| URN | urn:agi-llid:3643 |
|---|---|
| Connectivity | 749 |
| Name | Insr |
| Description | insulin receptor |
| Notes | receptor for insulin; involved in intracellular signalling; mutations in gene are associated with type 2 diabetes mellitus [RGD] |
| Pathway | InsulinR -> STAT signaling |
|---|---|
| InsulinR -> CTNNB/FOXA/FOXO signaling | |
| InsulinR -> ELK-SRF/SREBF signaling | |
| insulin signaling pathway | |
| insulin signaling pathway | |
| type 2 diabetes mellitus pathway | |
| altered insulin signaling pathway | |
| insulin signaling pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| lipoic acid binding | |
| protein domain specific binding | |
| protein complex binding | |
| insulin receptor substrate binding | |
| PTB domain binding | |
| SH2 domain binding | |
| insulin-like growth factor receptor binding | |
| protein kinase binding | |
| phosphoinositide 3-kinase binding | |
| protein phosphatase binding | |
| 3-phosphoinositide-dependent protein kinase binding | |
| insulin-like growth factor II binding | |
| insulin-like growth factor I binding | |
| ATP binding | |
| GTP binding | |
| insulin binding | |
| metal ion binding | |
| manganese ion binding | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| receptor signaling protein tyrosine kinase activity | |
| transmembrane receptor protein tyrosine kinase activity | |
| insulin receptor activity | |
| receptor activity |
| GO Cellular Component | synapse |
|---|---|
| membrane | |
| soluble fraction | |
| plasma membrane | |
| endosome | |
| cytosol | |
| endosome membrane | |
| nucleus | |
| microsome | |
| insulin receptor complex | |
| caveola | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | positive regulation of cell proliferation |
|---|---|
| response to activity | |
| transformation of host cell by virus | |
| regulation of embryonic development | |
| positive regulation of developmental growth | |
| exocrine pancreas development | |
| organ morphogenesis | |
| male sex determination | |
| fat cell differentiation | |
| heart morphogenesis | |
| positive regulation of mitosis | |
| positive regulation of protein kinase B signaling cascade | |
| positive regulation of MAPKKK cascade | |
| activation of MAPK activity | |
| regulation of hydrogen peroxide metabolic process | |
| positive regulation of glycolysis | |
| negative regulation of protein amino acid phosphorylation | |
| positive regulation of DNA replication | |
| positive regulation of glycogen biosynthetic process | |
| positive regulation of glycoprotein biosynthetic process | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of phosphorylation | |
| positive regulation of protein amino acid phosphorylation | |
| regulation of gene-specific transcription | |
| activation of protein kinase activity | |
| activation of protein kinase B activity | |
| positive regulation of cell migration | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| peptidyl-tyrosine phosphorylation | |
| cellular response to insulin stimulus | |
| insulin receptor signaling pathway | |
| response to hormone stimulus | |
| response to protein stimulus | |
| response to ethanol | |
| response to manganese ion | |
| response to tumor necrosis factor | |
| response to peptide hormone stimulus | |
| response to insulin stimulus | |
| response to testosterone stimulus | |
| response to estradiol stimulus | |
| response to glucocorticoid stimulus | |
| response to glucose stimulus | |
| response to vitamin D | |
| response to nutrient levels | |
| negative regulation of transporter activity | |
| negative regulation of gene expression | |
| positive regulation of respiratory burst | |
| positive regulation of glucose import | |
| protein heterotetramerization | |
| carbohydrate metabolic process | |
| G-protein coupled receptor protein signaling pathway | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| glucose homeostasis |
| Ariadne Ontology | INSR |
|---|
| Group | INSR |
