| URN | urn:agi-llid:5167 |
|---|---|
| Connectivity | 64 |
| Name | Enpp1 |
| Description | ectonucleotide pyrophosphatase/phosphodiesterase 1 |
| Notes | mutation of the human homolog is detected in patients with idiopathic infantile arterial calcification [RGD] |
| Pathway | insulin signaling pathway |
|---|---|
| insulin signaling pathway | |
| altered insulin signaling pathway | |
| insulin signaling pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| nucleic acid binding | |
| hydrolase activity | |
| polysaccharide binding | |
| protein homodimerization activity | |
| insulin receptor binding | |
| 3'-phosphoadenosine 5'-phosphosulfate binding | |
| ATP binding | |
| metal ion binding | |
| phosphodiesterase I activity | |
| nucleotide diphosphatase activity | |
| nucleoside-triphosphate diphosphatase activity | |
| scavenger receptor activity |
| GO Cellular Component | cell surface |
|---|---|
| membrane | |
| extracellular space | |
| plasma membrane | |
| basolateral plasma membrane | |
| integral to membrane |
| GO Biological Process | metabolic process |
|---|---|
| immune response | |
| negative regulation of ossification | |
| regulation of bone mineralization | |
| biomineral formation | |
| negative regulation of fat cell differentiation | |
| bone remodeling | |
| negative regulation of cell growth | |
| generation of precursor metabolites and energy | |
| negative regulation of insulin receptor signaling pathway | |
| negative regulation of glycogen biosynthetic process | |
| negative regulation of protein amino acid autophosphorylation | |
| phosphate metabolic process | |
| 3'-phosphoadenosine 5'-phosphosulfate metabolic process | |
| nucleoside triphosphate catabolic process | |
| cellular phosphate ion homeostasis | |
| cellular response to insulin stimulus | |
| negative regulation of glucose import | |
| inorganic diphosphate transport | |
| sequestering of triglyceride |
| Ariadne Ontology | Glucose metabolism |
|---|
| Group | Glucose metabolism |
|---|---|
| catalytic activity | |
| metabolic process | |
| immune response | |
| negative regulation of ossification | |
| regulation of bone mineralization | |
| biomineral formation | |
| negative regulation of fat cell differentiation | |
| bone remodeling | |
| negative regulation of cell growth | |
| generation of precursor metabolites and energy | |
| negative regulation of insulin receptor signaling pathway | |
| negative regulation of glycogen biosynthetic process | |
| negative regulation of protein amino acid autophosphorylation | |
| phosphate metabolic process | |
| 3'-phosphoadenosine 5'-phosphosulfate metabolic process | |
| nucleoside triphosphate catabolic process | |
| cellular phosphate ion homeostasis | |
| cellular response to insulin stimulus | |
| negative regulation of glucose import | |
| inorganic diphosphate transport | |
| sequestering of triglyceride | |
| nucleic acid binding | |
| hydrolase activity | |
| polysaccharide binding | |
| protein homodimerization activity | |
| insulin receptor binding | |
| 3'-phosphoadenosine 5'-phosphosulfate binding | |
| ATP binding | |
| metal ion binding | |
| phosphodiesterase I activity | |
| nucleotide diphosphatase activity | |
| nucleoside-triphosphate diphosphatase activity | |
| scavenger receptor activity | |
| cell surface | |
| membrane | |
| extracellular space | |
| plasma membrane | |
| basolateral plasma membrane | |
| integral to membrane |
| MedScan ID | 5167 |
|---|
| Hugo ID | 3356 |
|---|
| Human chromosome position | 6q22-q23 |
|---|
| LocusLink ID | 5167 |
|---|---|
| 18605 | |
| 85496 | |
| 97628 | |
| 615535 | |
| 562399 |
| Alias | M6S1 |
|---|---|
| NPP1 | |
| NPPS | |
| PC-1 | |
| PCA1 | |
| ARHR2 | |
| PDNP1 | |
| ectonucleotide pyrophosphatase/phosphodiesterase family member 1 | |
| E-NPP 1 | |
| Ly-41 antigen | |
| alkaline phosphodiesterase 1 | |
| plasma-cell membrane glycoprotein 1 | |
| plasma-cell membrane glycoprotein PC-1 | |
| membrane component chromosome 6 surface marker 1 | |
