| URN | urn:agi-llid:9021 |
|---|---|
| Connectivity | 554 |
| Name | Socs3 |
| Description | suppressor of cytokine signaling 3 |
| Notes | regulates cytokine levels to modulate inflammation [RGD] |
| Pathway | insulin signaling pathway |
|---|---|
| leptin system pathway | |
| insulin signaling pathway | |
| altered insulin signaling pathway | |
| leptin system pathway | |
| insulin signaling pathway |
| GO Molecular Function | protein kinase inhibitor activity |
|---|
| GO Cellular Component | cytoplasm |
|---|
| GO Biological Process | aging |
|---|---|
| regulation of growth | |
| response to bacterium | |
| positive regulation of cell differentiation | |
| regulation of cell differentiation | |
| placenta blood vessel development | |
| trophoblast giant cell differentiation | |
| spongiotrophoblast differentiation | |
| branching involved in embryonic placenta morphogenesis | |
| organ regeneration | |
| signal transduction | |
| regulation of cell growth | |
| negative regulation of signal transduction | |
| negative regulation of insulin receptor signaling pathway | |
| intracellular protein kinase cascade | |
| JAK-STAT cascade | |
| regulation of protein amino acid phosphorylation | |
| anti-apoptosis | |
| modification-dependent protein catabolic process | |
| response to drug | |
| response to food | |
| response to hypoxia | |
| response to heat | |
| response to hormone stimulus | |
| response to organic cyclic substance | |
| response to cytokine stimulus | |
| response to lipopolysaccharide | |
| response to peptide hormone stimulus | |
| response to insulin stimulus | |
| response to progesterone stimulus | |
| response to estradiol stimulus | |
| response to glucocorticoid stimulus | |
| response to gamma radiation | |
| intracellular signaling pathway |
| Ariadne Ontology | SOCS |
|---|
| Group | SOCS |
|---|---|
| aging | |
| regulation of growth | |
| response to bacterium | |
| positive regulation of cell differentiation | |
| regulation of cell differentiation | |
| placenta blood vessel development | |
| trophoblast giant cell differentiation | |
| spongiotrophoblast differentiation | |
| branching involved in embryonic placenta morphogenesis | |
| organ regeneration | |
| signal transduction | |
| regulation of cell growth | |
| negative regulation of signal transduction | |
| negative regulation of insulin receptor signaling pathway | |
| intracellular protein kinase cascade | |
| JAK-STAT cascade | |
| regulation of protein amino acid phosphorylation | |
| anti-apoptosis | |
| modification-dependent protein catabolic process | |
| response to drug | |
| response to food | |
| response to hypoxia | |
| response to heat | |
| response to hormone stimulus | |
| response to organic cyclic substance | |
| response to cytokine stimulus | |
| response to lipopolysaccharide | |
| response to peptide hormone stimulus | |
| response to insulin stimulus | |
| response to progesterone stimulus | |
| response to estradiol stimulus | |
| response to glucocorticoid stimulus | |
| response to gamma radiation | |
| intracellular signaling pathway | |
| protein kinase inhibitor activity | |
| cytoplasm |
| MedScan ID | 9021 |
|---|
| Hugo ID | 19391 |
|---|
| Human chromosome position | 17q25.3 |
|---|
| LocusLink ID | 9021 |
|---|---|
| 12702 | |
| 89829 | |
| 83407 | |
| 282081 | |
| 406596 |
| Alias | CIS3 |
|---|---|
| SSI3 | |
| ATOD4 | |
| Cish3 | |
| SSI-3 | |
| SOCS-3 | |
| MGC71791 | |
| suppressor of cytokine signaling 3 | |
| CIS-3 | |
| STAT-induced STAT inhibitor 3 | |
| cytokine-induced SH2 protein 3 | |
| cytokine-inducible SH2 protein 3 | |
| Ef10 | |
| EF-10 | |
| RP23-268N22.6 | |
| OTTMUSP00000003963 | |
| E2a-Pbx1 target gene in fibroblasts 10 | |
| cytokine inducible SH2-containing protein 3 | |
| cytokine inducible sh2-containing protein III | |
| cytokine-induced SH2 protein III | |
| cytokine-inducible SH2 protein III | |
| Dermatitis, atopic, 4 | |
| Dermatitis, atopic, IV | |
| EF X | |
| SOCS3 | |
| SSI III | |
| SSI IIIs | |
| STAT induced STAT inhibitor 3 | |
| STAT induced STAT inhibitor III | |
| suppressor of cytokine signaling III | |
| LOC406596 | |
| chromosome | |
| scaffold | |
| zgc:77038 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 604176 |
|---|---|
| 605805 |
| Mouse chromosome position | 11 |
|---|---|
| 11 E2 |
| GO ID | 0004860 |
|---|---|
| 0007259 | |
| 0007568 | |
| 0006916 | |
| 0060670 | |
| 0023034 | |
| 0046627 | |
| 0009968 | |
| 0031100 | |
| 0060674 | |
| 0045597 | |
| 0040008 | |
| 0001932 | |
| 0009617 | |
| 0034097 | |
| 0042493 | |
| 0032355 | |
| 0032094 | |
| 0010332 | |
| 0051384 | |
| 0009408 | |
| 0001666 | |
| 0032868 | |
| 0032496 | |
| 0014070 | |
| 0032570 | |
| 0060708 | |
| 0060707 | |
| 0005737 | |
| 0007243 | |
| 0045595 | |
| 0007165 | |
| 0001558 | |
| 0009725 | |
| 0043434 | |
| 0019941 | |
| 0005515 | |
| 0007242 | |
| 0006512 | |
| 0003674 | |
| 0005575 |
| Rat chromosome position | 10q32.3 |
|---|
| Swiss-Prot Accession | O14543 |
|---|---|
| Q6FI39 | |
| Q5U0H7 | |
| B1AQL6 | |
| O35718 | |
| Q3U9J8 | |
| O88583 | |
| P97803 | |
| Q3U7X5 | |
| Q9QYV5 | |
| O14509 |
| PIR ID | JC5627 |
|---|---|
| JC5761 |
| Unigene ID | Hs.527973 |
|---|---|
| Mm.3468 | |
| Rn.127801 | |
| Bt.8137 | |
| Dr.81607 |
| KEGG ID | hsa:9021 |
|---|---|
| mmu:12702 | |
| rno:89829 |
| Swiss-Prot ID | SOCS3_MOUSE |
|---|---|
| SOCS3_RAT | |
| SOCS3_HUMAN | |
| Q6FI39_HUMAN | |
| B1AQL6_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00133840 |
|---|---|
| IPI00210797 | |
| IPI00297349 |
| Homologene ID | 2941 |
|---|
| RGD ID | 621087 |
|---|
| MGI ID | 1201791 |
|---|
| Microarray ID | 162206_f_at |
|---|---|
| 92232_at | |
| 1455899_x_at | |
| 125 | |
| 1416576_at | |
| 1456212_x_at |
| FunctionalClass | protein binding |
|---|---|
| protein kinase inhibitor | |
| molecular_function |
| Mus musculus Chromosome position | 11 E2 |
|---|
| Source | Curated |
|---|---|
| ResNet | |
| RGD modified |
| KEGG pathway | Adipocytokine signaling pathway |
|---|---|
| Insulin signaling pathway | |
| Jak-STAT signaling pathway | |
| Type II diabetes mellitus |
| Homo sapiens Chromosome position | 17q25.3 |
|---|---|
| 17q25 |
| Bos taurus Chromosome position | 19 |
|---|
| Rattus norvegicus Chromosome position | 10q32.3 |
|---|