|---|---|
| synapse | |
| positive regulation of cell proliferation | |
| response to activity | |
| transformation of host cell by virus | |
| regulation of embryonic development | |
| positive regulation of developmental growth | |
| exocrine pancreas development | |
| organ morphogenesis | |
| male sex determination | |
| fat cell differentiation | |
| heart morphogenesis | |
| positive regulation of mitosis | |
| positive regulation of protein kinase B signaling cascade | |
| positive regulation of MAPKKK cascade | |
| activation of MAPK activity | |
| regulation of hydrogen peroxide metabolic process | |
| positive regulation of glycolysis | |
| negative regulation of protein amino acid phosphorylation | |
| positive regulation of DNA replication | |
| positive regulation of glycogen biosynthetic process | |
| positive regulation of glycoprotein biosynthetic process | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of phosphorylation | |
| positive regulation of protein amino acid phosphorylation | |
| regulation of gene-specific transcription | |
| activation of protein kinase activity | |
| activation of protein kinase B activity | |
| positive regulation of cell migration | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| peptidyl-tyrosine phosphorylation | |
| cellular response to insulin stimulus | |
| insulin receptor signaling pathway | |
| response to hormone stimulus | |
| response to protein stimulus | |
| response to ethanol | |
| response to manganese ion | |
| response to tumor necrosis factor | |
| response to peptide hormone stimulus | |
| response to insulin stimulus | |
| response to testosterone stimulus | |
| response to estradiol stimulus | |
| response to glucocorticoid stimulus | |
| response to glucose stimulus | |
| response to vitamin D | |
| response to nutrient levels | |
| negative regulation of transporter activity | |
| negative regulation of gene expression | |
| positive regulation of respiratory burst | |
| positive regulation of glucose import | |
| protein heterotetramerization | |
| carbohydrate metabolic process | |
| G-protein coupled receptor protein signaling pathway | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| glucose homeostasis | |
| nucleotide binding | |
| transferase activity | |
| lipoic acid binding | |
| protein domain specific binding | |
| protein complex binding | |
| insulin receptor substrate binding | |
| PTB domain binding | |
| SH2 domain binding | |
| insulin-like growth factor receptor binding | |
| protein kinase binding | |
| phosphoinositide 3-kinase binding | |
| protein phosphatase binding | |
| 3-phosphoinositide-dependent protein kinase binding | |
| insulin-like growth factor II binding | |
| insulin-like growth factor I binding | |
| ATP binding | |
| GTP binding | |
| insulin binding | |
| metal ion binding | |
| manganese ion binding | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| receptor signaling protein tyrosine kinase activity | |
| transmembrane receptor protein tyrosine kinase activity | |
| insulin receptor activity | |
| receptor activity | |
| membrane | |
| soluble fraction | |
| plasma membrane | |
| endosome | |
| cytosol | |
| endosome membrane | |
| nucleus | |
| microsome | |
| insulin receptor complex | |
| caveola | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 3643 |
|---|
| Hugo ID | 6091 |
|---|
| Human chromosome position | 19p13.3-p13.2 |
|---|
| LocusLink ID | 3643 |
|---|---|
| 16337 | |
| 24954 | |
| 281255 | |
| 408017 | |
| 245699 | |
| 319666 |
| Alias | HHF5 |
|---|---|
| CD220 | |
| insulin receptor | |
| IR | |
| IR-A | |
| IR-B | |
| 4932439J01Rik | |
| D630014A15Rik | |
| 4932439J01 | |
| D630014A15 | |
| human insulin receptor | |
| INS receptor | |
| INSR | |
| INSR_HUMAN | |
| InsRs | |
| insulin receptor catalytic subunit | |
| insulin receptors | |
| RIKEN cDNA D630014A15 gene | |
| IRa | |
| chromosome | |
| insra | |
| insulin receptor a | |
