| URN | urn:agi-llid:8660 |
|---|---|
| Connectivity | 335 |
| Name | Irs2 |
| Description | insulin receptor substrate 2 |
| Notes | plays a role in insulin-stimulated fetal liver growth [RGD] |
| Pathway | NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling |
|---|---|
| NTRK -> FOXO/MYCN signaling | |
| InsulinR -> CTNNB/FOXA/FOXO signaling | |
| InsulinR -> ELK-SRF/SREBF signaling | |
| IL4R -> ELK-SRF/HMGY signaling | |
| insulin signaling pathway | |
| leptin system pathway | |
| insulin signaling pathway | |
| altered insulin signaling pathway | |
| leptin system pathway | |
| insulin signaling pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| protein domain specific binding | |
| insulin receptor binding | |
| protein kinase binding | |
| phosphoinositide 3-kinase binding | |
| protein phosphatase binding | |
| receptor activity |
| GO Cellular Component | plasma membrane |
|---|---|
| cytoplasm | |
| cytosol |
| GO Biological Process | cell proliferation |
|---|---|
| positive regulation of cell proliferation | |
| brain development | |
| mammary gland development | |
| signal transduction | |
| positive regulation of insulin secretion | |
| positive regulation of fatty acid beta-oxidation | |
| positive regulation of glucose metabolic process | |
| positive regulation of glycogen biosynthetic process | |
| negative regulation of kinase activity | |
| positive regulation of mesenchymal cell proliferation | |
| positive regulation of B cell proliferation | |
| positive regulation of cell migration | |
| negative regulation of B cell apoptosis | |
| glucose metabolic process | |
| cellular response to insulin stimulus | |
| insulin receptor signaling pathway | |
| response to glucose stimulus | |
| negative regulation of plasma membrane long-chain fatty acid transport | |
| positive regulation of glucose import | |
| regulation of lipid metabolic process | |
| lipid homeostasis |
| Ariadne Ontology | IRS |
|---|
| Group | IRS |
|---|---|
| cell proliferation | |
| positive regulation of cell proliferation | |
| brain development | |
| mammary gland development | |
| signal transduction | |
| positive regulation of insulin secretion | |
| positive regulation of fatty acid beta-oxidation | |
| positive regulation of glucose metabolic process | |
| positive regulation of glycogen biosynthetic process | |
| negative regulation of kinase activity | |
| positive regulation of mesenchymal cell proliferation | |
| positive regulation of B cell proliferation | |
| positive regulation of cell migration | |
| negative regulation of B cell apoptosis | |
| glucose metabolic process | |
| cellular response to insulin stimulus | |
| insulin receptor signaling pathway | |
| response to glucose stimulus | |
| negative regulation of plasma membrane long-chain fatty acid transport | |
| positive regulation of glucose import | |
| regulation of lipid metabolic process | |
| lipid homeostasis | |
| signal transducer activity | |
| protein domain specific binding | |
| insulin receptor binding | |
| protein kinase binding | |
| phosphoinositide 3-kinase binding | |
| protein phosphatase binding | |
| receptor activity | |
| plasma membrane | |
| cytoplasm | |
| cytosol |
| MedScan ID | 8660 |
|---|
| Hugo ID | 6126 |
|---|
| Human chromosome position | 13q34 |
|---|
| LocusLink ID | 8660 |
|---|---|
| 384783 | |
| 29376 | |
| 16368 | |
| 572001 |
| Alias | IRS-2 |
|---|---|
| insulin receptor substrate 2 | |
| 4PS | |
| tyrosine kinase substrate | |
| INS receptor substrate 2 | |
| INS receptor substrate II | |
| insulin receptor substrate II | |
| IRS II | |
| LOC113071 | |
| LOC115972 | |
| LOC207125 | |
| LOC90066 | |
| OTTHUMP00000018696 | |
| 4-PS | |
| insulin receptor substrate-2 | |
| tyrosinekinase substrate | |
| IRS2 | |
| LOC572001 | |
| chromosome | |
| hypothetical LOC572001 | |
| scaffold |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Danio rerio |
| OMIM ID | 600797 |
|---|---|
| 125853 |
| Mouse chromosome position | 8 5.0 cM |
|---|---|
| 8 A1.1 |
| GO ID | 0005158 |
|---|---|
| 0043548 | |
| 0019904 | |
| 0019901 | |
| 0019903 | |
| 0004871 | |
| 0007420 | |
| 0032869 | |
| 0006006 | |
| 0008286 | |
| 0055088 | |
| 0030879 | |
| 0002903 | |
| 0033673 | |
| 0010748 | |
| 0030890 | |
| 0030335 | |
| 0008284 | |
| 0032000 | |
| 0046326 | |
| 0010907 | |
| 0045725 | |
| 0032024 | |
| 0002053 | |
| 0019216 | |
| 0009749 | |
| 0007165 | |
| 0005737 | |
| 0005829 | |
| 0005886 | |
| 0004872 | |
| 0008283 | |
| 0043434 | |
| 0005515 | |
| 0005575 |
| Rat chromosome position | 16q12.5 |
|---|
| Swiss-Prot Accession | Q9P084 |
|---|---|
| Q9Y4H2 | |
| Q8TF73 | |
| Q96RG4 | |
| Q96RG5 | |
| Q9UP29 | |
| B9EJW3 | |
| P81122 | |
| Q3U2I0 | |
| O70360 | |
| O88661 | |
| O88948 | |
| P97880 | |
| Q96RR2 | |
| Q9BZG0 | |
| Q9Y6I5 | |
| O88970 | |
| IRS2_MOUSE | |
| IRS2_HUMAN |
| Unigene ID | Hs.442344 |
|---|---|
| Mm.407207 | |
| Rn.10718 | |
| Rn.222293 | |
| Mm.247438 | |
| Rn.102309 | |
| Dr.53020 |
| KEGG ID | hsa:8660 |
|---|---|
| mmu:384783 | |
| rno:29376 |
| Swiss-Prot ID | IRS2_HUMAN |
|---|---|
| B9EJW3_MOUSE | |
| Q9P084_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00464978 |
|---|---|
| IPI00923679 | |
| IPI00000299 | |
| IPI00379844 | |
| IPI00470245 | |
| IPI00390437 |
| Homologene ID | 2778 |
|---|
| RGD ID | 69316 |
|---|
| MGI ID | 109334 |
|---|
| Microarray ID | 92205_at |
|---|
| FunctionalClass | insulin receptor binding |
|---|---|
| protein binding | |
| protein kinase binding | |
| signal transducer | |
| receptor | |
| phosphoinositide 3-kinase binding | |
| protein domain specific binding |
| Mus musculus Chromosome position | 8 5.0 cM |
|---|---|
| 8 A1.1 |
| Source | Curated |
|---|
| Homo sapiens Chromosome position | 13q34 |
|---|
| Rattus norvegicus Chromosome position | 16q12.5 |
|---|