| URN | urn:agi-Binding:inout-urn:agi-llid:3667:inout-urn:agi-llid:2885::unknown |
|---|---|
| References | 240 |
| Connectivity | 2 |
| Effect | unknown |
| TextRef | info:pmid/12917346#abs:6 |
|---|---|
| MedLine Reference | 12917346:5 |
| Sentence | However, the IRS-1/Grb2 complex was unaffected by chronic morphine treatment. |
| Organism | Mus musculus |
| TextRef | info:pmid/9607818#abs:2 |
|---|---|
| MedLine Reference | 9607818:1 |
| Sentence | Both Shc and IRS-1 associate with Growth Factor Receptor-Bound protein 2 (Grb2), an adaptor molecule. |
| Organism | Rattus norvegicus |
| TextRef | info:pmid/7648365#abs:11 |
|---|---|
| MedLine Reference | 7648365:10 |
| Sentence | The phosphorylated IRS-1 also associates Grb2, as does the phosphorylated Shc. |
| CellType | adipocyte |
| Tissue | Skeletal muscle |
| TextRef | info:pmid/17129375#abs:12 |
|---|---|
| MedLine Reference | 17129375:11 |
| Sentence | The interaction of Grb2 with IRS-1 progressively increased in response to IGF-1 in OA Obs whereas this was absent in normal Ob. |
| TextRef | info:pmid/10537317#body:387 |
|---|---|
| MedLine Reference | 10537317:1386 |
| Sentence | The latter pathway could also be activated by the binding of Grb2 to IRS-1 (17) . |
| Organism | mouse |
| Journal | Cancer Res |
| Journal Reference | v59 i20 p5331 (1999) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/59/20/5331 |
| Source | Curated |
| TextRef | info:pmid/9326223#body:35 |
|---|---|
| MedLine Reference | 9326223:1034 |
| Sentence | Association of Grb-2 with IRS-1 during insulin, but not IFN-alpha stimulation. |
| Organism | mouse |
| Tissue | hematological |
| Journal | Blood |
| Journal Reference | v90 i7 p2574 (1997) |
| Journal Link | http://www.bloodjournal.org/cgi/content/full/90/7/2574 |
| Source | Curated |
| TextRef | info:pmid/17129375#abs:16 |
|---|---|
| MedLine Reference | 17129375:15 |
| Sentence | This is mostly linked with abnormal IRS-1/Syp and IRS-1/Grb2 interaction in these cells. |
| TextRef | info:pmid/11559746#body:664 |
|---|---|
| MedLine Reference | 11559746:1663 |
| Sentence | PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model. |
| Journal | Cell Sci |
| Journal Reference | v114 i13 p2375 (1997) |
| Journal Link | http://jcs.biologists.org/cgi/content/full/114/13/2375 |
| Source | Curated |
| TextRef | info:pmid/10924365#abs:4 |
|---|---|
| MedLine Reference | 10924365:3 |
| Organism | Rattus norvegicus |
| CellType | adipocyte |
| TextRef | info:pmid/7651388#abs:5 |
|---|---|
| MedLine Reference | 7651388:4 |
| CellLineName | A960 |
| TextRef | info:pmid/16267404#abs:3 |
|---|---|
| MedLine Reference | 16267404:2 |
| CellLineName | SK-N-BE(2) |
| TextRef | info:pmid/8828504#abs:4 |
|---|---|
| MedLine Reference | 8828504:3 |
| Organism | Rattus norvegicus |
| CellType | fibroblast |
| CellLineName | Rat1 |
| TextRef | info:pmid/10188734#abs:6 |
|---|---|
| MedLine Reference | 10188734:5 |
| CellLineName | MCF7 |
| TextRef | info:pmid/15344880#abs:6 |
|---|---|
| MedLine Reference | 15344880:5 |
| Organism | Mus musculus |
| CellType | fibroblast |
| TextRef | info:pmid/11259577#abs:9 |
|---|---|
| MedLine Reference | 11259577:8 |
| Organism | Mus musculus |
| CellType | adipocyte |
| TextRef | info:pmid/7983051#abs:7 |
|---|---|
| MedLine Reference | 7983051:6 |
| TextRef | info:pmid/8007950#abs:8 |
|---|---|
| MedLine Reference | 8007950:7 |
| Organism | Rattus norvegicus |
| CellLineName | CHO |
| TextRef | info:pmid/7486683#abs:7 |
|---|---|
| MedLine Reference | 7486683:6 |
| Organism | Mus musculus |
| TextRef | info:pmid/12086960#abs:5 |
|---|---|
| MedLine Reference | 12086960:4 |
| Organism | Rattus norvegicus |
| TextRef | info:pmid/8491186#abs:6 |
