| URN | urn:agi-llid:5792 |
|---|---|
| Connectivity | 79 |
| Name | Ptprf |
| Description | protein tyrosine phosphatase, receptor type, F |
| Notes | 11 kDa ectodomain isoform of the LAR protein tyrosine phosphatase receptor family; may play a role in homophilic cell adhesion and neurite outgrowth [RGD] |
| Pathway | PTPRF -> CTNNB signaling |
|---|---|
| insulin signaling pathway | |
| insulin signaling pathway | |
| altered insulin signaling pathway | |
| insulin signaling pathway |
| GO Molecular Function | hydrolase activity |
|---|---|
| insulin receptor binding | |
| receptor tyrosine kinase binding | |
| phosphate binding | |
| phosphatase activity | |
| phosphoprotein phosphatase activity | |
| protein tyrosine phosphatase activity | |
| transmembrane receptor protein tyrosine phosphatase activity | |
| receptor activity |
| GO Cellular Component | membrane |
|---|---|
| excitatory synapse | |
| insoluble fraction | |
| plasma membrane | |
| neuron projection | |
| neuronal cell body | |
| growth cone | |
| endosome | |
| membrane fraction | |
| microsome | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | cell adhesion |
|---|---|
| negative regulation of cell proliferation | |
| nervous system development | |
| positive regulation of dendrite morphogenesis | |
| negative regulation of cell projection organization | |
| negative regulation of cytokine-mediated signaling pathway | |
| negative regulation of insulin receptor signaling pathway | |
| negative regulation of nerve growth factor receptor signaling pathway | |
| negative regulation of epidermal growth factor receptor signaling pathway | |
| positive regulation of apoptosis | |
| positive regulation of neuron apoptosis | |
| homophilic cell adhesion | |
| protein amino acid dephosphorylation | |
| dephosphorylation | |
| transmembrane receptor protein tyrosine phosphatase signaling pathway | |
| regulation of synapse structure and activity |
| Ariadne Ontology | Phosphatases |
|---|---|
| INSR phosphatase |
| Group | Phosphatases |
|---|---|
| INSR phosphatase | |
| cell adhesion | |
| negative regulation of cell proliferation | |
| nervous system development | |
| positive regulation of dendrite morphogenesis | |
| negative regulation of cell projection organization | |
| negative regulation of cytokine-mediated signaling pathway | |
| negative regulation of insulin receptor signaling pathway | |
| negative regulation of nerve growth factor receptor signaling pathway | |
| negative regulation of epidermal growth factor receptor signaling pathway | |
| positive regulation of apoptosis | |
| positive regulation of neuron apoptosis | |
| homophilic cell adhesion | |
| protein amino acid dephosphorylation | |
| dephosphorylation | |
| transmembrane receptor protein tyrosine phosphatase signaling pathway | |
| regulation of synapse structure and activity | |
| hydrolase activity | |
| insulin receptor binding | |
| receptor tyrosine kinase binding | |
| phosphate binding | |
| phosphatase activity | |
| phosphoprotein phosphatase activity | |
| protein tyrosine phosphatase activity | |
| transmembrane receptor protein tyrosine phosphatase activity | |
| receptor activity | |
| membrane | |
| excitatory synapse | |
| insoluble fraction | |
| plasma membrane | |
| neuron projection | |
| neuronal cell body | |
| growth cone | |
| endosome | |
| membrane fraction | |
| microsome | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 5792 |
|---|
| Hugo ID | 9670 |
|---|
| Human chromosome position | 1p34 |
|---|
| LocusLink ID | 5792 |
|---|---|
| 19268 | |
| 360406 | |
| 100011 | |
| 29615 | |
| 512072 | |
| 799867 |
| Alias | LAR |
|---|---|
| FLJ43335 | |
| FLJ45062 | |
| FLJ45567 | |
| receptor-type tyrosine-protein phosphatase F | |
| LCA-homolog | |
| OTTHUMP00000008683 | |
