| URN | urn:agi-llid:4903 |
|---|---|
| Connectivity | 601 |
| Name | Ptpn11 |
| Description | protein tyrosine phosphatase, non-receptor type 11 |
| Notes | catalyzes the tyrosine dephosphorylation of para-nitrophenylphosphate, nicotinic acetylcholine receptor, myelin basic protein, and other proteins [RGD] |
| Pathway | SELE -> ELK-SRF signaling |
|---|---|
| PECAM -> SP1 signaling | |
| ErythropoietinR -> ELK-SRF/FOS signaling | |
| LeptinR -> ELK-SRF signaling | |
| GHR -> ELK-SRF/MYC signaling | |
| IL6R -> CEBP/ELK-SRF signaling | |
| EDG2 -> ELK-SRF signaling | |
| AdrenergicRa -> ELK-SRF signaling | |
| AdrenergicRa -> STAT3 signaling | |
| AngiotensinR -> CREB/ELK-SRF/TP53 signaling | |
| insulin signaling pathway | |
| leptin system pathway | |
| scatter factor-hepatocyte growth factor signaling pathway | |
| insulin signaling pathway | |
| altered insulin signaling pathway | |
| New Pathway (1) | |
| interleukin 6 signaling pathway | |
| Interleukin-6 signaling pathway | |
| leptin system pathway | |
| insulin signaling pathway |
| GO Molecular Function | hydrolase activity |
|---|---|
| protein domain specific binding | |
| insulin receptor substrate binding | |
| insulin receptor binding | |
| phospholipase binding | |
| peptide hormone receptor binding | |
| phosphatase activity | |
| phosphoprotein phosphatase activity | |
| protein tyrosine phosphatase activity | |
| non-membrane spanning protein tyrosine phosphatase activity |
| GO Cellular Component | protein complex |
|---|---|
| soluble fraction | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| stress fiber | |
| membrane fraction | |
| cell junction |
| GO Biological Process | reproductive process in a multicellular organism |
|---|---|
| organ growth | |
| hormone metabolic process | |
| axonogenesis | |
| regulation of multicellular organism growth | |
| negative regulation of cortisol secretion | |
| signal transduction | |
| positive regulation of hormone secretion | |
| negative regulation of hormone secretion | |
| DNA damage checkpoint | |
| positive regulation of signal transduction | |
| activation of MAPK activity | |
| negative regulation of growth hormone secretion | |
| negative regulation of insulin secretion | |
| regulation of protein export from nucleus | |
| protein amino acid dephosphorylation | |
| triglyceride metabolic process | |
| dephosphorylation | |
| hormone-mediated signaling pathway | |
| lipid metabolic process | |
| nerve growth factor receptor signaling pathway | |
| glucose homeostasis |
| Ariadne Ontology | SHP2 |
|---|
| Group | SHP2 |
|---|---|
| reproductive process in a multicellular organism | |
| organ growth | |
| hormone metabolic process | |
| axonogenesis | |
| regulation of multicellular organism growth | |
| negative regulation of cortisol secretion | |
| signal transduction | |
| positive regulation of hormone secretion | |
| negative regulation of hormone secretion | |
| DNA damage checkpoint | |
| positive regulation of signal transduction | |
| activation of MAPK activity | |
| negative regulation of growth hormone secretion | |
| negative regulation of insulin secretion | |
| regulation of protein export from nucleus | |
| protein amino acid dephosphorylation | |
| triglyceride metabolic process | |
| dephosphorylation | |
| hormone-mediated signaling pathway | |
| lipid metabolic process | |
| nerve growth factor receptor signaling pathway | |
| glucose homeostasis | |
| hydrolase activity | |
| protein domain specific binding | |
| insulin receptor substrate binding | |
| insulin receptor binding | |
| phospholipase binding | |
| peptide hormone receptor binding | |
| phosphatase activity | |
| phosphoprotein phosphatase activity | |
| protein tyrosine phosphatase activity | |
| non-membrane spanning protein tyrosine phosphatase activity | |
| protein complex | |
| soluble fraction | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| stress fiber | |
| membrane fraction | |
| cell junction |
| MedScan ID | 4903 |
|---|
| Hugo ID | 9644 |
|---|
| Human chromosome position | 12q24 |
|---|
| LocusLink ID | 4903 |
|---|---|
| 5781 | |
| 19247 | |
| 25622 | |
| 55875 | |
| 84990 | |
| 100974 | |
| 72646 | |
| 533590 | |
| 333979 |
| Alias | CFC |
|---|---|
| NS1 | |
| SHP2 | |
| BPTP3 | |
| PTP2C | |
| PTP-1D | |
| SH-PTP2 | |
| SH-PTP3 | |
| MGC14433 | |
| tyrosine-protein phosphatase non-receptor type 11 | |
| PTP-2C | |
| OTTHUMP00000166108 | |
| protein tyrosine phosphatase-2 | |
| protein-tyrosine phosphatase 1D | |
| protein-tyrosine phosphatase 2C | |
| Syp | |
| PTP1D | |
| SAP-2 | |