|---|---|
| MedLine Reference | 8491186:5 |
| TextRef | info:pmid/8864852#abs:10 |
|---|---|
| MedLine Reference | 8864852:9 |
| Organ | Liver |
| Organism | Rattus norvegicus |
| TextRef | info:pmid/8144662#abs:5 |
|---|---|
| MedLine Reference | 8144662:4 |
| Organism | Rattus norvegicus |
| CellType | fibroblast |
| CellLineName | Rat1 |
| TextRef | info:pmid/8114695#abs:10 |
|---|---|
| MedLine Reference | 8114695:9 |
| Organism | Mus musculus |
| TextRef | info:pmid/8621590#abs:8 |
|---|---|
| MedLine Reference | 8621590:7 |
| Organism | Mus musculus |
| TextRef | info:pmid/8662827#abs:5 |
|---|---|
| MedLine Reference | 8662827:4 |
| Organism | Mus musculus |
| CellLineName | NIH 3T3 |
| TextRef | info:pmid/12173038#abs:9 |
|---|---|
| MedLine Reference | 12173038:8 |
| Organism | Mus musculus |
| CellLineName | R/R |
| TextRef | info:pmid/8282127#abs:3 |
|---|---|
| MedLine Reference | 8282127:2 |
| TextRef | info:pmid/7862167#abs:2 |
|---|---|
| MedLine Reference | 7862167:1 |
| Organism | Mus musculus |
| TextRef | info:pmid/8647950#abs:5 |
|---|---|
| MedLine Reference | 8647950:4 |
| CellType | Myeloid Progenitor |
| CellLineName | 32D |
| TextRef | info:pmid/7893993#abs:9 |
|---|---|
| MedLine Reference | 7893993:8 |
| TextRef | info:pmid/8196603#abs:3 |
|---|---|
| MedLine Reference | 8196603:2 |
| Organism | Rattus norvegicus |
| TextRef | info:pmid/7543044#abs:6 |
|---|---|
| MedLine Reference | 7543044:5 |
| CellLineName | CHO |
| TextRef | info:pmid/10594015#abs:3 |
|---|---|
| MedLine Reference | 10594015:2 |
| CellType | Myeloid Progenitor |
| CellLineName | 32D |
| TextRef | info:pmid/9822703#abs:11 |
|---|---|
| MedLine Reference | 9822703:10 |
| CellLineName | 293 |
| TextRef | info:pmid/11230180#abs:5 |
|---|---|
| MedLine Reference | 11230180:4 |
| CellLineName | MCF7 |
| Tissue | epithelia |
| TextRef | info:pmid/8910437#abs:4 |
|---|---|
| MedLine Reference | 8910437:3 |
| Organism | Mus musculus |
| CellLineName | NIH 3T3 |
| TextRef | info:pmid/8316835#abs:7 |
|---|---|
| MedLine Reference | 8316835:6 |
| TextRef | info:pmid/9605931#abs:7 |
|---|---|
| MedLine Reference | 9605931:6 |
| Organism | Rattus norvegicus |
| CellType | adipocyte |
| TextRef | info:pmid/9205064#abs:7 |
|---|---|
| MedLine Reference | 9205064:6 |
| CellLineName | MCF7 |
| TextRef | info:pmid/14687662#abs:3 |
|---|---|
| MedLine Reference | 14687662:2 |
| Organism | Mus musculus |
| CellType | adipocyte |
| CellLineName | 3T3 L1 |
| TextRef | info:pmid/11676840#abs:7 |
|---|---|
| MedLine Reference | 11676840:6 |
| Organ | Skin |
| Organism | Rattus norvegicus |
| TextRef | info:pmid/11694516#cont:247 |
|---|---|
| MedLine Reference | 11694516:10246 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i2 p1076 |
| Journal Link | http://www.jbc.org/cgi/content/full/277/2/1076 |
| TextRef | info:pmid/12960006#cont:153 |
|---|---|
| MedLine Reference | 12960006:10152 |
| Organism | Mus musculus |
| Journal | Endocrinology |
| Journal Reference | v144 i12 p5604 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/144/12/5604 |
| TextRef | info:pmid/9553137#cont:229 |
|---|---|
| MedLine Reference | 9553137:10228 |
| Journal | J. Biol. Chem |
| Journal Reference | v273 i17 p10726 |
| Journal Link | http://www.jbc.org/cgi/content/full/273/17/10726 |
| TextRef | info:pmid/11390373#cont:198 |
|---|---|
| MedLine Reference | 11390373:10197 |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i33 p31422 |
| Journal Link | http://www.jbc.org/cgi/content/full/276/33/31422 |
| TextRef | info:pmid/9083103#cont:167 |
|---|---|
| MedLine Reference | 9083103:10166 |
| Organism | Rattus norvegicus |
| Journal | J. Biol. Chem |
