| URN | urn:agi-llid:2885 |
|---|---|
| Connectivity | 470 |
| Name | Grb2 |
| Description | growth factor receptor bound protein 2 |
| Notes | acts as a link between tyrosine kinase receptors and Ras signaling [RGD] |
| Pathway | FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling |
|---|---|
| PDGFR -> AP-1/MYC signaling | |
| VEGFR -> AP-1/CREB/MYC signaling | |
| HGFR -> AP-1/CREB/MYC signaling | |
| ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> NCOR2 signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| GDNF -> HSF1 signaling | |
| InsulinR -> ELK-SRF/SREBF signaling | |
| IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling | |
| SELE -> ELK-SRF signaling | |
| NCAM1 -> CREB/ELK-SRF/MYC signaling | |
| PECAM -> SP1 signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| ThrombopoietinR -> SPI1 signaling | |
| ThrombopoietinR -> SP1 signaling | |
| ErythropoietinR -> ELK-SRF/FOS signaling | |
| LeptinR -> ELK-SRF signaling | |
| GHR -> ELK-SRF/MYC signaling | |
| EGFR -> SMAD1 signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| ERBB2/3 -> EP300/ETS/ETV/SP1 signaling | |
| EGFR/ERBB2 -> HIF1A signaling | |
| EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| FGFR -> RUNX2 signaling | |
| KIT -> MITF signaling | |
| VEGFR -> NFATC signaling | |
| VEGFR -> ATF/CREB/ELK-SRF signaling | |
| IL2R -> ELK-SRF/MYC signaling | |
| IL4R -> ELK-SRF/HMGY signaling | |
| IL6R -> CEBP/ELK-SRF signaling | |
| TNFRSF1A -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> CREB/ELK-SRF signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| ThrombinR -> NF-kB signaling | |
| CholinergicRm -> CREB/ELK-SRF signaling | |
| DopamineR2 -> AP-1/CREB/ELK-SRF signaling | |
| DopamineR2 -> NF-kB signaling | |
| EDG2 -> ELK-SRF signaling | |
| AdrenergicRa -> ELK-SRF signaling | |
| AdrenergicRa -> STAT3 signaling | |
| GRM1/5 -> CREB signaling | |
| NeurotensinR -> ELK-SRF/AP-1/EGR signaling | |
| VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling | |
| AngiotensinR -> CREB/ELK-SRF/TP53 signaling | |
| VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling | |
| FcIgER -> ELK-SRF signaling | |
| T-cell receptor -> AP-1 signaling | |
| PTPRC -> BCL6 signaling | |
| UrokinaseR -> ELK-SRF signaling | |
| CholinergicRn -> CREB signaling | |
| insulin signaling pathway | |
| scatter factor-hepatocyte growth factor signaling pathway | |
| insulin signaling pathway | |
| altered insulin signaling pathway | |
| epidermal growth factor/neuregulin signaling pathway | |
| New Pathway (1) | |
| epidermal growth factor-neuregulin signaling pathway | |
| interleukin 6 signaling pathway | |
| Interleukin-6 signaling pathway | |
| insulin signaling pathway |
| GO Molecular Function | phosphoprotein binding |
|---|---|
| protein domain specific binding | |
| insulin receptor substrate binding | |
| SH3-SH2 adaptor activity | |
| epidermal growth factor receptor binding | |
| phosphotyrosine binding | |
| receptor activity |
| GO Cellular Component | protein complex |
|---|---|
| membrane | |
| cytoplasm | |
| cytosol | |
| Golgi apparatus | |
| vesicle membrane |
| GO Biological Process | anatomical structure formation involved in morphogenesis |
|---|---|
| aging | |
| interspecies interaction between organisms | |
| cell-cell signaling | |
| cell differentiation | |
| branching involved in embryonic placenta morphogenesis | |
| regulation of MAPKKK cascade | |
| Ras protein signal transduction | |
| receptor internalization | |
| insulin receptor signaling pathway | |
| protein heterooligomerization | |
| epidermal growth factor receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway |
| Ariadne Ontology | Grb |
|---|
| Group | Grb |
|---|---|
| anatomical structure formation involved in morphogenesis | |
| aging | |
| interspecies interaction between organisms | |
| cell-cell signaling | |
| cell differentiation | |
| branching involved in embryonic placenta morphogenesis | |
| regulation of MAPKKK cascade | |
| Ras protein signal transduction | |
| receptor internalization | |
| insulin receptor signaling pathway | |
| protein heterooligomerization | |
| epidermal growth factor receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| phosphoprotein binding | |
| protein domain specific binding | |
| insulin receptor substrate binding | |
| SH3-SH2 adaptor activity | |