| SHP-2 | |
| AW536184 | |
| 2700084A17Rik | |
| OTTMUSP00000017430 | |
| protein-tyrosine phosphatase SYP | |
| SH2 domain-containing protein tyrosine phosphatase-2 | |
| null | |
| encodes catalytic domain | |
| protein tyrosine phosphatase SH-PTP2 | |
| SH-PTP2 protein tyrosine phosphatase non-receptor type 11 | |
| SH-PTP2 protein tyrosine phosphatase, non-receptor type 11 | |
| SHPTP2 | |
| 2700084A17 | |
| Noonan syndrome 1 gene | |
| Noonan syndrome 1 protein | |
| Noonan syndrome I gene | |
| Noonan syndrome I protein | |
| NS I | |
| PRO1847 | |
| protein tyrosine phosphatase, non-receptor type 11 | |
| protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | |
| protein tyrosine phosphatase, non-receptor type 11 isoform 1 | |
| protein tyrosine phosphatase, non-receptor type 11 isoform 2 | |
| protein tyrosine phosphatase, non-receptor type 11 isoform I | |
| protein tyrosine phosphatase, non-receptor type 11 isoform II | |
| protein-tyrosine-phosphatase , nonreceptor type 11 | |
| PTNB | |
| PTNB_HUMAN | |
| PTP-1Ds | |
| PTPN11 | |
| SH2 domain-containing protein tyrosine phosphatase II | |
| SH2 domain-containing protein tyrosine phosphatase SHP-2 | |
| SHP2/pp75 | |
| SH-PTP2 tyrosine phosphatase, non-receptor type | |
| Src homology 2 domain protein tyrosine phosphatase SHP-2 | |
| Src homology 2 domain-containing protein tyrosine phosphatase SHP-2 | |
| Src homology phosphatase SHP2 | |
| Src homology phosphotyrosyl phosphatase SHP2 | |
| tyrosine-phosphatase , nonreceptor type | |
| RIKEN cDNA 2700084A17 gene | |
| Ptpn11s | |
| SHPTP2s | |
| expressed sequence AW536184 | |
| hypothetical protein MGC14433 | |
| hypothetical protein PRO1847 | |
| Noonan syndrome 1 | |
| chromosome | |
| fi24f03 | |
| non-receptor type 11 | |
| non-receptor type 11 (Noonan syndrome 1) | |
| nonreceptor | |
| protein tyrosine phosphatase | |
| scaffold | |
| wu:fi24f03 | |
| zgc:55388 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 176876 |
|---|---|
| 151100 | |
| 607785 | |
| 163950 | |
| 163955 |
| Mouse chromosome position | 5 |
|---|---|
| 5 F |
| GO ID | 0016787 |
|---|---|
| 0005158 | |
| 0043560 | |
| 0004726 | |
| 0051428 | |
| 0043274 | |
| 0019904 | |
| 0004725 | |
| 0000077 | |
| 0000187 | |
| 0007409 | |
| 0042593 | |
| 0042445 | |
| 0009755 | |
| 0006629 | |
| 0051463 | |
| 0060125 | |
| 0046676 | |
| 0048011 | |
| 0035265 | |
| 0046887 | |
| 0009967 | |
| 0006470 | |
| 0040014 | |
| 0046825 | |
| 0048609 | |
| 0007165 | |
| 0006641 | |
| 0005737 | |
| 0005829 | |
| 0005739 | |
| 0043234 | |
| 0005625 | |
| 0016791 | |
| 0004721 | |
| 0016311 | |
| 0046888 | |
| 0030054 | |
| 0005624 | |
| 0001725 | |
| 0005515 | |
| 0007605 | |
| 0004872 | |
| 0004727 | |
| 0007242 |
| Rat chromosome position | 12q16 |
|---|
| Swiss-Prot Accession | Q06124 |
|---|---|
| Q16344 | |
| Q96I26 | |
| P35235 | |
| Q05C78 | |
| Q63848 | |
| Q9CT18 | |
| P41499 | |
| Q62987 | |
| Q9QWQ8 | |
| A8K1D9 | |
| Q96HD7 | |
| Q62626 | |
| Q3TQ84 | |
| Q64509 | |
| Q6PCL5 |
| PIR ID | JN0805 |
|---|---|
| A53593 | |
| A46209 |
| Unigene ID | Hs.506852 |
|---|---|
| Mm.8681 | |
| Rn.98209 | |
| Hs.646231 | |
| Mm.474046 | |
| Mm.470687 | |
| Mm.400440 | |
| Mm.432246 | |
| Bt.18947 | |
| Dr.104919 | |
| Mm.456884 |
| KEGG ID | hsa:5781 |
|---|---|
| mmu:19247 | |
| rno:25622 |
| EC Number | 3.1.3.48 |
|---|
| Swiss-Prot ID | PTN11_HUMAN |
|---|---|
| PTN11_RAT | |
| PTN11_MOUSE | |
| A8K1D9_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00298347 |
|---|---|
| IPI00658002 | |
| IPI00658023 | |
| IPI00324561 | |
| IPI00563975 | |
| IPI00116554 | |
| IPI00316479 | |
| IPI00063246 |
| Homologene ID | 2122 |
|---|
| RGD ID | 3447 |
|---|
| MGI ID | 99511 |
|---|---|
| 1919896 |
| Microarray ID | 102874_at |
|---|---|
| 212610_at |
| FunctionalClass | hydrolase |
|---|---|
| non-membrane spanning protein tyrosine phosphatase | |
| protein binding | |
| phosphoprotein phosphatase | |
| protein tyrosine phosphatase | |
| receptor | |
| prenylated protein tyrosine phosphatase | |
| phosphoric monoester hydrolase | |
| phospholipase binding |
| Mus musculus Chromosome position | 5 F |
|---|
| Source | Curated |
|---|---|
| ResNet | |
| GO component | |
| RGD modified |
| KEGG pathway | Adipocytokine signaling pathway |
|---|---|
| Chronic myeloid leukemia | |
| Jak-STAT signaling pathway | |
| Leukocyte transendothelial migration | |
| Natural killer cell mediated cytotoxicity | |
| Renal cell carcinoma |
| Homo sapiens Chromosome position | 12q24 |
|---|---|
| 12 | |
| 12q24.21 |
| Rattus norvegicus Chromosome position | 12q16 |
|---|