| Journal Reference | v272 i14 p9581 |
| Journal Link | http://www.jbc.org/cgi/content/full/272/14/9581 |
| TextRef | info:pmid/9915848#abs:5 |
|---|---|
| MedLine Reference | 9915848:4 |
| Organism | Mus musculus |
| CellLineName | L6 |
| Tissue | muscle |
| TextRef | info:pmid/12560071#abs:2 |
|---|---|
| MedLine Reference | 12560071:1 |
| CellLineName | K 562 |
| TextRef | info:pmid/10537317#cont:386 |
|---|---|
| MedLine Reference | 10537317:10385 |
| Organism | Mus musculus |
| Journal | Cancer Res |
| Journal Reference | v59 i20 p5331 |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/59/20/5331 |
| TextRef | info:pmid/9003010#cont:168 |
|---|---|
| MedLine Reference | 9003010:10167 |
| Journal | Endocrinology |
| Journal Reference | v138 i2 p741 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/138/2/741 |
| TextRef | info:pmid/9326223#cont:35 |
|---|---|
| MedLine Reference | 9326223:10034 |
| Organism | Mus musculus |
| Journal | Blood |
| Journal Reference | v90 i7 p2574 |
| Journal Link | http://www.bloodjournal.org/cgi/content/full/90/7/2574 |
| TextRef | info:pmid/8943955#cont:233 |
|---|---|
| MedLine Reference | 8943955:10232 |
| Organism | Mus musculus |
| Journal | Circulation Res |
| Journal Reference | v79 i6 p1167 |
| Journal Link | http://circres.ahajournals.org/cgi/content/full/79/6/1167 |
| TextRef | info:pmid/9886807#cont:95 |
|---|---|
| MedLine Reference | 9886807:10094 |
| Organism | Rattus norvegicus |
| Journal | Endocrinology |
| Journal Reference | v140 i1 p55 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/140/1/55 |
| TextRef | info:pmid/9006905#cont:177 |
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| MedLine Reference | 9006905:10176 |
| Organism | Rattus norvegicus |
| Journal | J. Biol. Chem |
| Journal Reference | v272 i5 p2688 |
| Journal Link | http://www.jbc.org/cgi/content/full/272/5/2688 |
| TextRef | info:pmid/9280068#cont:24 |
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| MedLine Reference | 9280068:10023 |
| Organism | Rattus norvegicus |
| Journal | Mol. Endocrin |
| Journal Reference | v11 i10 p1532 |
| Journal Link | http://mend.endojournals.org/cgi/content/full/11/10/1532 |
| TextRef | info:pmid/7559579#cont:123 |
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| MedLine Reference | 7559579:10122 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v270 i42 p24670 |
| Journal Link | http://www.jbc.org/cgi/content/full/270/42/24670 |
| TextRef | info:pmid/11724768#cont:481 |
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| MedLine Reference | 11724768:10480 |
| Organism | Rattus norvegicus |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i7 p5667 |
| Journal Link | http://www.jbc.org/cgi/content/full/277/7/5667 |
| TextRef | info:pmid/7541045#cont:159 |
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| MedLine Reference | 7541045:10158 |
| Journal | J. Biol. Chem |
| Journal Reference | v270 i26 p15639 |
| Journal Link | http://www.jbc.org/cgi/content/full/270/26/15639 |
| TextRef | info:pmid/8631859#cont:126 |
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| MedLine Reference | 8631859:10125 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v271 i18 p10583 |
| Journal Link | http://www.jbc.org/cgi/content/full/271/18/10583 |
| TextRef | info:pmid/12388170#cont:43 |
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| MedLine Reference | 12388170:10042 |
| Organism | Mus musculus |
| Journal | Endocrin. Metabol |
| Journal Reference | v284 i1 pE47 |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/284/1/E47 |
| TextRef | info:pmid/8824290#cont:157 |
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| MedLine Reference | 8824290:10156 |
