| URN | urn:agi-llid:8651 |
|---|---|
| Connectivity | 448 |
| Name | Socs1 |
| Description | suppressor of cytokine signaling 1 |
| Notes | suppressor of cytokine signalling [RGD] |
| Pathway | insulin signaling pathway |
|---|---|
| insulin signaling pathway | |
| altered insulin signaling pathway | |
| insulin signaling pathway |
| GO Molecular Function | insulin-like growth factor receptor binding |
|---|---|
| protein kinase binding | |
| kinase inhibitor activity | |
| protein kinase inhibitor activity |
| GO Cellular Component | cytoplasm |
|---|
| GO Biological Process | regulation of growth |
|---|---|
| fat cell differentiation | |
| organ regeneration | |
| negative regulation of signal transduction | |
| negative regulation of JAK-STAT cascade | |
| negative regulation of tyrosine phosphorylation of Stat3 protein | |
| negative regulation of insulin receptor signaling pathway | |
| JAK-STAT cascade | |
| regulation of protein amino acid phosphorylation | |
| modification-dependent protein catabolic process | |
| cytokine-mediated signaling pathway | |
| response to drug | |
| response to cytokine stimulus | |
| response to lipopolysaccharide | |
| response to peptide hormone stimulus | |
| response to progesterone stimulus | |
| response to estradiol stimulus | |
| intracellular signaling pathway | |
| regulation of catalytic activity |
| Ariadne Ontology | SOCS |
|---|
| Group | SOCS |
|---|---|
| regulation of growth | |
| fat cell differentiation | |
| organ regeneration | |
| negative regulation of signal transduction | |
| negative regulation of JAK-STAT cascade | |
| negative regulation of tyrosine phosphorylation of Stat3 protein | |
| negative regulation of insulin receptor signaling pathway | |
| JAK-STAT cascade | |
| regulation of protein amino acid phosphorylation | |
| modification-dependent protein catabolic process | |
| cytokine-mediated signaling pathway | |
| response to drug | |
| response to cytokine stimulus | |
| response to lipopolysaccharide | |
| response to peptide hormone stimulus | |
| response to progesterone stimulus | |
| response to estradiol stimulus | |
| intracellular signaling pathway | |
| regulation of catalytic activity | |
| insulin-like growth factor receptor binding | |
| protein kinase binding | |
| kinase inhibitor activity | |
| protein kinase inhibitor activity | |
| cytoplasm |
| MedScan ID | 8651 |
|---|
| Hugo ID | 19383 |
|---|
| Human chromosome position | 16p13.13 |
|---|
| LocusLink ID | 8651 |
|---|---|
| 12703 | |
| 252971 | |
| 29590 | |
| 518795 | |
| 445073 |
| Alias | JAB |
|---|---|
| CIS1 | |
| SSI1 | |
| TIP3 | |
| CISH1 | |
| SSI-1 | |
| SOCS-1 | |
| suppressor of cytokine signaling 1 | |
| TIP-3 | |
| JAK binding protein | |
| JAK-binding protein | |
| Tec-interacting protein 3 | |
| STAT induced SH3 protein 1 | |
| STAT-induced STAT inhibitor 1 | |
| cytokine-inducible SH2 protein 1 | |
| Cish7 | |
| JAK2-binding protein | |
| cytokine inducible SH2-containing protein 1 | |
| cytokine inducible SH2-containing protein 7 | |
| Cish I | |
| cytokine-inducible SH2 protein I | |
| JAB/SOCS1/SSI-1 | |
| JAK2 binding protein | |
| SOCS1 | |
| SSI I | |
| STAT induced SH3 protein I | |
| STAT-induced STAT inhibitor I | |
| suppressor of cytokine signaling I | |
| Tec-interacting protein III | |
| Tec-interactive protein 3 | |
| Tec-interactive protein III | |
| Socs I | |
| chromosome | |
| scaffold | |
| suppressor of cytokine signalling | |
| zgc:91868 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 603597 |
|---|
| Mouse chromosome position | 16 3.4 cM |
|---|
| GO ID | 0005159 |
|---|---|
| 0019210 | |
| 0019901 | |
| 0004860 | |
| 0007259 | |
| 0019221 | |
| 0045444 | |
| 0023034 | |
| 0046426 | |
| 0046627 | |
| 0009968 | |
| 0042518 | |
| 0031100 | |
| 0040008 | |
| 0001932 | |
| 0034097 | |
| 0042493 | |
| 0032355 | |
| 0032496 | |
| 0043434 | |
| 0032570 | |
| 0005737 | |
| 0050790 | |
| 0019941 | |
| 0007242 | |
| 0006512 | |
| 0005515 | |
| 0005575 | |
| 0003674 | |
| 0001558 | |
| 0008372 | |
| 0007165 |
| Rat chromosome position | 10q11 |
|---|
| Swiss-Prot Accession | O15524 |
|---|---|
| Q4JHT5 | |
| O35716 | |
| Q9QX78 | |
| A2RT46 | |
| O35960 | |
| Q3U3L0 | |
| O15097 | |
| Q9NSA7 |
| Unigene ID | Hs.50640 |
|---|---|
| Mm.130 | |
| Rn.82754 | |
| Bt.1736 | |
| Dr.79974 |
| KEGG ID | hsa:8651 |
|---|---|
| mmu:12703 | |
| rno:252971 |
| Swiss-Prot ID | SOCS1_MOUSE |
|---|---|
| SOCS1_HUMAN | |
| SOCS1_RAT | |
| Q4JHT5_HUMAN | |
| A2RT46_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00133836 |
|---|---|
| IPI00021491 | |
| IPI00212707 |
| Homologene ID | 2776 |
|---|
| RGD ID | 69272 |
|---|
| MGI ID | 1354910 |
|---|
| Microarray ID | 92832_at |
|---|
| FunctionalClass | insulin-like growth factor receptor binding |
|---|---|
| protein binding | |
| protein kinase binding | |
| protein kinase inhibitor | |
| kinase inhibitor | |
| molecular_function |
| Mus musculus Chromosome position | 16 3.4 cM |
|---|
| Source | Curated |
|---|---|
| GO component |
| KEGG pathway | Insulin signaling pathway |
|---|---|
| Jak-STAT signaling pathway | |
| Type II diabetes mellitus |
| Homo sapiens Chromosome position | 16p13.13 |
|---|
| Bos taurus Chromosome position | 25 |
|---|
| Rattus norvegicus Chromosome position | 10q11 |
|---|