| epidermal growth factor receptor binding | |
| phosphotyrosine binding | |
| receptor activity | |
| protein complex | |
| membrane | |
| cytoplasm | |
| cytosol | |
| Golgi apparatus | |
| vesicle membrane |
| MedScan ID | 2885 |
|---|
| Hugo ID | 4566 |
|---|
| Human chromosome position | 17q24-q25 |
|---|
| LocusLink ID | 2885 |
|---|---|
| 14784 | |
| 81504 | |
| 80299 | |
| 103536 | |
| 80715 | |
| 281211 | |
| 535298 | |
| 406308 | |
| 321539 | |
| 321785 |
| Alias | ASH |
|---|---|
| Grb3-3 | |
| MST084 | |
| NCKAP2 | |
| MSTP084 | |
| EGFRBP-GRB2 | |
| growth factor receptor-bound protein 2 | |
| HT027 | |
| protein Ash | |
| OTTHUMP00000166097 | |
| OTTHUMP00000166098 | |
| SH2/SH3 adapter GRB2 | |
| adapter protein GRB2 | |
| abundant SRC homology | |
| growth factor receptor-bound protein 3 | |
| epidermal growth factor receptor-binding protein GRB2 | |
| AA408164 | |
| RP23-28I4.1 | |
| OTTMUSP00000003660 | |
| OTTMUSP00000003661 | |
| OTTMUSP00000003662 | |
| OTTMUSP00000003663 | |
| MGC108668 | |
| FLJ20886 | |
| Grb2 | |
| GRB2 adapter protein | |
| GRB2_HUMAN | |
| Grb3 III | |
| growth factor receptor bound protein 2 | |
| Growth factor receptor-bound protein II | |
| HT(027) | |
| OTTHUMP00000166096 | |
| SH2/SH3 adapter GRB2 | |
| Grb3-3s | |
| hypothetical protein FLJ20886 | |
| HT 027 | |
| HT-027 | |
| fb18e12 | |
| wu:fb18e12 | |
| fb34e06 | |
| wu:fb34e06 | |
| chromosome | |
| scaffold | |
| zgc:73077 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 108355 |
|---|
| Mouse chromosome position | 11 75.0 cM |
|---|
| GO ID | 0005070 |
|---|---|
| 0005154 | |
| 0043560 | |
| 0051219 | |
| 0001784 | |
| 0019904 | |
| 0007265 | |
| 0007568 | |
| 0048646 | |
| 0060670 | |
| 0030154 | |
| 0007267 | |
| 0007173 | |
| 0008543 | |
| 0008286 | |
| 0044419 | |
| 0051291 | |
| 0031623 | |
| 0043408 | |
| 0005794 | |
| 0005737 | |
| 0005829 | |
| 0016020 | |
| 0043234 | |
| 0012506 | |
| 0004872 | |
| 0005515 | |
| 0000165 | |
| 0007242 |
| Rat chromosome position | 10q32.3 |
|---|
| Swiss-Prot Accession | B0LPF3 |
|---|---|
| P62993 | |
| Q6ICN0 | |
| Q3U5I5 | |
| Q60631 | |
| Q3U1Q4 | |
| P62994 | |
| Q63058 | |
| P29354 | |
| Q14450 | |
| Q63057 | |
| Q63059 | |
| Q5BKA7 | |
| Q61240 | |
| Q7Z4F5 | |
| Q9H2Q4 | |
| Q9H7G8 | |
| Q9HAU2 |
| PIR ID | A43321 |
|---|---|
| S26050 | |
| A54688 |
| Unigene ID | Hs.444356 |
|---|---|
| Mm.439649 | |
| Rn.3360 | |
| Hs.708119 | |
| Mm.6900 | |
| Hs.633064 | |
| Rn.163461 | |
| Mm.383426 | |
| Hs.651330 | |
| Bt.8815 | |
| Dr.114331 | |
| Dr.74564 | |
| Hs.699367 |
| KEGG ID | hsa:2885 |
|---|---|
| mmu:14784 | |
| rno:81504 |
| Swiss-Prot ID | GRB2_HUMAN |
|---|---|
| GRB2_RAT | |
| GRB2_MOUSE | |
| B0LPF3_HUMAN | |
| Q3U5I5_MOUSE |
| Cell Localization | Golgi apparatus |
|---|---|
| Cytoplasm |
| IPI ID | IPI00021327 |
|---|---|
| IPI00218070 | |
| IPI00203630 | |
| IPI00231574 | |
| IPI00382077 | |
| IPI00119058 | |
| IPI00230539 | |
| IPI00018782 | |
| IPI00790124 | |
| IPI00792746 | |
| IPI00648993 | |
| IPI00649256 | |
| IPI00204921 | |
| IPI00567134 |
| Homologene ID | 1576 |
|---|
| RGD ID | 619758 |
|---|
| MGI ID | 95805 |
|---|---|
| 2143976 |
| Microarray ID | 101034_at |
|---|
| FunctionalClass | SH3/SH2 adaptor |
|---|---|
| epidermal growth factor receptor binding | |
| insulin receptor substrate binding | |
| protein binding | |
| receptor | |
| phosphotyrosine binding | |
| phosphoprotein binding |
| Mus musculus Chromosome position | 11 75.0 cM |
|---|---|
| 11 |
| Source | Curated |
|---|---|
| ResNet | |
| GO component |
| KEGG pathway | Chronic myeloid leukemia |
|---|---|
| Colorectal cancer | |
| Dorso-ventral axis formation | |
| Endometrial cancer | |
| ErbB signaling pathway | |
| Fc epsilon RI signaling pathway | |
| Focal adhesion | |
| Gap junction | |
| Glioma | |
| GnRH signaling pathway | |
| Huntington's disease | |
| Insulin signaling pathway | |
| Jak-STAT signaling pathway | |
| MAPK signaling pathway | |
| Natural killer cell mediated cytotoxicity | |
| Neurodegenerative Disorders | |
| Non-small cell lung cancer | |
| Renal cell carcinoma | |
| T cell receptor signaling pathway |
| Homo sapiens Chromosome position | 17q24-q25 |
|---|---|
| 17q25.3 |
| Bos taurus Chromosome position | 19 |
|---|
| Danio rerio Chromosome position | LG 3 |
|---|
| Rattus norvegicus Chromosome position | 10q32.3 |
|---|