| Organism | Rattus norvegicus |
| Journal | J. Biol. Chem |
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| Journal Link | http://www.jbc.org/cgi/content/full/271/42/26356 |
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| MedLine Reference | 8910363:10107 |
| Journal | J. Biol. Chem |
| Journal Reference | v271 i44 p27707 |
| Journal Link | http://www.jbc.org/cgi/content/full/271/44/27707 |
| TextRef | info:pmid/15272025#abs:7 |
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| MedLine Reference | 15272025:6 |
| Organism | Mus musculus |
| TextRef | info:pmid/7935386#abs:5 |
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| MedLine Reference | 7935386:4 |
| CellLineName | CHO |
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| MedLine Reference | 9468545:10033 |
| Journal | J. Biol. Chem |
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| Journal Link | http://www.jbc.org/cgi/content/full/273/8/4800 |
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| MedLine Reference | 9202243:10176 |
| Organism | Mus musculus |
| Journal | Endocrinology |
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| Journal Link | http://endo.endojournals.org/cgi/content/full/138/7/2979 |
| TextRef | info:pmid/11872675#cont:185 |
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| MedLine Reference | 11872675:10184 |
| Organism | Mus musculus |
| Journal | Diabetes |
| Journal Reference | v51 i3 p743 |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/51/3/743 |
| TextRef | info:pmid/12700235#cont:29 |
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| Organism | Rattus norvegicus |
| Journal | Mol. Endocrin |
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| Organism | Mus musculus |
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| Journal Link | http://endo.endojournals.org/cgi/content/full/142/7/3098 |
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| Journal | J. Cell Biol |
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| Organism | Mus musculus |
| Journal | Endocrinology |
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| MedLine Reference | 10847583:10146 |
| Organism | Mus musculus |
| Journal | Mol. Endocrin |
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| Journal Link | http://mend.endojournals.org/cgi/content/full/14/6/805 |
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| MedLine Reference | 10092867:10228 |
| Organism | Mus musculus |
| Journal | Eur. J. Biochem |
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| Journal Link | http://www.ejbiochem.org/cgi/content/full/259/3/801 |
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| Journal | Endocrinology |
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| Journal Link | http://endo.endojournals.org/cgi/content/full/141/4/1289 |
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| Organism | Mus musculus |
| Journal | J. Biol. Chem |
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| Organism | Mus musculus |
| Journal | Endocrinology |
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| Journal Link | http://endo.endojournals.org/cgi/content/full/139/4/1638 |
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| Journal | Mol. Cell. Biol |
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| Journal Link | http://mcb.asm.org/cgi/content/full/21/15/5082 |
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| Journal | Mol. Endocrin |
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| Organism | Rattus norvegicus |
| Journal | Endocrinology |
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| Journal | Mol. Cell. Biol |
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