| URN | urn:agi-llid:10603 |
|---|---|
| Connectivity | 105 |
| Name | Sh2b2 |
| Description | SH2B adaptor protein 2 |
| Notes | plays a role in Trk mediated signalling during neurogenesis [RGD] |
| Pathway | InsulinR -> STAT signaling |
|---|---|
| insulin signaling pathway | |
| altered insulin signaling pathway | |
| insulin signaling pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| JAK pathway signal transduction adaptor activity | |
| transmembrane receptor protein tyrosine kinase adaptor protein activity | |
| SH3-SH2 adaptor activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| ruffle | |
| cytoplasm | |
| actin filament | |
| stress fiber |
| GO Biological Process | regulation of metabolic process |
|---|---|
| nervous system development | |
| brown fat cell differentiation | |
| signal transduction | |
| actin cytoskeleton organization | |
| regulation of Ras protein signal transduction | |
| insulin receptor signaling pathway | |
| regulation of immune response | |
| B-1 B cell homeostasis | |
| antigen receptor-mediated signaling pathway | |
| cytokine-mediated signaling pathway | |
| negative regulation of glucose import | |
| intracellular signaling pathway | |
| glucose homeostasis |
| Ariadne Ontology | Actin-based cytoskeleton assembly |
|---|
| Group | Actin-based cytoskeleton assembly |
|---|---|
| regulation of metabolic process | |
| nervous system development | |
| brown fat cell differentiation | |
| signal transduction | |
| actin cytoskeleton organization | |
| regulation of Ras protein signal transduction | |
| insulin receptor signaling pathway | |
| regulation of immune response | |
| B-1 B cell homeostasis | |
| antigen receptor-mediated signaling pathway | |
| cytokine-mediated signaling pathway | |
| negative regulation of glucose import | |
| intracellular signaling pathway | |
| glucose homeostasis | |
| signal transducer activity | |
| JAK pathway signal transduction adaptor activity | |
| transmembrane receptor protein tyrosine kinase adaptor protein activity | |
| SH3-SH2 adaptor activity | |
| membrane | |
| plasma membrane | |
| ruffle | |
| cytoplasm | |
| actin filament | |
| stress fiber |
| MedScan ID | 10603 |
|---|
| Hugo ID | 17381 |
|---|
| Human chromosome position | 7q22 |
|---|
| LocusLink ID | 10603 |
|---|---|
| 23921 | |
| 114203 |
| Alias | APS |
|---|---|
| SH2B adapter protein 2 | |
| SH2 and PH domain-containing adapter protein APS | |
| adapter protein with pleckstrin homology and Src homology 2 domains | |
| adaptor protein with pleckstrin homology and src homology 2 domains | |
| insulin receptor substrate 5 | |
| adapter containing Pleckstrin homology (PH) Src homology-2 (SH2) domains | |
| adapter molecule containing PH and SH2 domains | |
| adapter protein with pleckstrin homology and src | |
| adaptor containing Pleckstrin homology (PH) Src homology-2 (SH2) domains | |
| adaptor molecule containing PH and SH2 domains | |
| adaptor protein with pleckstrin homology and src | |
| APS adapter containing Pleckstrin homology PH Src homology-2 (SH2) domains | |
| APS adapter molecule containing PH and SH2 domains | |
| APS adaptor containing Pleckstrin homology PH Src homology-2 (SH2) domains | |
| APS adaptor molecule containing PH and SH2 domains | |
| INS receptor substrate 5 | |
| INS receptor substrate V | |
| insulin receptor substrate V | |
| Irs5 | |
| SH2B adaptor protein 2 | |
| SH2B2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605300 |
|---|
| Mouse chromosome position | 5 |
|---|---|
| 5 G1 |
| GO ID | 0008269 |
|---|---|
| 0005070 | |
| 0005068 | |
| 0001922 | |
| 0030036 | |
| 0050851 | |
| 0050873 | |
| 0019221 | |
| 0008286 | |
| 0023034 | |
| 0007399 | |
| 0046578 | |
| 0050776 | |
| 0019222 | |
| 0007165 | |
| 0005884 | |
| 0005737 | |
| 0005886 | |
| 0001726 | |
| 0001725 | |
| 0004871 | |
| 0042593 | |
| 0046325 | |
| 0016020 | |
| 0007242 | |
| 0005515 | |
| 0019735 |
| Rat chromosome position | 12q12 |
|---|
| Swiss-Prot Accession | O14492 |
|---|---|
| Q6PG00 | |
| Q9JID9 | |
| Q9Z200 | |
| A6ND74 |
| Unigene ID | Hs.489448 |
|---|---|
| Mm.425294 | |
| Rn.163202 |
| KEGG ID | hsa:10603 |
|---|---|
| mmu:23921 | |
| rno:114203 |
| Swiss-Prot ID | SH2B2_HUMAN |
|---|---|
| SH2B2_RAT | |
| Q6PG00_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Cell membrane | |
| Membrane | |
| Plasma membrane |
| IPI ID | IPI00155706 |
|---|---|
| IPI00194572 | |
| IPI00876236 | |
| IPI00879791 | |
| IPI00120433 |
| Homologene ID | 10309 |
|---|
| RGD ID | 69284 |
|---|
| MGI ID | 1345171 |
|---|