| phosphodiesterase I/nucleotide pyrophosphatase 1 | |
| membrane component, chromosome 6, surface marker 1 | |
| Pca | |
| ttw | |
| twy | |
| Ly-41 | |
| Pca-1 | |
| C76301 | |
| CD203c | |
| E-NPP1 | |
| AI428932 | |
| 4833416E15Rik | |
| tiptoe walking | |
| OTTMUSP00000021307 | |
| lymphocyte antigen 41 | |
| 1 ectonucleotide pyrophosphatase/phosphodiesterase 1 | |
| phosphodiesterase I/nucleotide pyrophosphatase 1; 1 ectonucleotide pyrophosphatase/phosphodiesterase 1 | |
| Pc1 | |
| 1 ectonucleotide pyrophosphatase/phosphodiesterase I | |
| 4833416E15 | |
| alkaline phosphodiesterase I | |
| ectonucleotide pyrophosphatase/phosphodiesterase 1 | |
| ectonucleotide pyrophosphatase/phosphodiesterase I | |
| ENPP I | |
| E-NPP I | |
| ENPP1 | |
| homologous to Ly-41 antigen | |
| LOC209552 | |
| M6S I | |
| membrane component, chromosome 6, surface marker I | |
| NPP I | |
| nucleotide pyrophosphatase 1 | |
| nucleotide pyrophosphatase I | |
| OTTHUMP00000043194 | |
| PCA I | |
| PDNP I | |
| phosphodiesterase I/nucleotide pyrophosphatase I | |
| plasma-cell membrane glycoprotein | |
| plasma-cell membrane glycoprotein I | |
| Plasma-cell membrane glycoprotein PC I | |
| Plasma-cell membrane glycoprotein PC-1 | |
| homologous to Ly-41 antigen | |
| Plasma-cell membrane glycoprotein PC I | |
| C76301s | |
| E-NPP1s | |
| E-NPP Is | |
| PC I | |
| PC(I) | |
| PC-I | |
| CH211-142E24.2 | |
| chromosome | |
| ectonucleotide pyrophosphatase/phosphodiesterase-like | |
| scaffold | |
| si:ch211-142e24.2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 173335 |
|---|---|
| 208000 | |
| 125853 | |
| 613312 | |
| 601665 | |
| 602475 |
| Mouse chromosome position | 10 19.0 cM |
|---|
| GO ID | 0050656 |
|---|---|
| 0005524 | |
| 0016787 | |
| 0005158 | |
| 0046872 | |
| 0003676 | |
| 0047429 | |
| 0004551 | |
| 0004528 | |
| 0030247 | |
| 0042803 | |
| 0005044 | |
| 0050427 | |
| 0031214 | |
| 0046849 | |
| 0030643 | |
| 0032869 | |
| 0006091 | |
| 0006955 | |
| 0030505 | |
| 0008152 | |
| 0030308 | |
| 0045599 | |
| 0046325 | |
| 0045719 | |
| 0046627 | |
| 0030279 | |
| 0031953 | |
| 0009143 | |
| 0006796 | |
| 0030500 | |
| 0030730 | |
| 0016323 | |
| 0009986 | |
| 0005615 | |
| 0016021 | |
| 0005886 | |
| 0003824 | |
| 0016020 | |
| 0005515 | |
| 0001503 | |
| 0003674 | |
| 0008150 | |
| 0005575 | |
| 0004519 | |
| 0032403 | |
| 0016791 | |
| 0009117 | |
| 0007584 | |
| 0001501 |
| Rat chromosome position | 1p12 |
|---|
| Swiss-Prot Accession | P22413 |
|---|---|
| Q7Z3P5 | |
| Q9NS95 | |
| Q3V3C8 | |
| P06802 | |
| Q924C3 | |
| O88827 | |
| Q91XQ3 | |
| Q920C8 | |
| Q5T9R6 | |
| Q9NPZ3 | |
| Q9P1P6 | |
| Q9UP61 | |
| Q9Y6K3 | |
| Q542E9 |
| PIR ID | A39216 |
|---|
| Unigene ID | Hs.527295 |
|---|---|
| Mm.478860 | |
| Rn.1199 | |
| Mm.477765 | |
| Mm.27254 | |
| Bt.60975 | |
| Dr.78641 |
| KEGG ID | hsa:5167 |
|---|---|
| mmu:18605 | |
| rno:85496 |
| EC Number | 3.6.1.9 |
|---|---|
| 3.1.4.1 |
| Swiss-Prot ID | ENPP1_RAT |
|---|---|
| ENPP1_HUMAN | |
| Q3V3C8_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Basolateral cell membrane | |
| Cytoplasm | |
| Plasma membrane |
| IPI ID | IPI00339118 |
|---|---|
| IPI00390328 | |
| IPI00184311 | |
| IPI00265291 | |
| IPI00478248 | |
| IPI00877960 | |
| IPI00128859 |
| Homologene ID | 38151 |
|---|
| RGD ID | 628825 |
|---|
| MGI ID | 97370 |
|---|---|
| 2143909 |
| Microarray ID | 104174_at |
|---|
| FunctionalClass | endonuclease |
|---|---|
| hydrolase | |
| nucleic acid binding | |
| nucleotide diphosphatase | |
| catalytic | |
| phosphodiesterase I | |
| metal ion binding | |
| molecular_function |
| Mus musculus Chromosome position | 10 19.0 cM |
|---|---|
| 10 |
| Source | GO component |
|---|
| KEGG pathway | Nicotinate and nicotinamide metabolism |
|---|---|
| Pantothenate and CoA biosynthesis | |
| Purine metabolism | |
| Riboflavin metabolism | |
| Starch and sucrose metabolism |
| Homo sapiens Chromosome position | 6q22-q23 |
|---|
| Bos taurus Chromosome position | 9 |
|---|
| Rattus norvegicus Chromosome position | 1p12 |
|---|