apparatus | |
| endosome membrane | |
| Golgi membrane | |
| microsome |
| GO Biological Process | signal transduction |
|---|---|
| negative regulation of insulin receptor signaling pathway | |
| intracellular signaling pathway |
| Group | signal transduction |
|---|---|
| negative regulation of insulin receptor signaling pathway | |
| intracellular signaling pathway | |
| phosphoprotein binding | |
| SH3-SH2 adaptor activity | |
| insulin receptor binding | |
| receptor activity | |
| membrane | |
| plasma membrane | |
| cytoplasm | |
| endosome | |
| Golgi apparatus | |
| endosome membrane | |
| Golgi membrane | |
| microsome |
| MedScan ID | 2888 |
|---|
| Hugo ID | 4565 |
|---|
| Human chromosome position | 2q22-q24 |
|---|
| LocusLink ID | 2888 |
|---|---|
| 50915 | |
| 58844 | |
| 99012 | |
| 360361 | |
| 497029 |
| Alias | growth factor receptor-bound protein 14 |
|---|---|
| OTTHUMP00000204702 | |
| GRB14 adapter protein | |
| AI505286 | |
| RP23-308K19.2 | |
| OTTMUSP00000013796 | |
| Grb14 | |
| growth factor receptor bound protein 14 | |
| LOC360361 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Human |
| OMIM ID | 601524 |
|---|---|
| OMIM:601524 |
| Mouse chromosome position | 2 |
|---|---|
| 2 C1.3 |
| GO ID | 0005070 |
|---|---|
| 0005158 | |
| 0051219 | |
| 0046627 | |
| 0007165 | |
| 0005794 | |
| 0000139 | |
| 0005737 | |
| 0005768 | |
| 0010008 | |
| 0005792 | |
| 0005886 | |
| 0004872 | |
| 0016020 | |
| 0023034 | |
| 0007242 | |
| 0005515 | |
| 0007218 |
| Rat chromosome position | 3q21 |
|---|
| Swiss-Prot Accession | Q14449 |
|---|---|
| Q53QM9 | |
| Q53QQ0 | |
| A2ASX2 | |
| Q9JLM9 | |
| O88900 | |
| Q3UI77 | |
| Q8VDI2 | |
| Q9CR03 | |
| Q7Z6I1 |
| Unigene ID | Hs.411881 |
|---|---|
| Mm.214554 | |
| Rn.30028 |
| KEGG ID | hsa:2888 |
|---|---|
| mmu:50915 | |
| rno:58844 |
| Swiss-Prot ID | GRB14_MOUSE |
|---|---|
| GRB14_RAT | |
| GRB14_HUMAN | |
| A2ASX2_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Golgi apparatus membrane | |
| Endosome membrane | |
| Plasma membrane |
| IPI ID | IPI00124500 |
|---|---|
| IPI00214149 | |
| IPI00030917 | |
| IPI00755884 | |
| IPI00752105 | |
| IPI00752387 | |
| IPI00564045 |
| Homologene ID | 3303 |
|---|
| RGD ID | 61869 |
|---|
| MGI ID | 1355324 |
|---|---|
| 2138995 |
| Microarray ID | 1368618_at |
|---|---|
| af076619_at | |
| 114784_at | |
| 135440_f_at | |
| 1417673_at | |
| A_51_P517216 | |
| A_51_P517215 | |
| 40683_at | |
| 206204_at | |
| L76687_at | |
| RC_AA398124_s_at | |
| A_23_P154526 | |
| A_14_P113828 | |
| A_14_P109275 | |
| A_14_P112100 | |
| A_14_P115686 | |
| A_14_P117935 |
| FunctionalClass | SH3/SH2 adaptor |
|---|---|
| insulin receptor binding | |
| receptor |
| Mus musculus Chromosome position | 2 C1.3 |
|---|---|
| 2 |
| Source | Curated |
|---|
| Homo sapiens Chromosome position | 2q22-q24 |
|---|
| Bos taurus Chromosome position | 2 |
|---|
| Rattus norvegicus Chromosome position | 3q21 |
|---|