| scaffold |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 147670 |
|---|---|
| 610549 | |
| 609968 | |
| 246200 | |
| 262190 |
| Mouse chromosome position | 8 1.0 cM |
|---|
| GO ID | 0043423 |
|---|---|
| 0005524 | |
| 0005525 | |
| 0051425 | |
| 0042169 | |
| 0043559 | |
| 0005009 | |
| 0043560 | |
| 0031994 | |
| 0031995 | |
| 0005159 | |
| 0031405 | |
| 0046872 | |
| 0000166 | |
| 0043548 | |
| 0032403 | |
| 0019903 | |
| 0004713 | |
| 0004872 | |
| 0004716 | |
| 0016740 | |
| 0007186 | |
| 0000187 | |
| 0032148 | |
| 0032147 | |
| 0005975 | |
| 0032869 | |
| 0031017 | |
| 0045444 | |
| 0042593 | |
| 0003007 | |
| 0008286 | |
| 0030238 | |
| 0010629 | |
| 0001933 | |
| 0032410 | |
| 0018108 | |
| 0045740 | |
| 0043410 | |
| 0030335 | |
| 0008284 | |
| 0048639 | |
| 0046326 | |
| 0045725 | |
| 0045821 | |
| 0010560 | |
| 0045840 | |
| 0045429 | |
| 0001934 | |
| 0051897 | |
| 0060267 | |
| 0046777 | |
| 0051290 | |
| 0045995 | |
| 0032583 | |
| 0010310 | |
| 0014823 | |
| 0032355 | |
| 0045471 | |
| 0051384 | |
| 0009749 | |
| 0010042 | |
| 0031667 | |
| 0051789 | |
| 0033574 | |
| 0034612 | |
| 0033280 | |
| 0019087 | |
| 0005901 | |
| 0005829 | |
| 0005768 | |
| 0010008 | |
| 0005899 | |
| 0005887 | |
| 0016020 | |
| 0005792 | |
| 0005634 | |
| 0005886 | |
| 0005625 | |
| 0045202 | |
| 0016301 | |
| 0019904 | |
| 0004672 | |
| 0019901 | |
| 0004714 | |
| 0009887 | |
| 0042327 | |
| 0006468 | |
| 0043434 | |
| 0007169 | |
| 0016021 | |
| 0009725 | |
| 0032868 | |
| 0030145 | |
| 0005515 | |
| 0005066 | |
| 0006091 | |
| 0007275 | |
| 0007165 | |
| 0005006 |
| Rat chromosome position | 12q12 |
|---|
| Swiss-Prot Accession | P06213 |
|---|---|
| Q2MKN9 | |
| Q2MKP0 | |
| Q2MKP2 | |
| Q2PJC1 | |
| Q2PJC2 | |
| Q2PJC3 | |
| Q2PJC4 | |
| Q2PJC5 | |
| Q4U0V1 | |
| Q86WY9 | |
| P15208 | |
| Q3TPM5 | |
| O35466 | |
| Q3V2X8 | |
| Q3V313 | |
| Q9Z1H5 | |
| P15127 | |
| Q6Q2A2 | |
| Q9R1G8 | |
| Q9R1G9 | |
| Q9R1H0 | |
| Q9R1H1 | |
| Q9R1H2 | |
| Q9R1H3 | |
| Q9R1H4 | |
| Q9R1H5 | |
| Q9R1H6 | |
| Q9R1H7 | |
| Q9WVI2 | |
| Q9WVI3 | |
| Q17RW0 | |
| Q59H98 | |
| Q9UCB7 | |
| Q9UCB8 | |
| Q9UCB9 | |
| P97681 |
| PIR ID | A37348 |
|---|---|
| A34157 | |
| A36080 |
| Unigene ID | Hs.465744 |
|---|---|
| Mm.268003 | |
| Rn.9876 | |
| Hs.591381 | |
| Mm.378945 | |
| Bt.32551 | |
| Dr.85773 | |
| Mm.439671 | |
| Mm.440959 |
| KEGG ID | hsa:3643 |
|---|---|
| mmu:16337 | |
| rno:24954 |
| EC Number | 2.7.10.1 |
|---|
| Swiss-Prot ID | INSR_HUMAN |
|---|---|
| INSR_MOUSE | |
| INSR_RAT | |
| Q3TPM5_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00025803 |
|---|---|
| IPI00220325 | |
| IPI00128358 | |
| IPI00393267 | |
| IPI00563042 | |
| IPI00783573 | |
| IPI00845756 | |
| IPI00652963 | |
| IPI00881454 |
| Homologene ID | 20090 |
|---|
| RGD ID | 2917 |
|---|
| MGI ID | 96575 |
|---|---|
| 2442502 |
| Microarray ID | 102146_at |
|---|
| FunctionalClass | ATP binding |
|---|---|
| PTB domain binding | |
| SH2 domain binding | |
| epidermal growth factor receptor | |
| insulin binding | |
| insulin receptor | |
| insulin receptor substrate binding | |
| nucleotide binding | |
| phosphoinositide 3-kinase binding | |
| receptor | |
| receptor signaling protein tyrosine kinase | |
| transferase | |
| transmembrane receptor protein tyrosine kinase signaling protein | |
| kinase | |
| protein binding | |
| protein kinase | |
| protein-tyrosine kinase | |
| transmembrane receptor protein tyrosine kinase | |
| 3-phosphoinositide-dependent protein kinase binding | |
| protein phosphatase binding |
| Mus musculus Chromosome position | 8 1.0 cM |
|---|---|
| 8 A1.1 |
| Source | Curated |
|---|---|
| GO component |
| KEGG pathway | Adherens junction |
|---|---|
| Dentatorubropallidoluysian atrophy (DRPLA) | |
| Insulin signaling pathway | |
| Type II diabetes mellitus |
| Homo sapiens Chromosome position | 19p13.3-p13.2 |
|---|
| Bos taurus Chromosome position | 7 |
|---|
| Rattus norvegicus Chromosome position | 12q12 |
|---|