| OTTHUMP00000008684 | |
| OTTHUMP00000008687 | |
| OTTHUMP00000008688 | |
| OTTHUMP00000192913 | |
| OTTHUMP00000192914 | |
| leukocyte common antigen related | |
| leukocyte antigen-related (LAR) PTP receptor | |
| leukocyte antigen-related tyrosine phosphatase | |
| receptor-linked protein-tyrosine phosphatase LAR | |
| protein tyrosine phosphatase, receptor type, F polypeptide | |
| LARS | |
| AA591035 | |
| RPTP-LAR | |
| RP23-94L18.2 | |
| OTTMUSP00000009082 | |
| OTTMUSP00000009083 | |
| OTTMUSP00000009084 | |
| LARFN5C | |
| protein tyrosine phosphatase receptor-type F | |
| LAR phosphatase | |
| LAR protein precursor | |
| LAR-PTP | |
| Leukocyte antigen related | |
| leukocyte antigen-related (LAR) PTP receptors | |
| leukocyte common antigen-related | |
| phosphatase LAR | |
| protein tyrosine phosphatase, receptor type, F | |
| PTPRF | |
| tyrosine phosphatase LAR | |
| LOC799867 | |
| DKEY-21K10.1 | |
| F | |
| F (PTPRF) | |
| MGC154028 | |
| chromosome | |
| novel protein similar to vertebrate protein tyrosine phosphatase | |
| receptor type | |
| scaffold | |
| si:dkey-21k10.1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 179590 |
|---|
| Mouse chromosome position | 4 |
|---|---|
| 4 C6-D1 |
| GO ID | 0016787 |
|---|---|
| 0005158 | |
| 0042301 | |
| 0004725 | |
| 0004872 | |
| 0030971 | |
| 0005001 | |
| 0007155 | |
| 0007156 | |
| 0031345 | |
| 0008285 | |
| 0001960 | |
| 0042059 | |
| 0046627 | |
| 0051387 | |
| 0007399 | |
| 0050775 | |
| 0043525 | |
| 0006470 | |
| 0050803 | |
| 0007185 | |
| 0005768 | |
| 0060076 | |
| 0030426 | |
| 0005887 | |
| 0005624 | |
| 0005792 | |
| 0043025 | |
| 0005886 | |
| 0016791 | |
| 0004721 | |
| 0016311 | |
| 0043065 | |
| 0005626 | |
| 0016021 | |
| 0016020 | |
| 0043005 | |
| 0005515 | |
| 0004727 | |
| 0005615 |
| Rat chromosome position | 5q36 |
|---|
| Swiss-Prot Accession | P10586 |
|---|---|
| Q308M3 | |
| Q59FI2 | |
| Q5W9G3 | |
| Q7Z3X4 | |
| A2A8L5 | |
| Q3V0J9 | |
| Q3TT24 | |
| Q4JFB8 | |
| Q4U1Z0 | |
| Q64696 | |
| Q64604 | |
| Q4JFC5 | |
| Q4JFC6 | |
| Q62917 | |
| Q6PG86 | |
| Q9EQ17 | |
| Q5T021 | |
| Q5T022 | |
| Q5W9G2 | |
| Q86WS0 | |
| Q4JFJ1 | |
| Q63294 | |
| Q63295 | |
| Q63296 | |
| D3DPX7 | |
| D3DPX6 | |
| Q6PJS2 | |
| Q86XY3 |
| PIR ID | S03841 |
|---|---|
| S46216 |
| Unigene ID | Hs.272062 |
|---|---|
| Mm.29855 | |
| Rn.11386 | |
| Bt.5379 | |
| Dr.110644 |
| KEGG ID | hsa:5792 |
|---|---|
| mmu:19268 | |
| rno:360406 |
| EC Number | 3.1.3.48 |
|---|
| Swiss-Prot ID | PTPRF_MOUSE |
|---|---|
| PTPRF_HUMAN | |
| PTPRF_RAT | |
| D3DPX7_HUMAN | |
| Q3V0J9_MOUSE | |
| D3DPX6_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Cytoplasm | |
| Plasma membrane |
| IPI ID | IPI00110264 |
|---|---|
| IPI00107831 | |
| IPI00465186 | |
| IPI00231988 | |
| IPI00647973 | |
| IPI00853550 | |
| IPI00853169 | |
| IPI00642154 | |
| IPI00871665 | |
| IPI00384626 | |
| IPI00641061 | |
| IPI00480183 | |
| IPI00655814 | |
| IPI00648298 | |
| IPI00647979 |
| Homologene ID | 20623 |
|---|
| RGD ID | 3453 |
|---|
| MGI ID | 102695 |
|---|---|
| 2140169 |
| Microarray ID | 96272_at |
|---|---|
| 200636_s_at | |
| 1420841_at | |
| 1420842_at |
| FunctionalClass | hydrolase |
|---|---|
| protein binding | |
| protein tyrosine phosphatase | |
| receptor | |
| transmembrane receptor protein tyrosine phosphatase | |
| phosphoprotein phosphatase | |
| prenylated protein tyrosine phosphatase | |
| phosphoric monoester hydrolase |
| Mus musculus Chromosome position | 4 C6-D1 |
|---|---|
| 4 |
| Source | Curated |
|---|---|
| GO component |
| KEGG pathway | Adherens junction |
|---|---|
| Cell adhesion molecules (CAMs) | |
| Insulin signaling pathway |
| Homo sapiens Chromosome position | 1p34 |
|---|
| Bos taurus Chromosome position | 3 |
|---|
| Rattus norvegicus Chromosome position | 1q22 |
|---|---|
| 5q36 |